Fignl2 (fidgetin-like 2) - Rat Genome Database

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Gene: Fignl2 (fidgetin-like 2) Rattus norvegicus
Analyze
Symbol: Fignl2
Name: fidgetin-like 2
RGD ID: 1566321
Description: Predicted to enable ATP binding activity and ATP hydrolysis activity. Involved in negative regulation of axon regeneration. Predicted to be located in cell leading edge. Orthologous to human FIGNL2 (fidgetin like 2); INTERACTS WITH 6-propyl-2-thiouracil; methoxychlor; Monobutylphthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AABR07058914.1; fidgetin-like protein 2; LOC102555469; LOC300238; putative fidgetin-like protein 2; putative fidgetin-like protein 2-like; RGD1566321; similar to fidgetin-like 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,038,734 - 134,066,626 (-)NCBIGRCr8
mRatBN7.27132,160,006 - 132,187,896 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,162,390 - 132,164,336 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7133,961,636 - 133,989,506 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,191,152 - 136,219,022 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,101,893 - 136,129,789 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0155,127,315 - 5,133,550 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,694,759 - 142,696,347 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.07140,494,661 - 140,501,240 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,805,382 - 139,807,381 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7128,628,426 - 128,651,176 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration. Baker L, etal., JCI Insight. 2021 May 10;6(9):e138484. doi: 10.1172/jci.insight.138484.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Fignl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,038,734 - 134,066,626 (-)NCBIGRCr8
mRatBN7.27132,160,006 - 132,187,896 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,162,390 - 132,164,336 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7133,961,636 - 133,989,506 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,191,152 - 136,219,022 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,101,893 - 136,129,789 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0155,127,315 - 5,133,550 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,694,759 - 142,696,347 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.07140,494,661 - 140,501,240 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,805,382 - 139,807,381 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7128,628,426 - 128,651,176 (-)NCBICelera
Cytogenetic Map7q36NCBI
FIGNL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381251,817,899 - 51,848,718 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1251,817,899 - 51,848,718 (-)EnsemblGRCh38hg38GRCh38
GRCh371252,211,683 - 52,242,502 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,497,943 - 50,502,475 (-)NCBINCBI36Build 36hg18NCBI36
Celera1251,013,783 - 51,018,315 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1249,244,544 - 49,258,562 (-)NCBIHuRef
CHM1_11252,178,134 - 52,192,159 (-)NCBICHM1_1
T2T-CHM13v2.01251,781,425 - 51,812,316 (-)NCBIT2T-CHM13v2.0
Fignl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915100,948,075 - 100,976,465 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15100,948,075 - 100,976,448 (-)EnsemblGRCm39 Ensembl
GRCm3815101,050,192 - 101,078,584 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,050,194 - 101,078,567 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715100,882,896 - 100,884,830 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615100,879,984 - 100,882,439 (-)NCBIMGSCv36mm8
Celera15103,199,310 - 103,201,244 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.39NCBI
Fignl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555472,205,614 - 2,234,417 (-)NCBIChiLan1.0ChiLan1.0
FIGNL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21042,346,719 - 42,377,486 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11242,343,492 - 42,374,250 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01236,914,415 - 36,945,018 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11237,698,429 - 37,718,699 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1237,716,039 - 37,718,001 (+)Ensemblpanpan1.1panPan2
FIGNL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,138,800 - 3,168,264 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2743,091,187 - 43,117,719 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0273,135,508 - 3,162,038 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1273,152,136 - 3,178,852 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0273,138,359 - 3,164,826 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,489,583 - 43,516,095 (-)NCBIUU_Cfam_GSD_1.0
Fignl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,870,170 - 63,877,428 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365129,289,926 - 9,291,931 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365129,287,391 - 9,293,741 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FIGNL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl517,180,773 - 17,182,743 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1517,178,239 - 17,209,297 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2517,773,665 - 17,787,384 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FIGNL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,010,951 - 48,021,889 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037198,070,808 - 198,101,348 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fignl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624816487,821 - 489,773 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624816464,601 - 493,218 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fignl2
97 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000044982   ⟹   ENSRNOP00000092082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,162,390 - 132,164,336 (-)Ensembl
RefSeq Acc Id: NM_001401883   ⟹   NP_001388812
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,038,740 - 134,066,626 (-)NCBI
mRatBN7.27132,160,006 - 132,187,896 (-)NCBI
RefSeq Acc Id: XM_063262858   ⟹   XP_063118928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,038,734 - 134,066,366 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001388812 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118928 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000092082
  ENSRNOP00000092082.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000092082   ⟸   ENSRNOT00000044982
RefSeq Acc Id: NP_001388812   ⟸   NM_001401883
- UniProtKB: A0A8I6AGW3 (UniProtKB/TrEMBL),   A6KCM6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118928   ⟸   XM_063262858
- Peptide Label: isoform X1
Protein Domains
AAA+ ATPase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566321 AgrOrtholog
Ensembl Genes ENSRNOG00000032026 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044982 ENTREZGENE
  ENSRNOT00000044982.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.60 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  ATPase_AAA_core UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene Fignl2 ENTREZGENE
PANTHER AAA DOMAIN-CONTAINING UniProtKB/TrEMBL
  FIDGETIN-LIKE PROTEIN 2 UniProtKB/TrEMBL
Pfam AAA UniProtKB/TrEMBL
PhenoGen Fignl2 PhenoGen
RatGTEx ENSRNOG00000032026 RatGTEx
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6AGW3 ENTREZGENE, UniProtKB/TrEMBL
  A6KCM6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Fignl2  fidgetin-like 2  AABR07058914.1    Data merged from RGD:15003924 737654 PROVISIONAL
2021-03-09 Fignl2  fidgetin-like 2  LOC102555469  putative fidgetin-like protein 2-like  Data merged from RGD:7552859 737654 PROVISIONAL
2019-11-08 AABR07058914.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2013-12-17 LOC102555469  putative fidgetin-like protein 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-09 Fignl2  fidgetin-like 2  RGD1566321  similar to fidgetin-like 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1566321  similar to fidgetin-like 1   RGD1566321_predicted  similar to fidgetin-like 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1566321_predicted  similar to fidgetin-like 1 (predicted)  LOC300238  similar to fidgetin-like 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC300238  similar to fidgetin-like 1      Symbol and Name status set to provisional 70820 PROVISIONAL