Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | autoimmune thyroiditis | | ISO | RGD:735819 | 8554872 | ClinVar more ... | ClinVar | PMID:10403171 more ... | benign neonatal seizures | | ISO | RGD:735819 | 8554872 | ClinVar Annotator: match by term: Benign neonatal seizures | ClinVar | PMID:28492532 more ... | Charcot-Marie-Tooth disease type 4 | | ISO | RGD:735819 | 8554872 | ClinVar Annotator: match by term: Charcot-Marie-Tooth disease type 4 | ClinVar | PMID:12872253 more ... | congenital hypothyroidism | | ISO | RGD:735819 | 8554872 | ClinVar Annotator: match by term: Congenital hypothyroidism | ClinVar | PMID:10404833 more ... | familial thyroid dyshormonogenesis | | ISO | RGD:735819 | 8554872 | ClinVar Annotator: match by term: Thyroid dyshormonogenesis | ClinVar | | genetic disease | | ISO | RGD:735819 | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | PMID:25741868, PMID:28492532 | hereditary breast ovarian cancer syndrome | | ISO | RGD:735819 | 8554872 | ClinVar Annotator: match by term: Hereditary breast and ovarian cancer | ClinVar | PMID:25741868 | hypothyroidism | | ISO | RGD:735819 | 8554872 | ClinVar Annotator: match by term: Hypothyroidism | ClinVar | PMID:25741868 | Primary Ovarian Failure | | ISO | RGD:735819 | 8554872 | ClinVar Annotator: match by term: Primary ovarian failure | ClinVar | PMID:16187910 more ... | primary ovarian insufficiency | | ISO | RGD:735819 | 8554872 | ClinVar Annotator: match by term: Premature ovarian failure | ClinVar | PMID:16187910 more ... | prostate cancer | | ISO | RGD:735819 | 8554872 | ClinVar Annotator: match by term: Malignant tumor of prostate | ClinVar | PMID:23265383 | thyroid dyshormonogenesis 3 | | ISO | RGD:735819 | 8554872 | ClinVar more ... | ClinVar | PMID:10199792 more ... | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 |
Welcome {{ username}}
Message Center
{{ messageCount }} Messages
Watched Genes
{{$index + 1}}. {{ watchedObject.symbol }} (RGD ID:{{watchedObject.rgdId}})
Watched Ontology Terms
{{gene.symbol}}: {{ gene.description }}
|
| Save what matters to you |
| {{ loginError }} |
| Sign in with your RGD account |
| Create New Account | Recover Password |
Analyze GeneStrainQTL List |
 Gene Annotator (Functional Annotation) unavailable |
 Gene Annotator (Annotation Distribution) unavailable |
 Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable |
Gene Annotator (Functional Annotation) |
Gene Annotator (Annotation Distribution) |
Variant Visualizer (Genomic Variants) |
 InterViewer (Protein-Protein Interactions) unavailable |
 Gviewer (Genome Viewer) unavailable |
 Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable |
InterViewer (Protein-Protein Interactions) |
GViewer (Genome Viewer) |
Variant Visualizer (Damaging Variants) |
 Gene Annotator (Annotation Comparison) unavailable |
 OLGA (Gene List Generator) unavailable |
 |
Gene Annotator (Annotation Comparison) |
OLGA (Gene List Generator) |
Excel (Download) |
 MOET (Multi-Ontology Enrichement) unavailable |
 GOLF (Gene-Ortholog Location Finder) unavailable |
|
MOET (Multi-Ontology Enrichement) |
GOLF (Gene-Ortholog Location Finder) |
|
||||||||
Imported Disease Annotations - CTD
Imported Disease Annotations - MGI
Imported Disease Annotations - OMIM
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
Cellular Component
Molecular Function
Molecular Pathway Annotations Click to see Annotation Detail View
Imported Annotations - SMPDB
Imported Annotations - KEGG (archival)
Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Disease Annotations
Click to see Annotation Detail View
|
|
|
Gene-Chemical Interaction Annotations
Click to see Annotation Detail View
Gene Ontology Annotations
Click to see Annotation Detail View
Biological Process
|
|
|
Cellular Component
|
|
Molecular Function
|
|
|
Phenotype Annotations
Click to see Annotation Detail View
Mammalian Phenotype
|
|
|
References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Structural organization of the 3' half of the rat thyroglobulin gene. | Avvedimento VE, etal., Nucleic Acids Res 1984 Apr 25;12(8):3461-72. |
| 2. | Multiple SNPs in intron 41 of thyroglobulin gene are associated with autoimmune thyroid disease in the Japanese population. | Ban Y, etal., PLoS One. 2012;7(5):e37501. doi: 10.1371/journal.pone.0037501. Epub 2012 May 25. |
| 3. | Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease. | Ban Y, etal., Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15119-24. Epub 2003 Dec 1. |
| 4. | Thyroglobulin polymorphisms in Tunisian patients with autoimmune thyroid diseases (AITD). | Belguith-Maalej S, etal., Immunobiology. 2008;213(7):577-83. doi: 10.1016/j.imbio.2008.01.004. Epub 2008 Mar 4. |
| 5. | Electron microscopy of low iodinated thyroglobulin molecules. | Berg G and Ekholm R, Biochim Biophys Acta. 1975 Apr 29;386(2):422-31. |
| 6. | Sortilin is a putative postendocytic receptor of thyroglobulin. | Botta R, etal., Endocrinology. 2009 Jan;150(1):509-18. doi: 10.1210/en.2008-0953. Epub 2008 Aug 7. |
| 7. | Folding of thyroglobulin in the calnexin/calreticulin pathway and its alteration by loss of Ca2+ from the endoplasmic reticulum. | Di Jeso B, etal., Biochem J. 2003 Mar 1;370(Pt 2):449-58. |
| 8. | The sequence of 967 amino acids at the carboxyl-end of rat thyroglobulin. Location and surroundings of two thyroxine-forming sites. | Di Lauro R, etal., Eur J Biochem 1985 Apr 1;148(1):7-11. |
| 9. | Rescue from dwarfism by thyroid function compensation in rdw rats. | Furudate S, etal., Exp Anim. 2005 Oct;54(5):455-60. doi: 10.1538/expanim.54.455. |
| 10. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 11. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
| 12. | A second thyroglobulin messenger RNA species (rTg-2) in rat thyrocytes. | Graves PN and Davies TF, Mol Endocrinol 1990 Jan;4(1):155-61. |
| 13. | A novel missense mutation (G2320R) in thyroglobulin causes hypothyroidism in rdw rats. | Hishinuma A, etal., Endocrinology 2000 Nov;141(11):4050-5. |
| 14. | Association between a C/T polymorphism in exon 33 of the thyroglobulin gene is associated with relapse of Graves' hyperthyroidism after antithyroid withdrawal in Taiwanese. | Hsiao JY, etal., J Clin Endocrinol Metab. 2007 Aug;92(8):3197-201. Epub 2007 Jun 5. |
| 15. | A 3' splice site mutation in the thyroglobulin gene responsible for congenital goiter with hypothyroidism. | Ieiri T, etal., J Clin Invest. 1991 Dec;88(6):1901-5. |
| 16. | cDNA immunization of mice with human thyroglobulin generates both humoral and T cell responses: a novel model of thyroid autoimmunity. | Jacobson EM, etal., PLoS One. 2011 Apr 29;6(4):e19200. doi: 10.1371/journal.pone.0019200. |
| 17. | Early stages of synthesis of thyroglobulin (Tg), thyroxine (T4), and triiodothyronine (T3) in fetal rat thyroid. An immunoelectron microscopic study. | Kawaoi A J Histochem Cytochem. 1987 Oct;35(10):1137-42. |
| 18. | A missense mutation G2320R in the thyroglobulin gene causes non-goitrous congenital primary hypothyroidism in the WIC-rdw rat. | Kim PS, etal., Mol Endocrinol 2000 Dec;14(12):1944-53. |
| 19. | Efficacy of HLA-DRB1 *03:01 and H2E transgenic mouse strains to correlate pathogenic thyroglobulin epitopes for autoimmune thyroiditis. | Kong YC, etal., J Autoimmun. 2011 Jun 17. |
| 20. | [rdw rats, a new hereditary dwarf model in the rat]. | Koto M, etal., Jikken Dobutsu. 1988 Jan;37(1):21-30. |
| 21. | Several endoplasmic reticulum stress proteins, including ERp72, interact with thyroglobulin during its maturation. | Kuznetsov G, etal., J Biol Chem. 1994 Sep 16;269(37):22990-5. |
| 22. | Targeting of thyroglobulin to transcytosis following megalin-mediated endocytosis: evidence for a preferential pH-independent pathway. | Marino M, etal., J Endocrinol Invest. 2003 Mar;26(3):222-9. |
| 23. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
| 24. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 25. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
| 26. | Thyroglobulin binding and TSH regulation of the RHL-1 subunit of the asialoglycoprotein receptor in rat thyroid. | Pacifico F, etal., Biochimie. 1999 May;81(5):493-6. |
| 27. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 28. | SMPDB Annotation Import Pipeline | Pipeline to import SMPDB annotations from SMPDB into RGD |
| 29. | GOA pipeline | RGD automated data pipeline |
| 30. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 31. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 32. | Missing secretory granules, dilated endoplasmic reticulum, and nuclear dislocation in the thyroid gland of rdw rats with hereditary dwarfism. | Sakai Y, etal., Anat Rec. 2000 May 1;259(1):60-6. |
| 33. | Increased sensitivity of a new assay for anti-thyroglobulin antibody detection in patients with autoimmune thyroid disease. | Sapin R, etal., Clin Biochem. 2003 Nov;36(8):611-6. |
| 34. | Identification of ERp29, an endoplasmic reticulum lumenal protein, as a new member of the thyroglobulin folding complex. | Sargsyan E, etal., J Biol Chem 2002 May 10;277(19):17009-15. |
| 35. | Analysis of the spectrotypes of autoantibodies against thyroglobulin in two rat models of autoimmune thyroiditis. | Stott DI, etal., Clin Exp Immunol. 1988 Aug;73(2):269-75. |
| 36. | Correction to the Genomic Sequence of the Thyroglobulin gene | Submitted by Dr. Daniel Christophe via email |
| 37. | Differential regulation of apical and basal iodide transporters in the thyroid by thyroglobulin. | Suzuki K and Kohn LD, J Endocrinol. 2006 May;189(2):247-55. |
| 38. | Release of thyroid hormone from circulating thyroglobulin in the rat. | Taura M, etal., Acta Endocrinol (Copenh). 1986 Feb;111(2):209-12. |
| 39. | Effect of therapy on serum thyroglobulin levels in patients with Graves' disease. | Uller RP and Van Herle AJ, J Clin Endocrinol Metab. 1978 May;46(5):747-55. |
| 40. | Bacterial lipopolysaccharide stimulates the thyrotropin-dependent thyroglobulin gene expression at the transcriptional level by involving the transcription factors thyroid transcription factor-1 and paired box domain transcription factor 8. | Velez ML, etal., Endocrinology. 2006 Jul;147(7):3260-75. Epub 2006 Apr 20. |
Additional References at PubMed
| PMID:1508304 | PMID:2775280 | PMID:3455768 | PMID:3803305 | PMID:8626858 | PMID:9006956 | PMID:9707574 | PMID:11082042 | PMID:12387814 | PMID:12782676 | PMID:15181011 | PMID:15494458 |
| PMID:16260597 | PMID:16260629 | PMID:17200118 | PMID:17455082 | PMID:17714035 | PMID:18437010 | PMID:19276074 | PMID:19716808 | PMID:19776016 | PMID:20629314 | PMID:21619833 | PMID:24479877 |
| PMID:24582622 | PMID:26599499 | PMID:27321819 | PMID:27998776 | PMID:31972331 | PMID:32025030 | PMID:35618019 | PMID:36547798 |
Genomics
Comparative Map Data
| Tg (Rattus norvegicus - Norway rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| TG (Homo sapiens - human) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tg (Mus musculus - house mouse) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tg (Chinchilla lanigera - long-tailed chinchilla) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| TG (Pan paniscus - bonobo/pygmy chimpanzee) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| TG (Canis lupus familiaris - dog) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tg (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| TG (Sus scrofa - pig) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| TG (Chlorocebus sabaeus - green monkey) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tg (Heterocephalus glaber - naked mole-rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Variants
.
Variants in Tg
548 total Variants 
|
