Gene: Srebf2 (sterol regulatory element binding transcription factor 2) Rattus norvegicus
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Symbol: Srebf2
Name: sterol regulatory element binding transcription factor 2
Description: ENCODES a protein that exhibits chromatin binding; sequence-specific DNA binding; DNA binding (ortholog); INVOLVED IN aging; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; PARTICIPATES IN altered p53 signaling pathway; sterol regulatory element-binding protein signaling pathway; ASSOCIATED WITH end stage renal failure; Hypercholesterolemia; kidney disease; FOUND IN cytoplasm; dendrite; intracellular membrane-bounded organelle; INTERACTS WITH (R)-mevalonic acid; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene
AGR Description: Exhibits chromatin binding activity and sequence-specific DNA binding activity; involved in several processes, including aging, positive regulation of transcription by RNA polymerase II, and response to drug; localizes to the cytoplasm, dendrite, and nucleus; biomarker of several diseases, including kidney disease (multiple), lipid storage disease, and obesity; orthologous to human SREBF2 (sterol regulatory element binding transcription factor 2).
Merged Description: Exhibits chromatin binding activity and sequence-specific DNA binding activity; involved in several processes, including aging, positive regulation of transcription by RNA polymerase II, and response to drug; localizes to the cytoplasm, dendrite, and nucleus; biomarker of several diseases, including kidney disease (multiple), lipid storage disease, and obesity; orthologous to human SREBF2 (sterol regulatory element binding transcription factor 2); PARTICIPATES IN altered p53 signaling pathway; sterol regulatory element-binding protein signaling pathway; INTERACTS WITH (R)-mevalonic acid; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC124823; Srebf2_retired; SREBP-2; SREBP2; sterol regulatory element binding factor 2; sterol regulatory element binding protein 2; sterol regulatory element-binding protein 2; sterol regulatory element-binding transcription factor 2
Orthologs:
Homo sapiens (human) : SREBF2 (sterol regulatory element binding transcription factor 2)  HGNC  Alliance
Mus musculus (house mouse) : Srebf2 (sterol regulatory element binding factor 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Srebf2 (sterol regulatory element binding transcription factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SREBF2 (sterol regulatory element binding transcription factor 2)
Canis lupus familiaris (dog) : SREBF2 (sterol regulatory element binding transcription factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Srebf2 (sterol regulatory element binding transcription factor 2)
Sus scrofa (pig) : SREBF2 (sterol regulatory element binding transcription factor 2)
more info ...
Allele / Splice: Srebf2_v2   Srebf2_v1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07123,381,082 - 123,438,605 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07123,364,495 - 123,422,296 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47120,522,511 - 120,580,212 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17120,556,723 - 120,612,972 (+)NCBI
Celera7109,978,519 - 110,036,018 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model

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Genomics

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QTLs in Region (Rnor_6.0)
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Sequence

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Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

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Nomenclature History
RGD Curation Notes
  
More on Srebf2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1307751
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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