cytochrome P450, family 2, subfamily d, polypeptide 2
RGD ID:
2471
Description:
Enables monooxygenase activity. Involved in female pregnancy; response to genistein; and response to xenobiotic stimulus. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to human CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)) and CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-schisandrin B; 1,2-dichlorobenzene; 17beta-estradiol.
[2-dichlorobenzene analog co-treated with NADP] results in decreased activity of CYP2D2 protein and CAT protein inhibits the reaction [[2-dichlorobenzene analog co-treated with NADP] results in decreased activity of CYP2D2 protein]
acetonitrile inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N and N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]
[Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CYP2D2 mRNA
Clotrimazole inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N and N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]
Dimethyl Sulfoxide inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N and N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]
Fluoxetine inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N and N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]
[Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CYP2D2 mRNA
Ketoconazole inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N and N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]
[Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CYP2D2 mRNA
[2-dichlorobenzene analog co-treated with NADP] results in decreased activity of CYP2D2 protein and CAT protein inhibits the reaction [[2-dichlorobenzene analog co-treated with NADP] results in decreased activity of CYP2D2 protein]
[2-dichlorobenzene analog co-treated with NADP] results in decreased activity of CYP2D2 protein and CAT protein inhibits the reaction [[2-dichlorobenzene analog co-treated with NADP] results in decreased activity of CYP2D2 protein]
[Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CYP2D2 mRNA
Propranolol inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N and N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]
Quinidine inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N and N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]
Quinine inhibits the reaction [CYP2D2 protein results in increased metabolism of 3-(2-(N and N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin]
[Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CYP2D2 mRNA
The influence of soybean extract on the expression level of selected drug transporters, transcription factors and cytochrome P450 genes encoding phase I drug-metabolizing enzymes.
Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism.
Four species of cDNAs for cytochrome P450 isozymes immunorelated to P450C-M/F encode for members of P450IID subfamily, increasing the number of members within the subfamily.
The rat P450 IID subfamily: complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme-binding region of the cytochrome P450 active site.