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Gene: Hoxc8 (homeobox C8) Rattus norvegicus

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Symbol:

Hoxc8

Name:

homeobox C8

RGD ID:

2821

Description:

Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to act upstream of or within several processes, including anterior/posterior pattern specification; negative regulation of transcription by RNA polymerase II; and skeletal system morphogenesis. Predicted to be located in microtubule cytoskeleton and nucleoplasm. Orthologous to human HOXC8 (homeobox C8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

homeo box C8; homeo box C8 (mapped); Homeobox gene C8; homeobox protein Hox-C8; homeobox protein R4; Hox3r4; Hoxc8_mapped

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HOXC8 (homeobox C8)	HGNC	Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Mus musculus (house mouse):	Hoxc8 (homeobox C8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Hoxc8 (homeobox C8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HOXC8 (homeobox C8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HOXC8 (homeobox C8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hoxc8 (homeobox C8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HOXC8 (homeobox C8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HOXC8 (homeobox C8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hoxc8 (homeobox C8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	HOXB8 (homeobox B8)	HGNC	OrthoDB
Homo sapiens (human):	CACUL1 (CDK2 associated cullin domain 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	HOXC8 (homeobox C8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Hoxc8 (homeobox C8)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	hoxc8a (homeobox C8a)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	hoxc8	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	136,006,407 - 136,008,973 (+)	NCBI		GRCr8
mRatBN7.2	7	134,127,937 - 134,130,503 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	134,127,913 - 134,130,503 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	135,883,327 - 135,885,892 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	138,112,704 - 138,115,269 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	138,098,652 - 138,101,223 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	144,605,072 - 144,607,639 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	144,605,058 - 144,608,538 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	142,396,429 - 142,398,996 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	7	130,553,925 - 130,556,402 (+)	NCBI		Celera
Cytogenetic Map	7	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

aldrin (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

chloroethene (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

cytarabine (ISO)

DDE (ISO)

lead diacetate (ISO)

lipopolysaccharide (ISO)

methylparaben (ISO)

perfluorooctanoic acid (EXP)

potassium chromate (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

temozolomide (ISO)

thapsigargin (ISO)

trichloroethene (EXP)

triclosan (ISO)

troglitazone (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterior/posterior pattern specification (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

neuron differentiation (IEA,ISO)

regulation of DNA-templated transcription (IEA)

skeletal system morphogenesis (IEA,ISO)

Cellular Component

microtubule cytoskeleton (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IEA,ISO)

Molecular Function

DNA binding (IEA,ISO)

DNA-binding transcription factor activity (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

protein binding (ISO)

sequence-specific double-stranded DNA binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:2907739	PMID:7702549	PMID:7906969	PMID:7911971	PMID:8649375	PMID:11311170	PMID:11870622	PMID:12971990	PMID:15632090	PMID:15753214

Genomics

Comparative Map Data

Hoxc8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	136,006,407 - 136,008,973 (+)	NCBI		GRCr8
mRatBN7.2	7	134,127,937 - 134,130,503 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	134,127,913 - 134,130,503 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	135,883,327 - 135,885,892 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	138,112,704 - 138,115,269 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	138,098,652 - 138,101,223 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	144,605,072 - 144,607,639 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	144,605,058 - 144,608,538 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	142,396,429 - 142,398,996 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	7	130,553,925 - 130,556,402 (+)	NCBI		Celera
Cytogenetic Map	7	q36	NCBI

HOXC8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	54,008,985 - 54,012,769 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	54,008,985 - 54,012,769 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	54,402,769 - 54,406,553 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	52,689,157 - 52,692,814 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	52,689,156 - 52,692,810	NCBI
Celera	12	54,052,507 - 54,056,164 (+)	NCBI		Celera
Cytogenetic Map	12	q13.13	NCBI
HuRef	12	51,440,618 - 51,444,277 (+)	NCBI		HuRef
CHM1_1	12	54,369,593 - 54,373,250 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	53,960,328 - 53,978,298 (+)	NCBI		T2T-CHM13v2.0

Hoxc8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	102,898,971 - 102,902,707 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	102,899,039 - 102,902,543 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	102,990,539 - 102,994,275 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	102,990,607 - 102,994,111 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	102,820,970 - 102,824,685 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	102,818,573 - 102,821,404 (+)	NCBI		MGSCv36	mm8
Celera	15	105,151,461 - 105,155,164 (+)	NCBI		Celera
Cytogenetic Map	15	F3	NCBI
cM Map	15	58.05	NCBI

Hoxc8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	1,267,247 - 1,272,690 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	1,267,247 - 1,271,354 (+)	NCBI	ChiLan1.0	ChiLan1.0

HOXC8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	40,173,187 - 40,180,313 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	40,169,953 - 40,173,734 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	34,742,674 - 34,746,451 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	35,531,176 - 35,534,420 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	35,531,200 - 35,534,420 (-)	Ensembl	panpan1.1		panPan2

HOXC8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	1,251,314 - 1,262,809 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	44,996,515 - 44,999,967 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	1,253,300 - 1,256,754 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	1,254,553 - 1,256,700 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	1,271,025 - 1,274,474 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	1,252,555 - 1,256,007 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	45,400,137 - 45,403,590 (+)	NCBI		UU_Cfam_GSD_1.0

Hoxc8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	61,929,891 - 61,933,369 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	11,231,467 - 11,234,496 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936512	11,231,467 - 11,234,515 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HOXC8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	19,222,057 - 19,225,835 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	19,222,124 - 19,225,734 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	19,677,573 - 19,684,240 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HOXC8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	50,119,515 - 50,123,276 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	50,119,932 - 50,123,411 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	195,918,803 - 195,926,317 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hoxc8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624904	2,063,841 - 2,067,430 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624904	2,063,884 - 2,067,040 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Hoxc8
5 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	156
Count of miRNA genes:	115
Interacting mature miRNAs:	126
Transcripts:	ENSRNOT00000031404
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
1354582	Stl11	Serum triglyceride level QTL 11	3.42		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	119513385	135012528	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	111182207	135012528	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
2306821	Bp335	Blood pressure QTL 335		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	106571501	135012528	Rat
631663	Bw6	Body weight QTL 6	3.4		body mass (VT:0001259)	body weight (CMO:0000012)	7	111075573	134976056	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
731174	Uae23	Urinary albumin excretion QTL 23	2.4	0.0042	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	7	104603555	135012528	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat

Markers in Region

Hoxc8

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	134,129,956 - 134,130,058 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	144,607,093 - 144,607,194	NCBI	Rnor6.0
Rnor_5.0	7	142,398,450 - 142,398,551	UniSTS	Rnor5.0
RGSC_v3.4	7	141,756,303 - 141,756,404	UniSTS	RGSC3.4
Celera	7	130,555,856 - 130,555,957	UniSTS
Cytogenetic Map	7	q35	UniSTS
Cytogenetic Map	7	q36	UniSTS

MARC_41665-41666:1086710236:1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	134,128,189 - 134,129,758 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	144,605,325 - 144,606,894	NCBI	Rnor6.0
Rnor_5.0	7	142,396,682 - 142,398,251	UniSTS	Rnor5.0
RGSC_v3.4	7	141,754,536 - 141,756,104	UniSTS	RGSC3.4
Celera	7	130,554,088 - 130,555,657	UniSTS
Cytogenetic Map	7	q35	UniSTS
Cytogenetic Map	7	q36	UniSTS

Hoxc8

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	134,128,335 - 134,129,757 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	144,605,471 - 144,606,893	NCBI	Rnor6.0
Rnor_5.0	7	142,396,828 - 142,398,250	UniSTS	Rnor5.0
Celera	7	130,554,234 - 130,555,656	UniSTS
Cytogenetic Map	7	q35	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
8	11	13	45	55	53	26	24	26	6	147	60	25	45	59	27

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001177326	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC116663	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M37568	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S76301	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000031404 ⟹ ENSRNOP00000035473

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	134,127,913 - 134,130,503 (+)	Ensembl
Rnor_6.0 Ensembl	7	144,605,058 - 144,608,538 (+)	Ensembl

RefSeq Acc Id:

NM_001177326 ⟹ NP_001170797

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	136,006,407 - 136,008,973 (+)	NCBI
mRatBN7.2	7	134,127,937 - 134,130,503 (+)	NCBI
Rnor_6.0	7	144,605,072 - 144,607,639 (+)	NCBI
Rnor_5.0	7	142,396,429 - 142,398,996 (+)	NCBI
Celera	7	130,553,925 - 130,556,402 (+)	NCBI

Sequence:

show sequence

ATGAGCTCCTACTTCGTCAACCCCCTGTTCTCCAAATACAAAGGCGGCGAGTCCCTGGAACCGG
CCTATTACGACTGCCGGTTCCCTCAGAGCGTGGGCAGAAGCCATGCGCTGGTGTACGGGCCCGG
CGGCTCAGCGCCCGGCTTCCAGCACGCCTCGCACCACGTCCAAGACTTCTTCCACCACGGCACC
TCCGGCATCTCCAACTCGGGCTACCAGCAGAACCCGTGCTCGCTGAGCTGCCACGGAGACGCCT
CCAAATTCTATGGCTACGAGGCGCTCCCCAGACAGTCCCTTTATGGGGCTCAGCAAGAGGCGAG
CGTGGTGCAATATCCCGACTGTAAATCCTCCGCCAACACTAACAGTAGCGAAGGACAAGGCCAC
TTAAATCAGAACTCGTCTCCCAGCCTCATGTTTCCATGGATGAGACCCCACGCTCCTGGGCGGC
GCAGCGGACGACAAACTTACAGCCGGTATCAGACCTTGGAACTAGAGAAGGAGTTTCTCTTTAA
TCCTTATTTGACCAGAAAGCGCCGGATTGAAGTCTCTCACGCCCTGGGACTGACGGAAAGACAA
GTGAAGATTTGGTTCCAGAATCGAAGGATGAAGTGGAAAAAGGAGAACAACAAGGATAAACTTC
CTGGGGCCCGAGATGAGGAGAAGGTGGAAGAAGAAGGGAATGAGGAAGAGGAGAAGGAGGAGGA
GGAAAAGGAAGAAAATAAGGACTAAGAAAAAAGAGAAAATCAGCCCCCCCCACAACTCCCTTGA
AGTTTCGTTTTATGGTAGCAGATAAATTGAGAAGTTTACGACTGTCATTTGCTTTTATAGAGAA
TAGAATGACACTCACAACTGTAACTACCTGTCAGATAGTTGCAGCTCTGCTTTTATTACCTTTG
GCCTTCCCCCACTCTTTATTTGTCTGGGGGTTGGGAGGGGGAACCTGAGACACAGGGAAAAGTT
CTGTTCCACTCCATGCCCAGCACACACTCACTTGTCCCTACTTCCACTTCTGAGCCCTTCCCGA
TAAAGCCTAACCCTACACACACACACACACACACACACACACACACACACACACACACCACACA
CACTTCTCTCCACACTCTTTACACGATTCTCTGGTATTTATTTTAAAAGGGATTCCCCTGAAGA
TGTAGAAGATGATTCCTGGCTTTGCTTGTATGCTGGGAATTAGAATACTGGATTGACTTTTTTT
TTTAAATGAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001170797	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41344	(Get FASTA)	NCBI Sequence Viewer
	AAP31869	(Get FASTA)	NCBI Sequence Viewer
	EDL86803	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000035473
	ENSRNOP00000035473.4
GenBank Protein	P18866	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001170797 ⟸ NM_001177326

- UniProtKB:

F1MAK7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSSYFVNPLFSKYKGGESLEPAYYDCRFPQSVGRSHALVYGPGGSAPGFQHASHHVQDFFHHGT
SGISNSGYQQNPCSLSCHGDASKFYGYEALPRQSLYGAQQEASVVQYPDCKSSANTNSSEGQGH
LNQNSSPSLMFPWMRPHAPGRRSGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQ
VKIWFQNRRMKWKKENNKDKLPGARDEEKVEEEGNEEEEKEEEEKEENKD

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Ensembl Acc Id:

ENSRNOP00000035473 ⟸ ENSRNOT00000031404

Protein Domains

Homeobox

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P18866-F1-model_v2	AlphaFold	P18866	1-108	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2821	AgrOrtholog
BioCyc Gene	G2FUF-31912	BioCyc
Ensembl Genes	ENSRNOG00000028619	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000031404	ENTREZGENE
	ENSRNOT00000031404.7	UniProtKB/TrEMBL
Gene3D-CATH	Homeodomain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Antp_homeobox_TF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_Antennapedia_CS	UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Homeobox_metazoa	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HTH_motif	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:24460	UniProtKB/TrEMBL
NCBI Gene	24460	ENTREZGENE
PANTHER	HOMEOBOX DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HOMEOBOX PROTEIN HOX-C8	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Homeodomain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Hoxc8	PhenoGen
PRINTS	HOMEOBOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HTHREPRESSR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ANTENNAPEDIA	UniProtKB/TrEMBL
	HOMEOBOX_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000028619	RatGTEx
SMART	HOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	F1MAK7	ENTREZGENE, UniProtKB/TrEMBL
	HXC8_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2000-05-25	Hoxc8	homeobox C8			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar