Klhdc7b (kelch domain containing 7B) - Rat Genome Database

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Gene: Klhdc7b (kelch domain containing 7B) Rattus norvegicus
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Symbol: Klhdc7b
Name: kelch domain containing 7B
RGD ID: 1562257
Description: Orthologous to human KLHDC7B (kelch domain containing 7B); INTERACTS WITH bisphenol A; 4,4'-sulfonyldiphenol (ortholog); benzene-1,2,4-triol (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: kelch domain-containing protein 7B; LOC300150; RGD1562257; similar to hypothetical protein BC009980
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27120,452,081 - 120,455,737 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7120,453,932 - 120,455,737 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7122,203,577 - 122,207,233 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07124,429,731 - 124,433,387 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07124,392,448 - 124,396,104 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07130,357,589 - 130,359,529 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7130,357,643 - 130,359,448 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07130,042,825 - 130,044,630 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47127,681,681 - 127,683,486 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7116,926,841 - 116,928,781 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Klhdc7b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27120,452,081 - 120,455,737 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7120,453,932 - 120,455,737 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7122,203,577 - 122,207,233 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07124,429,731 - 124,433,387 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07124,392,448 - 124,396,104 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07130,357,589 - 130,359,529 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7130,357,643 - 130,359,448 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07130,042,825 - 130,044,630 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47127,681,681 - 127,683,486 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7116,926,841 - 116,928,781 (+)NCBICelera
Cytogenetic Map7q34NCBI
KLHDC7B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382250,545,899 - 50,551,023 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2250,545,899 - 50,551,023 (+)EnsemblGRCh38hg38GRCh38
GRCh372250,984,328 - 50,989,452 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362249,333,328 - 49,335,409 (+)NCBINCBI36Build 36hg18NCBI36
Celera2234,862,494 - 34,865,484 (+)NCBICelera
Cytogenetic Map22q13.33NCBI
HuRef2233,877,486 - 33,880,476 (+)NCBIHuRef
CHM1_12250,945,155 - 50,948,145 (+)NCBICHM1_1
T2T-CHM13v2.02251,056,466 - 51,061,530 (+)NCBIT2T-CHM13v2.0
Klhdc7b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391589,268,262 - 89,274,025 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1589,269,120 - 89,273,070 (+)EnsemblGRCm39 Ensembl
GRCm381589,384,059 - 89,389,822 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1589,384,917 - 89,388,867 (+)EnsemblGRCm38mm10GRCm38
MGSCv371589,217,322 - 89,219,139 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361589,212,684 - 89,216,475 (+)NCBIMGSCv36mm8
Celera1591,516,029 - 91,517,846 (+)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1544.87NCBI
Klhdc7b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541333,534,794 - 33,536,614 (+)NCBIChiLan1.0ChiLan1.0
KLHDC7B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12263,156,559 - 63,161,639 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02230,792,136 - 30,797,297 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12249,902,965 - 49,908,006 (+)NCBIpanpan1.1PanPan1.1panPan2
KLHDC7B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11016,772,594 - 16,775,506 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1016,750,383 - 16,754,844 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01017,499,142 - 17,503,603 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11017,223,444 - 17,234,300 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01017,546,486 - 17,550,947 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01017,678,672 - 17,683,134 (-)NCBIUU_Cfam_GSD_1.0
Klhdc7b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945281,412 - 286,093 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936629282,194 - 284,017 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHDC7B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl5202,137 - 203,951 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.15202,137 - 203,951 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25110,576,801 - 110,578,615 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLHDC7B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11933,020,849 - 33,022,961 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604592,318,563 - 92,324,913 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhdc7b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624752235,932 - 238,153 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Klhdc7b
17 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:127
Count of miRNA genes:102
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000040769
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1582240Sffal1Serum free fatty acids level QTL 13.40.0021blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)7116677010124049952Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)7116677189127103496Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

nervous system reproductive system respiratory system
High
Medium
Low 1
Below cutoff 6 6 1

Sequence


RefSeq Acc Id: ENSRNOT00000040769   ⟹   ENSRNOP00000049515
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7120,453,932 - 120,455,737 (+)Ensembl
Rnor_6.0 Ensembl7130,357,643 - 130,359,448 (+)Ensembl
RefSeq Acc Id: NM_001399730   ⟹   NP_001386659
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27120,452,081 - 120,455,737 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001386659 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000049515.3
RefSeq Acc Id: ENSRNOP00000049515   ⟸   ENSRNOT00000040769
RefSeq Acc Id: NP_001386659   ⟸   NM_001399730

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M150-F1-model_v2 AlphaFold F1M150 1-601 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562257 AgrOrtholog
BioCyc Gene G2FUF-32437 BioCyc
Ensembl Genes ENSRNOG00000032419 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040769.4 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.80 UniProtKB/TrEMBL
InterPro Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
KEGG Report rno:300150 UniProtKB/TrEMBL
NCBI Gene 300150 ENTREZGENE
PANTHER BTB_2 DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  KELCH DOMAIN-CONTAINING PROTEIN 7B UniProtKB/TrEMBL
Pfam Kelch_1 UniProtKB/TrEMBL
PhenoGen Klhdc7b PhenoGen
RatGTEx ENSRNOG00000032419 RatGTEx
SMART Kelch UniProtKB/TrEMBL
Superfamily-SCOP SSF117281 UniProtKB/TrEMBL
UniProt F1M150_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-29 Klhdc7b  kelch domain containing 7B  RGD1562257_predicted  similar to hypothetical protein BC009980 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562257_predicted  similar to hypothetical protein BC009980 (predicted)  LOC300150  similar to hypothetical protein BC009980  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC300150  similar to hypothetical protein BC009980      Symbol and Name status set to provisional 70820 PROVISIONAL