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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2471
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d2
Name: cytochrome P450, family 2, subfamily d, polypeptide 2
Acc ID: CHEBI:4470
Term: dextromethorphan
Definition: A 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene in which the sterocenters at positions 4a, 10 and 10a have S-configuration. It is a prodrug of dextrorphan and used as an antitussive drug for suppressing cough.
Chemical ID: MESH:D003915
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2d2decreases methylationEXP 6480464CTDCYP2D2 protein results in decreased methylation of Dextromethorphan

PMID:11911841
Cyp2d2increases metabolic processingEXP 6480464CTDCYP2D2 protein results in increased metabolism of Dextromethorphan

PMID:28438436
Cyp2d2multiple interactionsEXP 6480464CTD[CYP2D2 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan

PMID:28438436
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