Gene: Hnrnpa1 (heterogeneous nuclear ribonucleoprotein A1) Rattus norvegicus
Analyze
Symbol:
Hnrnpa1
Name:
heterogeneous nuclear ribonucleoprotein A1
Description:
Exhibits nucleic acid binding activity and transcription factor binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; cellular response to thapsigargin; and cellular response to tunicamycin. Localizes to the cytosol and nucleoplasmic periphery of the nuclear pore complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 20; inclusion body myopathy with Paget disease of bone and frontotemporal dementia; and tropical spastic paraparesis. Orthologous to human HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
HDP; helix-destabilizing protein; hnRNP A1; hnRNP core protein A1; Hnrpa1; single-strand RNA-binding protein
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) HGNC
EggNOG, Ensembl, HomoloGene, NCBI, OrthoDB
Mus musculus (house mouse):
Hnrnpa1 (heterogeneous nuclear ribonucleoprotein A1) HGNC
NCBI, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Hnrnpa1 (heterogeneous nuclear ribonucleoprotein A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Hnrnpa1 (heterogeneous nuclear ribonucleoprotein A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
HNRNPA1L2 (heterogeneous nuclear ribonucleoprotein A1 like 2) HGNC
Inparanoid, OrthoDB
Alliance orthologs 3
Mus musculus (house mouse):
Hnrnpa1 (heterogeneous nuclear ribonucleoprotein A1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, PANTHER)
Homo sapiens (human):
HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, OMA, OrthoFinder, PANTHER)
Danio rerio (zebrafish):
hnrnpa1b (heterogeneous nuclear ribonucleoprotein A1b)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER)
Danio rerio (zebrafish):
hnrnpa1a (heterogeneous nuclear ribonucleoprotein A1a)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER)
Caenorhabditis elegans (roundworm):
hrp-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, PhylomeDB)
Drosophila melanogaster (fruit fly):
Hrb87F
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
Hrb98DE
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
Rb97D
Alliance
DIOPT (Ensembl Compara, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Related Pseudogenes:
Hnrnpa1-ps1
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 7 144,865,302 - 144,871,592 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 7 144,865,608 - 144,871,585 (+) Ensembl Rnor_5.0 7 142,647,071 - 142,652,967 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 7 142,150,229 - 142,154,520 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 7 142,230,417 - 142,234,709 (+) NCBI Celera 7 130,801,278 - 130,805,569 (+) NCBI Celera Cytogenetic Map 7 q36 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
amyotrophic lateral sclerosis type 20 ISO RGD:1348965 8554872 ClinVar Annotator: match by term: Amyotrophic lateral sclerosis 20 ClinVar PMID:23455423 inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3 ISO RGD:1348965 8554872 ClinVar Annotator: match by OMIM:615424 ClinVar PMID:20116073 more ... inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3 ISO RGD:1348965 8554872 ClinVar Annotator: match by term: Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 3 ClinVar PMID:25741868 Neurodevelopmental Disorders ISO RGD:1348965 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868 primary progressive multiple sclerosis ISO RGD:1348965 8554872 ClinVar Annotator: match by term: Chronic progressive multiple sclerosis, UMLS MESH term: Multiple Sclerosis, Chronic Progressive ClinVar relapsing-remitting multiple sclerosis ISO RGD:1348965 8554872 ClinVar Annotator: match by term: Relapsing remitting multiple sclerosis, UMLS MESH term: Multiple Sclerosis, Relapsing-Remitting ClinVar
Imported Annotations - CTD
Animal Disease Models ISO RGD:1348965 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27602772 Animal Mammary Neoplasms ISO RGD:1348965 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16316942 carcinoma ISO RGD:1348965 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16316942 inclusion body myopathy with Paget disease of bone and frontotemporal dementia ISO RGD:1348965 11554173 CTD Direct Evidence: marker/mechanism CTD Mammary Neoplasms, Experimental ISO RGD:1348965 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16316942 Imported Annotations - OMIM
amyotrophic lateral sclerosis type 20 ISO RGD:1348965 7240710 OMIM inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3 ISO RGD:1348965 7240710 OMIM
(-)-epigallocatechin 3-gallate increases expression ISO RGD:1348965 6480464 epigallocatechin gallate results in increased expression of HNRNPA1 protein CTD PMID:31195006 14-Deoxy-11,12-didehydroandrographolide increases expression ISO RGD:1348965 6480464 14-deoxy-11, 12-didehydroandrographolide results in increased expression of HNRNPA1 mRNA CTD PMID:22101062 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of HNRNPA1 mRNA CTD PMID:15576828 , PMID:17557909 17alpha-ethynylestradiol multiple interactions ISO RGD:735271 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HNRNPA1 mRNA CTD PMID:17942748 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of HNRNPA1 mRNA CTD PMID:20068009 1H-pyrazole increases expression ISO RGD:735271 6480464 pyrazole results in increased expression of HNRNPA1 protein CTD PMID:11901218 1H-pyrazole multiple interactions ISO RGD:735271 6480464 pyrazole promotes the reaction [HNRNPA1 protein binds to CYP2A5 mRNA] CTD PMID:11901218 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:735271 6480464 Tetrachlorodibenzodioxin results in increased expression of HNRNPA1 mRNA CTD PMID:17949056 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:735271 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HNRNPA1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:735271 6480464 Tetrachlorodibenzodioxin affects the expression of HNRNPA1 mRNA CTD PMID:21570461 2,4-dibromophenyl 2,4,5-tribromophenyl ether decreases expression EXP 6480464 2 more ... CTD PMID:19954255 2,6-di-tert-butyl-4-methylphenol affects localization ISO RGD:735271 6480464 Butylated Hydroxytoluene affects the localization of HNRNPA1 protein CTD PMID:15390079 2,6-di-tert-butyl-4-methylphenol multiple interactions ISO RGD:735271 6480464 [Butylated Hydroxytoluene co-treated with Methylcholanthrene] affects the localization of HNRNPA1 protein, [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of HNRNPA1 protein CTD PMID:15390079 2,6-di-tert-butyl-4-methylphenol increases expression ISO RGD:735271 6480464 Butylated Hydroxytoluene results in increased expression of HNRNPA1 protein CTD PMID:15390079 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of HNRNPA1 mRNA CTD PMID:21346803 2-hydroxypropanoic acid increases expression ISO RGD:1348965 6480464 Lactic Acid results in increased expression of HNRNPA1 mRNA CTD PMID:30851411 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:735271 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of HNRNPA1 mRNA CTD PMID:20188158 3-methylcholanthrene multiple interactions ISO RGD:735271 6480464 [Butylated Hydroxytoluene co-treated with Methylcholanthrene] affects the localization of HNRNPA1 protein, [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of HNRNPA1 protein CTD PMID:15390079 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of HNRNPA1 mRNA CTD PMID:19162173 4,4'-diaminodiphenylmethane increases expression ISO RGD:735271 6480464 4, 4'-diaminodiphenylmethane results in increased expression of HNRNPA1 mRNA CTD PMID:18648102 4-hydroxyphenyl retinamide increases expression ISO RGD:735271 6480464 Fenretinide results in increased expression of HNRNPA1 mRNA CTD PMID:28973697 5-fluorouracil decreases expression ISO RGD:1348965 6480464 Fluorouracil results in decreased expression of HNRNPA1 mRNA CTD PMID:16101138 5-fluorouracil multiple interactions ISO RGD:1348965 6480464 TP53 protein affects the reaction [Fluorouracil results in decreased expression of HNRNPA1 mRNA] CTD PMID:15016801 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of HNRNPA1 mRNA CTD PMID:24780913 acetylsalicylic acid decreases expression EXP 6480464 Aspirin results in decreased expression of HNRNPA1 mRNA CTD PMID:12800193 actinomycin D multiple interactions ISO RGD:735271 6480464 Dactinomycin affects the reaction [HNRNPA1 protein binds to CYP2A5 mRNA] CTD PMID:12754101 actinomycin D affects localization ISO RGD:735271 6480464 Dactinomycin affects the localization of HNRNPA1 protein CTD PMID:12754101 aflatoxin B1 increases expression ISO RGD:735271 6480464 Aflatoxin B1 results in increased expression of HNRNPA1 mRNA CTD PMID:19770486 alachlor increases expression EXP 6480464 alachlor results in increased expression of HNRNPA1 mRNA CTD PMID:12419858 amiodarone increases expression ISO RGD:1348965 6480464 Amiodarone results in increased expression of HNRNPA1 mRNA CTD PMID:21163907 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of HNRNPA1 mRNA CTD PMID:16483693 Aroclor 1254 decreases expression ISO RGD:735271 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of HNRNPA1 mRNA CTD PMID:23650126 arsane affects methylation ISO RGD:1348965 6480464 Arsenic affects the methylation of HNRNPA1 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1348965 6480464 Arsenic affects the methylation of HNRNPA1 gene CTD PMID:25304211 arsenous acid increases expression ISO RGD:1348965 6480464 Arsenic Trioxide results in increased expression of HNRNPA1 mRNA CTD PMID:20458559 , PMID:25258189 benzo[a]pyrene decreases expression ISO RGD:1348965 6480464 Benzo(a)pyrene results in decreased expression of HNRNPA1 mRNA CTD PMID:20064835 benzo[a]pyrene increases expression ISO RGD:735271 6480464 Benzo(a)pyrene results in increased expression of HNRNPA1 mRNA CTD PMID:19770486 , PMID:22228805 benzo[a]pyrene increases expression ISO RGD:1348965 6480464 Benzo(a)pyrene results in increased expression of HNRNPA1 protein CTD PMID:25628927 benzo[a]pyrene multiple interactions ISO RGD:1348965 6480464 PARG affects the reaction [Benzo(a)pyrene results in increased expression of HNRNPA1 protein] CTD PMID:25628927 benzo[a]pyrene diol epoxide I increases expression ISO RGD:1348965 6480464 7 more ... CTD PMID:26238291 beryllium sulfate increases expression ISO RGD:1348965 6480464 beryllium sulfate results in increased expression of HNRNPA1 mRNA CTD PMID:16314022 bisphenol A decreases expression ISO RGD:735271 6480464 bisphenol A results in decreased expression of HNRNPA1 mRNA CTD PMID:26063408 bisphenol A decreases expression ISO RGD:1348965 6480464 bisphenol A results in decreased expression of HNRNPA1 mRNA CTD PMID:29275510 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of HNRNPA1 gene CTD PMID:28505145 buspirone decreases expression EXP 6480464 Buspirone results in decreased expression of HNRNPA1 mRNA CTD PMID:24136188 butanal increases expression ISO RGD:1348965 6480464 butyraldehyde results in increased expression of HNRNPA1 mRNA CTD PMID:26079696 butyric acid decreases expression EXP 6480464 Butyric Acid results in decreased expression of HNRNPA1 mRNA CTD PMID:12800193 cadmium atom increases oxidation ISO RGD:735271 6480464 Cadmium results in increased oxidation of HNRNPA1 protein CTD PMID:24077948 caffeine decreases expression ISO RGD:1348965 6480464 Caffeine results in decreased expression of HNRNPA1 protein CTD PMID:31195006 calcitriol decreases expression ISO RGD:1348965 6480464 Calcitriol results in decreased expression of HNRNPA1 mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:1348965 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of HNRNPA1 mRNA CTD PMID:21592394 capsaicin increases expression EXP 6480464 Capsaicin results in increased expression of HNRNPA1 mRNA CTD PMID:20349343 carbon nanotube increases expression ISO RGD:735271 6480464 Nanotubes, Carbon analog results in increased expression of HNRNPA1 mRNA, Nanotubes, Carbon results in increased expression of HNRNPA1 mRNA CTD PMID:25620056 carvedilol multiple interactions ISO RGD:1348965 6480464 carvedilol promotes the reaction [ARRB1 protein binds to HNRNPA1 protein] CTD PMID:24334028 carvedilol multiple interactions ISO RGD:735271 6480464 carvedilol promotes the reaction [ARRB1 protein binds to HNRNPA1 protein] CTD PMID:24334028 cefaloridine increases expression EXP 6480464 Cephaloridine results in increased expression of HNRNPA1 mRNA CTD PMID:18500788 chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of HNRNPA1 mRNA CTD PMID:23125180 choline multiple interactions ISO RGD:735271 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HNRNPA1 mRNA CTD PMID:20938992 chromium(6+) affects expression ISO RGD:735271 6480464 chromium hexavalent ion affects the expression of HNRNPA1 mRNA CTD PMID:28472532 cisplatin increases expression ISO RGD:1348965 6480464 Cisplatin results in increased expression of HNRNPA1 protein CTD PMID:16803524 cisplatin decreases expression ISO RGD:735271 6480464 Cisplatin results in decreased expression of HNRNPA1 mRNA CTD PMID:21151649 Colforsin dapropate hydrochloride multiple interactions EXP 6480464 HNRNPA1 mutant form inhibits the reaction [Colforsin affects the splicing of RUNX1 exon], HNRNPA1 mutant form inhibits the reaction [Colforsin affects the splicing of SNAP25 exon] CTD PMID:22684629 copper atom increases expression ISO RGD:735271 6480464 Copper results in increased expression of HNRNPA1 protein CTD PMID:21146535 copper(0) increases expression ISO RGD:735271 6480464 Copper results in increased expression of HNRNPA1 protein CTD PMID:21146535 corticosterone decreases expression EXP 6480464 Corticosterone results in decreased expression of HNRNPA1 mRNA CTD PMID:15755911 crocidolite asbestos increases expression ISO RGD:735271 6480464 Asbestos, Crocidolite results in increased expression of HNRNPA1 mRNA CTD PMID:19446018 curcumin decreases expression ISO RGD:1348965 6480464 Curcumin results in decreased expression of HNRNPA1 mRNA CTD PMID:17999991 diarsenic trioxide increases expression ISO RGD:1348965 6480464 Arsenic Trioxide results in increased expression of HNRNPA1 mRNA CTD PMID:20458559 , PMID:25258189 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of HNRNPA1 mRNA CTD PMID:17379624 dicrotophos decreases expression ISO RGD:1348965 6480464 dicrotophos results in decreased expression of HNRNPA1 mRNA CTD PMID:28302478 diuron decreases expression EXP 6480464 Diuron results in decreased expression of HNRNPA1 mRNA CTD PMID:21551480 doxorubicin affects expression ISO RGD:1348965 6480464 Doxorubicin affects the expression of HNRNPA1 protein CTD PMID:29385562 doxorubicin increases expression ISO RGD:1348965 6480464 Doxorubicin results in increased expression of HNRNPA1 mRNA CTD PMID:29803840 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of HNRNPA1 mRNA CTD PMID:29391264 enzyme inhibitor multiple interactions ISO RGD:1348965 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HNRNPA1 protein CTD PMID:23301498 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of HNRNPA1 mRNA CTD PMID:17920746 flutamide increases expression EXP 6480464 Flutamide results in increased expression of HNRNPA1 mRNA CTD PMID:24136188 folic acid multiple interactions ISO RGD:735271 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HNRNPA1 mRNA CTD PMID:20938992 furan increases expression EXP 6480464 furan results in increased expression of HNRNPA1 mRNA CTD PMID:25539665 , PMID:26194646 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of HNRNPA1 mRNA CTD PMID:22061828 glafenine increases expression EXP 6480464 Glafenine results in increased expression of HNRNPA1 mRNA CTD PMID:24136188 glycidol decreases expression EXP 6480464 glycidol results in decreased expression of HNRNPA1 mRNA CTD PMID:24915197 hydrazine increases expression ISO RGD:735271 6480464 hydrazine results in increased expression of HNRNPA1 mRNA CTD PMID:15282401 irinotecan decreases expression ISO RGD:1348965 6480464 Irinotecan analog results in decreased expression of HNRNPA1 mRNA CTD PMID:18927307 L-methionine multiple interactions ISO RGD:735271 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HNRNPA1 mRNA CTD PMID:20938992 lead(0) affects expression ISO RGD:1348965 6480464 Lead affects the expression of HNRNPA1 mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:1348965 6480464 Lead affects the expression of HNRNPA1 mRNA CTD PMID:28903495 methylmercury chloride decreases expression ISO RGD:1348965 6480464 methylmercuric chloride results in decreased expression of HNRNPA1 mRNA CTD PMID:28001369 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:1348965 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Thapsigargin affects the localization of HNRNPA1 protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tunicamycin affects the localization of HNRNPA1 protein] CTD PMID:23106379 N-methyl-4-phenylpyridinium increases expression ISO RGD:735271 6480464 1-Methyl-4-phenylpyridinium results in increased expression of HNRNPA1 protein CTD PMID:26558463 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of HNRNPA1 mRNA CTD PMID:19041683 nickel sulfate increases expression ISO RGD:1348965 6480464 nickel sulfate results in increased expression of HNRNPA1 mRNA CTD PMID:18651567 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of HNRNPA1 mRNA CTD PMID:25729387 paracetamol increases expression ISO RGD:1348965 6480464 Acetaminophen results in increased expression of HNRNPA1 mRNA CTD PMID:21420995 paracetamol decreases expression ISO RGD:1348965 6480464 Acetaminophen results in decreased expression of HNRNPA1 mRNA CTD PMID:29067470 paracetamol affects expression ISO RGD:735271 6480464 Acetaminophen affects the expression of HNRNPA1 mRNA CTD PMID:17562736 pentachlorophenol increases expression ISO RGD:735271 6480464 Pentachlorophenol results in increased expression of HNRNPA1 mRNA CTD PMID:23892564 perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of HNRNPA1 mRNA CTD PMID:19162173 phorone affects expression EXP 6480464 phorone affects the expression of HNRNPA1 mRNA CTD PMID:18198479 pirinixic acid affects expression EXP 6480464 pirinixic acid affects the expression of HNRNPA1 mRNA CTD PMID:19162173 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of HNRNPA1 mRNA CTD PMID:19162173 propiconazole decreases expression ISO RGD:735271 6480464 propiconazole results in decreased expression of HNRNPA1 mRNA CTD PMID:21278054 quercetin decreases expression ISO RGD:1348965 6480464 Quercetin results in decreased expression of HNRNPA1 protein CTD PMID:19207037 quercetin affects expression EXP 6480464 Quercetin affects the expression of HNRNPA1 mRNA CTD PMID:18178720 rac-lactic acid increases expression ISO RGD:1348965 6480464 Lactic Acid results in increased expression of HNRNPA1 mRNA CTD PMID:30851411 resveratrol decreases expression ISO RGD:735271 6480464 resveratrol results in decreased expression of HNRNPA1 protein CTD PMID:25505154 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of HNRNPA1 protein CTD PMID:29459688 sodium dichromate affects expression EXP 6480464 sodium bichromate affects the expression of HNRNPA1 mRNA CTD PMID:22110744 sodium dichromate increases expression EXP 6480464 sodium bichromate results in increased expression of HNRNPA1 mRNA CTD PMID:25993096 testosterone multiple interactions ISO RGD:1348965 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of HNRNPA1 mRNA CTD PMID:21592394 testosterone decreases expression ISO RGD:1348965 6480464 Testosterone results in decreased expression of HNRNPA1 mRNA CTD PMID:21592394 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of HNRNPA1 mRNA CTD PMID:31150632 thapsigargin affects localization ISO RGD:1348965 6480464 Thapsigargin affects the localization of HNRNPA1 protein CTD PMID:23106379 thapsigargin multiple interactions ISO RGD:1348965 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Thapsigargin affects the localization of HNRNPA1 protein], Thapsigargin promotes the reaction [HNRNPA1 protein binds to SREBF1 5' UTR] CTD PMID:23106379 thapsigargin affects localization EXP 6480464 Thapsigargin affects the localization of HNRNPA1 protein CTD PMID:23106379 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of HNRNPA1 mRNA CTD PMID:25729387 trichostatin A increases expression ISO RGD:1348965 6480464 trichostatin A results in increased expression of HNRNPA1 mRNA CTD PMID:24935251 trimellitic anhydride increases expression ISO RGD:735271 6480464 trimellitic anhydride results in increased expression of HNRNPA1 mRNA CTD PMID:19042947 troglitazone decreases expression ISO RGD:735271 6480464 troglitazone results in decreased expression of HNRNPA1 mRNA CTD PMID:28973697 troglitazone decreases expression ISO RGD:1348965 6480464 troglitazone results in decreased expression of HNRNPA1 mRNA CTD PMID:19140230 tunicamycin increases activity ISO RGD:1348965 6480464 Tunicamycin results in increased activity of HNRNPA1 protein CTD PMID:23106379 tunicamycin multiple interactions ISO RGD:1348965 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Tunicamycin affects the localization of HNRNPA1 protein] more ... CTD PMID:23106379 tunicamycin multiple interactions EXP 6480464 HNRNPA1 mutant form inhibits the reaction [Tunicamycin results in increased expression of SREBF1 protein] CTD PMID:23106379 tunicamycin increases activity EXP 6480464 Tunicamycin results in increased activity of HNRNPA1 protein CTD PMID:23106379 tunicamycin affects localization ISO RGD:1348965 6480464 Tunicamycin affects the localization of HNRNPA1 protein CTD PMID:23106379 tunicamycin affects localization EXP 6480464 Tunicamycin affects the localization of HNRNPA1 protein CTD PMID:23106379 valproic acid decreases expression ISO RGD:735271 6480464 Valproic Acid results in decreased expression of HNRNPA1 mRNA CTD PMID:15799026 , PMID:21427059 valproic acid decreases expression ISO RGD:1348965 6480464 Valproic Acid results in decreased expression of HNRNPA1 mRNA CTD PMID:23179753 , PMID:27188386 valproic acid affects expression ISO RGD:735271 6480464 Valproic Acid affects the expression of HNRNPA1 mRNA CTD PMID:17292431 , PMID:17963808 vancomycin decreases expression ISO RGD:735271 6480464 Vancomycin results in decreased expression of HNRNPA1 mRNA CTD PMID:18930951 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of HNRNPA1 mRNA CTD PMID:22570695 zinc sulfate affects expression ISO RGD:1348965 6480464 Zinc Sulfate affects the expression of HNRNPA1 protein CTD PMID:25162517
Biological Process alternative mRNA splicing, via spliceosome ISO RGD:735271 1624291 (MGI:MGI:3575934, PMID:15798186) RGD MGI:MGI:3575934 , PMID:15798186 cellular response to epidermal growth factor stimulus IEP 10041005 RGD cellular response to glucose starvation IEA UniProtKB:P09651 , ensembl:ENSP000003418261600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to glucose starvation ISO RGD:1348965 1624291 (PMID:25689357) RGD PMID:25689357 cellular response to potassium ion IDA 10045993 RGD cellular response to sodium arsenite ISO RGD:1348965 1624291 (PMID:27694260) RGD PMID:27694260 cellular response to sodium arsenite ISS UniProtKB:P09651 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cellular response to sodium arsenite IEA UniProtKB:P09651 , ensembl:ENSP000003418261600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to thapsigargin IEP 10045574 RGD cellular response to tunicamycin IMP 10045574 RGD DNA strand renaturation IEA GO:0036310 1600115 GO_REF:0000108 GOC GO_REF:0000108 import into nucleus IEA UniProtKB:P09651 , ensembl:ENSP000003418261600115 GO_REF:0000107 Ensembl GO_REF:0000107 import into nucleus ISS UniProtKB:P09651 1600115 GO_REF:0000024 HGNC GO_REF:0000024 import into nucleus ISO RGD:1348965 1624291 (PMID:8521471) RGD PMID:8521471 lung development IEP 10045983 RGD male gonad development IEP 9685421 RGD mRNA processing IEA UniProtKB-KW:KW-0507 1600115 GO_REF:0000037 UniProt GO_REF:0000037 mRNA transport IEA UniProtKB-KW:KW-0509 1600115 GO_REF:0000037 UniProt GO_REF:0000037 negative regulation of telomere maintenance via telomerase IEA UniProtKB:P09651 , ensembl:ENSP000003418261600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of telomere maintenance via telomerase ISO RGD:1348965 1624291 (PMID:23935072) RGD PMID:23935072 nuclear export IEA UniProtKB:P09651 , ensembl:ENSP000003418261600115 GO_REF:0000107 Ensembl GO_REF:0000107 nuclear export ISS UniProtKB:P09651 1600115 GO_REF:0000024 HGNC GO_REF:0000024 nuclear export ISO RGD:1348965 1624291 (PMID:8521471) RGD PMID:8521471 positive regulation of action potential IMP 10045966 RGD positive regulation of gene expression IMP 10045574 Srebf1 RGD positive regulation of telomere maintenance via telomerase IEA UniProtKB:P09651 , ensembl:ENSP000003418261600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of telomere maintenance via telomerase ISO RGD:1348965 1624291 (PMID:23935072) RGD PMID:23935072 regulation of alternative mRNA splicing, via spliceosome IEA UniProtKB:P09651 , ensembl:ENSP000003418261600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of alternative mRNA splicing, via spliceosome ISO RGD:1348965 1624291 (PMID:25689357) RGD PMID:25689357 regulation of RNA metabolic process IBA PANTHER:PTN002689974 more ... 13792537 PMID:21873635 GO_Central RNA metabolic process TAS 68800 RGD RNA splicing ISO RGD:735271 1624291 (MGI:MGI:3575934, PMID:15798186) RGD MGI:MGI:3575934 , PMID:15798186 RNA splicing IEA UniProtKB-KW:KW-0508 1600115 GO_REF:0000037 UniProt GO_REF:0000037 transformation of host cell by virus IEP 10045968 RGD Cellular Component catalytic step 2 spliceosome ISO RGD:1348965 1624291 (PMID:11991638) RGD PMID:11991638 catalytic step 2 spliceosome IEA UniProtKB:P09651 , ensembl:ENSP000003418261600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytoplasm IEA UniProtKB:P09651 , ensembl:ENSP000003418261600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytoplasm ISS UniProtKB:P09651 1600115 GO_REF:0000024 HGNC GO_REF:0000024 cytoplasm ISO RGD:1348965 1624291 (PMID:8521471) RGD PMID:8521471 cytosol IDA 10045574 RGD nucleoplasm IEA UniProtKB:A0A024RAZ7 , ensembl:ENSP000003418261600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm ISS UniProtKB:P09651 1600115 GO_REF:0000024 HGNC GO_REF:0000024 nucleoplasm ISO RGD:1348965 1624291 (PMID:21984414), (PMID:8521471) RGD GO_REF:0000052 more ... nucleoplasm IEA UniProtKB:P09651 , ensembl:ENSP000003418261600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasmic periphery of the nuclear pore complex IDA 10045985 RGD nucleus ISO RGD:735271 1624291 (MGI:MGI:3522382, PMID:15615787) RGD MGI:MGI:3522382 , PMID:15615787 nucleus IBA FB:FBgn0001215 more ... 13792537 PMID:21873635 GO_Central nucleus IBA FB:FBgn0001215 more ... 13792537 PMID:21873635 GO_Central nucleus ISO RGD:1348965 1624291 (PMID:23935072), (PMID:27694260) RGD PMID:23935072 , PMID:27694260 nucleus IDA 10040980 RGD ribonucleoprotein complex ISS UniProtKB:P09651 1600115 GO_REF:0000024 UniProt GO_REF:0000024 ribonucleoprotein complex IBA FB:FBgn0001215 more ... 13792537 PMID:21873635 GO_Central ribonucleoprotein complex IBA FB:FBgn0001215 more ... 13792537 PMID:21873635 GO_Central ribonucleoprotein complex ISO RGD:1348965 1624291 (PMID:17289661), (PMID:18809582), (PMID:23935072) RGD PMID:17289661 more ... spliceosomal complex ISO RGD:1348965 1624291 (PMID:25689357), (PMID:9731529) RGD PMID:25689357 , PMID:9731529 spliceosomal complex ISS UniProtKB:P09651 1600115 GO_REF:0000024 HGNC GO_REF:0000024 Molecular Function annealing helicase activity IDA 10045979 RGD G-rich strand telomeric DNA binding IEA UniProtKB:P09651 , ensembl:ENSP000003418261600115 GO_REF:0000107 Ensembl GO_REF:0000107 G-rich strand telomeric DNA binding ISO RGD:1348965 1624291 (PMID:23935072) RGD PMID:23935072 identical protein binding ISO RGD:1348965 1624291 UniProtKB:P09651-2 (PMID:23455423), (PMID:25009770) RGD PMID:23455423 , PMID:25009770 miRNA binding ISO RGD:1348965 1624291 (PMID:28431233) RGD PMID:28431233 miRNA binding ISS UniProtKB:P09651 1600115 GO_REF:0000024 UniProt GO_REF:0000024 miRNA binding IEA UniProtKB:P09651 , ensembl:ENSP000003418261600115 GO_REF:0000107 Ensembl GO_REF:0000107 mRNA 3'-UTR binding IDA 10045969 RGD mRNA binding IDA 10045574 RGD mRNA binding IBA PANTHER:PTN002690576 more ... 13792537 PMID:21873635 GO_Central mRNA binding IBA PANTHER:PTN002690576 more ... 13792537 PMID:21873635 GO_Central pre-mRNA binding IEA UniProtKB:P09651 , ensembl:ENSP000003418261600115 GO_REF:0000107 Ensembl GO_REF:0000107 pre-mRNA binding ISO RGD:1348965 1624291 (PMID:25689357) RGD PMID:25689357 protein binding IPI RGD:71058 10054427 RGD protein binding ISO RGD:1348965 1624291 UniProtKB:O00233 more ... RGD PMID:11546873 more ... protein binding IPI RGD:628780 10040996 RGD protein domain specific binding IEA UniProtKB:P09651 , ensembl:ENSP000003418261600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein domain specific binding ISO RGD:1348965 1624291 UniProtKB:P0DJD4 , UniProtKB:P62995 (PMID:10332027), (PMID:10749975) RGD PMID:10332027 , PMID:10749975 RNA binding TAS 68800 RGD RNA binding IBA MGI:MGI:104819 more ... 13792537 PMID:21873635 GO_Central RNA binding IBA FB:FBgn0003742 more ... 13792537 PMID:21873635 GO_Central RNA binding IDA 10040996 RGD RNA binding IEA UniRule:UR000414619 1600115 GO_REF:0000104 UniProt GO_REF:0000104 RNA strand annealing activity IDA 10045979 RGD sequence-specific mRNA binding IDA 625404 RGD single-stranded DNA binding TAS 68800 RGD single-stranded DNA binding ISS UniProtKB:P09651 1600115 GO_REF:0000024 HGNC GO_REF:0000024 single-stranded DNA binding ISO RGD:1348965 1624291 (PMID:8521471) RGD PMID:8521471 single-stranded RNA binding IDA 10045982 RGD telomeric repeat-containing RNA binding IEA UniProtKB:P09651 , ensembl:ENSP000003418261600115 GO_REF:0000107 Ensembl GO_REF:0000107 telomeric repeat-containing RNA binding ISO RGD:1348965 1624291 (PMID:23935072), (PMID:24529708) RGD PMID:23935072 , PMID:24529708 transcription factor binding IPI RGD:71058 10040996 RGD
Gene-Chemical Interaction Annotations
