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Gene: CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)) Homo sapiens
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Symbol: CYP2D7
Name: cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)
Description: This gene is a member of the cytochrome P450 gene superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is a segregating pseudogene, where some individuals may have an allele that encodes a functional enzyme, while other individuals have an allele encoding a protein that is predicted to be non-functional. In this case, the functional allele is thought to be rare. This locus is part of a cluster of cytochrome P450 genes on chromosome 22. [provided by RefSeq, Jan 2017]
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CYP2D; CYP2D6; CYP2D7AP; CYP2D7P; CYP2D7P1; CYP2D@; cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 1; cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 1; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing) cluster; cytochrome P4502D6; nonfunctional cytochrome P450 family 2 subfamily D polypeptide 6; P450C2D; P450DB1; Putative cytochrome P450 2D7; RNA40057
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382242,139,591 - 42,144,575 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372242,536,214 - 42,540,575 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362240,866,158 - 40,870,519 (-)NCBINCBI36hg18NCBI36
Build 342240,860,713 - 40,865,074NCBI
Celera2226,342,407 - 26,346,769 (-)NCBI
Cytogenetic Map22q13.2NCBI
HuRef2225,502,024 - 25,506,388 (-)NCBIHuRef
CHM1_12242,495,953 - 42,500,316 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CYP2D7
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346997
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.