(R)-mevalonic acid multiple interactions ISO RGD:730972 6480464 Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]] CTD PMID:14500290 (R)-mevalonic acid multiple interactions EXP 6480464 Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of SREBF2 mRNA], Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of SREBF2 mRNA] CTD PMID:12056585 1,3-dichloropropan-2-ol increases expression ISO RGD:730972 6480464 1 more ... CTD PMID:29305303 1,3-dichloropropan-2-ol multiple interactions ISO RGD:730972 6480464 alliin inhibits the reaction [1 more ... CTD PMID:29305303 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile multiple interactions ISO RGD:730972 6480464 Citalopram results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:16324787 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:730973 6480464 Dihydrotestosterone results in increased expression of SREBF2 mRNA CTD PMID:16990341 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:730972 6480464 Dihydrotestosterone results in increased expression of SREBF2 mRNA CTD PMID:16541421 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:730973 6480464 Tetrachlorodibenzodioxin inhibits the reaction [2 more ... CTD PMID:21851831 2,2',4,4',5,5'-hexachlorobiphenyl decreases expression ISO RGD:730973 6480464 2 more ... CTD PMID:20005886 , PMID:21851831 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:730973 6480464 Tetrachlorodibenzodioxin affects the expression of SREBF2 mRNA CTD PMID:21570461 , PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SREBF2 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:730973 6480464 Tetrachlorodibenzodioxin results in decreased expression of SREBF2 mRNA CTD PMID:20005886 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:730973 6480464 Tetrachlorodibenzodioxin inhibits the reaction [2 more ... CTD PMID:21851831 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of SREBF2 mRNA CTD PMID:21346803 2-hydroxypropanoic acid increases expression ISO RGD:730972 6480464 Lactic Acid results in increased expression of SREBF2 mRNA CTD PMID:30851411 25-hydroxycholesterol multiple interactions ISO RGD:730972 6480464 25-hydroxycholesterol inhibits the reaction [[Resveratrol results in increased activity of and results in increased cleavage of SREBF2 protein] which results in increased expression of LDLR mRNA] more ... CTD PMID:17052361 more ... 25-hydroxycholesterol decreases activity ISO RGD:730972 6480464 25-hydroxycholesterol results in decreased activity of SREBF2 protein CTD PMID:17052361 aflatoxin B1 decreases methylation ISO RGD:730972 6480464 Aflatoxin B1 results in decreased methylation of SREBF2 intron CTD PMID:30157460 aldehydo-D-glucose increases expression ISO RGD:730972 6480464 Glucose results in increased expression of SREBF2 protein CTD PMID:23647015 aldehydo-D-glucose multiple interactions ISO RGD:730972 6480464 Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF2 protein] more ... CTD PMID:23647015 aldehydo-D-glucose increases expression EXP 6480464 Glucose results in increased expression of SREBF2 protein CTD PMID:23647015 aldehydo-D-glucose multiple interactions EXP 6480464 Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF2 protein] more ... CTD PMID:23647015 all-trans-retinoic acid decreases expression ISO RGD:730972 6480464 Tretinoin results in decreased expression of SREBF2 mRNA CTD PMID:23724009 alliin multiple interactions ISO RGD:730972 6480464 alliin inhibits the reaction [1 more ... CTD PMID:29305303 allopurinol multiple interactions EXP 6480464 Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF2 protein] more ... CTD PMID:23647015 allopurinol multiple interactions ISO RGD:730972 6480464 Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF2 protein] CTD PMID:23647015 amitriptyline multiple interactions ISO RGD:730972 6480464 Amitriptyline results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:16324787 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:730972 6480464 pyrazolanthrone inhibits the reaction [Quercetin results in increased metabolism of and affects the localization of SREBF2 protein] CTD PMID:22388943 atorvastatin calcium multiple interactions EXP 6480464 Atorvastatin results in increased activity of and results in increased localization of SREBF2 protein, Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of SREBF2 mRNA] CTD PMID:12056585 atorvastatin calcium increases expression EXP 6480464 Atorvastatin results in increased expression of SREBF2 mRNA CTD PMID:12056585 , PMID:12065722 atorvastatin calcium increases localization ISO RGD:730972 6480464 Atorvastatin results in increased localization of SREBF2 protein CTD PMID:11728391 atrazine increases expression ISO RGD:730972 6480464 Atrazine results in increased expression of SREBF2 mRNA CTD PMID:22378314 benzalkonium chloride increases expression ISO RGD:730972 6480464 Benzalkonium Compounds results in increased expression of SREBF2 mRNA CTD PMID:26919959 benzo[a]pyrene decreases expression ISO RGD:730972 6480464 Benzo(a)pyrene results in decreased expression of SREBF2 mRNA CTD PMID:20106945 bezafibrate increases expression ISO RGD:730972 6480464 Bezafibrate results in increased expression of SREBF2 mRNA CTD PMID:14685799 bisphenol A affects expression ISO RGD:730973 6480464 bisphenol A affects the expression of SREBF2 mRNA, bisphenol A affects the expression of SREBF2 protein CTD PMID:21932408 bisphenol A decreases methylation ISO RGD:730973 6480464 bisphenol A results in decreased methylation of SREBF2 gene, bisphenol A results in decreased methylation of SREBF2 promoter CTD PMID:27502578 , PMID:31470036 bisphenol A increases response to substance ISO RGD:730973 6480464 SREBF2 mRNA results in increased susceptibility to bisphenol A CTD PMID:27502578 bisphenol A affects methylation ISO RGD:730973 6480464 bisphenol A affects the methylation of SREBF2 promoter CTD PMID:27334623 bisphenol A multiple interactions ISO RGD:730972 6480464 SREBF2 promotes the reaction [bisphenol A results in increased expression of NPC1L1 mRNA] more ... CTD PMID:28057006 , PMID:31270304 bisphenol A multiple interactions ISO RGD:730973 6480464 SREBF2 mRNA promotes the reaction [bisphenol A results in increased expression of FASN mRNA] CTD PMID:27502578 bisphenol A increases expression ISO RGD:730972 6480464 bisphenol A results in increased expression of SREBF2 mRNA, bisphenol A results in increased expression of SREBF2 protein CTD PMID:28057006 , PMID:29275510 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SREBF2 mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:730973 6480464 bisphenol A results in increased expression of SREBF2 more ... CTD PMID:25168180 more ... cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of SREBF2 mRNA CTD PMID:17066326 cadmium atom multiple interactions EXP 6480464 [Streptozocin co-treated with Cadmium] results in increased expression of SREBF2 protein, myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased expression of SREBF2 protein] CTD PMID:25240712 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of SREBF2 mRNA CTD PMID:17066326 caffeine multiple interactions ISO RGD:730972 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA] more ... CTD PMID:30825513 caffeine increases expression ISO RGD:730972 6480464 Caffeine results in increased expression of SREBF2 mRNA, Caffeine results in increased expression of SREBF2 protein CTD PMID:30825513 caffeine increases expression EXP 6480464 Caffeine results in increased expression of SREBF2 mRNA, Caffeine results in increased expression of SREBF2 protein CTD PMID:30825513 carbamazepine decreases expression ISO RGD:730972 6480464 Carbamazepine results in decreased expression of SREBF2 mRNA CTD PMID:21123845 carbon nanotube increases expression ISO RGD:730973 6480464 Nanotubes, Carbon analog results in increased expression of SREBF2 mRNA, Nanotubes, Carbon results in increased expression of SREBF2 mRNA CTD PMID:25554681 carbon nanotube increases expression ISO RGD:730972 6480464 Nanotubes, Carbon results in increased expression of SREBF2 mRNA CTD PMID:31047983 CGS-21680 multiple interactions ISO RGD:730972 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA] CTD PMID:30825513 chlorpromazine multiple interactions ISO RGD:730972 6480464 Chlorpromazine results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:17052361 cholesterol multiple interactions ISO RGD:730972 6480464 [25-hydroxycholesterol co-treated with Cholesterol] results in decreased cleavage of SREBF2 protein more ... CTD PMID:16946405 more ... cholesterol multiple interactions EXP 6480464 [Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein, Cholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein] CTD PMID:20578043 choline multiple interactions ISO RGD:730973 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with RXRA gene mutant form] results in increased expression of SREBF2 mRNA CTD PMID:18952117 chromium(6+) affects expression ISO RGD:730973 6480464 chromium hexavalent ion affects the expression of SREBF2 mRNA CTD PMID:28472532 cisplatin multiple interactions ISO RGD:730972 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of SREBF2 mRNA CTD PMID:27392435 citalopram multiple interactions ISO RGD:730972 6480464 Citalopram results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:16324787 clofibrate decreases expression EXP 6480464 Clofibrate results in decreased expression of SREBF2 mRNA, Clofibrate results in decreased expression of SREBF2 protein CTD PMID:17126302 clomipramine multiple interactions ISO RGD:730972 6480464 Clomipramine results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:16324787 clozapine multiple interactions ISO RGD:730972 6480464 Clozapine inhibits the reaction [25-hydroxycholesterol results in decreased activity of SREBF2 protein], Clozapine results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:17052361 clozapine increases expression ISO RGD:730972 6480464 Clozapine results in increased expression of SREBF2 mRNA CTD PMID:17052361 cobalt dichloride decreases expression ISO RGD:730972 6480464 cobaltous chloride results in decreased expression of SREBF2 mRNA CTD PMID:19320972 Colforsin dapropate hydrochloride multiple interactions ISO RGD:730972 6480464 Colforsin inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA] CTD PMID:30825513 crizotinib increases expression ISO RGD:730972 6480464 crizotinib results in increased expression of SREBF2 mRNA CTD PMID:23707608 CU-O LINKAGE increases expression ISO RGD:730972 6480464 cupric oxide results in increased expression of SREBF2 mRNA CTD PMID:22077320 curcumin affects expression ISO RGD:730973 6480464 Curcumin affects the expression of SREBF2 mRNA, Curcumin affects the expression of SREBF2 protein CTD PMID:27208389 curcumin decreases expression EXP 6480464 Curcumin results in decreased expression of SREBF2 mRNA CTD PMID:27208389 cyclosporin A increases expression ISO RGD:730972 6480464 Cyclosporine results in increased expression of SREBF2 mRNA CTD PMID:25562108 D-glucose increases expression ISO RGD:730972 6480464 Glucose results in increased expression of SREBF2 protein CTD PMID:23647015 D-glucose multiple interactions ISO RGD:730972 6480464 Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF2 protein] more ... CTD PMID:23647015 D-glucose increases expression EXP 6480464 Glucose results in increased expression of SREBF2 protein CTD PMID:23647015 D-glucose multiple interactions EXP 6480464 Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF2 protein] more ... CTD PMID:23647015 DDT increases methylation EXP 6480464 DDT results in increased methylation of SREBF2 gene CTD PMID:30207508 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of SREBF2 protein CTD PMID:21266533 diclofenac increases expression ISO RGD:730973 6480464 Diclofenac results in increased expression of SREBF2 mRNA CTD PMID:26934552 dicrotophos increases expression ISO RGD:730972 6480464 dicrotophos results in increased expression of SREBF2 mRNA CTD PMID:28302478 Dinophysistoxin 1 decreases expression ISO RGD:730972 6480464 dinophysistoxin 1 results in decreased expression of SREBF2 mRNA CTD PMID:28939011 dorsomorphin multiple interactions ISO RGD:730972 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 , PMID:29499335 dorsomorphin increases cleavage ISO RGD:730973 6480464 dorsomorphin results in increased cleavage of SREBF2 protein CTD PMID:29499335 dorsomorphin multiple interactions ISO RGD:730973 6480464 dorsomorphin promotes the reaction [Hydrogen Peroxide results in increased cleavage of SREBF2 protein] CTD PMID:29499335 doxorubicin decreases expression ISO RGD:730972 6480464 Doxorubicin results in decreased expression of SREBF2 mRNA CTD PMID:29803840 elemental selenium increases expression ISO RGD:730972 6480464 Selenium results in increased expression of SREBF2 mRNA CTD PMID:19244175 ethanol increases expression ISO RGD:730973 6480464 Ethanol results in increased expression of SREBF2 mRNA CTD PMID:30319688 ethanol affects splicing ISO RGD:730973 6480464 Ethanol affects the splicing of SREBF2 mRNA CTD PMID:30319688 ezetimibe decreases expression ISO RGD:730972 6480464 Ezetimibe results in decreased expression of SREBF2 mRNA CTD PMID:16177187 fenarimol increases expression EXP 6480464 fenarimol results in increased expression of SREBF2 mRNA CTD PMID:28970091 fisetin increases expression ISO RGD:730972 6480464 fisetin results in increased expression of SREBF2 protein alternative form CTD PMID:23524313 geraniol increases expression ISO RGD:730972 6480464 geraniol results in increased expression of SREBF2 mRNA CTD PMID:23668785 glafenine increases expression EXP 6480464 Glafenine results in increased expression of SREBF2 mRNA CTD PMID:24136188 glucose increases expression ISO RGD:730972 6480464 Glucose results in increased expression of SREBF2 protein CTD PMID:23647015 glucose increases expression EXP 6480464 Glucose results in increased expression of SREBF2 protein CTD PMID:23647015 glucose multiple interactions ISO RGD:730972 6480464 Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF2 protein] more ... CTD PMID:23647015 glucose multiple interactions EXP 6480464 Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF2 protein] more ... CTD PMID:23647015 haloperidol multiple interactions ISO RGD:730972 6480464 Haloperidol results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:17052361 hydrogen peroxide multiple interactions ISO RGD:730972 6480464 [isoquercitrin co-treated with Hydrogen Peroxide] results in increased cleavage of and results in increased activity of SREBF2 protein more ... CTD PMID:18032389 hydrogen peroxide increases cleavage ISO RGD:730973 6480464 Hydrogen Peroxide results in increased cleavage of SREBF2 protein CTD PMID:29499335 hydrogen peroxide multiple interactions ISO RGD:730973 6480464 Buthionine Sulfoximine inhibits the reaction [Metformin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of SREBF2 protein]] more ... CTD PMID:29499335 imipramine multiple interactions ISO RGD:730972 6480464 Imipramine results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:16324787 ketoconazole increases expression EXP 6480464 Ketoconazole results in increased expression of SREBF2 mRNA CTD PMID:28263823 L-methionine multiple interactions ISO RGD:730973 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with RXRA gene mutant form] results in increased expression of SREBF2 mRNA CTD PMID:18952117 lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of SREBF2 mRNA, lead acetate results in increased expression of SREBF2 protein CTD PMID:29908845 lead nitrate increases expression EXP 6480464 lead nitrate results in increased expression of SREBF2 mRNA CTD PMID:15475176 , PMID:16705668 linalool decreases expression ISO RGD:730972 6480464 linalool results in decreased expression of SREBF2 mRNA, linalool results in decreased expression of SREBF2 protein CTD PMID:21944868 linalool decreases expression ISO RGD:730973 6480464 linalool results in decreased expression of SREBF2 mRNA, linalool results in decreased expression of SREBF2 protein CTD PMID:21944868 linalool multiple interactions ISO RGD:730972 6480464 linalool inhibits the reaction [SREBF2 protein binds to HMGCR promoter] CTD PMID:21944868 lovastatin increases localization ISO RGD:730972 6480464 Lovastatin results in increased localization of SREBF2 protein CTD PMID:11728391 lovastatin multiple interactions ISO RGD:730973 6480464 [Dietary Fats co-treated with Lovastatin] affects the expression of SREBF2 mRNA CTD PMID:29852127 lovastatin multiple interactions EXP 6480464 [Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein, Cholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein] CTD PMID:20578043 mercury dichloride decreases expression ISO RGD:730972 6480464 Mercuric Chloride results in decreased expression of SREBF2 mRNA CTD PMID:27188386 metformin multiple interactions ISO RGD:730973 6480464 Buthionine Sulfoximine inhibits the reaction [Metformin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of SREBF2 protein]] more ... CTD PMID:29499335 metformin multiple interactions ISO RGD:730972 6480464 Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of SREBF2 protein] CTD PMID:29499335 mevastatin increases expression EXP 6480464 mevastatin results in increased expression of SREBF2 protein CTD PMID:17526932 mevastatin increases cleavage ISO RGD:730973 6480464 mevastatin results in increased cleavage of SREBF2 protein CTD PMID:16330322 microcystin-LR increases expression ISO RGD:730973 6480464 cyanoginosin LR results in increased expression of SREBF2 mRNA CTD PMID:25497113 mono(2-ethylhexyl) phthalate increases expression ISO RGD:730972 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of SREBF2 mRNA CTD PMID:23118965 myricetin multiple interactions EXP 6480464 myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased expression of SREBF2 protein] CTD PMID:25240712 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO RGD:730972 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [CGA protein results in increased cleavage of SREBF2 protein] CTD PMID:26125464 obeticholic acid multiple interactions ISO RGD:730973 6480464 obeticholic acid inhibits the reaction [Dietary Fats results in increased expression of SREBF2 mRNA] CTD PMID:26655953 obeticholic acid decreases expression ISO RGD:730972 6480464 obeticholic acid results in decreased expression of SREBF2 mRNA CTD PMID:27939613 okadaic acid decreases expression ISO RGD:730972 6480464 Okadaic Acid results in decreased expression of SREBF2 mRNA CTD PMID:28939011 olanzapine multiple interactions ISO RGD:730972 6480464 olanzapine results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:17052361 olanzapine multiple interactions EXP 6480464 [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of SREBF2 mRNA CTD PMID:23226405 ozone decreases expression EXP 6480464 Ozone results in decreased expression of SREBF2 mRNA CTD PMID:25838073 p-chloromercuribenzoic acid decreases expression ISO RGD:730972 6480464 p-Chloromercuribenzoic Acid results in decreased expression of SREBF2 mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions ISO RGD:730972 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SREBF2 mRNA CTD PMID:27188386 p-menthan-3-ol decreases expression ISO RGD:730972 6480464 Menthol results in decreased expression of SREBF2 mRNA CTD PMID:26760959 paracetamol decreases expression ISO RGD:730972 6480464 Acetaminophen results in decreased expression of SREBF2 mRNA CTD PMID:29067470 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:730973 6480464 perfluorooctane sulfonic acid results in decreased expression of SREBF2 mRNA CTD PMID:20936131 perfluorooctanoic acid decreases expression ISO RGD:730973 6480464 perfluorooctanoic acid results in decreased expression of SREBF2 mRNA CTD PMID:20936131 more ... perfluorooctanoic acid increases expression ISO RGD:730973 6480464 perfluorooctanoic acid results in increased expression of SREBF2 mRNA CTD PMID:30711707 perfluorooctanoic acid increases cleavage ISO RGD:730973 6480464 perfluorooctanoic acid results in increased cleavage of SREBF2 protein CTD PMID:25092180 phenylpropanolamine multiple interactions ISO RGD:730972 6480464 Phenylpropanolamine results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:27756839 phorbol 13-acetate 12-myristate increases cleavage ISO RGD:730972 6480464 Tetradecanoylphorbol Acetate results in increased cleavage of SREBF2 protein CTD PMID:29499335 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:730972 6480464 dorsomorphin promotes the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of SREBF2 protein], Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of SREBF2 protein] CTD PMID:29499335 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of SREBF2 mRNA, pirinixic acid results in decreased expression of SREBF2 protein CTD PMID:17126302 propiconazole increases expression EXP 6480464 propiconazole results in increased expression of SREBF2 mRNA CTD PMID:28970091 quercetin multiple interactions ISO RGD:730972 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased metabolism of and affects the localization of SREBF2 protein] more ... CTD PMID:20728021 more ... quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Glucose results in increased expression of SREBF2 protein] more ... CTD PMID:23647015 quercetin 3-O-beta-D-glucofuranoside multiple interactions ISO RGD:730972 6480464 [isoquercitrin co-treated with Hydrogen Peroxide] results in increased cleavage of and results in increased activity of SREBF2 protein more ... CTD PMID:18032389 quercetin 3-O-beta-D-glucopyranoside multiple interactions ISO RGD:730972 6480464 [isoquercitrin co-treated with Hydrogen Peroxide] results in increased cleavage of and results in increased activity of SREBF2 protein more ... CTD PMID:18032389 rac-lactic acid increases expression ISO RGD:730972 6480464 Lactic Acid results in increased expression of SREBF2 mRNA CTD PMID:30851411 resveratrol increases expression ISO RGD:730972 6480464 resveratrol results in increased expression of SREBF2 protein modified form CTD PMID:22153697 resveratrol multiple interactions ISO RGD:730972 6480464 25-hydroxycholesterol inhibits the reaction [[Resveratrol results in increased activity of and results in increased cleavage of SREBF2 protein] which results in increased expression of LDLR mRNA] more ... CTD PMID:22153697 , PMID:30825513 rotenone increases expression EXP 6480464 Rotenone results in increased expression of SREBF2 mRNA CTD PMID:28374803 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO RGD:730973 6480464 Buthionine Sulfoximine inhibits the reaction [Metformin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of SREBF2 protein]], Buthionine Sulfoximine promotes the reaction [Hydrogen Peroxide results in increased cleavage of SREBF2 protein] CTD PMID:29499335 SB 431542 multiple interactions ISO RGD:730972 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SREBF2 mRNA CTD PMID:27188386 selenium atom increases expression ISO RGD:730972 6480464 Selenium results in increased expression of SREBF2 mRNA CTD PMID:19244175 silicon dioxide decreases expression ISO RGD:730972 6480464 Silicon Dioxide analog results in decreased expression of SREBF2 mRNA CTD PMID:25895662 simvastatin multiple interactions ISO RGD:730972 6480464 Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]], Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter] CTD PMID:14500290 simvastatin increases expression EXP 6480464 Simvastatin results in increased expression of SREBF2 mRNA CTD PMID:12056585 simvastatin multiple interactions EXP 6480464 Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of SREBF2 mRNA], Simvastatin results in increased activity of and results in increased localization of SREBF2 protein CTD PMID:12056585 simvastatin increases expression ISO RGD:730972 6480464 Simvastatin results in increased expression of SREBF2 protein modified form CTD PMID:20018177 sodium arsenate increases expression ISO RGD:730973 6480464 sodium arsenate results in increased expression of SREBF2 mRNA CTD PMID:30953684 Soman decreases expression EXP 6480464 Soman results in decreased expression of SREBF2 mRNA CTD PMID:19281266 streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of SREBF2 mRNA, Streptozocin results in increased expression of SREBF2 protein CTD PMID:23647015 streptozocin increases expression ISO RGD:730973 6480464 Streptozocin results in increased expression of SREBF2 protein CTD PMID:29420703 streptozocin multiple interactions ISO RGD:730973 6480464 fatostatin inhibits the reaction [Streptozocin results in increased expression of SREBF2 protein] CTD PMID:29420703 streptozocin multiple interactions EXP 6480464 [Streptozocin co-treated with Cadmium] results in increased expression of SREBF2 protein more ... CTD PMID:23647015 , PMID:25240712 sulindac sulfide decreases expression ISO RGD:730972 6480464 sulindac sulfide results in decreased expression of SREBF2 mRNA CTD PMID:16184548 testosterone increases expression ISO RGD:730973 6480464 Testosterone results in increased expression of SREBF2 mRNA CTD PMID:16579987 tributyl phosphate increases expression ISO RGD:730972 6480464 tributyl phosphate results in increased expression of SREBF2 mRNA CTD PMID:30966736 trimellitic anhydride increases expression ISO RGD:730973 6480464 trimellitic anhydride results in increased expression of SREBF2 mRNA CTD PMID:19042947 triphenyl phosphate increases expression ISO RGD:730972 6480464 triphenyl phosphate results in increased expression of SREBF2 mRNA CTD PMID:30966736 troglitazone multiple interactions ISO RGD:730972 6480464 [[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 protein] which results in decreased abundance of Cholesterol more ... CTD PMID:16946405 tungsten decreases expression ISO RGD:730973 6480464 Tungsten results in decreased expression of SREBF2 mRNA CTD PMID:30912803 tunicamycin decreases expression ISO RGD:730972 6480464 Tunicamycin results in decreased expression of SREBF2 mRNA CTD PMID:22378314 valdecoxib increases expression EXP 6480464 valdecoxib results in increased expression of SREBF2 mRNA CTD PMID:24136188 valproic acid affects expression ISO RGD:730973 6480464 Valproic Acid affects the expression of SREBF2 mRNA CTD PMID:17963808 valproic acid decreases expression ISO RGD:730972 6480464 Valproic Acid results in decreased expression of SREBF2 mRNA CTD PMID:23179753 , PMID:27188386 valproic acid increases methylation ISO RGD:730972 6480464 Valproic Acid results in increased methylation of SREBF2 gene CTD PMID:29154799 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of SREBF2 mRNA CTD PMID:22570695 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of SREBF2 mRNA CTD PMID:23034163 vorinostat decreases expression ISO RGD:730972 6480464 vorinostat results in decreased expression of SREBF2 mRNA CTD PMID:27188386
Biological Process aging IEP 1581819 RGD cellular response to low-density lipoprotein particle stimulus IEA UniProtKB:Q12772 , ensembl:ENSP000003544761600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to low-density lipoprotein particle stimulus ISO RGD:730972 1624291 (PMID:15358760) RGD PMID:15358760 cellular response to starvation ISO RGD:730972 1624291 (PMID:25339898) RGD PMID:25339898 cellular response to starvation IEA UniProtKB:Q12772 , ensembl:ENSP000003544761600115 GO_REF:0000107 Ensembl GO_REF:0000107 cholesterol homeostasis ISO RGD:730973 1624291 MGI:MGI:3619343 (MGI:MGI:4456895 , PMID:20466882) RGD MGI:MGI:4456895 , PMID:20466882 cholesterol homeostasis IEA UniProtKB:Q3U1N2 , ensembl:ENSMUSP000000231001600115 GO_REF:0000107 Ensembl GO_REF:0000107 cholesterol metabolic process IEA UniProtKB-KW:KW-0153 1600115 GO_REF:0000037 UniProt GO_REF:0000037 lipid biosynthetic process TAS 1625196 RGD negative regulation of cholesterol efflux ISO RGD:730972 1624291 (PMID:15358760) RGD PMID:15358760 negative regulation of cholesterol efflux IEA UniProtKB:Q12772 , ensembl:ENSP000003544761600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription by RNA polymerase II ISO RGD:730972 1624291 (PMID:15358760), (PMID:19098903) RGD PMID:15358760 , PMID:19098903 negative regulation of transcription by RNA polymerase II IBA MGI:MGI:107606 more ... 13792537 PMID:21873635 GO_Central positive regulation of cholesterol storage ISO RGD:730972 1624291 (PMID:15358760) RGD PMID:15358760 positive regulation of cholesterol storage IEA UniProtKB:Q12772 , ensembl:ENSP000003544761600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of pri-miRNA transcription by RNA polymerase II IBA MGI:MGI:107585 more ... 13792537 PMID:21873635 GO_Central positive regulation of pri-miRNA transcription by RNA polymerase II IEA UniProtKB:Q3U1N2 , ensembl:ENSMUSP000000231001600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of pri-miRNA transcription by RNA polymerase II ISO RGD:730973 1624291 (MGI:MGI:5501359, PMID:23823476) RGD MGI:MGI:5501359 , PMID:23823476 positive regulation of transcription by RNA polymerase II ISO RGD:730973 1624291 (MGI:MGI:3770077, PMID:16890542) RGD MGI:MGI:3770077 , PMID:16890542 positive regulation of transcription by RNA polymerase II ISO RGD:730972 1624291 (PMID:12242332), (PMID:12446768) RGD PMID:12242332 , PMID:12446768 positive regulation of transcription by RNA polymerase II IDA 628485 PMID:12446768 MGI positive regulation of transcription, DNA-templated IMP 2308817 RGD regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter ISO RGD:730972 1624291 (PMID:15358760) RGD PMID:15358760 regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter IEA UniProtKB:Q12772 , ensembl:ENSP000003544761600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of transcription, DNA-templated ISO RGD:730973 1624291 (MGI:MGI:2388133, PMID:12242332) RGD MGI:MGI:2388133 , PMID:12242332 response to drug IEP 2308837 gemfibrozil RGD response to hormone IMP 2308817 triiodothyronine RGD response to lead ion IEP 2308832 RGD response to lipid IEP 2308819 oxidized sunflower oil RGD response to lipid IBA PANTHER:PTN002488844 more ... 13792537 PMID:21873635 GO_Central spermatogenesis IEP 2308831 RGD SREBP signaling pathway ISO RGD:730972 1624291 (PMID:27614840) RGD PMID:27614840 SREBP signaling pathway IEA UniProtKB:Q12772 , ensembl:ENSP000003544761600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component cytoplasm IDA 2308818 RGD cytoplasm ISO RGD:730972 1624291 (PMID:12941800), (PMID:19098903) RGD PMID:12941800 , PMID:19098903 cytoplasm ISO RGD:730973 1624291 (MGI:MGI:3603108, PMID:16100574) RGD MGI:MGI:3603108 , PMID:16100574 dendrite IDA 2308818 RGD endoplasmic reticulum ISO RGD:730972 1624291 (PMID:12202038), (PMID:12941800) RGD GO_REF:0000052 more ... endoplasmic reticulum membrane IEA UniProtKB-SubCell:SL-0097 1600115 GO_REF:0000039 UniProt GO_REF:0000039 ER to Golgi transport vesicle membrane IEA UniProtKB-SubCell:SL-0078 1600115 GO_REF:0000039 UniProt GO_REF:0000039 Golgi membrane IEA UniProtKB-SubCell:SL-0134 1600115 GO_REF:0000039 UniProt GO_REF:0000039 integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000037 UniProt GO_REF:0000037 intracellular membrane-bounded organelle IDA 1581819 RGD intracellular membrane-bounded organelle ISO RGD:730972 1624291 RGD GO_REF:0000052 membrane ISO RGD:730973 1624291 (MGI:MGI:1927704, PMID:11090130) RGD MGI:MGI:1927704 , PMID:11090130 mitochondrion IEA UniProtKB:A0A024R1Q0 , ensembl:ENSP000003544761600115 GO_REF:0000107 Ensembl GO_REF:0000107 mitochondrion IEA UniProtKB:Q12772 , ensembl:ENSP000003544761600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm IEA UniProtKB:A0A024R1Q0 , ensembl:ENSP000003544761600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm ISO RGD:730972 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:Q12772 , ensembl:ENSP000003544761600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus IDA 1625196 RGD nucleus IBA FB:FBgn0261283 more ... 13792537 PMID:21873635 GO_Central nucleus ISO RGD:730972 1624291 (PMID:12202038), (PMID:12242332), (PMID:12941800), (PMID:15358760), (PMID:19098903) RGD PMID:12202038 more ... nucleus ISO RGD:730973 1624291 (MGI:MGI:1927704, PMID:11090130) RGD MGI:MGI:1927704 , PMID:11090130 SREBP-SCAP-Insig complex ISO RGD:730972 1624291 (PMID:12202038), (PMID:12242332) RGD PMID:12202038 , PMID:12242332 SREBP-SCAP-Insig complex IEA UniProtKB:Q12772 , ensembl:ENSP000003544761600115 GO_REF:0000107 Ensembl GO_REF:0000107 Molecular Function C-8 sterol isomerase activity NOT ISO RGD:730972 1624291 (PMID:12941800) RGD PMID:12941800 chromatin binding IDA 2308817 RGD DNA binding ISO RGD:730973 1624291 (MGI:MGI:2159547, PMID:11829742) RGD MGI:MGI:2159547 , PMID:11829742 DNA-binding transcription factor activity ISO RGD:730973 1624291 (MGI:MGI:2177036 more ... RGD MGI:MGI:2177036 more ... DNA-binding transcription factor activity IBA FB:FBgn0261283 more ... 13792537 PMID:21873635 GO_Central DNA-binding transcription repressor activity, RNA polymerase II-specific ISO RGD:730972 1624291 (PMID:15358760) RGD PMID:15358760 DNA-binding transcription repressor activity, RNA polymerase II-specific IEA UniProtKB:Q12772 , ensembl:ENSP000003544761600115 GO_REF:0000107 Ensembl GO_REF:0000107 E-box binding ISO RGD:730972 1624291 (PMID:15358760) RGD PMID:15358760 E-box binding IEA UniProtKB:Q12772 , ensembl:ENSP000003544761600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein binding ISO RGD:730973 1624291 UniProtKB:Q9JM73 (MGI:MGI:3688344 , PMID:15102471) RGD MGI:MGI:3688344 , PMID:15102471 protein binding ISO RGD:730972 1624291 UniProtKB:P04637 more ... RGD PMID:10976766 more ... protein C-terminus binding ISO RGD:730972 1624291 UniProtKB:P97260 (PMID:9242699) RGD PMID:9242699 protein C-terminus binding IEA UniProtKB:Q12772 , ensembl:ENSP000003544761600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein dimerization activity IEA InterPro:IPR011598 , InterPro:IPR036638 1600115 GO_REF:0000002 InterPro GO_REF:0000002 RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO RGD:730972 1624291 (PMID:15358760) RGD PMID:15358760 RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA MGI:MGI:107606 more ... 13792537 PMID:21873635 GO_Central sequence-specific DNA binding IDA 628485 PMID:12446768 MGI transcription regulatory region DNA binding ISO RGD:730973 1624291 (MGI:MGI:2177036, PMID:11739104) RGD MGI:MGI:2177036 , PMID:11739104
Gene-Chemical Interaction Annotations
