Txn2 (thioredoxin 2) - Rat Genome Database

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Gene: Txn2 (thioredoxin 2) Rattus norvegicus
Analyze
Symbol: Txn2
Name: thioredoxin 2
RGD ID: 71040
Description: Contributes to peptide-methionine (R)-S-oxide reductase activity; peptide-methionine (S)-S-oxide reductase activity; and protein-disulfide reductase activity. Involved in several processes, including response to axon injury; response to glucose; and response to hypoxia. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 29. Orthologous to human TXN2 (thioredoxin 2); INTERACTS WITH 1,1'-azobis(N,N-dimethylformamide); 4,4'-sulfonyldiphenol; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC93312; mt-Trx; MTRX; thioredoxin mitochondrial; thioredoxin, mitochondrial; thioredoxin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau6
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87111,377,338 - 111,390,940 (-)NCBIGRCr8
mRatBN7.27109,496,772 - 109,510,378 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7109,496,761 - 109,510,359 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7111,246,688 - 111,260,193 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07113,470,248 - 113,483,753 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07113,438,298 - 113,451,891 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07119,144,350 - 119,158,173 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,144,351 - 119,158,201 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07119,139,112 - 119,152,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47115,833,695 - 115,847,690 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17115,867,761 - 115,881,914 (-)NCBI
Celera7105,837,884 - 105,851,486 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(E)-cinnamyl alcohol  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
abexinostat  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
alpha-hexylcinnamaldehyde  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
auranofin  (EXP,ISO)
Bandrowski's base  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
bosentan  (ISO)
brilliant green  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (EXP,ISO)
cinnamyl alcohol  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
corosolic acid  (ISO)
crystal violet  (ISO)
cyclosporin A  (EXP,ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
dimethylarsinic acid  (EXP)
diquat  (ISO)
disulfiram  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (ISO)
etoposide  (ISO)
eugenol  (ISO)
flavonoids  (EXP)
flutamide  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
hydrogen peroxide  (EXP,ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoeugenol  (ISO)
isoniazide  (ISO)
L-ascorbic acid  (EXP)
lipopolysaccharide  (ISO)
liquiritigenin  (EXP)
liquiritin  (EXP)
lycopene  (ISO)
mercury dichloride  (ISO)
methylene blue  (ISO)
monocrotaline  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
peptidoglycan  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phlorizin  (ISO)
potassium dichromate  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
sodium azide  (ISO)
sodium chromate  (ISO)
TCEP  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
toluene  (EXP)
trans-isoeugenol  (ISO)
triapine  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
dendrite  (IDA)
mitochondrion  (IBA,ISO)
neuronal cell body  (IDA)
nucleolus  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system. Aon-Bertolino ML, etal., Biochim Biophys Acta. 2011 Jan;1810(1):93-110. Epub 2010 Jul 8.
2. Gene expression profiling reveals complex changes following MEK-EE expression in cardiac myocytes. Badrian B and Bogoyevitch MA, Int J Biochem Cell Biol. 2007;39(2):349-65. Epub 2006 Sep 14.
3. Redox regulation of resveratrol-mediated switching of death signal into survival signal. Das S, etal., Free Radic Biol Med. 2008 Jan 1;44(1):82-90. Epub 2007 Sep 21.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Severe liver steatosis correlates with nitrosative and oxidative stress in rats. Grattagliano I, etal., Eur J Clin Invest. 2008 Jul;38(7):523-30.
7. Protective effect of tetraethyl pyrazine against focal cerebral ischemia/reperfusion injury in rats: therapeutic time window and its mechanism. Jia J, etal., Thromb Res. 2009 Mar;123(5):727-30. Epub 2009 Jan 6.
8. Thioredoxin as a reducing agent for mammalian methionine sulfoxide reductases B lacking resolving cysteine. Kim HY and Kim JR, Biochem Biophys Res Commun. 2008 Jul 4;371(3):490-4. Epub 2008 Apr 29.
9. Impaired vasodilator activity in deoxycorticosterone acetate-salt hypertension is associated with increased protein O-GlcNAcylation. Lima VV, etal., Hypertension. 2009 Feb;53(2):166-74. Epub 2009 Jan 12.
10. Gene Data Set MGD Curation, June 12, 2002
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Effect of high glucose on gene expression in mesangial cells: upregulation of the thiol pathway is an adaptational response. Morrison J, etal., Physiol Genomics. 2004 May 19;17(3):271-82.
13. Broccoli: a unique vegetable that protects mammalian hearts through the redox cycling of the thioredoxin superfamily. Mukherjee S, etal., J Agric Food Chem. 2008 Jan 23;56(2):609-17. Epub 2007 Dec 29.
14. Protective effect of thioredoxins 1 and 2 in retinal ganglion cells after optic nerve transection and oxidative stress. Munemasa Y, etal., Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3535-43. Epub 2008 Apr 25.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Expression of novel antioxidant thioredoxin-2 in the rat brain. Rybnikova E, etal., Eur J Neurosci. 2000 May;12(5):1669-78.
19. The mitochondrial antioxidants thioredoxin-2 and Mn-superoxide dismutase are involved in the mechanisms of brain hypoxic tolerance. Samoilov MO, etal., Dokl Biol Sci 2002 Nov-Dec;387:498-500.
20. Cloning and expression of a novel mammalian thioredoxin. Spyrou G, etal., J Biol Chem 1997 Jan 31;272(5):2936-41.
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. Preconditioning enhances the expression of mitochondrial antioxidant thioredoxin-2 in the forebrain of rats exposed to severe hypobaric hypoxia. Stroev SA, etal., J Neurosci Res. 2004 Nov 15;78(4):563-9.
23. Characterization of alternative cytosolic forms and cellular targets of mouse mitochondrial thioredoxin reductase. Turanov AA, etal., J Biol Chem. 2006 Aug 11;281(32):22953-63. Epub 2006 Jun 14.
24. N-acetylcysteine reduces lipopolysaccharide-sensitized hypoxic-ischemic brain injury. Wang X, etal., Ann Neurol. 2007 Mar;61(3):263-71.
25. [The change of thioredoxin system in myocardial tissue of type 2 diabetic rats undergoing myocardial injury]. Zhao XQ, etal., Sheng Li Xue Bao. 2010 Jun 25;62(3):261-8.
26. Therapeutic time window and mechanism of tetramethylpyrazine on transient focal cerebral ischemia/reperfusion injury in rats. Zhu XL, etal., Neurosci Lett. 2009 Jan 2;449(1):24-7. Epub 2008 Sep 6.
Additional References at PubMed
PMID:12032145   PMID:14651853   PMID:15489334   PMID:16675629   PMID:17068286   PMID:18614015   PMID:20238036   PMID:20929858   PMID:23949220   PMID:25996168   PMID:26975474   PMID:28529127  
PMID:30236513  


Genomics

Comparative Map Data
Txn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87111,377,338 - 111,390,940 (-)NCBIGRCr8
mRatBN7.27109,496,772 - 109,510,378 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7109,496,761 - 109,510,359 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7111,246,688 - 111,260,193 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07113,470,248 - 113,483,753 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07113,438,298 - 113,451,891 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07119,144,350 - 119,158,173 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,144,351 - 119,158,201 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07119,139,112 - 119,152,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47115,833,695 - 115,847,690 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17115,867,761 - 115,881,914 (-)NCBI
Celera7105,837,884 - 105,851,486 (-)NCBICelera
Cytogenetic Map7q34NCBI
TXN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382236,467,046 - 36,481,640 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2236,467,046 - 36,481,640 (-)EnsemblGRCh38hg38GRCh38
GRCh372236,863,093 - 36,877,687 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,193,039 - 35,207,633 (-)NCBINCBI36Build 36hg18NCBI36
Build 342235,187,592 - 35,202,187NCBI
Celera2220,665,238 - 20,679,833 (-)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2219,831,327 - 19,845,504 (-)NCBIHuRef
CHM1_12236,822,047 - 36,836,640 (-)NCBICHM1_1
T2T-CHM13v2.02236,927,219 - 36,941,813 (-)NCBIT2T-CHM13v2.0
Txn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391577,799,251 - 77,813,194 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1577,799,247 - 77,813,206 (-)EnsemblGRCm39 Ensembl
GRCm381577,915,051 - 77,928,994 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1577,915,047 - 77,929,006 (-)EnsemblGRCm38mm10GRCm38
MGSCv371577,745,481 - 77,759,424 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361577,742,306 - 77,756,249 (-)NCBIMGSCv36mm8
Celera1579,374,296 - 79,388,239 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1536.92NCBI
Txn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541323,041,559 - 23,056,018 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541323,044,866 - 23,056,017 (-)NCBIChiLan1.0ChiLan1.0
TXN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22346,323,599 - 46,338,770 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12249,014,850 - 49,030,016 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02217,384,017 - 17,398,965 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12235,220,721 - 35,235,891 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2235,220,721 - 35,235,877 (-)Ensemblpanpan1.1panPan2
TXN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11027,947,647 - 27,960,634 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1027,948,571 - 27,959,910 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1027,901,673 - 27,914,661 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01028,733,351 - 28,746,338 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11028,461,701 - 28,474,674 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01028,769,602 - 28,782,587 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01028,948,151 - 28,961,119 (+)NCBIUU_Cfam_GSD_1.0
Txn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494511,299,941 - 11,310,299 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364924,311,287 - 4,321,763 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364924,310,394 - 4,320,714 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl511,264,645 - 11,283,395 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1511,264,470 - 11,289,388 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.258,997,069 - 9,010,525 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TXN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11919,168,693 - 19,185,898 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1919,169,286 - 19,185,735 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045106,687,070 - 106,704,531 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Txn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475211,249,656 - 11,260,118 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475211,248,640 - 11,260,118 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Txn2
78 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:304
Count of miRNA genes:163
Interacting mature miRNAs:210
Transcripts:ENSRNOT00000067483
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat

Markers in Region
RH127320  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27109,496,832 - 109,497,027 (+)MAPPERmRatBN7.2
Rnor_6.07119,144,411 - 119,144,605NCBIRnor6.0
Rnor_5.07119,139,173 - 119,139,367UniSTSRnor5.0
RGSC_v3.47115,833,756 - 115,833,950UniSTSRGSC3.4
Celera7105,837,945 - 105,838,139UniSTS
RH 3.4 Map7811.2UniSTS
Cytogenetic Map7q34UniSTS
RH132125  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27109,508,226 - 109,508,411 (+)MAPPERmRatBN7.2
Rnor_6.07119,156,022 - 119,156,206NCBIRnor6.0
Rnor_5.07119,150,784 - 119,150,968UniSTSRnor5.0
RGSC_v3.47115,845,539 - 115,845,723UniSTSRGSC3.4
Celera7105,849,335 - 105,849,519UniSTS
RH 3.4 Map7811.2UniSTS
Cytogenetic Map7q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC081760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U73525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000067483   ⟹   ENSRNOP00000060694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,496,761 - 109,510,359 (-)Ensembl
Rnor_6.0 Ensembl7119,144,351 - 119,158,173 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078528   ⟹   ENSRNOP00000074086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,506,243 - 109,510,359 (-)Ensembl
Rnor_6.0 Ensembl7119,144,351 - 119,158,201 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114822   ⟹   ENSRNOP00000088234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,505,286 - 109,510,359 (-)Ensembl
RefSeq Acc Id: NM_053331   ⟹   NP_445783
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87111,377,338 - 111,390,940 (-)NCBI
mRatBN7.27109,496,772 - 109,510,378 (-)NCBI
Rnor_6.07119,144,350 - 119,158,173 (-)NCBI
Rnor_5.07119,139,112 - 119,152,935 (-)NCBI
RGSC_v3.47115,833,695 - 115,847,690 (-)RGD
Celera7105,837,884 - 105,851,486 (-)RGD
Sequence:
RefSeq Acc Id: NP_445783   ⟸   NM_053331
- Peptide Label: precursor
- UniProtKB: P97615 (UniProtKB/Swiss-Prot),   A6HSH4 (UniProtKB/TrEMBL),   A6HSH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000060694   ⟸   ENSRNOT00000067483
RefSeq Acc Id: ENSRNOP00000074086   ⟸   ENSRNOT00000078528
RefSeq Acc Id: ENSRNOP00000088234   ⟸   ENSRNOT00000114822
Protein Domains
Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97615-F1-model_v2 AlphaFold P97615 1-166 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695453
Promoter ID:EPDNEW_R5978
Type:initiation region
Name:Txn2_1
Description:thioredoxin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07119,158,177 - 119,158,237EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71040 AgrOrtholog
BioCyc Gene G2FUF-32851 BioCyc
Ensembl Genes ENSRNOG00000005614 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055031594 UniProtKB/Swiss-Prot
  ENSRNOG00060029554 UniProtKB/Swiss-Prot
  ENSRNOG00065032853 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000067483 ENTREZGENE
  ENSRNOT00000067483.4 UniProtKB/Swiss-Prot
  ENSRNOT00000078528.2 UniProtKB/TrEMBL
  ENSRNOT00000114822.1 UniProtKB/TrEMBL
  ENSRNOT00055054713 UniProtKB/Swiss-Prot
  ENSRNOT00060051329 UniProtKB/Swiss-Prot
  ENSRNOT00065056481 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7190504 IMAGE-MGC_LOAD
InterPro Thioredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79462 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93312 IMAGE-MGC_LOAD
NCBI Gene 79462 ENTREZGENE
PANTHER THIOREDOXIN, MITOCHONDRIAL UniProtKB/Swiss-Prot
  THIOREDOXIN, MITOCHONDRIAL UniProtKB/Swiss-Prot
  THIOREDOXIN, MITOCHONDRIAL UniProtKB/TrEMBL
  THIOREDOXIN, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam Thioredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Txn2 PhenoGen
PRINTS THIOREDOXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOREDOXIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOREDOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005614 RatGTEx
  ENSRNOG00055031594 RatGTEx
  ENSRNOG00060029554 RatGTEx
  ENSRNOG00065032853 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AIE6_RAT UniProtKB/TrEMBL
  A0A8L2R8B7_RAT UniProtKB/TrEMBL
  A6HSH0 ENTREZGENE, UniProtKB/TrEMBL
  A6HSH1_RAT UniProtKB/TrEMBL
  A6HSH4 ENTREZGENE, UniProtKB/TrEMBL
  P97615 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Txn2  thioredoxin 2      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains the thioredoxin-active site, Trp-Cys-Gly-Pro-Cys, but lacks structural cysteines and has a 60-amino acid extension at the N terminus which may be a mitochondrial translocation signal 70610
gene_expression expressed in heart, muscle, kidney, and adrenal gland 70610
gene_protein 166 amino acids 70610