Krt83 (keratin 83) - Rat Genome Database

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Gene: Krt83 (keratin 83) Rattus norvegicus
Analyze
Symbol: Krt83
Name: keratin 83
RGD ID: 1303024
Description: Predicted to be a structural constituent of skin epidermis. Predicted to be involved in hair cycle; intermediate filament organization; and keratinization. Predicted to be located in intermediate filament. Predicted to be active in keratin filament. Human ortholog(s) of this gene implicated in breast cancer; erythrokeratodermia variabilis et progressiva 5; hair disease; and monilethrix. Orthologous to several human genes including KRT81 (keratin 81); KRT83 (keratin 83); and KRT86 (keratin 86); INTERACTS WITH 2-bromohexadecanoic acid (ortholog); arsane (ortholog); arsenic atom (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Kb23; type II keratin 23; type II keratin Kb23
RGD Orthologs
Human
Mouse
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,482,911 - 134,489,600 (-)NCBIGRCr8
mRatBN7.27132,604,180 - 132,610,869 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,604,128 - 132,610,799 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,405,898 - 134,412,585 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,635,422 - 136,642,105 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,545,244 - 136,551,957 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,134,980 - 143,141,659 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,135,074 - 143,141,589 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,935,551 - 140,942,097 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,235,288 - 140,241,803 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,311,724 - 140,318,240 (-)NCBI
Celera7129,067,226 - 129,073,737 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, etal., Eur J Cell Biol 2004 Feb;83(1):19-26.
3. The hairless phenotype of the Hirosaki hairless rat is due to the deletion of an 80-kb genomic DNA containing five basic keratin genes. Nanashima N, etal., J Biol Chem. 2008 Jun 13;283(24):16868-75. Epub 2008 Apr 16.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:25002582  


Genomics

Comparative Map Data
Krt83
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,482,911 - 134,489,600 (-)NCBIGRCr8
mRatBN7.27132,604,180 - 132,610,869 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,604,128 - 132,610,799 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,405,898 - 134,412,585 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,635,422 - 136,642,105 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,545,244 - 136,551,957 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,134,980 - 143,141,659 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,135,074 - 143,141,589 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,935,551 - 140,942,097 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,235,288 - 140,241,803 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,311,724 - 140,318,240 (-)NCBI
Celera7129,067,226 - 129,073,737 (-)NCBICelera
Cytogenetic Map7q36NCBI
KRT83
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,314,301 - 52,321,398 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,314,301 - 52,321,398 (-)EnsemblGRCh38hg38GRCh38
GRCh371252,708,085 - 52,715,182 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,994,352 - 51,001,438 (-)NCBINCBI36Build 36hg18NCBI36
Build 341250,994,351 - 51,001,438NCBI
Cytogenetic Map12q13.13NCBI
HuRef1249,741,813 - 49,743,633 (-)NCBIHuRef
HuRef1249,751,738 - 49,758,855 (-)NCBIHuRef
CHM1_11252,674,734 - 52,681,831 (-)NCBICHM1_1
T2T-CHM13v2.01252,278,221 - 52,285,323 (-)NCBIT2T-CHM13v2.0
Krt83
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,383,011 - 101,389,393 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,383,011 - 101,389,393 (-)EnsemblGRCm39 Ensembl
GRCm3815101,485,130 - 101,491,512 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,485,130 - 101,491,512 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715101,315,561 - 101,321,937 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,303,909 - 101,310,414 (+)NCBIMGSCv36mm8
Celera15103,633,781 - 103,640,158 (-)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1556.9NCBI
KRT83
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21041,873,704 - 41,880,741 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11241,870,404 - 41,877,504 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01236,441,225 - 36,448,317 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11237,218,229 - 37,225,324 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1237,218,286 - 37,224,994 (+)Ensemblpanpan1.1panPan2

Variants

.
Variants in Krt83
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:93
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000068505
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 3 2 17 13 17 3 5 3 2 25 9 14 1 27 14

Sequence


Ensembl Acc Id: ENSRNOT00000068505   ⟹   ENSRNOP00000059981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,604,284 - 132,610,799 (-)Ensembl
Rnor_6.0 Ensembl7143,135,074 - 143,141,589 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077207   ⟹   ENSRNOP00000075208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,604,284 - 132,610,799 (-)Ensembl
Rnor_6.0 Ensembl7143,135,074 - 143,141,589 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093094   ⟹   ENSRNOP00000079111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,604,920 - 132,610,799 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098914   ⟹   ENSRNOP00000078891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,604,213 - 132,610,799 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102535   ⟹   ENSRNOP00000091396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,604,128 - 132,610,799 (-)Ensembl
RefSeq Acc Id: NM_001389278   ⟹   NP_001376207
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,482,911 - 134,489,600 (-)NCBI
mRatBN7.27132,604,180 - 132,610,869 (-)NCBI
RefSeq Acc Id: XM_039079712   ⟹   XP_038935640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,483,015 - 134,489,530 (-)NCBI
mRatBN7.27132,604,284 - 132,610,793 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001376207 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935640 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAF75860 (Get FASTA)   NCBI Sequence Viewer  
  DAA02222 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000059981.3
  ENSRNOP00000075208.2
  ENSRNOP00000078891.1
  ENSRNOP00000091396.1
Ensembl Acc Id: ENSRNOP00000075208   ⟸   ENSRNOT00000077207
Ensembl Acc Id: ENSRNOP00000059981   ⟸   ENSRNOT00000068505
RefSeq Acc Id: NP_001376207   ⟸   NM_001389278
- UniProtKB: D3ZWS9 (UniProtKB/TrEMBL),   A7M776 (UniProtKB/TrEMBL),   A0A8I6AFC7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935640   ⟸   XM_039079712
- Peptide Label: isoform X1
- UniProtKB: Q6IG08 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078891   ⟸   ENSRNOT00000098914
Ensembl Acc Id: ENSRNOP00000079111   ⟸   ENSRNOT00000093094
Ensembl Acc Id: ENSRNOP00000091396   ⟸   ENSRNOT00000102535
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IG08-F1-model_v2 AlphaFold Q6IG08 1-555 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695681
Promoter ID:EPDNEW_R6200
Type:single initiation site
Name:Kb23_1
Description:type II keratin 23
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,141,649 - 143,141,709EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303024 AgrOrtholog
BioCyc Gene G2FUF-31981 BioCyc
Ensembl Genes ENSRNOG00000030814 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068505.4 UniProtKB/TrEMBL
  ENSRNOT00000077207.2 UniProtKB/TrEMBL
  ENSRNOT00000098914.1 UniProtKB/TrEMBL
  ENSRNOT00000102535.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
  Single helix bin UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/TrEMBL
InterPro IF_rod_dom UniProtKB/TrEMBL
  Intermediate_filament_CS UniProtKB/TrEMBL
  Keratin_2_head UniProtKB/TrEMBL
  Keratin_II UniProtKB/TrEMBL
NCBI Gene 407759 ENTREZGENE
PANTHER GATA-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  KERATIN, TYPE II CUTICULAR HB1 UniProtKB/TrEMBL
Pfam Filament UniProtKB/TrEMBL
  Keratin_2_head UniProtKB/TrEMBL
PhenoGen Krt83 PhenoGen
PRINTS TYPE2KERATIN UniProtKB/TrEMBL
PROSITE IF_ROD_2 UniProtKB/TrEMBL
  PS00226 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030814 RatGTEx
SMART Filament UniProtKB/TrEMBL
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/TrEMBL
UniProt A0A0G2KA07_RAT UniProtKB/TrEMBL
  A0A8I5ZLV7_RAT UniProtKB/TrEMBL
  A0A8I6AFC7 ENTREZGENE, UniProtKB/TrEMBL
  A7M776 ENTREZGENE, UniProtKB/TrEMBL
  D3ZWS9 ENTREZGENE
  Q6IG08 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary D3ZWS9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-21 Krt83  keratin 83  Kb23  type II keratin 23  Name and Symbol changed 629549 APPROVED
2013-07-09 Kb23  type II keratin 23  Kb23  type II keratin Kb23  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-14 Kb23  type II keratin Kb23      Symbol and Name status set to provisional 70820 PROVISIONAL