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Gene: Mlc1 (modulator of VRAC current 1) Rattus norvegicus
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Symbol: Mlc1
Name: modulator of VRAC current 1
Description: Involved in caveolin-mediated endocytosis; cellular response to cholesterol; and protein transport. Localizes to several cellular components, including the caveola; endosome; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in megalencephalic leukoencephalopathy with subcortical cysts 1. Orthologous to human MLC1 (modulator of VRAC current 1); INTERACTS WITH 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC315215; megalencephalic leukoencephalopathy with subcortical cysts 1; megalencephalic leukoencephalopathy with subcortical cysts 1 homolog; megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human); membrane protein MLC1
Orthologs:
Homo sapiens (human) : MLC1 (modulator of VRAC current 1)  HGNC  Alliance
Mus musculus (house mouse) : Mlc1 (megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mlc1 (modulator of VRAC current 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MLC1 (modulator of VRAC current 1)
Canis lupus familiaris (dog) : MLC1 (modulator of VRAC current 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mlc1 (modulator of VRAC current 1)
Sus scrofa (pig) : MLC1 (modulator of VRAC current 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07129,949,984 - 129,970,314 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7129,949,967 - 129,970,550 (-)Ensembl
Rnor_5.07129,636,392 - 129,656,289 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47127,265,491 - 127,288,102 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17127,300,452 - 127,321,877 (-)NCBI
Celera7116,519,839 - 116,540,135 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Mlc1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308552
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.