Srebf2 (sterol regulatory element binding transcription factor 2) - Rat Genome Database

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Gene: Srebf2 (sterol regulatory element binding transcription factor 2) Rattus norvegicus
Analyze
Symbol: Srebf2
Name: sterol regulatory element binding transcription factor 2
RGD ID: 1307751
Description: Enables chromatin binding activity and sequence-specific DNA binding activity. Involved in several processes, including aging; response to lead ion; and spermatogenesis. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm; dendrite; and nucleus. Biomarker of kidney disease (multiple); lipid storage disease; obesity; and visual epilepsy. Human ortholog(s) of this gene implicated in carotid artery disease; diabetes mellitus (multiple); prostate cancer; sarcoma; and vascular dementia. Orthologous to human SREBF2 (sterol regulatory element binding transcription factor 2); PARTICIPATES IN altered p53 signaling pathway; sterol regulatory element-binding protein signaling pathway; INTERACTS WITH (R)-mevalonic acid; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC124823; Srebf2_retired; SREBP-2; SREBP2; sterol regulatory element binding factor 2; sterol regulatory element binding protein 2; sterol regulatory element-binding protein 2; sterol regulatory element-binding transcription factor 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Srebf2_v2   Srebf2_v1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27113,663,202 - 113,720,850 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,663,202 - 113,720,848 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7115,419,363 - 115,476,823 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07117,642,866 - 117,700,330 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07117,612,307 - 117,669,771 (+)NCBIRnor_WKY
Rnor_6.07123,381,082 - 123,438,605 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7123,381,077 - 123,438,603 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07123,364,495 - 123,422,296 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47120,522,511 - 120,580,212 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17120,556,723 - 120,612,972 (+)NCBI
Celera7109,978,519 - 110,036,018 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R)-mevalonic acid  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
25-hydroxycholesterol  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alliin  (ISO)
allopurinol  (EXP,ISO)
alpha-pinene  (ISO)
amitriptyline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid  (ISO)
aspartame  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
beta-cyclodextrin  (ISO)
bezafibrate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
caffeine  (EXP,ISO)
carbamazepine  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
CGS-21680  (ISO)
chlorpromazine  (ISO)
cholesterol  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
citalopram  (ISO)
clofibrate  (EXP)
clomipramine  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) chloride  (ISO)
crizotinib  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
DDT  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (ISO)
dinophysistoxin 1  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ezetimibe  (ISO)
fenarimol  (EXP)
fenvalerate  (EXP)
fisetin  (ISO)
Ganoderic acid A  (ISO)
geraniol  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glyphosate  (ISO)
haloperidol  (ISO)
herbacetin  (ISO)
hydrogen peroxide  (ISO)
imipramine  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (EXP)
linalool  (ISO)
lipopolysaccharide  (EXP,ISO)
lovastatin  (EXP,ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methylarsonic acid  (ISO)
mevastatin  (EXP,ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (ISO)
Morroniside  (ISO)
myricetin  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
olanzapine  (EXP,ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenylpropanolamine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP)
propiconazole  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
streptozocin  (EXP,ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
tributyl phosphate  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
withaferin A  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47. Amemiya-Kudo M, etal., J Biol Chem. 2005 Oct 14;280(41):34577-89. Epub 2005 Jul 29.
2. Obesity-related overexpression of fatty-acid synthase gene in adipose tissue involves sterol regulatory element-binding protein transcription factors. Boizard M, etal., J Biol Chem. 1998 Oct 30;273(44):29164-71.
3. In vivo identification of promoter elements and transcription factors mediating activation of hepatic HMG-CoA reductase by T(3). Boone LR, etal., Biochem Biophys Res Commun. 2009 May 24.
4. Increased gene expression of liver SREBP-2 in experimental chronic renal failure. Chmielewski M, etal., Atherosclerosis. 2007 Apr;191(2):326-32. Epub 2006 Jun 30.
5. Protective effect of Chinese prescription Kangen-karyu and its crude drug Tanjin against age-related lipidosis in rats. Cho EJ, etal., J Pharm Pharmacol. 2007 May;59(5):687-94.
6. The effect of sterol regulatory element-binding protein 2 polymorphism on the serum lipid in northern Chinese subjects. Duan X, etal., J Lipid Res. 2005 Feb;46(2):252-7. Epub 2004 Nov 16.
7. Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence. Ettinger SL, etal., Cancer Res. 2004 Mar 15;64(6):2212-21.
8. Mutant p53: one name, many proteins. Freed-Pastor WA and Prives C, Genes Dev. 2012 Jun 15;26(12):1268-86. doi: 10.1101/gad.190678.112.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity. Ishikawa M, etal., J Lipid Res. 2008 Dec;49(12):2524-34. Epub 2008 Aug 5.
12. Calorie restriction modulates renal expression of sterol regulatory element binding proteins, lipid accumulation, and age-related renal disease. Jiang T, etal., J Am Soc Nephrol. 2005 Aug;16(8):2385-94. Epub 2005 Jun 8.
13. Role of altered renal lipid metabolism and the sterol regulatory element binding proteins in the pathogenesis of age-related renal disease. Jiang T, etal., Kidney Int. 2005 Dec;68(6):2608-20.
14. Sterol Regulatory Element-Binding Proteins, Liver X Receptor, ABCA1 Transporter, CD36, Scavenger Receptors A1 and B1 in Nephrotic Kidney. Kim HJ and Vaziri ND, Am J Nephrol. 2009 Jan 16;29(6):607-614.
15. Localization of the transcription factor, sterol regulatory element binding protein-2 (SREBP-2) in the normal rat brain and changes after kainate-induced excitotoxic injury. Kim JH and Ong WY, J Chem Neuroanat. 2009 Mar;37(2):71-7. Epub 2008 Dec 13.
16. Analysis of the SREBF2 gene as a genetic risk factor for vascular dementia. Kim Y, etal., Am J Med Genet B Neuropsychiatr Genet. 2005 Nov 5;139(1):19-22.
17. Thermally oxidized oil increases the expression of insulin-induced genes and inhibits activation of sterol regulatory element-binding protein-2 in rat liver. Koch A, etal., J Nutr. 2007 Sep;137(9):2018-23.
18. Gender-related difference in altered gene expression of a sterol regulatory element binding protein, SREBP-2, by lead nitrate in rats: correlation with development of hypercholesterolemia. Kojima M and Degawa M, J Appl Toxicol. 2006 Jul-Aug;26(4):381-4.
19. Progesterone stimulates adipocyte determination and differentiation 1/sterol regulatory element-binding protein 1c gene expression. potential mechanism for the lipogenic effect of progesterone in adipose tissue. Lacasa D, etal., J Biol Chem. 2001 Apr 13;276(15):11512-6. Epub 2001 Jan 16.
20. Suppression of hepatic cholesteryl ester transfer protein expression in obese humans with the development of type 2 diabetes mellitus. MacLean PS, etal., J Clin Endocrinol Metab. 2005 Apr;90(4):2250-8. Epub 2005 Jan 11.
21. Impact of maternal circulating cholesterol and gestational diabetes mellitus on lipid metabolism in human term placenta. Marseille-Tremblay C, etal., Mol Reprod Dev. 2008 Jun;75(6):1054-62.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. p53 mutations in cancer. Muller PA and Vousden KH, Nat Cell Biol. 2013 Jan;15(1):2-8. doi: 10.1038/ncb2641.
24. Identification of mutations in the gene encoding sterol regulatory element binding protein (SREBP)-2 in hypercholesterolaemic subjects. Muller PY and Miserez AR, J Med Genet. 2002 Apr;39(4):271-5.
25. Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been. Osborne TF and Espenshade PJ, Genes Dev. 2009 Nov 15;23(22):2578-91.
26. Modified HMG-CoA reductase and LDLr regulation is deeply involved in age-related hypercholesterolemia. Pallottini V, etal., J Cell Biochem. 2006 Aug 1;98(5):1044-53.
27. Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes. Proctor G, etal., Diabetes. 2006 Sep;55(9):2502-9.
28. GOA pipeline RGD automated data pipeline
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Characterization of polymorphic structure of SREBP-2 gene: role in atherosclerosis. Robinet P, etal., Atherosclerosis. 2003 Jun;168(2):381-7.
31. Increase in hepatic expression of SREBP-2 by gemfibrozil administration to rats. Roglans N, etal., Biochem Pharmacol. 2001 Sep 15;62(6):803-9.
32. Endometriosis of the ureter. Ryan JF and Booth CM, Br J Urol. 1992 Apr;69(4):430-1.
33. A phase II study of ENMD-2076 in advanced soft tissue sarcoma (STS). Veitch Z, etal., Sci Rep. 2019 May 14;9(1):7390. doi: 10.1038/s41598-019-43222-6.
34. A developmental switch in transcription factor isoforms during spermatogenesis controlled by alternative messenger RNA 3'-end formation. Wang H, etal., Biol Reprod. 2006 Sep;75(3):318-23. Epub 2006 May 24.
35. Expression of a novel, sterol-insensitive form of sterol regulatory element binding protein 2 (SREBP2) in male germ cells suggests important cell- and stage-specific functions for SREBP targets during spermatogenesis. Wang H, etal., Mol Cell Biol 2002 Dec;22(24):8478-90.
36. Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes. Wang Z, etal., Diabetes. 2005 Aug;54(8):2328-35.
37. Cyclosporin-induced dyslipoproteinemia is associated with selective activation of SREBP-2. Wu J, etal., Am J Physiol. 1999 Dec;277(6 Pt 1):E1087-94.
38. Impaired regulation of sterol regulatory element binding protein 2 in cholesterol gallstone-susceptible mice. Xu G, etal., Biochim Biophys Acta. 2004 Apr 5;1688(3):274-9.
Additional References at PubMed
PMID:9242699   PMID:11090130   PMID:11739104   PMID:11829742   PMID:12202038   PMID:12242332   PMID:12421847   PMID:12477932   PMID:12488438   PMID:12941800   PMID:15358760   PMID:16100574  
PMID:16890542   PMID:16941710   PMID:17526932   PMID:17572141   PMID:17884448   PMID:19098903   PMID:19808779   PMID:20466882   PMID:21726644   PMID:23542164   PMID:23823476   PMID:24068000  
PMID:24625548   PMID:24755036   PMID:24912190   PMID:25289390   PMID:25339898   PMID:27321819   PMID:27614840   PMID:29122977   PMID:29446047   PMID:30579780  


Genomics

Comparative Map Data
Srebf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27113,663,202 - 113,720,850 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,663,202 - 113,720,848 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7115,419,363 - 115,476,823 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07117,642,866 - 117,700,330 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07117,612,307 - 117,669,771 (+)NCBIRnor_WKY
Rnor_6.07123,381,082 - 123,438,605 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7123,381,077 - 123,438,603 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07123,364,495 - 123,422,296 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47120,522,511 - 120,580,212 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17120,556,723 - 120,612,972 (+)NCBI
Celera7109,978,519 - 110,036,018 (+)NCBICelera
Cytogenetic Map7q34NCBI
SREBF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,833,105 - 41,907,305 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2241,833,079 - 41,907,307 (+)EnsemblGRCh38hg38GRCh38
GRCh372242,229,109 - 42,303,309 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362240,559,052 - 40,632,321 (+)NCBINCBI36Build 36hg18NCBI36
Build 342240,553,605 - 40,626,873NCBI
Celera2226,035,175 - 26,108,609 (+)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2225,194,635 - 25,269,011 (+)NCBIHuRef
CHM1_12242,189,135 - 42,263,520 (+)NCBICHM1_1
T2T-CHM13v2.02242,311,716 - 42,386,086 (+)NCBIT2T-CHM13v2.0
Srebf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391582,031,470 - 82,089,580 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1582,031,382 - 82,089,580 (+)EnsemblGRCm39 Ensembl
GRCm381582,147,269 - 82,205,379 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1582,147,181 - 82,205,379 (+)EnsemblGRCm38mm10GRCm38
MGSCv371581,977,699 - 82,035,390 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361581,974,524 - 82,032,215 (+)NCBIMGSCv36mm8
Celera1584,270,919 - 84,328,680 (+)NCBICelera
Cytogenetic Map15E1NCBI
Srebf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541327,271,953 - 27,326,759 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541327,271,717 - 27,326,655 (+)NCBIChiLan1.0ChiLan1.0
SREBF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12240,811,459 - 40,884,947 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2240,811,459 - 40,884,947 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02222,725,790 - 22,799,749 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Srebf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049457,105,519 - 7,164,174 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936492115,821 - 174,775 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936492115,923 - 174,614 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SREBF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl56,719,490 - 6,784,671 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.156,719,484 - 6,784,724 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SREBF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11924,364,725 - 24,439,851 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1924,364,911 - 24,440,014 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045100,972,400 - 101,047,348 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srebf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247526,815,075 - 6,871,674 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Srebf2
283 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:202
Count of miRNA genes:135
Interacting mature miRNAs:164
Transcripts:ENSRNOT00000056041
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat

Markers in Region
D7Rat78  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.07123,378,628 - 123,378,833UniSTSRnor5.0
RGSC_v3.47120,536,569 - 120,536,775RGDRGSC3.4
RGSC_v3.47120,536,570 - 120,536,775UniSTSRGSC3.4
RGSC_v3.17120,570,799 - 120,571,005RGD
Celera7109,992,435 - 109,992,640UniSTS
RH 2.0 Map7678.9RGD
SHRSP x BN Map765.7799RGD
FHH x ACI Map753.35RGD
Cytogenetic Map7q34UniSTS
RH128235  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27113,720,511 - 113,720,711 (+)MAPPERmRatBN7.2
Rnor_6.07123,438,267 - 123,438,466NCBIRnor6.0
Rnor_5.07123,421,958 - 123,422,157UniSTSRnor5.0
RGSC_v3.47120,579,874 - 120,580,073UniSTSRGSC3.4
Celera7110,035,680 - 110,035,879UniSTS
RH 3.4 Map7893.1UniSTS
Cytogenetic Map7q34UniSTS
AA850446  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27113,661,749 - 113,661,966 (+)MAPPERmRatBN7.2
Rnor_6.07123,379,630 - 123,379,846NCBIRnor6.0
Rnor_5.07123,363,043 - 123,363,259UniSTSRnor5.0
RGSC_v3.47120,521,059 - 120,521,275UniSTSRGSC3.4
Celera7109,977,067 - 109,977,283UniSTS
RH 3.4 Map7892.0UniSTS
Cytogenetic Map7q34UniSTS
PMC165443P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27113,720,490 - 113,720,642 (+)MAPPERmRatBN7.2
Rnor_6.07123,438,246 - 123,438,397NCBIRnor6.0
Rnor_5.07123,421,937 - 123,422,088UniSTSRnor5.0
RGSC_v3.47120,579,853 - 120,580,004UniSTSRGSC3.4
Celera7110,035,659 - 110,035,810UniSTS
Cytogenetic Map7q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 57 41 19 41 5 8 74 35 41 11 5
Low 8 3 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000056041   ⟹   ENSRNOP00000052893
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7113,663,202 - 113,720,848 (+)Ensembl
Rnor_6.0 Ensembl7123,381,082 - 123,438,603 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082603   ⟹   ENSRNOP00000071436
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7123,381,077 - 123,437,466 (+)Ensembl
RefSeq Acc Id: NM_001033694   ⟹   NP_001028866
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27113,663,202 - 113,720,850 (+)NCBI
Rnor_6.07123,381,082 - 123,438,605 (+)NCBI
Rnor_5.07123,364,495 - 123,422,296 (+)NCBI
RGSC_v3.47120,522,511 - 120,580,212 (+)RGD
Celera7109,978,519 - 110,036,018 (+)RGD
Sequence:
RefSeq Acc Id: XM_006242079   ⟹   XP_006242141
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27113,663,555 - 113,720,850 (+)NCBI
Rnor_6.07123,381,425 - 123,438,605 (+)NCBI
Rnor_5.07123,364,495 - 123,422,296 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001028866 (Get FASTA)   NCBI Sequence Viewer  
  XP_006242141 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI01903 (Get FASTA)   NCBI Sequence Viewer  
  EDM15674 (Get FASTA)   NCBI Sequence Viewer  
  Q3T1I5 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001028866   ⟸   NM_001033694
- UniProtKB: F1MA23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242141   ⟸   XM_006242079
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000071436   ⟸   ENSRNOT00000082603
RefSeq Acc Id: ENSRNOP00000052893   ⟸   ENSRNOT00000056041
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3T1I5-F1-model_v2 AlphaFold Q3T1I5 1-1133 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695530
Promoter ID:EPDNEW_R6053
Type:multiple initiation site
Name:Srebf2_1
Description:sterol regulatory element binding transcription factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07123,381,080 - 123,381,140EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307751 AgrOrtholog
BioCyc Gene G2FUF-32642 BioCyc
Ensembl Genes ENSRNOG00000007400 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000052893 ENTREZGENE
  ENSRNOP00000052893.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000056041 ENTREZGENE
  ENSRNOT00000056041.3 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7934137 IMAGE-MGC_LOAD
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:300095 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124823 IMAGE-MGC_LOAD
NCBI Gene 300095 ENTREZGENE
Pfam HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Srebf2 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_MHC UniProtKB/TrEMBL
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1MA23 ENTREZGENE, UniProtKB/TrEMBL
  Q3T1I5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Srebf2  sterol regulatory element binding transcription factor 2  Srebf2  sterol regulatory element binding factor 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-28 Srebf2  sterol regulatory element binding factor 2   Srebf2  sterol regulatory element binding factor 2 (predicted)  'predicted' is removed from gene name 2292626 APPROVED
2007-04-13 Srebf2  UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1  Srebf2_predicted  sterol regulatory element binding factor 2 (predicted)  Symbol updated 737654 APPROVED
2007-04-13 Srebf2_predicted  sterol regulatory element binding factor 2 (predicted)  Srebf2_retired  sterol regulatory element binding factor 2  Data Merged 737654 APPROVED
2007-04-13 Srebf2_retired  UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1  Srebf2  sterol regulatory element binding factor 2  Symbol updated 737654 APPROVED
2005-01-12 Srebf2_predicted  sterol regulatory element binding factor 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization cytoplasmic(soluble)protein 628485
gene_cellular_localization a cytoplasmic(soluble) protein 628485
gene_domains SREBP characteristic membrane-spanning and SCAP binding domains absent 628485
gene_domains contains DNA binding, dimerization, nuclear localization and N-terminal transactivation domains with characteristic membrane-spanning and SCAP binding domains absent in isoform Srebf2_v1 628485
gene_expression preferentially enriched in adult spermatogenic cells; expressed druing meitoic and early haploid spermatogenic stages 628485
gene_expression expressed in somatic tissues, testis and enriched adult spermatogenic cells 628485
gene_function transcription factor 628485
gene_physical_interaction binds to SRE-containing (ATCACCCCAC) promoter region; binds to GCP1 repeat element(CTCCAG) 628485
gene_physical_interaction binds to (Sterol Regulatory elements) SRE-containing promoters 628485
gene_process involved in regulation of cholesterol and fatty acid biosynthesis 628485
gene_process constitutively active transcriptional regulator functioning during spermatogenesis in a sterol dependent way 628485
gene_product basic helix-loop-helix zip protein 628485
gene_protein 20 amino acids absent in C-terminal compared to Srebp2 protein 628485
gene_regulation independent of regulation by SCAP 628485