Mfsd5 (major facilitator superfamily domain containing 5) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Mfsd5 (major facilitator superfamily domain containing 5) Rattus norvegicus
Analyze
Symbol: Mfsd5
Name: major facilitator superfamily domain containing 5
RGD ID: 1305138
Description: Predicted to enable molybdate ion transmembrane transporter activity. Predicted to be involved in molybdate ion transport. Predicted to be located in plasma membrane. Orthologous to human MFSD5 (major facilitator superfamily domain containing 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC315329; LOC315329; major facilitator superfamily domain-containing protein 5; molybdate-anion transporter; RGD1305138; similar to expressed sequence AW556797
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27133,409,096 - 133,411,377 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,402,537 - 133,411,396 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7135,170,118 - 135,172,399 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07137,399,498 - 137,401,779 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07137,384,540 - 137,386,821 (+)NCBIRnor_WKY
Rnor_6.07143,882,000 - 143,884,281 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,882,000 - 143,884,280 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,678,906 - 141,681,187 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47141,032,928 - 141,035,209 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17141,109,434 - 141,111,641 (+)NCBI
Celera7129,842,507 - 129,844,808 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:19946888  


Genomics

Comparative Map Data
Mfsd5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27133,409,096 - 133,411,377 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,402,537 - 133,411,396 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7135,170,118 - 135,172,399 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07137,399,498 - 137,401,779 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07137,384,540 - 137,386,821 (+)NCBIRnor_WKY
Rnor_6.07143,882,000 - 143,884,281 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,882,000 - 143,884,280 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,678,906 - 141,681,187 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47141,032,928 - 141,035,209 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17141,109,434 - 141,111,641 (+)NCBI
Celera7129,842,507 - 129,844,808 (+)NCBICelera
Cytogenetic Map7q36NCBI
MFSD5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381253,251,197 - 53,254,406 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1253,251,251 - 53,254,406 (+)EnsemblGRCh38hg38GRCh38
GRCh371253,645,370 - 53,648,190 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,932,147 - 51,934,455 (+)NCBINCBI36Build 36hg18NCBI36
Celera1253,294,460 - 53,297,280 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,687,071 - 50,689,891 (+)NCBIHuRef
CHM1_11253,611,667 - 53,614,487 (+)NCBICHM1_1
T2T-CHM13v2.01253,217,176 - 53,219,996 (+)NCBIT2T-CHM13v2.0
Mfsd5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915102,187,891 - 102,190,179 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15102,187,889 - 102,190,189 (+)EnsemblGRCm39 Ensembl
GRCm3815102,279,456 - 102,281,744 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,279,454 - 102,281,754 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715102,109,887 - 102,112,175 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615102,107,488 - 102,109,778 (+)NCBIMGSCv36mm8
Celera15104,436,913 - 104,439,201 (+)NCBICelera
Cytogenetic Map15F2NCBI
Mfsd5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458519,566 - 521,778 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955458519,566 - 521,778 (+)NCBIChiLan1.0ChiLan1.0
MFSD5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11236,280,077 - 36,282,391 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,280,077 - 36,283,227 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01235,499,848 - 35,502,163 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MFSD5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,941,446 - 1,943,787 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,941,691 - 1,943,043 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2744,305,511 - 44,307,839 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0271,945,938 - 1,948,266 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl271,945,944 - 1,948,289 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1271,964,198 - 1,966,526 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,949,122 - 1,951,437 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,706,197 - 44,708,525 (+)NCBIUU_Cfam_GSD_1.0
Mfsd5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,616,748 - 62,619,070 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493651210,545,758 - 10,548,067 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFSD5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,476,366 - 18,478,737 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,476,366 - 18,478,745 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,912,089 - 18,914,471 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MFSD5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,359,286 - 49,362,027 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1149,360,455 - 49,361,807 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037196,697,445 - 196,700,570 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mfsd5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249041,296,292 - 1,298,379 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249041,296,224 - 1,298,419 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mfsd5
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:43
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000017110
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat

Markers in Region
AW556797  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,411,176 - 133,411,309 (+)MAPPERmRatBN7.2
mRatBN7.21117,328,176 - 117,328,304 (+)MAPPERmRatBN7.2
Rnor_6.01124,589,813 - 124,589,940NCBIRnor6.0
Rnor_6.07143,884,081 - 143,884,213NCBIRnor6.0
Rnor_5.07141,680,987 - 141,681,119UniSTSRnor5.0
Rnor_5.01125,702,275 - 125,702,402UniSTSRnor5.0
RGSC_v3.41118,188,383 - 118,188,510UniSTSRGSC3.4
RGSC_v3.47141,035,009 - 141,035,141UniSTSRGSC3.4
Celera7129,844,608 - 129,844,740UniSTS
Celera1109,585,321 - 109,585,448UniSTS
Cytogenetic Map7q36UniSTS
Cytogenetic Map1q22UniSTS
RH134321  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,411,163 - 133,411,349 (+)MAPPERmRatBN7.2
Rnor_6.07143,884,068 - 143,884,253NCBIRnor6.0
Rnor_5.07141,680,974 - 141,681,159UniSTSRnor5.0
RGSC_v3.47141,034,996 - 141,035,181UniSTSRGSC3.4
Celera7129,844,595 - 129,844,780UniSTS
RH 3.4 Map71056.4UniSTS
Cytogenetic Map7q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 34 32 32 4 32 2 66 27 31 11
Low 9 25 9 15 9 8 9 8 8 10 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000017110   ⟹   ENSRNOP00000017110
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7133,402,537 - 133,411,396 (+)Ensembl
Rnor_6.0 Ensembl7143,882,000 - 143,884,280 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091053   ⟹   ENSRNOP00000075435
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7133,409,154 - 133,411,368 (+)Ensembl
Rnor_6.0 Ensembl7143,882,091 - 143,884,275 (+)Ensembl
RefSeq Acc Id: NM_001126282   ⟹   NP_001119754
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27133,409,096 - 133,411,377 (+)NCBI
Rnor_6.07143,882,000 - 143,884,281 (+)NCBI
Rnor_5.07141,678,906 - 141,681,187 (+)NCBI
RGSC_v3.47141,032,928 - 141,035,209 (+)RGD
Celera7129,842,507 - 129,844,808 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001119754 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI61964 (Get FASTA)   NCBI Sequence Viewer  
  EDL86851 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001119754   ⟸   NM_001126282
- Peptide Label: precursor
- UniProtKB: B1WC12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017110   ⟸   ENSRNOT00000017110
RefSeq Acc Id: ENSRNOP00000075435   ⟸   ENSRNOT00000091053

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1WC12-F1-model_v2 AlphaFold B1WC12 1-450 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695695
Promoter ID:EPDNEW_R6220
Type:initiation region
Name:Mfsd5_1
Description:major facilitator superfamily domain containing 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,882,056 - 143,882,116EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305138 AgrOrtholog
BioCyc Gene G2FUF-31943 BioCyc
Ensembl Genes ENSRNOG00000012832 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000017110 ENTREZGENE
  ENSRNOP00000017110.3 UniProtKB/TrEMBL
  ENSRNOP00000075435.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017110 ENTREZGENE
  ENSRNOT00000017110.5 UniProtKB/TrEMBL
  ENSRNOT00000091053.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9028283 IMAGE-MGC_LOAD
InterPro DUF791 UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
  MFSD5 UniProtKB/TrEMBL
KEGG Report rno:315329 UniProtKB/TrEMBL
MGC_CLONE MGC:187769 IMAGE-MGC_LOAD
NCBI Gene 315329 ENTREZGENE
PANTHER PTHR23516 UniProtKB/TrEMBL
  PTHR23516:SF14 UniProtKB/TrEMBL
Pfam DUF791 UniProtKB/TrEMBL
PhenoGen Mfsd5 PhenoGen
Superfamily-SCOP MFS_gen_substrate_transporter UniProtKB/TrEMBL
UniProt A0A0G2KAK9_RAT UniProtKB/TrEMBL
  B1WC12 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Mfsd5  major facilitator superfamily domain containing 5  RGD1305138  similar to expressed sequence AW556797  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1305138  similar to expressed sequence AW556797   RGD1305138_predicted  similar to expressed sequence AW556797 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1305138_predicted  similar to expressed sequence AW556797 (predicted)  LOC315329_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC315329_predicted  similar to expressed sequence AW556797 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL