Angpt1 (angiopoietin 1) - Rat Genome Database

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Gene: Angpt1 (angiopoietin 1) Rattus norvegicus
Symbol: Angpt1
Name: angiopoietin 1
RGD ID: 628896
Description: Enables identical protein binding activity. Involved in several processes, including liver regeneration; response to estrogen; and response to vitamin B3. Located in extracellular space. Biomarker of gastric ulcer; in situ carcinoma; myocardial infarction; nephrosis; and pulmonary hypertension. Human ortholog(s) of this gene implicated in brain ischemia; diabetic retinopathy; hereditary angioedema; and hypertension. Orthologous to human ANGPT1 (angiopoietin 1); PARTICIPATES IN angiopoietin signaling pathway; rheumatoid arthritis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 3-chloropropane-1,2-diol.
Type: protein-coding
Previously known as: Agpt; Agpt1; Ang-1; angiopoietin; angiopoietin-1; LOC360422
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2773,528,345 - 73,783,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl773,531,486 - 73,784,067 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx775,390,636 - 75,634,234 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0777,593,123 - 77,836,716 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0777,461,245 - 77,704,839 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0781,338,327 - 81,592,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl781,342,280 - 81,592,206 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0781,364,881 - 81,618,559 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4778,195,504 - 78,451,471 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera770,543,119 - 70,792,915 (-)NCBICelera
Cytogenetic Map7q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
baicalin  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
daunorubicin  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
furan  (EXP)
geldanamycin  (ISO)
genistein  (ISO)
glyphosate  (EXP,ISO)
hydrogen peroxide  (ISO)
iloprost  (ISO)
indometacin  (ISO)
inulin  (ISO)
L-serine  (EXP)
Lasiocarpine  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
mercury dichloride  (EXP)
metformin  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
naringin  (EXP)
nicotinic acid  (EXP,ISO)
ochratoxin A  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PD123319  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
poly(vinyl chloride)  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (EXP)
rofecoxib  (ISO)
rotenone  (EXP)
roxarsone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sildenafil citrate  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
streptozocin  (EXP)
temozolomide  (ISO)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (ISO)
torcetrapib  (ISO)
trichostatin A  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IBA,ISO)
animal organ regeneration  (IEP)
cell-substrate adhesion  (IEA,ISO)
glomerulus vasculature development  (IEA,IMP,ISO)
hemopoiesis  (IEA,ISO)
heparin biosynthetic process  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
liver regeneration  (IEP)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of cell adhesion  (IEA,ISO)
negative regulation of cytokine production involved in immune response  (IEA,ISO)
negative regulation of endothelial cell apoptotic process  (IEA,ISO)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of protein import into nucleus  (IEA,ISO)
negative regulation of protein phosphorylation  (IEA,ISO)
negative regulation of vascular permeability  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
ovarian follicle development  (IMP)
positive chemotaxis  (IEA,ISO)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO)
positive regulation of blood-brain barrier permeability  (IEA,ISO)
positive regulation of cell adhesion  (IEA,ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein ubiquitination  (IEA,ISO)
positive regulation of receptor internalization  (IEA,ISO)
protein localization to cell surface  (IEA,ISO)
regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
regulation of endothelial cell proliferation  (ISO)
regulation of macrophage migration inhibitory factor signaling pathway  (IEA,ISO)
regulation of skeletal muscle satellite cell proliferation  (IEA,ISO)
regulation of tumor necrosis factor production  (IEA,ISO)
response to estrogen  (IEP)
response to hypoxia  (IEP)
response to vitamin B3  (IEP)
sprouting angiogenesis  (IEA,ISO)
Tie signaling pathway  (IBA,IEA,ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-alpha in a rodent experimental stroke model. Ardelt AA, etal., Stroke. 2005 Feb;36(2):337-41. Epub 2005 Jan 6.
2. High-grade clear cell renal cell carcinoma has a higher angiogenic activity than low-grade renal cell carcinoma based on histomorphological quantification and qRT-PCR mRNA expression profile. Baldewijns MM, etal., Br J Cancer. 2007 Jun 18;96(12):1888-95. Epub 2007 May 15.
3. Mutant animal models of stroke and gene expression: the stroke-prone spontaneously hypertensive rat. Carswell HV, etal., Methods Mol Med 2005;104:49-74.
4. Niaspan increases angiogenesis and improves functional recovery after stroke. Chen J, etal., Ann Neurol. 2007 Jul;62(1):49-58.
5. Angiopoietin-1 inhibits intrinsic apoptotic signaling and vascular hyperpermeability following hemorrhagic shock. Childs EW, etal., Am J Physiol Heart Circ Physiol. 2008 May;294(5):H2285-95. Epub 2008 Mar 14.
6. A new animal model for pulmonary hypertension based on the overexpression of a single gene, angiopoietin-1. Chu D, etal., Ann Thorac Surg. 2004 Feb;77(2):449-56; discussion 456-7.
7. Effect of ageing on the expression of protein kinase C and its activation by 1,25(OH)2-vitamin D3 in rat skeletal muscle. Facchinetti MM and de Boland AR, Cell Signal. 1999 Jan;11(1):39-44.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Localized expression of angiopoietin 1 and 2 may explain unique characteristics of the rat testicular microvasculature. Haggstrom Rudolfsson S, etal., Biol Reprod 2003 Oct;69(4):1231-7. Epub 2003 May 28.
10. Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy. Hammes HP, etal., Diabetes. 2004 Apr;53(4):1104-10.
11. Expression of angiopoietin-1, angiopoietin-2, and Tie2 genes in normal ovary with corpus luteum and in ovarian cancer. Hata K, etal., Oncology. 2002;62(4):340-8.
12. A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro. Hori S, etal., J Neurochem 2004 Apr;89(2):503-13.
13. Suppression of diabetic retinopathy with angiopoietin-1. Joussen AM, etal., Am J Pathol. 2002 May;160(5):1683-93.
14. AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis. Kim JW, etal., Lab Invest. 2000 Apr;80(4):587-94.
15. Angiopoietin-1 promotes neurite outgrowth from dorsal root ganglion cells positive for Tie-2 receptor. Kosacka J, etal., Cell Tissue Res. 2005 Apr;320(1):11-9. Epub 2005 Feb 16.
16. Vascular endothelial growth factor and angiopoietin in liver regeneration. Kraizer Y, etal., Biochem Biophys Res Commun 2001 Sep 14;287(1):209-15.
17. Angiopoietin-1 prevents hypertension and target organ damage through its interaction with endothelial Tie2 receptor. Lee JS, etal., Cardiovasc Res. 2008 Jun 1;78(3):572-80. Epub 2008 Feb 19.
18. Angiopoietins and Tie2 in health and disease. Li LY, etal., Pediatr Endocrinol Rev. 2005 Mar;2(3):399-408.
19. Changes in angiopoietin expression in glomeruli involved in glomerulosclerosis in rats with daunorubicin-induced nephrosis. Lu YH, etal., Acta Pharmacol Sin. 2006 May;27(5):579-87.
20. Angiopoietin-1 promotes tumor angiogenesis in a rat glioma model. Machein MR, etal., Am J Pathol 2004 Nov;165(5):1557-70.
21. Angiotensin II promotes development of the renal microcirculation through AT1 receptors. Madsen K, etal., J Am Soc Nephrol. 2010 Mar;21(3):448-59. doi: 10.1681/ASN.2009010045. Epub 2010 Jan 7.
22. Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia. Mandriota SJ and Pepper MS, Circ Res 1998 Oct 19;83(8):852-9.
23. Effects of aspirin on intra-platelet vascular endothelial growth factor, angiopoietin-1, and p-selectin levels in hypertensive patients. Nadar S, etal., Am J Hypertens. 2006 Sep;19(9):970-7; discussion 978.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified hMSCs after cerebral ischemia. Onda T, etal., J Cereb Blood Flow Metab. 2007 Jul 18;.
26. Intrabursal Administration of the Antiangiopoietin 1 Antibody Produces a Delay in Rat Follicular Development Associated with an Increase in Ovarian Apoptosis Mediated by Changes in the Expression of BCL2 Related Genes. Parborell F, etal., Biol Reprod. 2007 Nov 7;.
27. Expression of angiopoietin-1 and -2 in the rat brain during chronic hypoxia and de-adaptation. Pichiule P and LaManna JC, Adv Exp Med Biol 2003;510:331-5.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. Alteration of the vascular endothelial growth factor and angiopoietins-1 and -2 pathways in transitional cell carcinomas of the urinary bladder associated with tumor progression. Quentin T, etal., Anticancer Res. 2004 Sep-Oct;24(5A):2745-56.
30. Early effects of hypoxia/reoxygenation on VEGF, ang-1, ang-2 and their receptors in the rat myocardium: implications for myocardial angiogenesis. Ray PS, etal., Mol Cell Biochem. 2000 Oct;213(1-2):145-53.
31. The role of angiopoietins during angiogenesis in gliomas. Reiss Y, etal., Brain Pathol. 2005 Oct;15(4):311-7.
32. GOA pipeline RGD automated data pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Comprehensive gene review and curation RGD comprehensive gene curation
36. Angiogenic factors in normal endometrium and endometrial adenocarcinoma. Saito M, etal., Pathol Int. 2007 Mar;57(3):140-7.
37. Reciprocal regulation of angiopoietin-1 and angiopoietin-2 following myocardial infarction in the rat. Sandhu R, etal., Cardiovasc Res. 2004 Oct 1;64(1):115-24.
38. Vascular endothelial growth factor and angiopoietins regulate sinusoidal regeneration and remodeling after partial hepatectomy in rats. Shimizu H, etal., World J Gastroenterol. 2005 Dec 14;11(46):7254-60.
39. Protective role of COMP-Ang1 in ischemic rat brain. Shin HY, etal., J Neurosci Res. 2009 Nov 2.
40. Antiangiogenic treatment with Sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats. Tugues S, etal., Hepatology. 2007 Dec;46(6):1919-26.
41. Postischemic angiogenic factor expression in stroke-prone rats. Wang MM, etal., Exp Neurol 2002 Feb;173(2):283-8.
42. Expression of Tie-2 and angiopoietin-1 and -2 in early phase of ulcer healing. Wen CY, etal., J Gastroenterol. 2003;38(5):431-5.
43. The expression of angiopoietins and their receptor Tie-2 in human prostate carcinoma. Wurmbach JH, etal., Anticancer Res. 2000 Nov-Dec;20(6D):5217-20.
44. Downregulation of angiopoietin-1 and Tie2 in chronic hypoxic pulmonary hypertension. Yamamoto A, etal., Respiration. 2008;75(3):328-38. Epub 2007 Dec 10.
45. Expression of angiogenic factors is upregulated in DMBA-induced rat mammary pathologies. Yan M, etal., Pathobiology. 2004;71(5):253-60.
46. [The expression and significance of the angiopoietin-1 in the kidney of diabetic rats] Yang YB, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Jan;38(1):93-6, 104.
47. Regulation of angiopoietin and Tie-2 receptor expression in non-reproductive tissues by estrogen. Ye F, etal., Steroids 2002 Mar;67(3-4):305-10.
48. Angiopoietin1/Tie2 and VEGF/Flk1 induced by MSC treatment amplifies angiogenesis and vascular stabilization after stroke. Zacharek A, etal., J Cereb Blood Flow Metab. 2007 Mar 14;.
Additional References at PubMed
PMID:8980223   PMID:8980224   PMID:9560344   PMID:9660821   PMID:9846489   PMID:10218485   PMID:10617467   PMID:11172728   PMID:11507774   PMID:12458684   PMID:12958144   PMID:14512515  
PMID:14966366   PMID:14978158   PMID:15260986   PMID:15851516   PMID:16493688   PMID:16762501   PMID:17559808   PMID:17562701   PMID:18272601   PMID:18425120   PMID:18471417   PMID:18497305  
PMID:18505784   PMID:18929864   PMID:18947490   PMID:19148554   PMID:19199708   PMID:19297368   PMID:19379779   PMID:19409199   PMID:19424712   PMID:19615361   PMID:19674970   PMID:19689429  
PMID:19712575   PMID:19733541   PMID:19821086   PMID:19922791   PMID:20060382   PMID:20860549   PMID:20969813   PMID:21701128   PMID:21704119   PMID:22336210   PMID:22336306   PMID:22374674  
PMID:22843181   PMID:22869617   PMID:22927341   PMID:23486192   PMID:23850469   PMID:24606182   PMID:24664592   PMID:25004887   PMID:25446117   PMID:25759532   PMID:27439004   PMID:27868196  
PMID:29197611   PMID:29774773   PMID:30729120   PMID:31581897   PMID:33820492  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2773,528,345 - 73,783,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl773,531,486 - 73,784,067 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx775,390,636 - 75,634,234 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0777,593,123 - 77,836,716 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0777,461,245 - 77,704,839 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0781,338,327 - 81,592,459 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl781,342,280 - 81,592,206 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0781,364,881 - 81,618,559 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4778,195,504 - 78,451,471 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera770,543,119 - 70,792,915 (-)NCBICelera
Cytogenetic Map7q31NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh388107,249,482 - 107,497,918 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8107,249,482 - 107,498,055 (-)EnsemblGRCh38hg38GRCh38
GRCh378108,261,710 - 108,510,146 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368108,330,886 - 108,579,430 (-)NCBINCBI36Build 36hg18NCBI36
Build 348108,330,885 - 108,579,430NCBI
Celera8104,448,513 - 104,696,524 (-)NCBICelera
Cytogenetic Map8q23.1NCBI
HuRef8103,581,813 - 103,830,178 (-)NCBIHuRef
CHM1_18108,301,960 - 108,550,507 (-)NCBICHM1_1
T2T-CHM13v2.08108,377,097 - 108,625,564 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391542,288,063 - 42,540,373 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1542,288,119 - 42,540,373 (-)EnsemblGRCm39 Ensembl
GRCm381542,424,667 - 42,676,977 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1542,424,723 - 42,676,977 (-)EnsemblGRCm38mm10GRCm38
MGSCv371542,256,269 - 42,508,341 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361542,254,797 - 42,506,869 (-)NCBIMGSCv36mm8
Celera1542,923,801 - 43,172,633 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1516.69NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541730,198,842 - 30,386,266 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541730,199,508 - 30,386,695 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan18100,139,400 - 100,383,799 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08103,893,234 - 104,137,661 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18106,039,873 - 106,287,245 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8106,042,041 - 106,286,783 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1138,068,920 - 8,312,090 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl138,048,205 - 8,311,618 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha138,012,976 - 8,253,361 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0138,330,622 - 8,573,873 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl138,330,895 - 8,573,753 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1138,089,554 - 8,329,930 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0138,207,290 - 8,447,896 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0138,284,694 - 8,525,154 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440530329,679,371 - 29,900,106 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647037,105,466 - 37,328,190 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647037,105,469 - 37,328,183 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl429,933,135 - 30,233,960 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1429,925,203 - 30,233,434 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2432,833,909 - 32,855,132 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2432,433,135 - 32,433,409 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2432,646,874 - 32,751,649 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.18102,020,346 - 102,268,443 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603938,309,531 - 38,560,517 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462476322,646,231 - 22,718,294 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476322,645,807 - 22,818,592 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Angpt1
1343 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:32
Interacting mature miRNAs:35
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2773,593,761 - 73,593,956 (+)MAPPERmRatBN7.2
Rnor_6.0781,402,125 - 81,402,319NCBIRnor6.0
Rnor_5.0781,428,195 - 81,428,389UniSTSRnor5.0
RGSC_v3.4778,256,277 - 78,256,471UniSTSRGSC3.4
Celera770,603,605 - 70,603,799UniSTS
RH 3.4 Map7524.6UniSTS
Cytogenetic Map7q31UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2773,783,688 - 73,783,954 (+)MAPPERmRatBN7.2
Rnor_6.0781,592,035 - 81,592,300NCBIRnor6.0
Rnor_5.0781,618,105 - 81,618,370UniSTSRnor5.0
RGSC_v3.4778,451,207 - 78,451,472UniSTSRGSC3.4
Celera770,792,651 - 70,792,916UniSTS
Cytogenetic Map7q31UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2773,783,609 - 73,783,788 (+)MAPPERmRatBN7.2
Rnor_6.0781,591,956 - 81,592,134NCBIRnor6.0
Rnor_5.0781,618,026 - 81,618,204UniSTSRnor5.0
RGSC_v3.4778,451,128 - 78,451,306UniSTSRGSC3.4
Celera770,792,572 - 70,792,750UniSTS
Cytogenetic Map7q31UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 37 19 6 12 6 7 8 11 29 15 11 7
Low 3 6 37 34 7 34 1 3 63 6 25 1
Below cutoff 1 1 1 1


RefSeq Acc Id: ENSRNOT00000007979   ⟹   ENSRNOP00000007979
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl773,531,486 - 73,784,067 (-)Ensembl
Rnor_6.0 Ensembl781,342,280 - 81,592,206 (-)Ensembl
RefSeq Acc Id: NM_053546   ⟹   NP_445998
Rat AssemblyChrPosition (strand)Source
mRatBN7.2773,533,462 - 73,783,953 (-)NCBI
Rnor_6.0781,342,374 - 81,592,299 (-)NCBI
Rnor_5.0781,364,881 - 81,618,559 (-)NCBI
RGSC_v3.4778,195,504 - 78,451,471 (-)RGD
Celera770,543,119 - 70,792,915 (-)RGD
RefSeq Acc Id: XM_006241609   ⟹   XP_006241671
Rat AssemblyChrPosition (strand)Source
mRatBN7.2773,528,345 - 73,783,694 (-)NCBI
Rnor_6.0781,338,327 - 81,592,459 (-)NCBI
Rnor_5.0781,364,881 - 81,618,559 (-)NCBI
RefSeq Acc Id: NP_445998   ⟸   NM_053546
- Peptide Label: precursor
- UniProtKB: Q8K4Q4 (UniProtKB/Swiss-Prot),   O35460 (UniProtKB/Swiss-Prot),   A6HR97 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241671   ⟸   XM_006241609
- Peptide Label: isoform X1
- UniProtKB: Q8K4Q4 (UniProtKB/Swiss-Prot),   O35460 (UniProtKB/Swiss-Prot),   F1LSB2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007979   ⟸   ENSRNOT00000007979
Protein Domains
Fibrinogen C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35460-F1-model_v2 AlphaFold O35460 1-497 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628896 AgrOrtholog
BioCyc Gene G2FUF-33504 BioCyc
Ensembl Genes ENSRNOG00000005854 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007979 ENTREZGENE
  ENSRNOT00000007979.7 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fibrinogen-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fibrinogen_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:89807 UniProtKB/Swiss-Prot
  PTHR19143:SF156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Fibrinogen_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Angpt1 PhenoGen
  FIBRINOGEN_C_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005854 RatGTEx
SMART FBG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56496 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANGP1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q8K4Q4 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-02-23 Angpt1  angiopoietin 1  Agpt_predicted  angiopoietin (predicted)  Data merged from RGD:1308554 737654 APPROVED
2005-01-12 Agpt_predicted  angiopoietin (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Angpt1  angiopoietin 1      Symbol and Name updated 629477 APPROVED
2003-03-07 Angpt1  angiopoietin 1  Agpt1  angiopoietin 1  Data merged from RGD:621860 628472 PROVISIONAL
2003-02-27 Angpt1  angiopoietin 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-08-07 Agpt1  angiopoietin 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression is downregulated post MCAO in SHRSP rat strain compared with SHR and WKY rat strains 1553895
gene_function binds and activates Tie2 receptor by inducing its tyrosine phosphorylation. implicated in endothelial developmental processes later and distinct from that of Vegf 724707
gene_process plays a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and mediates blood vessel maturation/stability; it may play an important role in the heart early development 724707