Dnajb7 (DnaJ heat shock protein family (Hsp40) member B7) - Rat Genome Database

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Gene: Dnajb7 (DnaJ heat shock protein family (Hsp40) member B7) Rattus norvegicus
Analyze
Symbol: Dnajb7
Name: DnaJ heat shock protein family (Hsp40) member B7
RGD ID: 1589047
Description: Predicted to enable protein folding chaperone; protein-folding chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in chaperone-mediated protein folding. Predicted to be active in cytoplasm and nucleus. Orthologous to human DNAJB7 (DnaJ heat shock protein family (Hsp40) member B7); INTERACTS WITH bisphenol A; decabromodiphenyl ether; diclofenac.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DnaJ (Hsp40) homolog, subfamily B, member 7; dnaJ homolog subfamily B member 7; LOC685839; similar to DnaJ homolog subfamily B member 7 (mDJ5)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87114,812,886 - 114,814,200 (-)NCBIGRCr8
mRatBN7.27112,932,736 - 112,934,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7112,932,616 - 112,945,537 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7114,695,085 - 114,696,399 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07116,918,586 - 116,919,900 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07116,887,995 - 116,889,309 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07122,642,740 - 122,644,054 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7122,642,740 - 122,644,054 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07122,619,286 - 122,620,600 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47119,735,945 - 119,737,259 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7109,252,184 - 109,253,498 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21231916  


Genomics

Comparative Map Data
Dnajb7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87114,812,886 - 114,814,200 (-)NCBIGRCr8
mRatBN7.27112,932,736 - 112,934,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7112,932,616 - 112,945,537 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7114,695,085 - 114,696,399 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07116,918,586 - 116,919,900 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07116,887,995 - 116,889,309 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07122,642,740 - 122,644,054 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7122,642,740 - 122,644,054 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07122,619,286 - 122,620,600 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47119,735,945 - 119,737,259 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7109,252,184 - 109,253,498 (-)NCBICelera
Cytogenetic Map7q34NCBI
DNAJB7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382240,859,549 - 40,862,113 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2240,859,549 - 40,862,113 (-)EnsemblGRCh38hg38GRCh38
GRCh372241,255,553 - 41,258,117 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,585,499 - 39,588,076 (-)NCBINCBI36Build 36hg18NCBI36
Build 342239,580,052 - 39,582,630NCBI
Celera2225,059,224 - 25,061,801 (-)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2224,217,586 - 24,220,163 (-)NCBIHuRef
CHM1_12241,214,305 - 41,216,882 (-)NCBICHM1_1
T2T-CHM13v2.02241,331,741 - 41,334,305 (-)NCBIT2T-CHM13v2.0
Dnajb7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391581,291,289 - 81,292,474 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1581,291,127 - 81,292,500 (-)EnsemblGRCm39 Ensembl
GRCm381581,407,088 - 81,408,273 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1581,406,926 - 81,408,299 (-)EnsemblGRCm38mm10GRCm38
MGSCv371581,237,518 - 81,238,703 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361581,234,343 - 81,235,528 (-)NCBIMGSCv36mm8
Celera1583,525,125 - 83,526,310 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.09NCBI
Dnajb7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541326,511,834 - 26,512,849 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541326,510,844 - 26,512,855 (-)NCBIChiLan1.0ChiLan1.0
DNAJB7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22350,681,614 - 50,692,770 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12253,391,456 - 53,392,656 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02221,754,641 - 21,757,204 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12239,850,575 - 39,853,799 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2239,852,079 - 39,853,008 (-)Ensemblpanpan1.1panPan2
DNAJB7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11024,372,364 - 24,373,715 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1024,372,507 - 24,373,436 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1024,305,603 - 24,307,665 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01025,119,157 - 25,121,219 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11024,834,405 - 24,836,467 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01025,155,295 - 25,157,357 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01025,329,675 - 25,331,737 (+)NCBIUU_Cfam_GSD_1.0
Dnajb7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049457,960,172 - 7,961,323 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936492970,645 - 972,294 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNAJB7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.157,574,729 - 7,576,224 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.254,751,120 - 4,756,419 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNAJB7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11923,406,249 - 23,407,805 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045102,154,908 - 102,156,876 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:195
Count of miRNA genes:156
Interacting mature miRNAs:172
Transcripts:ENSRNOT00000025941
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 14 48 74 74 44 25 44 6 157 58 29 38 41 30

Sequence


Ensembl Acc Id: ENSRNOT00000025941   ⟹   ENSRNOP00000060598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7112,932,616 - 112,945,537 (-)Ensembl
Rnor_6.0 Ensembl7122,642,740 - 122,644,054 (-)Ensembl
RefSeq Acc Id: NM_001130510   ⟹   NP_001123982
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,812,886 - 114,814,200 (-)NCBI
mRatBN7.27112,932,736 - 112,934,050 (-)NCBI
Rnor_6.07122,642,740 - 122,644,054 (-)NCBI
Rnor_5.07122,619,286 - 122,620,600 (-)NCBI
RGSC_v3.47119,735,945 - 119,737,259 (-)RGD
Celera7109,252,184 - 109,253,498 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001123982 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM15725 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000060598.1
RefSeq Acc Id: NP_001123982   ⟸   NM_001130510
- UniProtKB: D3ZN46 (UniProtKB/TrEMBL),   A6HSZ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060598   ⟸   ENSRNOT00000025941
Protein Domains
J

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZN46-F1-model_v2 AlphaFold D3ZN46 1-303 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695510
Promoter ID:EPDNEW_R6035
Type:initiation region
Name:Dnajb7_1
Description:DnaJ heat shock protein family member B7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07122,644,079 - 122,644,139EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589047 AgrOrtholog
BioCyc Gene G2FUF-32678 BioCyc
Ensembl Genes ENSRNOG00000019187 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025941.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.110 UniProtKB/TrEMBL
InterPro DnaJ_dom_sf UniProtKB/TrEMBL
  DnaJ_N UniProtKB/TrEMBL
  DNJB2/6-like UniProtKB/TrEMBL
  Heat_shock_DnaJ_CS UniProtKB/TrEMBL
KEGG Report rno:685839 UniProtKB/TrEMBL
NCBI Gene 685839 ENTREZGENE
PANTHER DNAJ HOMOLOG SUBFAMILY B MEMBER 2 UniProtKB/TrEMBL
  SIMILAR TO DNAJ HOMOLOG SUBFAMILY B MEMBER 6 (HEAT SHOCK PROTEIN J2) (HSJ-2) (MRJ) (MDJ4) UniProtKB/TrEMBL
Pfam DnaJ UniProtKB/TrEMBL
PhenoGen Dnajb7 PhenoGen
PRINTS DNAJPROTEIN UniProtKB/TrEMBL
PROSITE DNAJ_1 UniProtKB/TrEMBL
  DNAJ_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019187 RatGTEx
SMART DnaJ UniProtKB/TrEMBL
Superfamily-SCOP DnaJ_N UniProtKB/TrEMBL
UniProt A6HSZ8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZN46 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Dnajb7  DnaJ heat shock protein family (Hsp40) member B7  Dnajb7  DnaJ (Hsp40) homolog, subfamily B, member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Dnajb7  DnaJ (Hsp40) homolog, subfamily B, member 7  LOC685839  similar to DnaJ homolog subfamily B member 7 (mDJ5)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC685839  similar to DnaJ homolog subfamily B member 7 (mDJ5)      Symbol and Name status set to provisional 70820 PROVISIONAL