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Gene: Hoxc10 (homeo box C10) Rattus norvegicus

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Symbol:

Hoxc10

Name:

homeo box C10

RGD ID:

1307250

Description:

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including embryonic limb morphogenesis; regionalization; and spinal cord motor neuron cell fate specification. Predicted to be located in nuclear body. Predicted to be active in nucleus. Orthologous to human HOXC10 (homeobox C10); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; all-trans-retinoic acid; atrazine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

homeobox protein Hox-C10; Hox3.5 homeobox; LOC315338; RGD1307250; similar to Homeobox protein Hox-C10 (Hox-3.6)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HOXC10 (homeobox C10)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Hoxc10 (homeobox C10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Hoxc10 (homeobox C10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HOXC10 (homeobox C10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HOXC10 (homeobox C10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hoxc10 (homeobox C10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HOXC10 (homeobox C10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HOXC10 (homeobox C10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hoxc10 (homeobox C10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Hoxc10 (homeobox C10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	HOXC10 (homeobox C10)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Hoxc10 (homeobox C10)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	hoxc10a (homeobox C10a)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	hoxc10a (homeobox C10a)	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Abd-B	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	php-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	php-3	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	nob-1	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	hoxc10	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	hoxc10	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	135,982,222 - 135,987,442 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	135,982,065 - 135,986,712 (+)	Ensembl				GRCr8
mRatBN7.2	7	134,103,741 - 134,108,966 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	134,103,643 - 134,108,966 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	135,859,132 - 135,864,346 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	138,088,515 - 138,093,726 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	138,074,491 - 138,079,716 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	144,577,578 - 144,582,802 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	144,577,465 - 144,582,622 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	142,368,850 - 142,374,159 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	141,717,910 - 141,734,613 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	130,529,927 - 130,535,151 (+)	NCBI		Celera
RGSC_v3.1	7	141,808,802 - 141,813,297 (+)	NCBI
Cytogenetic Map	7	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Kyphoscoliosis (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

8'-apo-beta,psi-caroten-8'-al (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (EXP,ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-carotene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

CGP 52608 (ISO)

cisplatin (ISO)

coumarin (ISO)

dimethylarsinic acid (EXP)

epoxiconazole (ISO)

flusilazole (EXP)

FR900359 (ISO)

gallic acid (ISO)

methamphetamine (ISO)

methotrexate (ISO)

monosodium L-glutamate (ISO)

nickel atom (ISO)

nickel sulfate (ISO)

ozone (ISO)

paracetamol (EXP)

potassium dichromate (ISO)

rac-lactic acid (ISO)

testosterone (ISO)

Theaflavin 3,3'-digallate (ISO)

titanium dioxide (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterior/posterior pattern specification (IEA,ISO)

embryonic limb morphogenesis (IEA,ISO)

negative regulation of cold-induced thermogenesis (IEA,ISO,ISS)

neuromuscular process (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

proximal/distal pattern formation (IEA,ISO)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IBA)

skeletal system development (IEA,ISO)

spinal cord motor neuron cell fate specification (IEA,ISO)

Cellular Component

nuclear body (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA,ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,IEA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IEA,ISO)

sequence-specific double-stranded DNA binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Changes in homeobox-containing gene expression during ectopic bone formation induced by bone morphogenetic protein.	Iimura T, etal., Biochem Biophys Res Commun 1994 Jun 15;201(2):980-7.
4.	HOXC10 suppresses browning of white adipose tissues.	Ng Y, etal., Exp Mol Med. 2017 Feb 10;49(2):e292. doi: 10.1038/emm.2016.144.
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Abnormalities of vertebral formation and Hox expression in congenital kyphoscoliotic rats.	Seki T, etal., Mol Cell Biochem. 2008 May;312(1-2):193-9. doi: 10.1007/s11010-008-9734-4. Epub 2008 Mar 9.

Additional References at PubMed

PMID:10835276	PMID:11445587	PMID:12869760	PMID:18065432	PMID:33369800

Genomics

Comparative Map Data

Hoxc10
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	135,982,222 - 135,987,442 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	135,982,065 - 135,986,712 (+)	Ensembl				GRCr8
mRatBN7.2	7	134,103,741 - 134,108,966 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	134,103,643 - 134,108,966 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	135,859,132 - 135,864,346 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	138,088,515 - 138,093,726 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	138,074,491 - 138,079,716 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	144,577,578 - 144,582,802 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	144,577,465 - 144,582,622 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	142,368,850 - 142,374,159 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	141,717,910 - 141,734,613 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	130,529,927 - 130,535,151 (+)	NCBI		Celera
RGSC_v3.1	7	141,808,802 - 141,813,297 (+)	NCBI
Cytogenetic Map	7	q36	NCBI

HOXC10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	53,985,146 - 53,990,279 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	53,985,065 - 53,990,279 (+)	Ensembl			hg38	GRCh38
GRCh37	12	54,378,930 - 54,384,063 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	52,665,213 - 52,670,330 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	52,665,220 - 52,670,327	NCBI
Celera	12	54,028,565 - 54,033,680 (+)	NCBI		Celera
Cytogenetic Map	12	q13.13	NCBI
HuRef	12	51,416,659 - 51,421,773 (+)	NCBI		HuRef
CHM1_1	12	54,345,653 - 54,350,768 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	53,950,654 - 53,955,785 (+)	NCBI		T2T-CHM13v2.0

Hoxc10
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	102,875,231 - 102,880,333 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	102,875,231 - 102,880,328 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	102,966,796 - 102,971,898 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	102,966,796 - 102,971,893 (+)	Ensembl			mm10	GRCm38
MGSCv37	15	102,797,296 - 102,802,152 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	102,794,899 - 102,799,755 (+)	NCBI		MGSCv36	mm8
Celera	15	105,127,796 - 105,132,646 (+)	NCBI		Celera
Cytogenetic Map	15	F3	NCBI
cM Map	15	58.03	NCBI

Hoxc10
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	1,243,529 - 1,248,661 (+)	Ensembl
ChiLan1.0	NW_004955458	1,243,529 - 1,248,653 (+)	NCBI	ChiLan1.0	ChiLan1.0

HOXC10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	40,195,618 - 40,201,937 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	40,192,386 - 40,198,918 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	34,764,956 - 34,770,088 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	35,553,262 - 35,558,393 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	35,553,262 - 35,558,393 (-)	Ensembl			panPan2	panpan1.1

HOXC10
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	1,272,272 - 1,277,411 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	1,273,131 - 1,323,370 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	44,972,213 - 44,976,533 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	1,276,751 - 1,281,074 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	1,275,931 - 1,280,977 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	1,294,448 - 1,298,772 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	1,275,967 - 1,280,296 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	45,375,816 - 45,380,136 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Hoxc10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	61,952,465 - 61,957,657 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	11,207,173 - 11,212,365 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936512	11,207,173 - 11,212,365 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HOXC10
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	19,197,807 - 19,202,970 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	19,197,810 - 19,202,975 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	19,670,823 - 19,675,191 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HOXC10
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	50,092,230 - 50,100,934 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	50,095,810 - 50,100,940 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	195,941,257 - 195,946,422 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hoxc10
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624904	2,039,754 - 2,045,096 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624904	2,040,018 - 2,044,881 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Hoxc10
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	260,110,982 - 260,116,189 (-)	NCBI		Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	80
Count of miRNA genes:	69
Interacting mature miRNAs:	76
Transcripts:	ENSRNOT00000021647
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354582	Stl11	Serum triglyceride level QTL 11	3.42		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	121393075	137014596	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	132099939	137014596	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	98549867	137014596	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	100548246	137014596	Rat
61397	Bw17	Body weight QTL 17	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	7	95485047	137014596	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	115313999	136544683	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	92362341	137014596	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	71827901	136544683	Rat
1357339	Stl14	Serum triglyceride level QTL 14	3.45	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	135371291	137014596	Rat

Markers in Region

AI506621

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	7	135,987,180 - 135,987,334 (+)	Marker Load Pipeline
mRatBN7.2	7	134,108,704 - 134,108,857 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	144,582,541 - 144,582,693	NCBI	Rnor6.0
Rnor_5.0	7	142,373,898 - 142,374,050	UniSTS	Rnor5.0
RGSC_v3.4	7	141,735,064 - 141,735,216	UniSTS	RGSC3.4
Celera	7	130,534,890 - 130,535,042	UniSTS
Cytogenetic Map	7	q36	UniSTS

Hoxc10

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	134,107,867 - 134,108,060 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	144,581,705 - 144,581,897	NCBI	Rnor6.0
Rnor_5.0	7	142,373,062 - 142,373,254	UniSTS	Rnor5.0
RGSC_v3.4	7	141,734,228 - 141,734,420	UniSTS	RGSC3.4
Celera	7	130,534,054 - 130,534,246	UniSTS
Cytogenetic Map	7	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
8	12	8	36	28	23	14	7	14	6	150	39	10	24	81	90	9

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001308636	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC116663	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S71286	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000021647 ⟹ ENSRNOP00000021647

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	135,982,065 - 135,986,712 (+)	Ensembl
mRatBN7.2 Ensembl	7	134,103,643 - 134,108,966 (+)	Ensembl
Rnor_6.0 Ensembl	7	144,577,465 - 144,582,622 (+)	Ensembl

RefSeq Acc Id:

NM_001308636 ⟹ NP_001295565

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	135,982,222 - 135,987,442 (+)	NCBI
mRatBN7.2	7	134,103,741 - 134,108,966 (+)	NCBI
Rnor_6.0	7	144,577,578 - 144,582,802 (+)	NCBI
Celera	7	130,529,927 - 130,535,151 (+)	NCBI

Sequence:

show sequence

ATGACATGCCCTCGCAATGTAACTCCGAACTCGTACGCGGAGCCCTTGGCTGCGCCGGGAGGAG
GAGAGCGCTATAACCGTAGCGCAGGAATGTATATGCAATCTGGGAGTGACTTCAACTGCGGGGT
GATGAGGGGCTGCGGGCTTGCGCCCTCTCTCTCCAAGAGGGACGAGGGAGGCAGCCCAAACCTG
GCCCTCAACACCTACCCGTCCTACCTCTCGCAGCTGGACTCCTGGGGCGACCCCAAAGCCGCCT
ACCGCCTGGAACAACCTGTTGGCAGGCCTCTGTCCTCCTGTTCCTACCCACCTAGTGTCAAGGA
GGAGAATGTCTGCTGCATGTACAGTGCAGAGAAGCGGGCGAAAAGTGGCCCTGAGGCAGCTCTC
TACTCCCACCCCCTGCCGGAGTCTTGCCTTGGGGAGCACGAGGTACCTGTACCCAGCTACTACC
GCGCCAGCCCGAGCTACTCCGCGCTGGACAAAACGCCCCACTGTGCTGGGGCCAACGAGTTTGA
AGCCCCTTTTGAGCAGCGGGCCAGTCTCAACCCGCGCACCGAACATCTGGAATCGCCTCAGCTT
GGGGGCAAAGTGAGTTTTCCTGAGACCCCCAAGTCCGACAGCCAGACCCCCAGTCCCAACGAGA
TCAAGACGGAGCAAAGCCTGGTGGGCCCAAAAGCCAGCCCCTCGGAGAGCGAAAAGGAACGGGC
CAAGACCGCAGACTCCAGCCCAGACACCTCGGATAATGAAGCTAAAGAGGAGATAAAGGCAGAA
AACACCACAGGAAATTGGCTGACAGCAAAGAGCGGAAGGAAGAAGAGGTGCCCCTATACTAAAC
ACCAGACGCTGGAATTGGAGAAAGAATTTCTGTTCAATATGTATTTGACGCGAGAGCGCCGCCT
GGAGATTAGCAAGACCATTAACCTTACAGACAGACAAGTCAAAATCTGGTTTCAAAATCGCAGA
ATGAAACTCAAGAAAATGAACCGAGAGAATCGGATCCGGGAACTGACCTCCAATTTTAATTTCA
CCTGAGCCAGCGTCATCTCCTCCCCCCTCCCCTTCTCTCCTTTCCCCGCCCCTCCTCCCTTTGT
GCCTGGTGATATATTTTTTCCCCTCCCTGAGTATAAATGCAATGCGCCTGCAAAAAAAAAAAAA
AAAAAAAAAAAGGCAAAGACCTCAGACTCTCCTTCCAAGGGACCTATGGTTCGTGCTTCGAGGA
TGCTTCCACCTAAAGCATGAAAATGGGGTGCTGGGTTTTGGGGTGTTGTGTGTGCCCTCATAGA
CAGGGTGGTAGTGTGGCCGGTGTGTGTGTCAACTCCTCAGTCACCCATGCACACACATGCAGCC
TTCTGTTCTCCATGCAAAGTTGAGGTCAAATCCACCCAATTATAGGGGAAAGAAAGGGGGATAA
AATCAGAGAGGGTCTGTAACCTCGTAGAGCACAGTTAGAATTGCTCCCTCCTTGCTGCATTCCC
CCTCTTAGAATAATAGATAGTCTTGAAAGTTCGGCTAGTATTTGTGTGTTTGTCATAGCACCCA
GTGTCTAGACTAACCCTCCCTGTGTGTTTCCCTCCCAATGGCTCTGAGAATATGCTTGAAGTAT
TTGTACTGCTTTCTGCTTTTCTCCCACCCTTCCCAACACACTGTATCTCTCTCTCTTCCTAACA
TCTCAGAAATTCCACACAGAAGAACAAAAACATTAAAAAATAGAACATAGCAAAGTAAAAACAA
ATTCCACCCCCACCCCAAGTTGTCCTGCTCCTGTCTGGGAGTTGTGTTATTTAAAGATAATCTG
TATGTTGTATCTTTTGCATGTAGCTTCCTTAATGGAGAAAAAATTCCTAATAAATTTCCGGAAT
CTTGATCCTCAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001295565	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB31006	(Get FASTA)	NCBI Sequence Viewer
	EDL86806	(Get FASTA)	NCBI Sequence Viewer
	EDL86807	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000021647
	ENSRNOP00000021647.4

RefSeq Acc Id:

NP_001295565 ⟸ NM_001308636

- UniProtKB:

G3V815 (UniProtKB/TrEMBL), A6KCY6 (UniProtKB/TrEMBL), A6KCY5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTCPRNVTPNSYAEPLAAPGGGERYNRSAGMYMQSGSDFNCGVMRGCGLAPSLSKRDEGGSPNL
ALNTYPSYLSQLDSWGDPKAAYRLEQPVGRPLSSCSYPPSVKEENVCCMYSAEKRAKSGPEAAL
YSHPLPESCLGEHEVPVPSYYRASPSYSALDKTPHCAGANEFEAPFEQRASLNPRTEHLESPQL
GGKVSFPETPKSDSQTPSPNEIKTEQSLVGPKASPSESEKERAKTADSSPDTSDNEAKEEIKAE
NTTGNWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISKTINLTDRQVKIWFQNRR
MKLKKMNRENRIRELTSNFNFT

hide sequence

Ensembl Acc Id:

ENSRNOP00000021647 ⟸ ENSRNOT00000021647

Protein Domains

Homeobox

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V815-F1-model_v2	AlphaFold	G3V815	1-342	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307250	AgrOrtholog
BioCyc Gene	G2FUF-31919	BioCyc
Ensembl Genes	ENSRNOG00000016149	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000021647	ENTREZGENE
	ENSRNOT00000021647.9	UniProtKB/TrEMBL
Gene3D-CATH	Homeodomain-like	UniProtKB/TrEMBL
InterPro	Homeobox	UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/TrEMBL
	Homeobox_metazoa	UniProtKB/TrEMBL
	Homeodomain-like	UniProtKB/TrEMBL
	HXA10/ABDB-like	UniProtKB/TrEMBL
KEGG Report	rno:315338	UniProtKB/TrEMBL
NCBI Gene	315338	ENTREZGENE
PANTHER	HOMEOBOX PROTEIN HOX-C10	UniProtKB/TrEMBL
	PTHR45874	UniProtKB/TrEMBL
Pfam	Homeobox	UniProtKB/TrEMBL
PhenoGen	Hoxc10	PhenoGen
PRINTS	HOMEOBOX	UniProtKB/TrEMBL
PROSITE	HOMEOBOX_1	UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000016149	RatGTEx
SMART	HOX	UniProtKB/TrEMBL
Superfamily-SCOP	Homeodomain_like	UniProtKB/TrEMBL
UniProt	A6KCY5	ENTREZGENE, UniProtKB/TrEMBL
	A6KCY6	ENTREZGENE, UniProtKB/TrEMBL
	G3V815	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Hoxc10	homeo box C10	RGD1307250	similar to Homeobox protein Hox-C10 (Hox-3.6)	Symbol and Name updated	1299863	APPROVED
2005-12-06	RGD1307250	similar to Homeobox protein Hox-C10 (Hox-3.6)	RGD1307250_predicted	similar to Homeobox protein Hox-C10 (Hox-3.6) (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1307250_predicted	similar to Homeobox protein Hox-C10 (Hox-3.6) (predicted)	LOC315338_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC315338_predicted	similar to Homeobox protein Hox-C10 (Hox-3.6) (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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