Gene: Cyp2d2 (cytochrome P450, family 2, subfamily d, polypeptide 2) Rattus norvegicus

Analyze

No known orthologs.

Symbol:

Cyp2d2

Name:

cytochrome P450, family 2, subfamily d, polypeptide 2

RGD ID:

2471

Description:

Enables monooxygenase activity. Involved in female pregnancy; response to genistein; and response to xenobiotic stimulus. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to human CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)) and CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-schisandrin B; 1,2-dichlorobenzene; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Cyp2d26; CYPIID26; cytochrome P450 2D26; cytochrome P450, family 2, subfamily d, polypeptide 26; Cytochrome P450, subfamily IID2; cytochrome P450-CMF2; cytochrome P450-DB2; debrisoquine 4-hydroxylase; P450-CMF2; P450-DB2

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Other homologs ²				less info ...
Homo sapiens (human):	CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene))	HGNC	Ensembl, OrthoDB, Panther, PhylomeDB
Homo sapiens (human):	CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene))	HGNC	Panther
Alliance orthologs ³
Homo sapiens (human):	CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene))	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Homo sapiens (human):	CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene))	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Cyp2d26 (cytochrome P450, family 2, subfamily d, polypeptide 26)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Cyp18a1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	cyp-14A2	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder)
Caenorhabditis elegans (roundworm):	cyp-14A4	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-14A5	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder)
Caenorhabditis elegans (roundworm):	cyp-23A1	Alliance	DIOPT (Hieranoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-34A7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	cyp-34A1	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-34A5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-34A6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-34A8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	cyp-35A3	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-14A1	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|SonicParanoid)
Caenorhabditis elegans (roundworm):	daf-9	Alliance	DIOPT (OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-33D3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-33D1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-35B1	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	dach-1	Alliance	DIOPT (Hieranoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-35A1	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-35B3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-36A1	Alliance	DIOPT (OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-35D1	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	cyp-35B2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-34A10	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-34A2	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-34A9	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	cyp-35A5	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-35A4	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-35A2	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-35C1	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100495518	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC101731511	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100494106	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100495359	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	XB5769266	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC116410450	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	115,815,212 - 115,819,281 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	115,815,212 - 115,819,281 (-)	Ensembl				GRCr8
mRatBN7.2	7	113,935,138 - 113,939,209 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	113,935,138 - 113,939,209 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	115,690,180 - 115,694,258 (-)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	117,914,310 - 117,918,388 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	117,883,760 - 117,887,838 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	7	117,854,209 - 117,858,287 (-)	NCBI
Lyon_Normotensive	7	118,795,822 - 118,799,889 (-)	NCBI
Lyon_Hypertensive	7	118,921,507 - 118,925,574 (-)	NCBI
F344_StmMcwi	7	117,412,492 - 117,416,570 (-)	NCBI
Rnor_6.0	7	123,651,827 - 123,655,896 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	123,651,827 - 123,655,896 (-)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	7	123,636,789 - 123,640,858 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	120,796,210 - 120,800,279 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	110,250,322 - 110,254,396 (-)	NCBI		Celera
RGSC_v3.1	7	120,830,439 - 120,834,509 (-)	NCBI
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dichlorobenzene (EXP)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-nitroanisole (EXP)

5-methoxy-N,N-diisopropyltryptamine (EXP)

acetamide (EXP)

acetonitrile (EXP)

all-trans-retinoic acid (EXP)

allopurinol (EXP)

ammonium chloride (EXP)

ampicillin (EXP)

bisphenol A (EXP)

Bufuralol (EXP)

carvedilol (EXP)

clotrimazole (EXP)

cobalt dichloride (EXP)

corticosterone (EXP)

dextromethorphan (EXP)

dextrorphan (EXP)

dimethyl sulfoxide (EXP)

endosulfan (EXP)

ethanol (EXP)

fipronil (EXP)

flavonoids (EXP)

fluoxetine (EXP)

formaldehyde (EXP)

furan (EXP)

genistein(1-) (EXP)

gentamycin (EXP)

glafenine (EXP)

ketoconazole (EXP)

lamotrigine (EXP)

methapyrilene (EXP)

metronidazole (EXP)

mitomycin C (EXP)

N-nitrosodiethylamine (EXP)

NADP zwitterion (EXP)

NADP(+) (EXP)

neomycin (EXP)

nitrofen (EXP)

ochratoxin A (EXP)

paracetamol (EXP)

phenacetin (EXP)

phenobarbital (EXP)

propranolol (EXP)

quercetin (EXP)

quinidine (EXP)

quinine (EXP)

sodium dichromate (EXP)

tetrachloromethane (EXP)

thioacetamide (EXP)

Triptolide (EXP)

vancomycin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

arachidonate metabolic process (IBA)

female pregnancy (IEP)

response to genistein (IEP)

response to xenobiotic stimulus (IDA)

serotonin biosynthetic process (IDA)

xenobiotic metabolic process (IBA)

Cellular Component

cytoplasm (IBA)

endoplasmic reticulum membrane (IEA)

Molecular Function

heme binding (IBA,IEA)

iron ion binding (IEA)

monooxygenase activity (IDA,IEA,TAS)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (IEA)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (IBA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

phase I biotransformation pathway via cytochrome P450 (IEA,NAS)

References

References - curated

#	Reference Title	Reference Citation
1.	The influence of soybean extract on the expression level of selected drug transporters, transcription factors and cytochrome P450 genes encoding phase I drug-metabolizing enzymes.	Bogacz A, etal., Ginekol Pol. 2014 May;85(5):348-53. doi: 10.17772/gp/1741.
2.	Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy.	Dickmann LJ, etal., Biochem Pharmacol. 2008 Apr 15;75(8):1677-87. Epub 2008 Feb 7.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Differential expression of cytochrome P450 enzymes in cultured and intact foetal rat ventral mesencephalon.	Gilbert EA, etal., J Neural Transm 2003 Oct;110(10):1091-101.
5.	Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism.	Gonzalez FJ, etal., DNA 1987 Apr;6(2):149-61.
6.	Metabolic activity of cytochrome p450 isoforms in hepatocytes cryopreserved with wheat protein extract.	Grondin M, etal., Drug Metab Dispos. 2008 Oct;36(10):2121-9. Epub 2008 Jul 10.
7.	The catalytic competence of cytochrome P450 in the synthesis of serotonin from 5-methoxytryptamine in the brain: an in vitro study.	Haduch A, etal., Pharmacol Res. 2013 Jan;67(1):53-9. doi: 10.1016/j.phrs.2012.10.009. Epub 2012 Oct 23.
8.	Four species of cDNAs for cytochrome P450 isozymes immunorelated to P450C-M/F encode for members of P450IID subfamily, increasing the number of members within the subfamily.	Ishida N, etal., Biochem Biophys Res Commun 1988 Oct 31;156(2):681-8.
9.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
10.	Down-regulation of hepatic cytochrome P450 enzymes associated with cisplatin-induced acute renal failure in male rats.	Masubuchi Y, etal., Arch Toxicol. 2006 Jun;80(6):347-53. Epub 2006 Feb 17.
11.	The rat P450 IID subfamily: complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme-binding region of the cytochrome P450 active site.	Matsunaga E, etal., J Mol Evol 1990 Feb;30(2):155-69.
12.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
13.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
14.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
15.	GOA pipeline	RGD automated data pipeline
16.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
17.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19.	Expression of four rat CYP2D isoforms in Saccharomyces cerevisiae and their catalytic specificity.	Wan J, etal., Arch Biochem Biophys 1997 Dec 15;348(2):383-90.

Additional References at PubMed

PMID:2819073	PMID:15474473	PMID:15489334	PMID:18191824	PMID:22162298	PMID:29415952	PMID:39063146

Genomics

Variants

Variants in Cyp2d2
15 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	53
Count of miRNA genes:	51
Interacting mature miRNAs:	53
Transcripts:	ENSRNOT00000012413
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	92388565	119280177	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	82111245	123048330	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	104186212	135371468	Rat
70159	Bp61	Blood pressure QTL 61		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	73618702	118618702	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	93302009	131686183	Rat
61397	Bw17	Body weight QTL 17	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	7	95485047	137014596	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	115313999	136544683	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	46307490	127866166	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	85043242	130043242	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	85497398	130497398	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	92362341	137014596	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	83626689	128626689	Rat
631529	Tls2	T-lymphoma susceptibility QTL 2	0	0.001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	7	82111382	132099989	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	98549867	137014596	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	77807807	122807807	Rat
631201	Panci1	Pancreas inflammation QTL 1	0	0.001	pancreas integrity trait (VT:0010560)	percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)	7	73557047	118557047	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	1509236	116977875	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	82111245	123048330	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	40540077	123682549	Rat
2313102	Bmd79	Bone mineral density QTL 79	2.3	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	7	96700404	118618702	Rat
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	110725024	135371468	Rat
10450862	Kidm55	Kidney mass QTL 55	4.9		kidney mass (VT:0002707)	kidney weight (CMO:0000081)	7	72725037	117725037	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	100548246	137014596	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	82111245	134948181	Rat
10450856	Livw4	Liver weight QTL 4	3.8		liver mass (VT:0003402)	liver weight (CMO:0000092)	7	72725037	117725037	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	77807807	122807807	Rat
10402855	Bp379	Blood pressure QTL 379		0.21	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	78682549	123682549	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	71621154	119349044	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	71827901	136544683	Rat

Markers in Region

D7Wox21

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	7	115,818,345 - 115,818,616 (+)	Marker Load Pipeline
mRatBN7.2	7	113,938,271 - 113,938,544 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	123,654,961 - 123,655,231	NCBI	Rnor6.0
Rnor_5.0	7	123,639,923 - 123,640,193	UniSTS	Rnor5.0
RGSC_v3.4	7	120,799,343 - 120,799,614	RGD	RGSC3.4
RGSC_v3.4	7	120,799,344 - 120,799,614	UniSTS	RGSC3.4
Celera	7	110,253,456 - 110,253,731	UniSTS
RGSC_v3.1	7	120,833,573 - 120,833,844	RGD
RH 3.4 Map	7	902.1	UniSTS
RH 3.4 Map	7	902.1	RGD
RH 2.0 Map	7	680.4	RGD
Cytogenetic Map	7	q34	UniSTS

BE110228

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	113,934,793 - 113,934,959 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	123,651,483 - 123,651,648	NCBI	Rnor6.0
Rnor_5.0	7	123,636,445 - 123,636,610	UniSTS	Rnor5.0
RGSC_v3.4	7	120,795,866 - 120,796,031	UniSTS	RGSC3.4
Celera	7	110,249,978 - 110,250,143	UniSTS
RH 3.4 Map	7	895.5	UniSTS
Cytogenetic Map	7	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	pharyngeal arch	renal system	reproductive system	respiratory system	sensory system	visual system
168	147	193	467	1483	975	1278	65	862	251	856	68	3206	1019	130	1442	14	1223	463	437	54	53

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012730	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB008423	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC107527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078897	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218496	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M16655	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M22330	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X52027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012413 ⟹ ENSRNOP00000012413

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	115,815,212 - 115,819,281 (-)	Ensembl
mRatBN7.2 Ensembl	7	113,935,138 - 113,939,209 (-)	Ensembl
Rnor_6.0 Ensembl	7	123,651,827 - 123,655,896 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000082473 ⟹ ENSRNOP00000070699

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	115,815,212 - 115,819,181 (-)	Ensembl
mRatBN7.2 Ensembl	7	113,935,138 - 113,939,109 (-)	Ensembl

RefSeq Acc Id:

NM_012730 ⟹ NP_036862

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	115,815,212 - 115,819,281 (-)	NCBI
mRatBN7.2	7	113,935,138 - 113,939,209 (-)	NCBI
Dahl_SR_JrHsd	7	117,854,209 - 117,858,287 (-)	NCBI
Lyon_Normotensive	7	118,795,822 - 118,799,889 (-)	NCBI
Lyon_Hypertensive	7	118,921,507 - 118,925,574 (-)	NCBI
F344_StmMcwi	7	117,412,492 - 117,416,570 (-)	NCBI
Rnor_6.0	7	123,651,827 - 123,655,896 (-)	NCBI
Rnor_5.0	7	123,636,789 - 123,640,858 (-)	NCBI
RGSC_v3.4	7	120,796,210 - 120,800,279 (-)	RGD
Celera	7	110,250,322 - 110,254,396 (-)	RGD

Sequence:

show sequence

CCTTAAAAGGGGGTAAAGCTGCACTTTAAGGGACCAGGTTCCCAGTCTGTTGTAAGAGGATCTT
TCCTGATTCTAAGTGTCTGGACAAGTATTCCTTCAAAAGCCTGCAAGCCGTGGGGCAGCCATGG
GGCTGCTGATTGGAGATGACCTCTGGGCTGTGGTCATATTCACAGCCATCTTCTTGCTTCTGGT
GGACCTGGTGCACCGGCACAAATTCTGGACTGCCCACTACCCTCCCGGCCCTGTGCCACTCCCT
GGGCTGGGAAACCTGCTGCAGGTGGACTTTGAGAACATGCCATATAGCTTATACAAGCTTCGAA
GCCGCTATGGTGACGTGTTCAGCCTACAGATAGCCTGGAAGCCTGTAGTTGTGATCAACGGGCT
GAAGGCCGTGCGGGAACTGCTGGTGACCTATGGAGAGGACACTGCTGACCGCCCCCTACTGCCC
ATCTATAATCACCTGGGCTATGGGGACAAATCAAAAGGTGTGGTCCTTGCACCTTACGGACCTG
AGTGGCGAGAGCAGAGACGATTCTCTGTGTCCACCCTGCGTGACTTCGGCGTGGGCAAGAAATC
GCTGGAGCAGTGGGTGACAGAGGAGGCCGGCCACCTCTGTGACACCTTCGCCAAGGAGGCTGAA
CATCCCTTCAATCCCAGCATCCTCCTGAGTAAGGCTGTGAGCAACGTGATTGCCTCCCTTGTTT
ATGCTCGTCGATTTGAGTATGAGGACCCTTTCTTCAACAGGATGCTCAAAACATTGAAGGAGAG
CTTTGGAGAGGACACCGGCTTCATGGCAGAGGTGCTGAACGCAATCCCAATTCTCCTTCAGATT
CCTGGGCTGCCTGGCAAAGTCTTCCCCAAGCTCAATTCATTTATAGCCTTAGTGGATAAGATGT
TAATTGAGCACAAGAAAAGCTGGGATCCTGCCCAGCCGCCCCGAGACATGACTGATGCCTTCCT
AGCAGAGATGCAAAAGGCCAAGGGGAATCCTGAGAGCAGCTTCAATGATGAAAATCTGCGCTTG
GTGGTGATTGACCTGTTCATGGCGGGGATGGTGACCACCTCAACCACACTGTCCTGGGCCCTTC
TGCTCATGATCCTGCATCCAGATGTGCAGCGCCGAGTCCACGAGGAGATTGATGAGGTCATAGG
GCAGGTGCGTCGTCCAGAGATGGCAGACCAGGCACGAATGCCGTTCACCAATGCTGTCATCCAT
GAGGTGCAGCGCTTTGCAGACATCGTCCCGACAAATATACCACATATGACATCCCGAGACATTA
AATTCCAAGGCTTCCTCATCCCCAAGGGGACAACCCTCATCCCCAACCTGTCCTCCGTGCTGAA
GGATGAGACTGTCTGGGAGAAGCCCCTCCGCTTCCATCCAGAACACTTCCTGGATGCCCAGGGC
AACTTTGTGAAGCATGAGGCCTTCATGCCATTCTCAGCAGGCCGCAGAGCATGCCTGGGGGAGC
CCCTGGCCCGCATGGAGCTCTTCCTCTTCTTCACCTGCCTCCTGCAGCGCTTCAGCTTCTCGGT
GCTGGCCGGCCGGCCCCGGCCCAGCACCCATGGCGTCTACGCATTGCCAGTTACTCCACAGCCT
TACCAACTCTGTGCAGTGGCTCGCTAGCAGGGGCAGGGGCTCCATTCTTCTCCCCGGTTTGGTC
TGATTGATGTCCAATAAACAACTTCTGTATCTTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_036862	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41049	(Get FASTA)	NCBI Sequence Viewer
	AAA41055	(Get FASTA)	NCBI Sequence Viewer
	AAH78897	(Get FASTA)	NCBI Sequence Viewer
	BAA23123	(Get FASTA)	NCBI Sequence Viewer
	CAA36269	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012413
	ENSRNOP00000012413.3
	ENSRNOP00055042591
	ENSRNOP00060036770
	ENSRNOP00065045421
GenBank Protein	P10634	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_036862 ⟸ NM_012730

- UniProtKB:

P10634 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MGLLIGDDLWAVVIFTAIFLLLVDLVHRHKFWTAHYPPGPVPLPGLGNLLQVDFENMPYSLYKL
RSRYGDVFSLQIAWKPVVVINGLKAVRELLVTYGEDTADRPLLPIYNHLGYGDKSKGVVLAPYG
PEWREQRRFSVSTLRDFGVGKKSLEQWVTEEAGHLCDTFAKEAEHPFNPSILLSKAVSNVIASL
VYARRFEYEDPFFNRMLKTLKESFGEDTGFMAEVLNAIPILLQIPGLPGKVFPKLNSFIALVDK
MLIEHKKSWDPAQPPRDMTDAFLAEMQKAKGNPESSFNDENLRLVVIDLFMAGMVTTSTTLSWA
LLLMILHPDVQRRVHEEIDEVIGQVRRPEMADQARMPFTNAVIHEVQRFADIVPTNIPHMTSRD
IKFQGFLIPKGTTLIPNLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSAGRRACLG
EPLARMELFLFFTCLLQRFSFSVLAGRPRPSTHGVYALPVTPQPYQLCAVAR

hide sequence

Ensembl Acc Id:

ENSRNOP00000012413 ⟸ ENSRNOT00000012413

Ensembl Acc Id:

ENSRNOP00000070699 ⟸ ENSRNOT00000082473

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P10634-F1-model_v2	AlphaFold	P10634	1-500	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695540

Promoter ID:

EPDNEW_R6064

Type:

multiple initiation site

Name:

Cyp2d2_1

Description:

cytochrome P450, family 2, subfamily d, polypeptide 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	123,655,867 - 123,655,927	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2471	AgrOrtholog
BioCyc Gene	G2FUF-32618	BioCyc
Ensembl Genes	ENSRNOG00000008988	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00055029804	UniProtKB/Swiss-Prot
	ENSRNOG00060025615	UniProtKB/Swiss-Prot
	ENSRNOG00065032069	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000012413	ENTREZGENE
	ENSRNOT00000012413.6	UniProtKB/Swiss-Prot
	ENSRNOT00055051650	UniProtKB/Swiss-Prot
	ENSRNOT00060044361	UniProtKB/Swiss-Prot
	ENSRNOT00065055230	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.630.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7109496	IMAGE-MGC_LOAD
InterPro	Cyt_P450	UniProtKB/Swiss-Prot
	Cyt_P450_CS	UniProtKB/Swiss-Prot
	Cyt_P450_E_grp-I	UniProtKB/Swiss-Prot
	Cyt_P450_E_grp-I_CYP2D-like	UniProtKB/Swiss-Prot
	Cyt_P450_sf	UniProtKB/Swiss-Prot
	Cytochrome_P450_fam2	UniProtKB/Swiss-Prot
KEGG Report	rno:25053	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93631	IMAGE-MGC_LOAD
NCBI Gene	25053	ENTREZGENE
PANTHER	CYTOCHROME P450 2D26	UniProtKB/Swiss-Prot
	CYTOCHROME P450 508A4-RELATED	UniProtKB/Swiss-Prot
Pfam	p450	UniProtKB/Swiss-Prot
PhenoGen	Cyp2d2	PhenoGen
PRINTS	EP450I	UniProtKB/Swiss-Prot
	EP450ICYP2D	UniProtKB/Swiss-Prot
	P450	UniProtKB/Swiss-Prot
PROSITE	CYTOCHROME_P450	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000008988	RatGTEx
	ENSRNOG00055029804	RatGTEx
	ENSRNOG00060025615	RatGTEx
	ENSRNOG00065032069	RatGTEx
Superfamily-SCOP	SSF48264	UniProtKB/Swiss-Prot
TIGR	TC230168
UniProt	A0A0G2JYL2_RAT	UniProtKB/TrEMBL
	CP2DQ_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2007-07-06	Cyp2d2	cytochrome P450, family 2, subfamily d, polypeptide 2	Cyp2d26	cytochrome P450, family 2, subfamily d, polypeptide 26	Name updated	1299863	APPROVED
2004-09-10	Cyp2d26	cytochrome P450, family 2, subfamily d, polypeptide 26	Cyp2d2	Cytochrome P450, subfamily IID2	Symbol and Name updated	1299863	APPROVED
2002-06-10	Cyp2d2	Cytochrome P450, subfamily IID2			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains a conserved heme binding region	727679
gene_transcript	gene contains nine exons	727761

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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RGD Manual Annotations

Imported Annotations - KEGG (archival)