Krt1 (keratin 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Krt1 (keratin 1) Rattus norvegicus
Analyze
Symbol: Krt1
Name: keratin 1
RGD ID: 1359664
Description: Predicted to enable carbohydrate binding activity and protein heterodimerization activity. Predicted to be a structural constituent of skin epidermis. Predicted to be involved in several processes, including complement activation, lectin pathway; keratinization; and protein heterotetramerization. Predicted to act upstream of or within establishment of skin barrier and negative regulation of inflammatory response. Predicted to be located in cytoplasm and membrane. Predicted to be active in cornified envelope and keratin filament. Human ortholog(s) of this gene implicated in KRT1-related nonepidermolytic palmoplantar keratoderma; epidermolytic hyperkeratosis; epidermolytic hyperkeratosis 1; epidermolytic palmoplantar keratoderma 2; and keratosis palmoplantaris striata 3. Orthologous to human KRT1 (keratin 1); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; arsane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CK-1; cytokeratin-1; K1; Kb1; keratin 1, type II; keratin, type II cytoskeletal 1; keratin-1; type II keratin Kb1; type-II keratin Kb1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,855,311 - 134,860,537 (-)NCBIGRCr8
mRatBN7.27132,976,618 - 132,981,844 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,976,620 - 132,981,844 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,737,926 - 134,743,154 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,967,444 - 136,972,672 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,946,099 - 136,951,327 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,448,318 - 143,453,544 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,448,318 - 143,453,544 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,245,846 - 141,251,072 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,540,960 - 140,546,186 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,617,874 - 140,622,575 (-)NCBI
Celera7129,414,872 - 129,420,098 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Krt1Ratepidermolytic hyperkeratosis susceptibilityISOKRT1 (Homo sapiens)1600166DNA:mutation: and 5191/5192GG>ARGD 
1 to 14 of 14 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Krt1RatAnnular Epidermolytic Ichthyosis  ISOKRT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Annular epidermolytic ichthyosisClinVarPMID:10053007 more ...
Krt1RatAnnular Epidermolytic Ichthyosis 1  ISOKRT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Ichthyosis and annular epidermolytic 1ClinVarPMID:25741868
Krt1RatAnnular Epidermolytic Ichthyosis 2  ISOKRT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Ichthyosis more ...ClinVarPMID:10053007 more ...
Krt1Ratbullous congenital ichthyosiform erythroderma  ISOKRT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital bullous ichthyosiform erythrodermaClinVarPMID:12406348 more ...
Krt1Ratepidermolytic hyperkeratosis  ISOKRT1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12406348 more ...
Krt1Ratepidermolytic hyperkeratosis 1  ISOKRT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Epidermolytic hyperkeratosis 1ClinVarPMID:25741868 more ...
Krt1Ratepidermolytic palmoplantar keratoderma 2  ISOKRT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Palmoplantar keratoderma more ...ClinVarPMID:11286630 more ...
Krt1Ratgenetic disease  ISOKRT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28492532
Krt1Ratichthyosis  ISOKRT1 (Homo sapiens)8554872ClinVar Annotator: match by term: IchthyosisClinVarPMID:25741868
Krt1RatIchthyosis Hystrix, Curth Macklin Type  ISOKRT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Ichthyosis hystrix and Curth Macklin typeClinVarPMID:16417221 more ...
Krt1Ratkeratosis palmoplantaris striata 3  ISOKRT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Keratosis palmoplantaris striata 3ClinVar 
Krt1Ratnonepidermolytic palmoplantar keratoderma  ISOKRT1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:19470048 more ...
Krt1Ratprostate cancer  ISOKRT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant tumor of prostateClinVarPMID:23265383
Krt1RatReticular Erythrokeratoderma  ISOKRT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital reticular ichthyosiform erythrodermaClinVarPMID:25774499
1 to 14 of 14 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Krt1Ratepidermolytic hyperkeratosis  ISOKRT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Krt1RatIchthyosis Hystrix, Curth Macklin Type  ISOKRT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Krt1Ratkeratosis  ISOKRT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35363433
Krt1Ratkeratosis palmoplantaris striata 3  ISOKRT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Krt1Ratnonepidermolytic palmoplantar keratoderma  ISOKRT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Krt1RatSkin Neoplasms  ISOKRT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18572023
Krt1Ratsquamous cell carcinoma  ISOKRT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18572023
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Krt1Ratepidermolytic hyperkeratosis  ISSKrt1 (Mus musculus)13592920 MouseDO 

1 to 20 of 130 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Krt1Rat(-)-epigallocatechin 3-gallate decreases expressionISOKRT1 (Homo sapiens)6480464epigallocatechin gallate results in decreased expression of KRT1 proteinCTDPMID:31195006
Krt1Rat(5Z,8Z,11Z,13E)-15-HETE multiple interactionsISOKrt1 (Mus musculus)648046415-hydroxy-5 more ...CTDPMID:12069687
Krt1Rat1,2-dimethylhydrazine decreases expressionISOKrt1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of KRT1 mRNACTDPMID:22206623
Krt1Rat17alpha-ethynylestradiol affects expressionISOKrt1 (Mus musculus)6480464Ethinyl Estradiol affects the expression of KRT1 mRNACTDPMID:17555576
Krt1Rat17beta-estradiol multiple interactionsISOKRT1 (Homo sapiens)6480464fulvestrant inhibits the reaction [Estradiol results in decreased expression of KRT1 mRNA]CTDPMID:28701262
Krt1Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of KRT1 mRNACTDPMID:32145629
Krt1Rat17beta-estradiol decreases expressionISOKRT1 (Homo sapiens)6480464Estradiol results in decreased expression of KRT1 mRNACTDPMID:28701262
Krt1Rat17beta-hydroxy-17-methylestra-4,9,11-trien-3-one decreases expressionISOKRT1 (Homo sapiens)6480464Metribolone results in decreased expression of KRT1 proteinCTDPMID:17152098
Krt1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOKRT1 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of KRT1 mRNACTDPMID:9525283
Krt1Rat2,6-dimethoxyphenol multiple interactionsISOKRT1 (Homo sapiens)6480464[pyrogallol 1 more ...CTDPMID:38598786
Krt1Rat2-bromohexadecanoic acid multiple interactionsISOKRT1 (Homo sapiens)64804642-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of KRT1 protein]CTDPMID:38195004
Krt1Rat5-fluorouracil affects expressionISOKrt1 (Mus musculus)6480464Fluorouracil affects the expression of KRT1 proteinCTDPMID:21296659
Krt1Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of KRT1 mRNACTDPMID:24780913
Krt1Rat7,12-dimethyltetraphene increases expressionISOKrt1 (Mus musculus)64804649 more ...CTDPMID:38307155
Krt1Rat9-cis-retinoic acid decreases expressionISOKRT1 (Homo sapiens)6480464Alitretinoin results in decreased expression of KRT1 mRNACTDPMID:15982314
Krt1Ratacetic acid decreases expressionISOKrt1 (Mus musculus)6480464Acetic Acid results in decreased expression of KRT1 proteinCTDPMID:21296659
Krt1Ratall-trans-4-oxoretinoic acid decreases expressionISOKRT1 (Homo sapiens)64804644-oxoretinoic acid results in decreased expression of KRT1 mRNACTDPMID:15982314
Krt1Ratall-trans-retinoic acid increases expressionISOKRT1 (Homo sapiens)6480464Tretinoin metabolite results in increased expression of KRT1 mRNACTDPMID:15982314
Krt1Ratall-trans-retinoic acid multiple interactionsISOKrt1 (Mus musculus)6480464[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of KRT1 mRNACTDPMID:36189433
Krt1Ratall-trans-retinoic acid decreases expressionISOKRT1 (Homo sapiens)6480464Tretinoin results in decreased expression of KRT1 mRNACTDPMID:15982314

1 to 20 of 130 rows

Biological Process
1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Krt1Ratbiological_process  ND 159840702/2007: no relevant rat dataRGD 
Krt1Ratcomplement activation, lectin pathway involved_inIEAUniProtKB:P04264 and ensembl:ENSP000002522441600115GO_REF:0000107EnsemblGO_REF:0000107
Krt1Ratcomplement activation, lectin pathway involved_inISOKRT1 (Homo sapiens)1624291UniProtKB:P11226 and PMID:11549596RGDPMID:11549596
Krt1Ratestablishment of skin barrier acts_upstream_of_or_withinISOKrt1 (Mus musculus)1624291MGI:5495252 PMID:23132931RGDPMID:23132931
Krt1Ratestablishment of skin barrier acts_upstream_of_or_withinIEAUniProtKB:P04104 and ensembl:ENSMUSP000000237901600115GO_REF:0000107EnsemblGO_REF:0000107
Krt1Ratintermediate filament organization involved_inIBAMGI:1100845 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Krt1Ratkeratinization involved_inIBAMGI:1100845 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Krt1Ratnegative regulation of inflammatory response acts_upstream_of_or_withinIEAUniProtKB:P04104 and ensembl:ENSMUSP000000237901600115GO_REF:0000107EnsemblGO_REF:0000107
Krt1Ratnegative regulation of inflammatory response acts_upstream_of_or_withinISOKrt1 (Mus musculus)1624291MGI:107936 more ...RGDPMID:23132931
Krt1Ratpeptide cross-linking involved_inISOKRT1 (Homo sapiens)1624291 PMID:7543090RGDPMID:7543090
Krt1Ratprotein heterotetramerization involved_inIEAUniProtKB:P04264 and ensembl:ENSP000002522441600115GO_REF:0000107EnsemblGO_REF:0000107
Krt1Ratprotein heterotetramerization involved_inISOKRT1 (Homo sapiens)1624291 PMID:27595935RGDPMID:27595935
Krt1Ratprotein heterotetramerization involved_inISSUniProtKB:P042641600115GO_REF:0000024UniProtGO_REF:0000024
1 to 13 of 13 rows

Cellular Component
1 to 20 of 21 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Krt1Ratcornified envelope located_inIEAUniProtKB:P04264 and ensembl:ENSP000002522441600115GO_REF:0000107EnsemblGO_REF:0000107
Krt1Ratcornified envelope is_active_inISOKrt1 (Mus musculus)1624291 PMID:26644517RGDPMID:26644517
Krt1Ratcornified envelope is_active_inIEAUniProtKB:P04104 and ensembl:ENSMUSP000000237901600115GO_REF:0000107EnsemblGO_REF:0000107
Krt1Ratcornified envelope located_inISOKRT1 (Homo sapiens)1624291 PMID:7543090RGDPMID:7543090
Krt1Ratcytoplasm located_inISOKRT1 (Homo sapiens)1624291 PMID:32179842RGDPMID:32179842
Krt1Ratcytoplasm located_inIEAUniProtKB:P04264 and ensembl:ENSP000002522441600115GO_REF:0000107EnsemblGO_REF:0000107
Krt1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Krt1Ratcytoplasm located_inISSUniProtKB:P042641600115GO_REF:0000024UniProtGO_REF:0000024
Krt1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Krt1Ratintermediate filament located_inIEAUniProtKB-KW:KW-0403 and UniProtKB-KW:KW-04161600115GO_REF:0000043UniProtGO_REF:0000043
Krt1Ratkeratin filament located_inIEAUniProtKB:P04104 and ensembl:ENSMUSP000000237901600115GO_REF:0000107EnsemblGO_REF:0000107
Krt1Ratkeratin filament located_inISOKrt1 (Mus musculus)1624291 PMID:2404337RGDPMID:2404337
Krt1Ratkeratin filament located_inISOKRT1 (Homo sapiens)1624291 PMID:27595935RGDPMID:27595935
Krt1Ratkeratin filament is_active_inIBAMGI:1861586 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Krt1Ratkeratin filament located_inIEAUniProtKB:P04264 and ensembl:ENSP000002522441600115GO_REF:0000107EnsemblGO_REF:0000107
Krt1Ratkeratin filament located_inIEAInterPro:IPR0030541600115GO_REF:0000002InterProGO_REF:0000002
Krt1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Krt1Ratmembrane located_inIEAUniProtKB:P04264 and ensembl:ENSP000002522441600115GO_REF:0000107EnsemblGO_REF:0000107
Krt1Ratmembrane located_inISOKRT1 (Homo sapiens)1624291 PMID:11290596RGDPMID:11290596
Krt1Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
1 to 20 of 21 rows

Molecular Function
1 to 10 of 10 rows

  
1 to 10 of 10 rows


1 to 9 of 9 rows
#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, etal., Eur J Cell Biol 2004 Feb;83(1):19-26.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Evidence for novel functions of the keratin tail emerging from a mutation causing ichthyosis hystrix. Sprecher E, etal., J Invest Dermatol. 2001 Apr;116(4):511-9.
9. Comparative analysis of gene expression between renal cortex and papilla in nedaplatin-induced nephrotoxicity in rats. Uehara T, etal., Hum Exp Toxicol. 2007 Oct;26(10):767-80.
1 to 9 of 9 rows
PMID:2404337   PMID:7543090   PMID:11290596   PMID:11487543   PMID:11549596   PMID:12477932   PMID:15057822   PMID:16903783   PMID:19199708   PMID:19946888   PMID:21630459   PMID:22082260  
PMID:22516433   PMID:22664934   PMID:23132931   PMID:23376485   PMID:23533145   PMID:23580065   PMID:23658023   PMID:23904609   PMID:26316108   PMID:27595935   PMID:32920982  



Krt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,855,311 - 134,860,537 (-)NCBIGRCr8
mRatBN7.27132,976,618 - 132,981,844 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,976,620 - 132,981,844 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,737,926 - 134,743,154 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,967,444 - 136,972,672 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,946,099 - 136,951,327 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,448,318 - 143,453,544 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,448,318 - 143,453,544 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,245,846 - 141,251,072 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,540,960 - 140,546,186 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,617,874 - 140,622,575 (-)NCBI
Celera7129,414,872 - 129,420,098 (-)NCBICelera
Cytogenetic Map7q36NCBI
KRT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,674,736 - 52,680,407 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,674,736 - 52,680,407 (-)EnsemblGRCh38hg38GRCh38
GRCh371253,068,520 - 53,074,191 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,354,787 - 51,360,458 (-)NCBINCBI36Build 36hg18NCBI36
Build 341251,354,718 - 51,360,446NCBI
Celera1252,714,762 - 52,720,433 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,112,373 - 50,118,022 (-)NCBIHuRef
CHM1_11253,035,321 - 53,040,992 (-)NCBICHM1_1
T2T-CHM13v2.01252,639,281 - 52,644,932 (-)NCBIT2T-CHM13v2.0
Krt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,753,861 - 101,759,221 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,753,861 - 101,759,229 (-)EnsemblGRCm39 Ensembl
GRCm3815101,845,426 - 101,850,786 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,845,426 - 101,850,794 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715101,675,857 - 101,681,217 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,673,548 - 101,678,828 (-)NCBIMGSCv36mm8
Celera15103,996,811 - 104,002,171 (-)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1557.06NCBI
Krt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545825,187 - 29,208 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545825,193 - 29,282 (-)NCBIChiLan1.0ChiLan1.0
LOC100970659
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21041,516,329 - 41,521,992 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11241,513,092 - 41,518,755 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01236,083,858 - 36,089,521 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11236,861,585 - 36,867,167 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,861,585 - 36,866,725 (+)Ensemblpanpan1.1panPan2
KRT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,422,150 - 2,427,160 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2743,826,847 - 43,831,858 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,422,007 - 2,427,021 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1272,438,328 - 2,443,333 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,423,403 - 2,428,399 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,225,282 - 44,230,293 (-)NCBIUU_Cfam_GSD_1.0
Krt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,074,440 - 63,080,066 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651210,084,763 - 10,090,414 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651210,084,764 - 10,090,312 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,012,925 - 18,018,582 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,012,922 - 18,018,582 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,506,173 - 18,511,790 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KRT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,810,671 - 48,817,436 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1148,810,677 - 48,816,363 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037197,255,673 - 197,261,492 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Krt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624904802,460 - 807,469 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624904801,979 - 816,463 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Krt1
24 total Variants

Predicted Target Of
Summary Value
Count of predictions:216
Count of miRNA genes:139
Interacting mature miRNAs:154
Transcripts:ENSRNOT00000034450
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 15 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat

1 to 10 of 15 rows
RH143261  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map71067.4UniSTS
Cytogenetic Map7q36UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 8 49 108 85 88 57 19 57 6 191 86 92 37 40 31



Ensembl Acc Id: ENSRNOT00000034450   ⟹   ENSRNOP00000029276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,976,620 - 132,981,844 (-)Ensembl
Rnor_6.0 Ensembl7143,448,318 - 143,453,544 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083956   ⟹   ENSRNOP00000073248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,977,096 - 132,981,844 (-)Ensembl
RefSeq Acc Id: NM_001008802   ⟹   NP_001008802
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,855,311 - 134,860,537 (-)NCBI
mRatBN7.27132,976,618 - 132,981,844 (-)NCBI
Rnor_6.07143,448,318 - 143,453,544 (-)NCBI
Rnor_5.07141,245,846 - 141,251,072 (-)NCBI
RGSC_v3.47140,540,960 - 140,546,186 (-)RGD
Celera7129,414,872 - 129,420,098 (-)RGD
Sequence:
Protein RefSeqs NP_001008802 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI27465 (Get FASTA)   NCBI Sequence Viewer  
  CAA38577 (Get FASTA)   NCBI Sequence Viewer  
  DAA02055 (Get FASTA)   NCBI Sequence Viewer  
  EDL86877 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000029276
GenBank Protein Q6IMF3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001008802   ⟸   NM_001008802
- UniProtKB: Q63115 (UniProtKB/Swiss-Prot),   A1L113 (UniProtKB/Swiss-Prot),   Q6IMF3 (UniProtKB/Swiss-Prot),   A0A0G2JST3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000029276   ⟸   ENSRNOT00000034450
Ensembl Acc Id: ENSRNOP00000073248   ⟸   ENSRNOT00000083956
IF rod

Name Modeler Protein Id AA Range Protein Structure
AF-Q6IMF3-F1-model_v2 AlphaFold Q6IMF3 1-625 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 35 of 35 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-31961 BioCyc
Ensembl Genes ENSRNOG00000028996 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000034450 ENTREZGENE
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  Single helix bin UniProtKB/Swiss-Prot
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8370075 IMAGE-MGC_LOAD
InterPro IF_conserved UniProtKB/Swiss-Prot
  IF_rod_dom UniProtKB/Swiss-Prot
  Keratin_2_1_tail UniProtKB/Swiss-Prot
  Keratin_2_head UniProtKB/Swiss-Prot
  Keratin_II UniProtKB/Swiss-Prot
KEGG Report rno:300250 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156535 IMAGE-MGC_LOAD
NCBI Gene 300250 ENTREZGENE
PANTHER GATA-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  KERATIN, TYPE II CYTOSKELETAL 1 UniProtKB/Swiss-Prot
Pfam Filament UniProtKB/Swiss-Prot
  Keratin_2_head UniProtKB/Swiss-Prot
  Keratin_2_tail UniProtKB/Swiss-Prot
PhenoGen Krt1 PhenoGen
PRINTS TYPE2KERATIN UniProtKB/Swiss-Prot
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot
  IF_ROD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000028996 RatGTEx
SMART Filament UniProtKB/Swiss-Prot
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot
UniProt A0A0G2JST3 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K509_RAT UniProtKB/TrEMBL
  A1L113 ENTREZGENE
  K2C1_RAT UniProtKB/Swiss-Prot
  Q63115 ENTREZGENE
  Q6IMF3 ENTREZGENE
UniProt Secondary A1L113 UniProtKB/Swiss-Prot
  Q63115 UniProtKB/Swiss-Prot
1 to 35 of 35 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Krt1  keratin 1  Krt1  keratin 1, type II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-28 Krt1  keratin 1, type II  Krt1  keratin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Krt1  keratin 1  Kb1  type II keratin Kb1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Kb1  type II keratin Kb1      Symbol and Name status set to approved 1299863 APPROVED
2005-07-29 Kb1  type II keratin Kb1      Symbol and Name status set to provisional 70820 PROVISIONAL