KRT1 (keratin 1) - Rat Genome Database

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Gene: KRT1 (keratin 1) Canis lupus familiaris
Analyze
Symbol: KRT1
Name: keratin 1
RGD ID: 12230450
Description: ENCODES a protein that exhibits carbohydrate binding (ortholog); protein heterodimerization activity (ortholog); structural constituent of skin epidermis (ortholog); INVOLVED IN complement activation, lectin pathway (ortholog); establishment of skin barrier (ortholog); negative regulation of inflammatory response (ortholog); ASSOCIATED WITH Cyclic Ichthyosis with Epidermolytic Hyperkeratosis (ortholog); epidermolytic hyperkeratosis (ortholog); Epidermolytic Hyperkeratosis, Late-Onset (ortholog); FOUND IN cornified envelope (ortholog); cytoplasm (ortholog); INTERACTS WITH clofibrate
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CK-1; cytokeratin-1; epithelial keratin 1; K1; KER1; keratin 1 (epidermolytic hyperkeratosis); keratin, type II cytoskeletal 1; type-II keratin Kb1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,422,150 - 2,427,160 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2743,826,847 - 43,831,858 (-)NCBI
ROS_Cfam_1.0272,422,007 - 2,427,021 (+)NCBI
UMICH_Zoey_3.1272,438,328 - 2,443,333 (+)NCBI
UNSW_CanFamBas_1.0272,423,403 - 2,428,399 (+)NCBI
UU_Cfam_GSD_1.02744,225,282 - 44,230,293 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
clofibrate  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:15627753  


Genomics

Comparative Map Data
KRT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,422,150 - 2,427,160 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2743,826,847 - 43,831,858 (-)NCBI
ROS_Cfam_1.0272,422,007 - 2,427,021 (+)NCBI
UMICH_Zoey_3.1272,438,328 - 2,443,333 (+)NCBI
UNSW_CanFamBas_1.0272,423,403 - 2,428,399 (+)NCBI
UU_Cfam_GSD_1.02744,225,282 - 44,230,293 (-)NCBI
KRT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,674,736 - 52,680,407 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1252,674,736 - 52,680,407 (-)EnsemblGRCh38hg38GRCh38
GRCh371253,068,520 - 53,074,191 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,354,787 - 51,360,458 (-)NCBINCBI36hg18NCBI36
Build 341251,354,718 - 51,360,446NCBI
Celera1252,714,762 - 52,720,433 (-)NCBI
Cytogenetic Map12q13.13NCBI
HuRef1250,112,373 - 50,118,022 (-)NCBIHuRef
CHM1_11253,035,321 - 53,040,992 (-)NCBICHM1_1
T2T-CHM13v2.01252,639,281 - 52,644,932 (-)NCBI
Krt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,753,861 - 101,759,221 (-)NCBIGRCm39mm39
GRCm39 Ensembl15101,753,861 - 101,759,229 (-)Ensembl
GRCm3815101,845,426 - 101,850,786 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,845,426 - 101,850,794 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715101,675,857 - 101,681,217 (-)NCBIGRCm37mm9NCBIm37
MGSCv3615101,673,548 - 101,678,828 (-)NCBImm8
Celera15103,996,811 - 104,002,171 (-)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1557.06NCBI
Krt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27132,976,618 - 132,981,844 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl7132,976,620 - 132,981,844 (-)Ensembl
Rnor_6.07143,448,318 - 143,453,544 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,448,318 - 143,453,544 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,245,846 - 141,251,072 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,540,960 - 140,546,186 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17140,617,874 - 140,622,575 (-)NCBI
Celera7129,414,872 - 129,420,098 (-)NCBICelera
Cytogenetic Map7q36NCBI
Krt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545825,187 - 29,208 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545825,193 - 29,282 (-)NCBIChiLan1.0ChiLan1.0
LOC100970659
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11236,861,585 - 36,867,167 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,861,585 - 36,866,725 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01236,083,858 - 36,089,521 (+)NCBIMhudiblu_PPA_v0panPan3
Krt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,074,440 - 63,080,066 (+)NCBI
SpeTri2.0NW_00493651210,084,764 - 10,090,312 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,012,925 - 18,018,582 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,012,922 - 18,018,582 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,506,173 - 18,511,790 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KRT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,810,671 - 48,817,436 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1148,810,677 - 48,816,363 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037197,255,673 - 197,261,492 (+)NCBIVero_WHO_p1.0
Krt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624904802,460 - 807,469 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624904801,979 - 816,463 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_001003392   ⟹   NP_001003392
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1272,422,150 - 2,427,160 (+)NCBI
Dog10K_Boxer_Tasha2743,826,847 - 43,831,858 (-)NCBI
ROS_Cfam_1.0272,422,007 - 2,427,021 (+)NCBI
UMICH_Zoey_3.1272,438,328 - 2,443,333 (+)NCBI
UNSW_CanFamBas_1.0272,423,403 - 2,428,399 (+)NCBI
UU_Cfam_GSD_1.02744,225,282 - 44,230,293 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001003392 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ83910 (Get FASTA)   NCBI Sequence Viewer  
  Q6EIY9 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001003392   ⟸   NM_001003392
- UniProtKB: Q6EIY9 (UniProtKB/Swiss-Prot)
- Sequence:
Protein Domains
IF rod

Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
27 2423987 2423988 G A snv Greater Swiss Mountain Dog (SH008)
27 2426018 2426019 C T snv Kunming Dog (KM5), Iranian Wolf (SRS661488)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00030020537 UniProtKB/TrEMBL
  ENSCAFG00040023563 UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030033022.1 UniProtKB/TrEMBL
  ENSCAFP00030033118.1 UniProtKB/TrEMBL
  ENSCAFP00030033176.1 UniProtKB/TrEMBL
  ENSCAFP00030033205.1 UniProtKB/TrEMBL
  ENSCAFP00030033268.1 UniProtKB/TrEMBL
  ENSCAFP00030033327.1 UniProtKB/TrEMBL
  ENSCAFP00030033369.1 UniProtKB/TrEMBL
  ENSCAFP00030033426.1 UniProtKB/TrEMBL
  ENSCAFP00040038381 UniProtKB/TrEMBL
  ENSCAFP00040038418 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030037842.1 UniProtKB/TrEMBL
  ENSCAFT00030037959.1 UniProtKB/TrEMBL
  ENSCAFT00030038024.1 UniProtKB/TrEMBL
  ENSCAFT00030038062.1 UniProtKB/TrEMBL
  ENSCAFT00030038133.1 UniProtKB/TrEMBL
  ENSCAFT00030038205.1 UniProtKB/TrEMBL
  ENSCAFT00030038256.1 UniProtKB/TrEMBL
  ENSCAFT00030038319.1 UniProtKB/TrEMBL
  ENSCAFT00040043971 UniProtKB/TrEMBL
  ENSCAFT00040044011 UniProtKB/TrEMBL
InterPro IF_conserved UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_rod_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Keratin_2_1_tail UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Keratin_2_head UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Keratin_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:444857 UniProtKB/Swiss-Prot
NCBI Gene KRT1 ENTREZGENE
Pfam Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Keratin_2_head UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Keratin_2_tail UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TYPE2KERATIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_ROD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0NXC2_CANLF UniProtKB/TrEMBL
  A0A8C0NY99_CANLF UniProtKB/TrEMBL
  A0A8C0P216_CANLF UniProtKB/TrEMBL
  A0A8C0P4P0_CANLF UniProtKB/TrEMBL
  A0A8C0P564_CANLF UniProtKB/TrEMBL
  A0A8C0PDE3_CANLF UniProtKB/TrEMBL
  A0A8C0TMD9_CANLF UniProtKB/TrEMBL
  A0A8C0TQZ9_CANLF UniProtKB/TrEMBL
  K2C1_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:42515 ENTREZGENE