Tuba1b (tubulin, alpha 1B) - Rat Genome Database

Name: Tuba1b
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Tuba1b (tubulin, alpha 1B) Rattus norvegicus

Analyze

Symbol:

Tuba1b (Ensembl: Tuba1a)

Name:

tubulin, alpha 1B (Ensembl:tubulin, alpha 1A)

RGD ID:

1565476

Description:

Predicted to enable several functions, including GTP binding activity; GTPase activity; and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to act upstream of or within cellular response to interleukin-4. Located in membrane raft. Orthologous to human TUBA1B (tubulin alpha 1b); PARTICIPATES IN docetaxel pharmacodynamics pathway; tyrosinemia type III pathway; vinblastine pharmacodynamics pathway; INTERACTS WITH (S)-colchicine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Alpha-tubulin 1; alpha-tubulin 2; LOC500929; RGD1565476; similar to Tubulin alpha-2 chain (Alpha-tubulin 2); Tuba1; Tuba1a; Tubulin alpha-1 chain; Tubulin alpha-1A chain; tubulin alpha-1B chain; tubulin alpha-2 chain

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TUBA1B (tubulin alpha 1b)	HGNC	Ensembl, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Tuba1b (tubulin, alpha 1B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LOC103782837 (tubulin alpha-1B chain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC106557476 (tubulin alpha-1A chain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101973055 (tubulin alpha-1B chain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TUBA1B (tubulin alpha 1b)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LOC103238260 (tubulin alpha-1B chain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tuba1b (tubulin alpha 1b)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TUBA1B (tubulin alpha 1b)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tuba1b (tubulin, alpha 1B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tuba1c (tubulin, alpha 1c)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector)
Saccharomyces cerevisiae (baker's yeast):	TUB1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TUB3	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mec-12	Alliance	DIOPT (InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	alphaTub85E	Alliance	DIOPT (Ensembl Compara\|OMA)
Xenopus tropicalis (tropical clawed frog):	tubal3.1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder)
Xenopus tropicalis (tropical clawed frog):	tuba1b	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER)

Related Pseudogenes:

Tuba1b-ps1 Tuba1b-ps2

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	130,090,663 - 130,093,644 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	130,081,032 - 130,196,186 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	131,895,962 - 131,898,943 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	134,121,536 - 134,124,517 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	134,034,040 - 134,037,021 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	140,614,746 - 140,617,721 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	140,614,752 - 140,617,721 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	115,121,815 - 115,124,065 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	137,706,858 - 137,709,839 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	126,575,851 - 126,578,847 (-)	NCBI		Celera
Cytogenetic Map	7	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

osteoporosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

(S)-colchicine (EXP)

1,1-dichloroethene (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4-hydroxynon-2-enal (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrolein (ISO)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

azathioprine (ISO)

azoxystrobin (ISO)

beauvericin (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

caffeine (ISO)

carbon nanotube (ISO)

chloropicrin (ISO)

clobetasol (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

dexamethasone (ISO)

diallyl trisulfide (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

dioxygen (ISO)

elemental selenium (ISO)

enniatin (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

fenbuconazole (ISO)

folic acid (ISO)

fulvestrant (ISO)

furan (ISO)

glyphosate (ISO)

hydrogen peroxide (ISO)

hydrogen sulfide (ISO)

indometacin (ISO)

isoprenaline (ISO)

ivermectin (ISO)

leflunomide (ISO)

lipopolysaccharide (ISO)

lovastatin (ISO)

maneb (ISO)

methamphetamine (EXP)

miconazole (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-methyl-D-aspartic acid (ISO)

Nivalenol (ISO)

octadecanoic acid (ISO)

ozone (ISO)

paraquat (ISO)

PCB138 (EXP)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (EXP)

picoxystrobin (ISO)

pinosylvin (ISO)

raloxifene (ISO)

rotenone (EXP,ISO)

selenium atom (ISO)

sevoflurane (EXP)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

sodium fluoride (ISO)

sunitinib (ISO)

tert-butyl hydroperoxide (ISO)

theophylline (ISO)

trans-pinosylvin (ISO)

tris(2-butoxyethyl) phosphate (ISO)

tungsten (ISO)

tunicamycin (ISO)

urethane (ISO)

vincaleukoblastine (EXP)

vincristine (EXP,ISO)

vitamin E (ISO)

warfarin (ISO)

zinc dichloride (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to interleukin-4 (ISO)

cytoskeleton organization (IEA)

microtubule cytoskeleton organization (IBA,ISO,ISS)

microtubule-based process (IEA)

mitotic cell cycle (IBA)

Cellular Component

cytoplasm (IBA,IEA)

cytoplasmic microtubule (ISO)

membrane raft (IDA)

microtubule (IBA,IEA,ISO)

microtubule cytoskeleton (ISO,ISS)

Molecular Function

double-stranded RNA binding (ISO)

GTP binding (IBA,IEA,ISO,ISS)

GTPase activity (ISO,ISS)

hydrolase activity (IEA)

metal ion binding (IEA)

protein binding (ISO)

structural constituent of cytoskeleton (IBA,IEA,ISO,ISS)

ubiquitin protein ligase binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

docetaxel pharmacodynamics pathway (ISO)

phagocytosis pathway (IEA)

tyrosinemia type III pathway (ISO)

vinblastine pharmacodynamics pathway (ISO)

vincristine pharmacodynamics pathway (ISO)

vindesine pharmacodynamics pathway (ISO)

vinorelbine pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	A revised nomenclature for the human and rodent alpha-tubulin gene family.	Khodiyar VK, etal., Genomics. 2007 May 31;.
3.	Proteomic characterisation of neuronal sphingolipid-cholesterol microdomains: role in plasminogen activation.	Ledesma MD, etal., Brain Res. 2003 Oct 10;987(1):107-16.
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:3753592	PMID:6269058	PMID:9798653	PMID:12477932	PMID:15489334	PMID:16418269	PMID:16854843	PMID:17634366	PMID:19103752	PMID:20131911	PMID:21266579	PMID:21525035
PMID:21753002	PMID:23376485	PMID:31686426	PMID:32357304	PMID:34274903

Genomics

Comparative Map Data

Tuba1b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	130,090,663 - 130,093,644 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	130,081,032 - 130,196,186 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	131,895,962 - 131,898,943 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	134,121,536 - 134,124,517 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	134,034,040 - 134,037,021 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	140,614,746 - 140,617,721 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	140,614,752 - 140,617,721 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	115,121,815 - 115,124,065 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	137,706,858 - 137,709,839 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	126,575,851 - 126,578,847 (-)	NCBI		Celera
Cytogenetic Map	7	q36	NCBI

TUBA1B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	49,127,782 - 49,131,395 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	49,127,782 - 49,131,397 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	49,521,565 - 49,525,178 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	47,807,832 - 47,811,571 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	48,315,719 - 48,319,458 (-)	NCBI		Celera
Cytogenetic Map	12	q13.12	NCBI
HuRef	12	46,552,484 - 46,556,221 (-)	NCBI		HuRef
CHM1_1	12	49,487,375 - 49,491,114 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	49,089,954 - 49,093,567 (-)	NCBI		T2T-CHM13v2.0

Tuba1b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	98,829,310 - 98,832,271 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	98,829,306 - 98,832,446 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	98,931,429 - 98,934,390 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	98,931,425 - 98,934,565 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	98,761,860 - 98,764,821 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	98,759,463 - 98,762,458 (-)	NCBI		MGSCv36	mm8
Celera	15	101,080,871 - 101,083,832 (-)	NCBI		Celera
Cytogenetic Map	15	F1	NCBI
cM Map	15	55.21	NCBI

LOC103782837
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	12	45,050,450 - 45,054,153 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	39,619,964 - 39,623,611 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	40,498,933 - 40,502,630 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	40,498,933 - 40,502,630 (+)	Ensembl	panpan1.1		panPan2

LOC106557476
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	5,407,906 - 5,412,265 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	5,407,906 - 5,463,809 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	40,844,807 - 40,849,166 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	5,459,258 - 5,463,625 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	5,459,258 - 5,515,230 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	5,423,976 - 5,428,332 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	5,413,310 - 5,417,672 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	41,237,770 - 41,242,127 (-)	NCBI		UU_Cfam_GSD_1.0

LOC101973055
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	66,234,375 - 66,238,196 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	6,926,820 - 6,930,307 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936512	6,926,634 - 6,930,481 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TUBA1B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	15,149,099 - 15,153,620 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	15,150,229 - 15,153,620 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	15,556,615 - 15,560,002 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103238260
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	45,365,071 - 45,368,807 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	45,364,873 - 45,368,752 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	200,771,441 - 200,775,190 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tuba1b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624816	3,047,272 - 3,050,777 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tuba1b
9 total Variants

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	73829340	130221005	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	86983365	131983365	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	102297359	133492884	Rat
731174	Uae23	Urinary albumin excretion QTL 23	2.4	0.0042	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	7	104603555	135012528	Rat
2306821	Bp335	Blood pressure QTL 335		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	106571501	135012528	Rat
631663	Bw6	Body weight QTL 6	3.4		body mass (VT:0001259)	body weight (CMO:0000012)	7	111075573	134976056	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	111182207	135012528	Rat
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	112308254	133492884	Rat
1357339	Stl14	Serum triglyceride level QTL 14	3.45	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	112729683	133492707	Rat
1354582	Stl11	Serum triglyceride level QTL 11	3.42		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	119513385	135012528	Rat

Markers in Region

D5Arb10

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RGSC_v3.1	7	137,893,337 - 137,893,591	RGD
Cytogenetic Map	7	q36	UniSTS

PMC154451P2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	7	q36	UniSTS

RH78682

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	4	209,800,159 - 209,800,341	UniSTS	Rnor5.0
Rnor_5.0	2	218,687,079 - 218,687,261	UniSTS	Rnor5.0
Cytogenetic Map	7	q36	UniSTS
Cytogenetic Map	9	q33	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	6	9	74	35	41	11	6
Low							2	2					2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001044270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017603502	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC114446	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC060572	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC076379	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212390	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212426	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212740	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213098	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213187	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213226	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213248	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213439	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213478	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213734	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213907	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214075	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214100	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214301	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214460	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218850	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ222644	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223081	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225339	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225425	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225650	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228903	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231550	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232160	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232623	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ233000	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ233388	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ233566	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ234135	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ234198	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ234318	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ234720	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ235311	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000187	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	V01226	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000081355 ⟹ ENSRNOP00000070868

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	130,090,668 - 130,196,186 (-)	Ensembl
Rnor_6.0 Ensembl	7	140,614,752 - 140,617,721 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000083156 ⟹ ENSRNOP00000075232

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	130,090,665 - 130,093,644 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000107560 ⟹ ENSRNOP00000094561

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	130,081,032 - 130,116,326 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000110990 ⟹ ENSRNOP00000097331

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	130,113,199 - 130,116,912 (-)	Ensembl

RefSeq Acc Id:

NM_001044270 ⟹ NP_001037735

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	130,090,663 - 130,093,644 (-)	NCBI
Rnor_6.0	7	140,614,746 - 140,617,721 (-)	NCBI
RGSC_v3.4	7	137,706,858 - 137,709,839 (-)	RGD

Sequence:

show sequence

GCCTCATTGCGTTACTTACCTCGACTCTTAGTTGTCGGGAACGGTAACCGGGACCCGGTGTCTG
CTTCTATCACCCTCGCCTTCTAACCCGTAGCTATCATGCGTGAGTGCATCTCCATCCACGTCGG
CCAGGCTGGTGTCCAGATCGGCAATGCCTGCTGGGAGCTCTACTGCCTGGAACATGGCATCCAG
CCTGATGGCCAGATGCCAAGCGACAAGACCATTGGGGGAGGAGATGACTCCTTCAACACCTTCT
TCAGTGAGACAGGAGCTGGCAAGCACGTGCCCCGGGCGGTGTTCGTAGACCTGGAACCCACAGT
TATTGATGAAGTTCGCACTGGCACCTACCGCCAGCTCTTCCACCCAGAGCAGCTCATCACAGGC
AAGGAAGATGCTGCCAATAACTATGCCCGTGGCCACTACACCATTGGCAAGGAGATCATTGACC
TTGTCTTGGACAGAATTCGCAAGCTGGCTGACCAGTGCACCGGTCTCCAGGGCTTCTTGGTTTT
CCACAGCTTTGGTGGGGGAACTGGCTCTGGGTTCACCTCCCTGCTGATGGAGAGGCTCTCTGTC
GACTACGGAAAGAAGTCCAAGCTGGAGTTCTCCATTTACCCAGCCCCCCAGGTTTCCACTGCTG
TGGTTGAGCCCTACAATTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGTGCCTT
CATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTCGACATTGAGCGCCCAACC
TACACTAACCTTAACCGCCTTATTAGCCAGATTGTGTCTTCCATCACTGCTTCCCTCAGATTTG
ATGGGGCCCTGAATGTTGATCTGACAGAATTCCAGACCAACCTGGTGCCCTACCCTCGCATCCA
CTTCCCTCTGGCCACTTATGCCCCTGTCATCTCTGCTGAGAAAGCCTACCATGAACAGCTTTCT
GTAGCAGAGATCACCAATGCCTGCTTTGAGCCAGCCAACCAGATGGTGAAATGTGACCCTCGCC
ATGGTAAATACATGGCTTGCTGCCTGCTGTACCGTGGTGATGTGGTCCCCAAAGATGTCAATGC
TGCCATTGCCACCATCAAGACCAAGCGCAGCATCCAGTTTGTGGACTGGTGCCCCACTGGCTTC
AAGGTTGGCATTAATTACCAGCCTCCCACTGTGGTACCTGGTGGCGACCTGGCCAAGGTCCAGA
GAGCTGTGTGTATGCTGAGCAACACCACAGCCATTGCTGAGGCTTGGGCTCGCCTGGATCACAA
GTTTGATCTGATGTATGCCAAGCGTGCCTTTGTGCACTGGTACGTGGGTGAGGGCATGGAGGAG
GGAGAGTTCTCTGAGGCCCGTGAGGACATGGCTGCCCTAGAGAAGGATTATGAGGAGGTTGGTG
TGGATTCTGTGGAGGGTGAGGGTGAGGAAGAAGGAGAGGAATACTAGTTCATTCCTGCAGTCCC
TGTATCATGTCAAACTCAACTCCAGCTCCAGCACTAGCTGCAGGCATCGATGCTTCTATGCTGT
TTCCCTTCTGTGATCATGTCTTCTCCATGTGTACCTCTTAAGTTTTCCATGACGTCTCAAAGTA
AAAGCTTTAAGAAATGAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001037735	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH60572	(Get FASTA)	NCBI Sequence Viewer
	AAH76379	(Get FASTA)	NCBI Sequence Viewer
	CAA24536	(Get FASTA)	NCBI Sequence Viewer
	Q6P9V9	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001037735 ⟸ NM_001044270

- UniProtKB:

Q6P9V9 (UniProtKB/Swiss-Prot), A0A8I6ALV8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPR
AVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQ
CTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTH
TTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQ
TNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYR
GDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAI
AEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEG
EEY

hide sequence

RefSeq Acc Id:

ENSRNOP00000070868 ⟸ ENSRNOT00000081355

RefSeq Acc Id:

ENSRNOP00000094561 ⟸ ENSRNOT00000107560

RefSeq Acc Id:

ENSRNOP00000097331 ⟸ ENSRNOT00000110990

RefSeq Acc Id:

ENSRNOP00000075232 ⟸ ENSRNOT00000083156

Protein Domains

Tubulin/FtsZ 2-layer sandwich Tubulin/FtsZ GTPase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6P9V9-F1-model_v2	AlphaFold	Q6P9V9	1-451	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1565476	AgrOrtholog
BioCyc Gene	G2FUF-32103	BioCyc
Ensembl Genes	ENSRNOG00000053468	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000070868.2	UniProtKB/TrEMBL
	ENSRNOP00000075232	ENTREZGENE
	ENSRNOP00000075232.2	UniProtKB/TrEMBL
	ENSRNOP00000094561.1	UniProtKB/TrEMBL
	ENSRNOP00000097331.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000081355.2	UniProtKB/TrEMBL
	ENSRNOT00000083156	ENTREZGENE
	ENSRNOT00000083156.2	UniProtKB/TrEMBL
	ENSRNOT00000107560.1	UniProtKB/TrEMBL
	ENSRNOT00000110990.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.287.600	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.1330.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.1440	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:6920989	IMAGE-MGC_LOAD
	IMAGE:7106502	IMAGE-MGC_LOAD
InterPro	Alpha_tubulin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tub_FtsZ_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin/FtsZ-like_C	UniProtKB/TrEMBL
	Tubulin/FtsZ_2-layer-sand-dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin/FtsZ_C_sf	UniProtKB/Swiss-Prot
	Tubulin/FtsZ_GTPase_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin_FtsZ_GTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:500929	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72839	IMAGE-MGC_LOAD
	MGC:93444	IMAGE-MGC_LOAD
NCBI Gene	500929	ENTREZGENE
PANTHER	PTHR11588	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TUBULIN ALPHA-1A CHAIN	UniProtKB/TrEMBL
	TUBULIN ALPHA-1B CHAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Tubulin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Tuba1b	PhenoGen
PRINTS	ALPHATUBULIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TUBULIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	TUBULIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	Tubulin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tubulin_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52490	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55307	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6ALV8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6B5M1_RAT	UniProtKB/TrEMBL
	A0A8L2R402_RAT	UniProtKB/TrEMBL
	A0A8L2RAD9_RAT	UniProtKB/TrEMBL
	Q6P9V9	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2007-05-17	Tuba1b	tubulin, alpha 1B	RGD1565476_predicted	similar to Tubulin alpha-2 chain (Alpha-tubulin 2) (predicted)	Symbol and Name updated	1624988	APPROVED
2006-03-07	RGD1565476_predicted	similar to Tubulin alpha-2 chain (Alpha-tubulin 2) (predicted)	LOC500929	similar to Tubulin alpha-2 chain (Alpha-tubulin 2)	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC500929	similar to Tubulin alpha-2 chain (Alpha-tubulin 2)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)