Hnrnpa1 (heterogeneous nuclear ribonucleoprotein A1) - Rat Genome Database

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Gene: Hnrnpa1 (heterogeneous nuclear ribonucleoprotein A1) Rattus norvegicus
Analyze
Symbol: Hnrnpa1
Name: heterogeneous nuclear ribonucleoprotein A1
RGD ID: 69234
Description: Enables nucleic acid binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; cellular response to potassium ion; and male gonad development. Located in nucleoplasmic periphery of the nuclear pore complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 20; distal myopathy 3; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3; and tropical spastic paraparesis. Orthologous to several human genes including HNRNPA1L2 (heterogeneous nuclear ribonucleoprotein A1 like 2); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: HDP; helix-destabilizing protein; hnRNP A1; hnRNP core protein A1; Hnrpa1; single-strand RNA-binding protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Hnrnpa1-ps1   Hnrnpa1-ps11  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87136,253,633 - 136,260,085 (+)NCBIGRCr8
mRatBN7.27134,375,318 - 134,381,610 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7134,375,150 - 134,381,609 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7136,130,862 - 136,135,162 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07138,360,240 - 138,364,540 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07138,346,358 - 138,350,660 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07144,865,302 - 144,871,592 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7144,865,608 - 144,871,585 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07142,647,071 - 142,652,967 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47142,150,229 - 142,154,520 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17142,230,417 - 142,234,709 (+)NCBI
Celera7130,801,278 - 130,805,569 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic UMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (EXP)
alpha-pinene  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beryllium sulfate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
buspirone  (EXP)
butanal  (ISO)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
carvedilol  (ISO)
cefaloridine  (EXP)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (EXP)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glycidol  (EXP)
glyphosate  (ISO)
hydrazine  (ISO)
inulin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
josamycin  (ISO)
L-methionine  (ISO)
lasalocid  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methylmercury chloride  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phorone  (EXP)
pirinixic acid  (EXP)
propiconazole  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetracaine  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (EXP,ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
Yessotoxin  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Exon silencing by UAGG motifs in response to neuronal excitation. An P and Grabowski PJ, PLoS Biol. 2007 Feb;5(2):e36.
2. Cholinergic-associated loss of hnRNP-A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice. Berson A, etal., EMBO Mol Med. 2012 Aug;4(8):730-42. doi: 10.1002/emmm.201100995. Epub 2012 May 25.
3. Deregulated expression of hnRNP A/B proteins in human non-small cell lung cancer: parallel assessment of protein and mRNA levels in paired tumour/non-tumour tissues. Boukakis G, etal., BMC Cancer. 2010 Aug 17;10:434. doi: 10.1186/1471-2407-10-434.
4. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
5. Mitogenic insulin receptor-A is overexpressed in human hepatocellular carcinoma due to EGFR-mediated dysregulation of RNA splicing factors. Chettouh H, etal., Cancer Res. 2013 Jul 1;73(13):3974-86. doi: 10.1158/0008-5472.CAN-12-3824. Epub 2013 Apr 30.
6. Structure of rodent helix-destabilizing protein revealed by cDNA cloning. Cobianchi F, etal., J Biol Chem 1986 Mar 15;261(8):3536-43.
7. hnRNP A1 mediates the activation of the IRES-dependent SREBP-1a mRNA translation in response to endoplasmic reticulum stress. Damiano F, etal., Biochem J. 2013 Jan 15;449(2):543-53. doi: 10.1042/BJ20120906.
8. Identification in the rat brain of a set of nuclear proteins interacting with H1 degrees mRNA. Di Liegro CM, etal., Neuroscience. 2013 Jan 15;229:71-6. doi: 10.1016/j.neuroscience.2012.10.072. Epub 2012 Nov 14.
9. Differential distribution of heterogeneous nuclear ribonucleoproteins in rat tissues. Faura M, etal., Biochem Biophys Res Commun. 1995 Dec 14;217(2):554-60.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors. Hanamura A, etal., RNA. 1998 Apr;4(4):430-44.
12. The expression profile of RNA-binding proteins in primary and metastatic colorectal cancer: relationship of heterogeneous nuclear ribonucleoproteins with prognosis. Hope NR and Murray GI, Hum Pathol. 2011 Mar;42(3):393-402. doi: 10.1016/j.humpath.2010.08.006. Epub 2010 Dec 30.
13. The path of RNA through nuclear pores: apparent entry from the sides into specialized pores. Iborra FJ, etal., J Cell Sci. 2000 Jan;113 Pt 2:291-302.
14. Regulation of in vitro nucleic acid strand annealing activity of heterogeneous nuclear ribonucleoprotein protein A1 by reversible phosphorylation. Idriss H, etal., Biochemistry. 1994 Sep 20;33(37):11382-90.
15. Molecular mimicry: cross-reactive antibodies from patients with immune-mediated neurologic disease inhibit neuronal firing. Kalume F, etal., J Neurosci Res. 2004 Jul 1;77(1):82-9.
16. Agonist-mediated down-regulation of rat beta1-adrenergic receptor transcripts: role of potential post-transcriptional degradation factors. Kirigiti P, etal., Mol Pharmacol. 2001 Dec;60(6):1308-24.
17. Studies of the strand-annealing activity of mammalian hnRNP complex protein A1. Kumar A and Wilson SH, Biochemistry. 1990 Dec 4;29(48):10717-22.
18. Autoimmunity due to molecular mimicry as a cause of neurological disease. Levin MC, etal., Nat Med. 2002 May;8(5):509-13.
19. Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking response element-binding protein. Ma AS, etal., J Biol Chem 2002 May 17;277(20):18010-20.
20. Testis- and developmental stage-specific expression of hnRNP A2/B1 splicing isoforms, B0a/b. Matsui M, etal., Biochim Biophys Acta. 2000 Sep 7;1493(1-2):33-40.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Landscape of the hnRNP K protein-protein interactome. Mikula M, etal., Proteomics. 2006 Apr;6(8):2395-406.
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. Modulation of hnRNP A1 protein gene expression by epidermal growth factor in Rat-1 cells. Planck SR, etal., Nucleic Acids Res. 1988 Dec 23;16(24):11663-73.
27. Expression and cDNA sequence of helix destabilizing protein (HDP) in rat lung. Rayani HH, etal., Exp Lung Res. 1998 Jan-Feb;24(1):101-18.
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
32. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
33. The spliceosome: design principles of a dynamic RNP machine. Wahl MC, etal., Cell. 2009 Feb 20;136(4):701-18. doi: 10.1016/j.cell.2009.02.009.
Additional References at PubMed
PMID:2447078   PMID:8521471   PMID:9731529   PMID:10332027   PMID:10749975   PMID:11991638   PMID:15615787   PMID:15798186   PMID:16396499   PMID:16641100   PMID:16854843   PMID:17289661  
PMID:18809582   PMID:19946888   PMID:20458337   PMID:21253564   PMID:21984414   PMID:22082260   PMID:22658674   PMID:22681889   PMID:23455423   PMID:23935072   PMID:24529708   PMID:24625528  
PMID:25009770   PMID:25689357   PMID:25931508   PMID:26316108   PMID:27694260   PMID:28431233   PMID:35352799   PMID:38003404  


Genomics

Comparative Map Data
Hnrnpa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87136,253,633 - 136,260,085 (+)NCBIGRCr8
mRatBN7.27134,375,318 - 134,381,610 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7134,375,150 - 134,381,609 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7136,130,862 - 136,135,162 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07138,360,240 - 138,364,540 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07138,346,358 - 138,350,660 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07144,865,302 - 144,871,592 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7144,865,608 - 144,871,585 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07142,647,071 - 142,652,967 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47142,150,229 - 142,154,520 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17142,230,417 - 142,234,709 (+)NCBI
Celera7130,801,278 - 130,805,569 (+)NCBICelera
Cytogenetic Map7q36NCBI
HNRNPA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381254,280,726 - 54,287,087 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1254,280,193 - 54,287,088 (+)EnsemblGRCh38hg38GRCh38
GRCh371254,674,510 - 54,680,871 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361252,960,755 - 52,965,297 (+)NCBINCBI36Build 36hg18NCBI36
Build 341252,960,754 - 52,965,297NCBI
Celera1254,326,467 - 54,331,009 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1251,713,759 - 51,718,301 (+)NCBIHuRef
CHM1_11254,641,226 - 54,645,768 (+)NCBICHM1_1
T2T-CHM13v2.01254,247,303 - 54,253,664 (+)NCBIT2T-CHM13v2.0
Hnrnpa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915103,148,840 - 103,155,119 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15103,148,859 - 103,155,119 (+)EnsemblGRCm39 Ensembl
GRCm3815103,239,943 - 103,246,698 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15103,240,432 - 103,246,692 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715103,070,863 - 103,075,386 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615103,068,466 - 103,072,989 (+)NCBIMGSCv36mm8
Celera15105,402,021 - 105,406,544 (+)NCBICelera
Cytogenetic Map15F3NCBI
cM Map1558.58NCBI
Hnrnpa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554581,530,163 - 1,536,874 (+)NCBIChiLan1.0ChiLan1.0
HNRNPA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21039,884,192 - 39,891,112 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11239,880,960 - 39,887,881 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01234,456,900 - 34,463,317 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11235,182,164 - 35,188,651 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1235,184,943 - 35,188,443 (-)Ensemblpanpan1.1panPan2
HNRNPA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,013,459 - 1,020,083 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,015,868 - 1,019,891 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2745,235,341 - 45,240,080 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0271,012,273 - 1,017,012 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl271,012,271 - 1,016,841 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1271,031,242 - 1,035,976 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,010,967 - 1,017,580 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02745,639,146 - 45,643,882 (+)NCBIUU_Cfam_GSD_1.0
Hnrnpa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494561,677,106 - 61,683,541 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493651211,481,017 - 11,487,737 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNRNPA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl519,485,096 - 19,491,417 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1519,485,033 - 19,491,418 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2520,329,539 - 20,334,145 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HNRNPA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11150,397,173 - 50,403,192 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1150,396,888 - 50,400,802 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037195,638,486 - 195,645,432 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hnrnpa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249042,314,249 - 2,318,791 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249042,314,197 - 2,320,900 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hnrnpa1
15 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:181
Count of miRNA genes:130
Interacting mature miRNAs:142
Transcripts:ENSRNOT00000055285
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000055285   ⟹   ENSRNOP00000052160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7134,375,216 - 134,381,609 (+)Ensembl
Rnor_6.0 Ensembl7144,865,623 - 144,871,585 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091596   ⟹   ENSRNOP00000074880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7134,375,150 - 134,379,006 (+)Ensembl
Rnor_6.0 Ensembl7144,865,608 - 144,869,926 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113929   ⟹   ENSRNOP00000094714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7134,375,150 - 134,379,557 (+)Ensembl
RefSeq Acc Id: NM_001399274   ⟹   NP_001386203
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87136,254,118 - 136,258,419 (+)NCBI
mRatBN7.27134,375,643 - 134,379,944 (+)NCBI
RefSeq Acc Id: NM_017248   ⟹   NP_058944
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87136,254,118 - 136,258,419 (+)NCBI
mRatBN7.27134,375,643 - 134,379,944 (+)NCBI
Rnor_6.07144,865,640 - 144,869,931 (+)NCBI
Rnor_5.07142,647,071 - 142,652,967 (+)NCBI
RGSC_v3.47142,150,229 - 142,154,520 (+)RGD
Celera7130,801,278 - 130,805,569 (+)RGD
Sequence:
RefSeq Acc Id: XM_063263120   ⟹   XP_063119190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87136,253,633 - 136,258,419 (+)NCBI
RefSeq Acc Id: XM_063263121   ⟹   XP_063119191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87136,253,633 - 136,258,419 (+)NCBI
RefSeq Acc Id: XR_010052947
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87136,253,633 - 136,260,085 (+)NCBI
RefSeq Acc Id: XR_356017
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87136,253,644 - 136,260,085 (+)NCBI
mRatBN7.27134,375,318 - 134,381,610 (+)NCBI
Rnor_6.07144,865,302 - 144,871,592 (+)NCBI
Rnor_5.07142,647,071 - 142,652,967 (+)NCBI
Sequence:
RefSeq Acc Id: NP_058944   ⟸   NM_017248
- Peptide Label: isoform 2
- UniProtKB: P04256 (UniProtKB/Swiss-Prot),   F7FEZ6 (UniProtKB/TrEMBL),   Q5I0M7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000052160   ⟸   ENSRNOT00000055285
Ensembl Acc Id: ENSRNOP00000074880   ⟸   ENSRNOT00000091596
Ensembl Acc Id: ENSRNOP00000094714   ⟸   ENSRNOT00000113929
RefSeq Acc Id: NP_001386203   ⟸   NM_001399274
- Peptide Label: isoform 1
- UniProtKB: P04256 (UniProtKB/Swiss-Prot),   A0A8I6ALC1 (UniProtKB/TrEMBL),   A6KD00 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119190   ⟸   XM_063263120
- Peptide Label: isoform X1
- UniProtKB: P04256 (UniProtKB/Swiss-Prot),   A0A8I6ALC1 (UniProtKB/TrEMBL),   A6KD00 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119191   ⟸   XM_063263121
- Peptide Label: isoform X2
- UniProtKB: P04256 (UniProtKB/Swiss-Prot),   F7FEZ6 (UniProtKB/TrEMBL),   Q5I0M7 (UniProtKB/TrEMBL)
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04256-F1-model_v2 AlphaFold P04256 1-320 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695728
Promoter ID:EPDNEW_R6238
Type:multiple initiation site
Name:Hnrnpa1_1
Description:heterogeneous nuclear ribonucleoprotein A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07144,865,608 - 144,865,668EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69234 AgrOrtholog
BioCyc Gene G2FUF-31884 BioCyc
Ensembl Genes ENSRNOG00000036839 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055285.5 UniProtKB/TrEMBL
  ENSRNOT00000091596.2 UniProtKB/TrEMBL
  ENSRNOT00000113929.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6920834 IMAGE-MGC_LOAD
  IMAGE:7374689 IMAGE-MGC_LOAD
InterPro HnRNPA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hnRNPA1/3_RRM2 UniProtKB/TrEMBL
  hnRNPA1_RRM1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29578 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108719 IMAGE-MGC_LOAD
  MGC:72886 IMAGE-MGC_LOAD
NCBI Gene 29578 ENTREZGENE
PANTHER HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HnRNPA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hnrnpa1 PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000036839 RatGTEx
SMART RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228827
UniProt A0A0G2K968_RAT UniProtKB/TrEMBL
  A0A8I6ALC1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8J8YF53_RAT UniProtKB/TrEMBL
  A6KD00 ENTREZGENE, UniProtKB/TrEMBL
  F7FEZ6 ENTREZGENE
  P04256 ENTREZGENE
  Q5I0M7 ENTREZGENE, UniProtKB/TrEMBL
  Q6P6G9_RAT UniProtKB/TrEMBL
  ROA1_RAT UniProtKB/Swiss-Prot
UniProt Secondary F7FEZ6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Hnrnpa1  heterogeneous nuclear ribonucleoprotein A1  Hnrpa1  heterogeneous nuclear ribonucleoprotein A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Hnrpa1  heterogeneous nuclear ribonucleoprotein A1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function protein has two repeats of quasi-RRM domains than bind to mRNA 68800
gene_process protein associated with pre-mRNAs in the nucleus and appear to influence mRNA processing, metabolism and transport 68800