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Gene: Cyp2d40 (cytochrome P450, family 2, subfamily d, polypeptide 40) Mus musculus

Analyze

No known orthologs.

Symbol:

Cyp2d40

Name:

cytochrome P450, family 2, subfamily d, polypeptide 40

RGD ID:

1622276

MGI Page

MGI

Description:

Predicted to enable anandamide epoxidase activity; aromatase activity; and heme binding activity. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to human CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)) and CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)).

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

1300013D18Rik; CYPIID3; cytochrome P450 2D3-like; debrisoquine 4-hydroxylase-like; P450-DB3

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

Related Pseudogenes:

Cyp2d41-ps

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	82,644,034 - 82,648,323 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	82,644,034 - 82,648,384 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	82,759,833 - 82,764,122 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	82,759,833 - 82,764,183 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	82,590,263 - 82,594,552 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	82,587,599 - 82,591,949 (-)	NCBI		MGSCv36	mm8
Celera	15	84,892,785 - 84,897,074 (-)	NCBI		Celera
Cytogenetic Map	15	E1	NCBI
cM Map	15	38.71	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (EXP)

1,2-dichloroethane (EXP)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-acetamidofluorene (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

4,4'-sulfonyldiphenol (EXP)

benzo[a]pyrene (EXP)

bisphenol A (EXP)

buta-1,3-diene (EXP)

dextromethorphan (EXP)

dextrorphan (EXP)

difenoconazole (EXP)

N-nitrosodiethylamine (EXP)

parathion (EXP)

perfluorooctane-1-sulfonic acid (EXP)

tamoxifen (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

cytoplasm (ISO)

mitochondrion (ISO)

Molecular Function

anandamide 11,12 epoxidase activity (ISO)

anandamide 14,15 epoxidase activity (ISO)

anandamide 8,9 epoxidase activity (ISO)

aromatase activity (ISO)

heme binding (ISO)

monooxygenase activity (ISO)

oxidoreductase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10349636	PMID:11042159	PMID:11076861	PMID:11217851	PMID:12466851	PMID:12477932	PMID:16141072	PMID:16141073	PMID:25598084

Genomics

Variants

Variants in Cyp2d40
98 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	148
Count of miRNA genes:	145
Interacting mature miRNAs:	148
Transcripts:	ENSMUST00000055721
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
26884442	Sklq6_m	skull length QTL 6, 5 week (mouse)					15	6129481	100797881	Mouse
38501067	Tip3_m	tuberculosis immunophenotype 3, IFN-g level (mouse)					15	53563396	89584203	Mouse
1300627	Sluc26_m	susceptibility to lung cancer 26 (mouse)			Not determined		15	70345653	104073951	Mouse
1357526	Hyplip2_m	hyperlipidemia 2 (mouse)			Not determined		15	12402203	102896555	Mouse
27226777	Tibl8_m	tibia length 8, 5 week (mouse)					15	6929481	84584201	Mouse
4142198	Hbtq_m	habituation QTL (mouse)			Not determined		15	51160708	85160833	Mouse
15092079	Igly6_m	IgG glycosylation 6, GP6 (mouse)					15	74100540	82674156	Mouse
1357407	Pfat4_m	predicted fat percentage 4 (mouse)	8.6		Body fat amount	predicted fat percentage	15	57117005	91117153	Mouse
14928306	Manh79_m	mandible shape 79 (mouse)					15	78847557	104073951	Mouse
1357894	Epfpq3_m	epididymal fat percentage QTL 3 (mouse)			Not determined		15	78601103	102901704	Mouse
26884425	Cvht2_m	cranial vault height 2, 5 week (mouse)					15	28800146	102008435	Mouse
1302080	Szs13_m	seizure susceptibility 13 (mouse)			Not determined		15	51685832	85694449	Mouse
1300800	Ses3_m	salmonella enteritidis susceptibility 3 (mouse)			Not determined		15	57117005	91117153	Mouse
4142060	W3q6_m	weight 3 weeks QTL 6 (mouse)			Not determined			78601103	102901704	Mouse
13504731	Cath5_m	carotid atherosclerosis 5 (mouse)					15	54789129	88789129	Mouse
15092080	Igly7_m	IgG glycosylation 7, GP10 (mouse)					15	77794919	82674156	Mouse
12791003	Aath8_m	aortic arch atherosclerosis 8 (mouse)					15	73430144	104073951	Mouse
10045637	Heal27_m	wound healing/regeneration 29 (mouse)			Not determined		15	51418361	85418511	Mouse
27095936	Ulnl4_m	ulna length 4, 5 week (mouse)					15	56763396	87684201	Mouse
1558985	Eae32_m	experimental allergic encephalomyelitis susceptibility 32 (mouse)			Not determined		15	32578416	103425899	Mouse
4141921	Pstc3_m	periosteal circumference 3 (mouse)			Not determined		15	67270698	101270847	Mouse
1301708	Cocrb14_m	cocaine related behavior 14 (mouse)			Not determined		15	51806515	85806651	Mouse
12880411	V125Dq11_m	vitamin D active form serum level QTL 11 (mouse)					15	78897881	104073951	Mouse
12880420	V25Dq8_m	vitamin D inactive form serum level QTL 8 (mouse)					15	61584200	95584200	Mouse
1301171	Brm2_m	brachyury modifier 2 (mouse)			Not determined		15	65525376	99525499	Mouse
1300851	Heal4_m	wound healing/regeneration 4 (mouse)			Not determined		15	77527592	104073951	Mouse
14747011	Mancz13_m	mandible centroid size 13 (mouse)					15	72382669	104073951	Mouse
10402490	Dipa5_m	drug induced psychomotor activation 5 (mouse)			Not determined		15	79163411	104073951	Mouse
1300726	Pitm4_m	prion incubation time 4 (mouse)			Not determined		15	70349271	104073951	Mouse
1302197	Bhr2_m	bronchial hyperresponsiveness 2 (mouse)			Not determined		15	64306334	103425899	Mouse
26884402	Cvht9_m	cranial vault height 9, 16 week (mouse)					15	42163396	95497881	Mouse
1302074	Bmd4_m	bone mineral density 4 (mouse)			Not determined		15	56186708	103425899	Mouse
1301119	Drb7_m	dopamine receptor binding 7 (mouse)			Not determined		15	65336578	99341028	Mouse
4141135	Cia35_m	collagen induced arthritis 35 (mouse)			Not determined		15	64811826	98811946	Mouse
27226734	Tibmd5_m	tibia midshaft diameter 5, 10 week (mouse)					15	6129481	86684201	Mouse
4141902	Cia37_m	collagen induced arthritis 37 (mouse)			Not determined		15	80884933	104073951	Mouse
1301601	Faq9_m	fluctuating asymmetry QTL 9 (mouse)			Not determined		15	63163903	97163995	Mouse
1301472	Pain1_m	pain 1 (mouse)			Not determined		15	75320846	90813185	Mouse
26884399	Humsd1_m	humerus midshaft diameter 1, 5 week (mouse)					15	48363396	101708435	Mouse
27226729	Tibmd2_m	tibia midshaft diameter 2, 5 week (mouse)					15	38000244	86684201	Mouse
4141897	Imrfq2_m	immune response to Factor IX QTL 2 (mouse)			Not determined			79908940	104073951	Mouse
26884397	Humsd5_m	humerus midshaft diameter 5, 10 week (mouse)					15	48363396	98397881	Mouse
1301284	Cosz3_m	cocaine seizure 3 (mouse)			Not determined		15	80313634	104073951	Mouse
4141511	Gdcr1_m	glycerolphosphate dehydrogenase regulator 1 (mouse)			Not determined			82615474	104073951	Mouse
1300648	Dbsty4_m	diabesity 4 (mouse)			Not determined		15	70349271	104073951	Mouse
10412067	Pain2_m	pain 2 (mouse)			Not determined		15	51645339	85645626	Mouse
1300974	Pgia9_m	proteoglycan induced arthritis 9 (mouse)			Not determined		15	80884933	104073951	Mouse

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_023623	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC087902	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK004984	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC061152	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC087906	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466550	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000055721 ⟹ ENSMUSP00000060524

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	15	82,644,034 - 82,648,384 (-)	Ensembl
GRCm38.p6 Ensembl	15	82,759,833 - 82,764,183 (-)	Ensembl

Ensembl Acc Id:

ENSMUST00000230433

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	15	82,644,036 - 82,648,384 (-)	Ensembl
GRCm38.p6 Ensembl	15	82,759,835 - 82,764,183 (-)	Ensembl

RefSeq Acc Id:

NM_023623 ⟹ NP_076112

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	15	82,644,034 - 82,648,323 (-)	NCBI
GRCm38	15	82,759,833 - 82,764,122 (-)	ENTREZGENE
MGSCv37	15	82,590,263 - 82,594,552 (-)	RGD
Celera	15	84,892,785 - 84,897,074 (-)	RGD
cM Map	15		ENTREZGENE

Sequence:

show sequence

AGTGGGGCAGCCATGGAGCTGCTGACTGGGACTGACCTGTGGCCTGTGGCCATATTCACAGTCA
TCTTCATATTACTGGTGGACCTGTTGCACCGGCGCCAGCGCTGGACTTCTCGCTACCCACCGGG
CCCTGTGCCATGGCCTGTGCTGGGTAACCTGCTGCAGGTGGACCTGGATAACATGCCATACAGC
TTTTACAAGGTTGTGAAGATGTTCCCAATTGTCCTGCGCATCCCAGGGTTGGCTGATAAAATCT
TCCCTGGGCAAAAGACATTTCTCACCATGGTGGATAAGCTGGTGACTGAGCACAAGAGGACCTG
GGACCCTGACCAGCCACCTCGTGACCTGACTGATGCCTTTATGGCTGAGATGGAGACGGCAAAG
GGGAACCCTGAGAGTAGCTTCAATGAAGCAAATCTACGTCTGGTTGTCCTTGACCTGTTTGGTG
GTGGGATTGTGACCACTTCAGCTACTCTGACCTGGGCCCTGCTACTCATGATTCTGCATCCAGA
TGTGCAGCGCCGAGTGCAAGAGGAAATCGACGAGGTCATAGGGCAGGCACGGCGTCCAGAGATG
GCAGACCAGGCCCGCATGCCCTACACCAATGCTGTCATTCATGAGGTGCAGCGCTTTGCTGACA
TCGCCCCAATGACTTTGCCACACAGGACTTCTTGTGACATTGAAGTGCAGGGCTTCCTTATCCC
TAAGGGGACAACCCTCATCTGCAACCTGTCCTCCGTGCTGAAGGATGAGACTGTCTGGGAGAAG
CCCCTCCGCTTCTATCCTGAACACTTCCTGGATGCCCAGGGCCACTTTGTGAAGCCTGAGGCCT
TCATGCCATTCTCAGCAGGCCGTCGAGCATGTCTGGGTGAGCCCCTGGTCCGCATGGAGCTCTT
CCTCTTCTTCACCTGCCTCCTGCAGCGCTTTAGCTTCTCAGTACCGGATGGACAGCCCCTTCCC
AGTGATTATGGCATCTACTCAATGGTAGTTAGTCCAGCACCCTACCAGCTCTGTGCAGTGGTTC
GCTAGAAGGGTCAGTGGTTCCAGTCTTCTCCCCAGTTTGGGCTTATTGATGTCCAATAAACAAG
TTCTGTGTCTGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_076112	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH61152	(Get FASTA)	NCBI Sequence Viewer
	AAH87906	(Get FASTA)	NCBI Sequence Viewer
	EDL04493	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000060524
	ENSMUSP00000060524.5

RefSeq Acc Id:

NP_076112 ⟸ NM_023623

- UniProtKB:

Q6P8N9 (UniProtKB/TrEMBL), Q5M8Q6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MELLTGTDLWPVAIFTVIFILLVDLLHRRQRWTSRYPPGPVPWPVLGNLLQVDLDNMPYSFYKV
VKMFPIVLRIPGLADKIFPGQKTFLTMVDKLVTEHKRTWDPDQPPRDLTDAFMAEMETAKGNPE
SSFNEANLRLVVLDLFGGGIVTTSATLTWALLLMILHPDVQRRVQEEIDEVIGQARRPEMADQA
RMPYTNAVIHEVQRFADIAPMTLPHRTSCDIEVQGFLIPKGTTLICNLSSVLKDETVWEKPLRF
YPEHFLDAQGHFVKPEAFMPFSAGRRACLGEPLVRMELFLFFTCLLQRFSFSVPDGQPLPSDYG
IYSMVVSPAPYQLCAVVR

hide sequence

Ensembl Acc Id:

ENSMUSP00000060524 ⟸ ENSMUST00000055721

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6P8N9-F1-model_v2	AlphaFold	Q6P8N9	1-338	view protein structure

Promoters

RGD ID:

8684532

Promoter ID:

EPDNEW_M20297

Type:

single initiation site

Name:

Cyp2d40_1

Description:

Mus musculus cytochrome P450, family 2, subfamily d, polypeptide40 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	15	82,764,183 - 82,764,243	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1919004	AgrOrtholog
Ensembl Genes	ENSMUSG00000068083	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000055721	ENTREZGENE
	ENSMUST00000055721.6	UniProtKB/TrEMBL
Gene3D-CATH	1.10.630.10	UniProtKB/TrEMBL
InterPro	Cyt_P450	UniProtKB/TrEMBL
	Cyt_P450_CS	UniProtKB/TrEMBL
	Cyt_P450_E_grp-I	UniProtKB/TrEMBL
	Cyt_P450_sf	UniProtKB/TrEMBL
	Cytochrome_P450_fam2	UniProtKB/TrEMBL
KEGG Report	mmu:71754	UniProtKB/TrEMBL
MGD	MGI:1919004	ENTREZGENE
NCBI Gene	71754	ENTREZGENE
PANTHER	CYTOCHROME P450 2D26	UniProtKB/TrEMBL
	CYTOCHROME P450 508A4-RELATED	UniProtKB/TrEMBL
Pfam	p450	UniProtKB/TrEMBL
PhenoGen	Cyp2d40	PhenoGen
PRINTS	EP450I	UniProtKB/TrEMBL
	P450	UniProtKB/TrEMBL
PROSITE	CYTOCHROME_P450	UniProtKB/TrEMBL
Superfamily-SCOP	Cytochrome_P450	UniProtKB/TrEMBL
UniProt	Q5M8Q6	ENTREZGENE, UniProtKB/TrEMBL
	Q6P8N9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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