Adm2 (adrenomedullin 2) - Rat Genome Database

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Gene: Adm2 (adrenomedullin 2) Rattus norvegicus
Analyze
Symbol: Adm2
Name: adrenomedullin 2
RGD ID: 1302971
Description: Predicted to enable hormone activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; feeding behavior; and negative regulation of blood pressure. Predicted to be located in extracellular region. Orthologous to human ADM2 (adrenomedullin 2); INTERACTS WITH (+)-schisandrin B; (S)-nicotine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Imd; intermedin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87122,272,808 - 122,274,594 (+)NCBIGRCr8
mRatBN7.27120,393,179 - 120,394,965 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7120,393,179 - 120,396,331 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7122,143,940 - 122,145,726 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07124,370,097 - 124,371,883 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07124,332,702 - 124,334,473 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07130,296,895 - 130,298,641 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7130,296,897 - 130,298,644 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07129,982,196 - 129,983,942 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47127,620,056 - 127,621,802 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17127,654,285 - 127,656,032 (+)NCBI
Celera7116,867,020 - 116,868,766 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes. Roh J, etal., J Biol Chem 2004 Feb 20;279(8):7264-74. Epub 2003 Nov 13.
6. Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator. Takei Y, etal., FEBS Lett 2004 Jan 2;556(1-3):53-8.
Additional References at PubMed
PMID:15652657   PMID:16002435   PMID:16227344   PMID:16269457   PMID:16412533   PMID:16434024   PMID:17218418   PMID:17437045   PMID:18299255   PMID:18418734   PMID:18692436   PMID:18768374  
PMID:18829738   PMID:19041918   PMID:19592612   PMID:19681873   PMID:19910445   PMID:19947495   PMID:20351561   PMID:20462970   PMID:20596610   PMID:21180135   PMID:21186603   PMID:21640761  
PMID:21816966   PMID:21881857   PMID:22009752   PMID:22244813   PMID:23018870   PMID:23165766   PMID:23442365   PMID:23750251   PMID:23777472   PMID:24006303   PMID:24218431   PMID:24709972  
PMID:24872434   PMID:25102228   PMID:25395681   PMID:26014968   PMID:26136070   PMID:26927337   PMID:27737007   PMID:28805491   PMID:29053988   PMID:29128104   PMID:30472381   PMID:33204068  
PMID:33300086   PMID:35175495   PMID:37879153  


Genomics

Comparative Map Data
Adm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87122,272,808 - 122,274,594 (+)NCBIGRCr8
mRatBN7.27120,393,179 - 120,394,965 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7120,393,179 - 120,396,331 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7122,143,940 - 122,145,726 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07124,370,097 - 124,371,883 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07124,332,702 - 124,334,473 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07130,296,895 - 130,298,641 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7130,296,897 - 130,298,644 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07129,982,196 - 129,983,942 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47127,620,056 - 127,621,802 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17127,654,285 - 127,656,032 (+)NCBI
Celera7116,867,020 - 116,868,766 (+)NCBICelera
Cytogenetic Map7q34NCBI
ADM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382250,481,543 - 50,486,437 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2250,481,543 - 50,486,440 (+)EnsemblGRCh38hg38GRCh38
GRCh372250,919,972 - 50,924,866 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362249,266,878 - 49,271,732 (+)NCBINCBI36Build 36hg18NCBI36
Build 342249,210,351 - 49,215,008NCBI
Celera2234,796,024 - 34,800,900 (+)NCBICelera
Cytogenetic Map22q13.33NCBI
HuRef2233,810,454 - 33,815,251 (+)NCBIHuRef
CHM1_12250,878,723 - 50,883,626 (+)NCBICHM1_1
T2T-CHM13v2.02250,990,725 - 50,995,619 (+)NCBIT2T-CHM13v2.0
Adm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391589,206,923 - 89,208,934 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1589,206,923 - 89,208,934 (+)EnsemblGRCm39 Ensembl
GRCm381589,322,720 - 89,324,731 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1589,322,720 - 89,324,731 (+)EnsemblGRCm38mm10GRCm38
MGSCv371589,153,403 - 89,155,162 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361589,150,739 - 89,152,498 (+)NCBIMGSCv36mm8
Celera1591,452,072 - 91,453,831 (+)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1544.81NCBI
Adm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541333,465,982 - 33,466,953 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541333,460,975 - 33,469,935 (+)NCBIChiLan1.0ChiLan1.0
ADM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22360,402,232 - 60,408,712 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12263,092,660 - 63,099,138 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02230,729,236 - 30,734,801 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12249,715,342 - 49,719,989 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2249,715,342 - 49,719,989 (+)Ensemblpanpan1.1panPan2
ADM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11016,818,026 - 16,822,463 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1016,816,319 - 16,820,440 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1016,795,539 - 16,799,886 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01017,543,911 - 17,546,431 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1017,544,092 - 17,546,500 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11017,268,576 - 17,272,924 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01017,591,785 - 17,596,133 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01017,723,835 - 17,728,183 (-)NCBIUU_Cfam_GSD_1.0
Adm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945360,451 - 367,145 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936629360,305 - 362,846 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936629360,845 - 362,499 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl5253,396 - 255,601 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.15254,397 - 255,478 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25110,520,845 - 110,529,768 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11932,951,199 - 32,953,251 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1932,952,115 - 32,953,157 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604592,387,682 - 92,389,447 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624752294,451 - 298,616 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624752294,451 - 302,405 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adm2
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:53
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000044854
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)7116677189127103496Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
1582240Sffal1Serum free fatty acids level QTL 13.40.0021blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)7116677010124049952Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 21
Low 2 14 45 37 19 37 14 23 1
Below cutoff 1 9 5 4 4 1 1 27 11 10 1

Sequence


Ensembl Acc Id: ENSRNOT00000044854   ⟹   ENSRNOP00000051266
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7120,393,179 - 120,396,331 (+)Ensembl
Rnor_6.0 Ensembl7130,296,897 - 130,298,644 (+)Ensembl
RefSeq Acc Id: NM_201426   ⟹   NP_958829
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,272,808 - 122,274,594 (+)NCBI
mRatBN7.27120,393,179 - 120,394,965 (+)NCBI
Rnor_6.07130,296,895 - 130,298,641 (+)NCBI
Rnor_5.07129,982,196 - 129,983,942 (+)NCBI
RGSC_v3.47127,620,056 - 127,621,802 (+)RGD
Celera7116,867,020 - 116,868,766 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_958829 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT01302 (Get FASTA)   NCBI Sequence Viewer  
  BAD07413 (Get FASTA)   NCBI Sequence Viewer  
  BAD22678 (Get FASTA)   NCBI Sequence Viewer  
  EDL76556 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051266.1
  ENSRNOP00055016522
  ENSRNOP00060040649
GenBank Protein P61312 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_958829   ⟸   NM_201426
- Peptide Label: preproprotein
- UniProtKB: Q6L5N4 (UniProtKB/Swiss-Prot),   P61312 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051266   ⟸   ENSRNOT00000044854

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61312-F1-model_v2 AlphaFold P61312 1-146 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695581
Promoter ID:EPDNEW_R6106
Type:initiation region
Name:Adm2_1
Description:adrenomedullin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07130,296,902 - 130,296,962EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1302971 AgrOrtholog
BioCyc Gene G2FUF-32449 BioCyc
Ensembl Genes ENSRNOG00000029830 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055012076 UniProtKB/Swiss-Prot
  ENSRNOG00060028063 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000044854.3 UniProtKB/Swiss-Prot
  ENSRNOT00055020521 UniProtKB/Swiss-Prot
  ENSRNOT00060048738 UniProtKB/Swiss-Prot
KEGG Report rno:399475 UniProtKB/Swiss-Prot
NCBI Gene 399475 ENTREZGENE
PANTHER ADRENOMEDULLIN, ADM UniProtKB/Swiss-Prot
  PROTEIN ADM2 UniProtKB/Swiss-Prot
PhenoGen Adm2 PhenoGen
RatGTEx ENSRNOG00000029830 RatGTEx
  ENSRNOG00055012076 RatGTEx
  ENSRNOG00060028063 RatGTEx
UniProt A6K7L3_RAT UniProtKB/TrEMBL
  ADM2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6L5N4 ENTREZGENE
UniProt Secondary Q6L5N4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-11-17 Adm2  adrenomedullin 2      Symbol and Name status set to approved 1299863 APPROVED
2005-02-14 Adm2  adrenomedullin 2      Symbol and Name status set to provisional 70820 PROVISIONAL