Cyp2d22 (cytochrome P450, family 2, subfamily d, polypeptide 22) - Rat Genome Database

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Gene: Cyp2d22 (cytochrome P450, family 2, subfamily d, polypeptide 22) Mus musculus
Analyze
Symbol: Cyp2d22
Name: cytochrome P450, family 2, subfamily d, polypeptide 22
RGD ID: 736218
MGI Page MGI
Description: Predicted to enable heme binding activity and monooxygenase activity. Predicted to be involved in several processes, including carboxylic acid metabolic process; dopamine biosynthetic process; and oxidative demethylation. Located in cytoplasm. Is expressed in several structures, including genitourinary system; heart; liver; lung; and skeletal muscle. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2D22; cytochrome P450, 2d22
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391582,254,728 - 82,264,461 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1582,254,728 - 82,264,461 (-)EnsemblGRCm39 Ensembl
GRCm381582,370,527 - 82,380,260 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1582,370,527 - 82,380,260 (-)EnsemblGRCm38mm10GRCm38
MGSCv371582,200,957 - 82,210,690 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361582,199,236 - 82,207,926 (-)NCBIMGSCv36mm8
Celera1584,494,227 - 84,513,082 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.57NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-epicatechin-3-O-gallate  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (EXP)
(E,E)-germacrone  (ISO)
(R)-lipoic acid  (ISO)
(R,R)-tramadol  (EXP,ISO)
(S)-duloxetine hydrochloride  (ISO)
(S)-nicotine  (EXP)
(S)-timolol (anhydrous)  (ISO)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (ISO)
1,4-naphthoquinone  (ISO)
1-(3-chlorophenyl)piperazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-aminobenzotriazole  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-naphthol  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
1H-pyrazole  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
3,4-Methylenedioxyamphetamine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-xylenol  (ISO)
3-methylcholanthrene  (ISO)
3-methylthiopropanal  (ISO)
4'-hydroxydiclofenac  (ISO)
4'-hydroxypropanolol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(methylsulfinyl)phenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenol  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
4-Hydroxyclonidine  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-Ipomeanol  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-hydroxydiclofenac  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-methoxy-N,N-diisopropyltryptamine  (ISO)
5-methoxyindole  (ISO)
5-methoxytryptamine  (ISO)
5-methyltryptamine  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
a-Methyldopamine  (ISO)
AB-Fubinaca  (ISO)
aconitine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
ajmalicine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
almotriptan  (ISO)
alpha-methyltryptamine  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
amitriptylinoxide  (ISO)
ammonium chloride  (ISO)
amodiaquine  (ISO)
amphetamine  (ISO)
amphetamines  (ISO)
aniline  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atomoxetine hydrochloride  (ISO)
Auriculasin  (ISO)
bacitracin  (ISO)
barnidipine  (ISO)
benidipine  (ISO)
benzbromarone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-carboline  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Bufuralol  (EXP,ISO)
buprenorphine  (ISO)
buspirone  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (ISO)
cannabidiol  (ISO)
Cannabidivarin  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbendazim  (ISO)
carbon nanotube  (EXP)
Carnosol  (ISO)
carvedilol  (ISO)
chelidonine  (ISO)
chlordecone  (EXP)
chloroquine  (ISO)
chlorotoluron  (ISO)
chlorphenamine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
cimetidine  (ISO)
cinacalcet  (ISO)
cisplatin  (ISO)
citalopram  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clopidogrel  (ISO)
clozapine  (ISO)
Clozapine N-oxide  (ISO)
codeine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
coumarins  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
dacomitinib  (ISO)
daidzein  (EXP,ISO)
dapsone  (ISO)
DDE  (ISO)
debrisoquin  (ISO)
dehydroepiandrosterone sulfate  (ISO)
Desethylchloroquine  (ISO)
desipramine  (ISO)
desloratadine  (ISO)
dexamethasone  (EXP,ISO)
dextromethorphan  (EXP,ISO)
dextrorphan  (EXP,ISO)
diarsenic trioxide  (ISO)
diarylheptanoid  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dihydrocapsaicin  (ISO)
Dihydrocorynantheine  (ISO)
dihydroergotamine  (EXP,ISO)
dimemorfan  (ISO)
dimethocaine  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
diquat  (EXP)
domperidone  (ISO)
dopamine  (ISO)
doxorubicin  (ISO)
dronedarone  (ISO)
ellipticine  (ISO)
emodin  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
erythromycin A  (EXP)
ethambutol  (ISO)
ethanol  (EXP,ISO)
Ethylenethiourea  (ISO)
eugenol  (ISO)
eupatorin  (ISO)
fenofibrate  (ISO)
fenproporex  (ISO)
fenvalerate  (ISO)
fipronil  (ISO)
fipronil-sulfone  (ISO)
flavonoids  (ISO)
fluoxetine  (EXP,ISO)
flutamide  (ISO)
folic acid  (EXP)
formononetin  (ISO)
furan  (ISO)
gallocatechin  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gefitinib  (ISO)
glafenine  (ISO)
glutathione  (ISO)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
haloperidol  (ISO)
hemin  (ISO)
heroin  (EXP)
HET0016  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
hyodeoxycholic acid  (ISO)
Hypaconitine  (ISO)
ifosfamide  (ISO)
imipramine  (ISO)
imipramine oxide  (ISO)
imiquimod  (ISO)
inulin  (EXP)
isatin  (ISO)
isocarbophos  (ISO)
isoimperatorin  (ISO)
isoproturon  (ISO)
ivermectin  (EXP,ISO)
ketoconazole  (EXP,ISO)
kojic acid  (ISO)
L-ethionine  (ISO)
L-methionine  (EXP)
lamotrigine  (ISO)
lefetamine  (ISO)
Licochalcone A  (ISO)
lipoic acid  (ISO)
lithocholic acid  (EXP,ISO)
loratadine  (ISO)
loxapine  (ISO)
maneb  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
mangiferin  (ISO)
manidipine  (ISO)
Melarsoprol  (ISO)
Mequitazine  (ISO)
methadone  (EXP,ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methiocarb  (ISO)
methiocarb-sulfoxide  (ISO)
methoxsalen  (ISO)
methoxychlor  (ISO)
metoclopramide  (ISO)
metoprolol  (ISO)
midazolam  (EXP)
Mitragynine  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monosodium L-glutamate  (EXP)
morphine  (EXP,ISO)
myricetin  (ISO)
N,N-Didesmethyltamoxifen  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N,N-diisopropyltryptamine  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-S-phenyl-L-cysteine  (ISO)
N-desmethylclozapine  (ISO)
N-Desmethyltamoxifen  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalene  (ISO)
Neferine  (ISO)
nicardipine  (ISO)
niclosamide  (ISO)
nicotine  (EXP)
nifedipine  (EXP)
nimesulide  (ISO)
Norbuprenorphine  (ISO)
norcodeine  (EXP)
nortriptyline  (ISO)
Notopterol  (ISO)
o-anisidine  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
olivetol  (ISO)
omeprazole  (EXP,ISO)
Ondansetron  (ISO)
osthole  (ISO)
oxatomide  (ISO)
oxycodone  (ISO)
ozagrel  (ISO)
ozone  (EXP)
p-cresol  (ISO)
paclitaxel  (ISO)
paliperidone palmitate  (ISO)
paraquat  (EXP)
parathion  (EXP,ISO)
paroxetine  (ISO)
pentamidine  (ISO)
perfluorodecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (ISO)
Perhexiline maleate  (ISO)
phenanthrene  (ISO)
phencyclidine  (ISO)
phenobarbital  (ISO)
phenthoate  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phlorizin  (EXP)
pirinixic acid  (EXP,ISO)
poly(styrene)  (ISO)
potassium bromate  (EXP)
potassium dichromate  (EXP,ISO)
primaquine  (ISO)
prochloraz  (ISO)
proguanil  (ISO)
promethazine  (ISO)
propafenone  (ISO)
propranolol  (ISO)
pyrantel  (ISO)
pyrazinecarboxamide  (ISO)
pyrrolidines  (ISO)
quercetin  (EXP,ISO)
quinidine  (EXP,ISO)
quinine  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
rifampicin  (EXP,ISO)
risperidone  (ISO)
ritonavir  (ISO)
rotenone  (ISO)
rubiadin  (ISO)
Sabeluzole  (ISO)
safrole  (ISO)
Salinomycin  (ISO)
saracatinib  (ISO)
sarpogrelate  (ISO)
Senkirkine  (ISO)
serpentine  (ISO)
sertraline  (ISO)
Shikonin  (ISO)
sibutramine  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sophoranone  (ISO)
sparteine  (ISO)
Sudan I  (ISO)
sulindac  (ISO)
tamoxifen  (EXP,ISO)
tegaserod  (ISO)
terbinafine  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
thioridazine  (ISO)
ticlopidine  (ISO)
titanium dioxide  (EXP,ISO)
tofacitinib  (ISO)
tolterodine tartrate  (ISO)
toluene  (ISO)
tramadol  (EXP,ISO)
trans-cinnamic acid  (ISO)
tranylcypromine  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
triflumuron  (ISO)
trimellitic anhydride  (EXP)
troglitazone  (ISO)
tryptamines  (ISO)
tyramine  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
veliparib  (ISO)
venlafaxine hydrochloride  (ISO)
verapamil  (EXP)
vernakalant  (ISO)
vinclozolin  (ISO)
warfarin  (ISO)
yohimbine  (ISO)
zerumbone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA,ISO)
mitochondrion  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Effect of Traumatic Brain Injury, Erythropoietin, and Anakinra on Hepatic Metabolizing Enzymes and Transporters in an Experimental Rat Model. Anderson GD, etal., AAPS J. 2015 Sep;17(5):1255-67. doi: 10.1208/s12248-015-9792-y. Epub 2015 Jun 12.
2. [Association of xenobiotic-metabolizing gene polymorphisms with childhood atopic diseases in Russian patients from the Republic of Bashkortostan]. Fedorova IuIu, etal., Mol Biol (Mosk). 2009 Nov-Dec;43(6):1032-9.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics. Miksys S, etal., J Neurochem. 2002 Sep;82(6):1376-87. doi: 10.1046/j.1471-4159.2002.01069.x.
6. Detection of anti-LKM-1(anti-CYP2D6) by an enzyme-linked immunosorbent assay in adult patients with chronic liver diseases. Miyakawa H, etal., Autoimmunity. 1999;30(2):107-14.
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. Genetic variation of genes for xenobiotic-metabolizing enzymes and risk of bronchial asthma: the importance of gene-gene and gene-environment interactions for disease susceptibility. Polonikov AV, etal., J Hum Genet. 2009 Aug;54(8):440-9. Epub 2009 Jul 3.
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Poor metabolizers at the cytochrome P450 2D6 and 2C19 loci are at increased risk of developing adult acute leukaemia. Roddam PL, etal., Pharmacogenetics. 2000 Oct;10(7):605-15.
14. Cytochrome P450 2D6 and treatment of codeine dependence. Romach MK, etal., J Clin Psychopharmacol. 2000 Feb;20(1):43-5. doi: 10.1097/00004714-200002000-00008.
15. Antipsychotic-induced extrapyramidal syndromes and cytochrome P450 2D6 genotype: a case-control study. Schillevoort I, etal., Pharmacogenetics. 2002 Apr;12(3):235-40. doi: 10.1097/00008571-200204000-00008.
16. Role of the CYP2D6, EPHX1, MPO, and NQO1 genes in the susceptibility to acute lymphoblastic leukemia in Brazilian children. Silveira Vda S, etal., Environ Mol Mutagen. 2010 Jan;51(1):48-56. doi: 10.1002/em.20510.
17. No influence of the polymorphisms CYP2C19 and CYP2D6 on the efficacy of cyclophosphamide, thalidomide, and bortezomib in patients with Multiple Myeloma. Vangsted AJ, etal., BMC Cancer. 2010 Aug 4;10:404. doi: 10.1186/1471-2407-10-404.
18. [Relationships between the gene polymorphisms of drug metabolizing enzymes and the outcome of the first induction chemotherapy in patients with de novo acute myeloid leukemia]. Wang N, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Apr;19(2):327-31.
19. Metabolic gene polymorphisms and risk of dysmenorrhea. Wu D, etal., Epidemiology. 2000 Nov;11(6):648-53. doi: 10.1097/00001648-200011000-00006.
20. Interaction of drug metabolizing cytochrome P450 2D6 poor metabolizers with cytochrome P450 2C9 and 2C19 genotypes modify the susceptibility to head and neck cancer and treatment response. Yadav SS, etal., Mutat Res. 2010 Feb 3;684(1-2):49-55. doi: 10.1016/j.mrfmmm.2009.11.010. Epub 2009 Nov 30.
21. Fatal intoxication cases: cytochrome P450 2D6 and 2C19 genotype distributions. Zackrisson AL, etal., Eur J Clin Pharmacol. 2004 Oct;60(8):547-52. doi: 10.1007/s00228-004-0800-x. Epub 2004 Sep 2.
22. Effect of Genetic Polymorphism of the CYP2D6 Gene on the Efficacy and Safety of Fluvoxamine in Major Depressive Disorder. Zastrozhin M, etal., Am J Ther. 2021 Jun 3;29(1):e26-e33. doi: 10.1097/MJT.0000000000001388.
23. Correlation of CpG Island Methylation of the Cytochrome P450 2E1/2D6 Genes with Liver Injury Induced by Anti-Tuberculosis Drugs: A Nested Case-Control Study. Zhang J, etal., Int J Environ Res Public Health. 2016 Aug 1;13(8). pii: ijerph13080776. doi: 10.3390/ijerph13080776.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11032406   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12745259   PMID:14681479   PMID:16141072   PMID:16141073   PMID:19594327  
PMID:21677750   PMID:21873635   PMID:25808902   PMID:30944282   PMID:38355793  


Genomics

Comparative Map Data
Cyp2d22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391582,254,728 - 82,264,461 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1582,254,728 - 82,264,461 (-)EnsemblGRCm39 Ensembl
GRCm381582,370,527 - 82,380,260 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1582,370,527 - 82,380,260 (-)EnsemblGRCm38mm10GRCm38
MGSCv371582,200,957 - 82,210,690 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361582,199,236 - 82,207,926 (-)NCBIMGSCv36mm8
Celera1584,494,227 - 84,513,082 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.57NCBI
CYP2D6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382242,126,499 - 42,130,810 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2242,126,499 - 42,130,865 (-)EnsemblGRCh38hg38GRCh38
GRCh372242,522,501 - 42,526,812 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362240,852,445 - 40,856,827 (-)NCBINCBI36Build 36hg18NCBI36
Build 342240,847,000 - 40,851,379NCBI
Celera2226,328,694 - 26,333,076 (-)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2225,488,519 - 25,492,901 (-)NCBIHuRef
CHM1_12242,482,242 - 42,486,624 (-)NCBICHM1_1
T2T-CHM13v2.02242,605,990 - 42,610,301 (-)NCBIT2T-CHM13v2.0
Cyp2d4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87115,762,662 - 115,771,832 (-)NCBIGRCr8
GRCr8 Ensembl7115,761,696 - 115,771,837 (-)EnsemblGRCr8 Ensembl
mRatBN7.27113,882,584 - 113,891,754 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,881,618 - 113,891,759 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7115,638,375 - 115,646,935 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07117,861,892 - 117,871,066 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07117,831,341 - 117,840,516 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07123,599,264 - 123,608,436 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7123,599,266 - 123,608,436 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07123,583,983 - 123,593,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47120,742,273 - 120,752,274 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7110,197,422 - 110,206,650 (-)NCBICelera
RGSC_v3.17120,775,536 - 120,786,502 (-)NCBI
Cytogenetic Map7q34NCBI
LOC100988273
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22351,959,870 - 51,969,146 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12254,654,160 - 54,664,840 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02223,022,449 - 23,031,627 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CYP2D15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11023,255,259 - 23,259,380 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1023,255,249 - 23,259,298 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1023,190,268 - 23,194,223 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01024,000,262 - 24,004,211 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1024,000,212 - 24,004,212 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11023,717,484 - 23,721,432 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01024,037,966 - 24,041,898 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01024,212,712 - 24,216,661 (+)NCBIUU_Cfam_GSD_1.0
LOC101961588
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049456,804,025 - 6,843,868 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936718153,340 - 157,966 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP2D6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl56,538,907 - 6,543,642 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.156,539,021 - 6,543,643 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.253,810,426 - 3,815,068 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP2D6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11924,667,207 - 24,672,580 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1924,667,282 - 24,671,513 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045100,727,530 - 100,732,209 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Cyp2d22
339 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:325
Count of miRNA genes:255
Interacting mature miRNAs:280
Transcripts:ENSMUST00000023083
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
38501067Tip3_mtuberculosis immunophenotype 3, IFN-g level (mouse)155356339689584203Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15692948184584201Mouse
4142198Hbtq_mhabituation QTL (mouse)Not determined155116070885160833Mouse
15092079Igly6_mIgG glycosylation 6, GP6 (mouse)157410054082674156Mouse
1357407Pfat4_mpredicted fat percentage 4 (mouse)8.6Body fat amountpredicted fat percentage155711700591117153Mouse
14928306Manh79_mmandible shape 79 (mouse)1578847557104073951Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578601103102901704Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
1302080Szs13_mseizure susceptibility 13 (mouse)Not determined155168583285694449Mouse
1300800Ses3_msalmonella enteritidis susceptibility 3 (mouse)Not determined155711700591117153Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78601103102901704Mouse
13504731Cath5_mcarotid atherosclerosis 5 (mouse)155478912988789129Mouse
15092080Igly7_mIgG glycosylation 7, GP10 (mouse)157779491982674156Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
10045637Heal27_mwound healing/regeneration 29 (mouse)Not determined155141836185418511Mouse
27095936Ulnl4_mulna length 4, 5 week (mouse)155676339687684201Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567270698101270847Mouse
1301708Cocrb14_mcocaine related behavior 14 (mouse)Not determined155180651585806651Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1578897881104073951Mouse
12880420V25Dq8_mvitamin D inactive form serum level QTL 8 (mouse)156158420095584200Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156552537699525499Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577527592104073951Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579163411104073951Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
1301429Pcir3_mperiosteal circumference 3 (mouse)Not determined154846536282465496Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154216339695497881Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
1301119Drb7_mdopamine receptor binding 7 (mouse)Not determined156533657899341028Mouse
4141135Cia35_mcollagen induced arthritis 35 (mouse)Not determined156481182698811946Mouse
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15612948186684201Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580884933104073951Mouse
1301601Faq9_mfluctuating asymmetry QTL 9 (mouse)Not determined156316390397163995Mouse
1301472Pain1_mpain 1 (mouse)Not determined157532084690813185Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800024486684201Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined79908940104073951Mouse
26884397Humsd5_mhumerus midshaft diameter 5, 10 week (mouse)154836339698397881Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580313634104073951Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
10412067Pain2_mpain 2 (mouse)Not determined155164533985645626Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580884933104073951Mouse

Markers in Region
Cyp2d22  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381582,373,165 - 82,374,014UniSTSGRCm38
MGSCv371582,203,595 - 82,204,444UniSTSGRCm37
Celera1584,496,865 - 84,497,714UniSTS
Cytogenetic Map15E2UniSTS
cM Map15 UniSTS
Cyp2d22  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15E2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000023083   ⟹   ENSMUSP00000023083
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1582,254,728 - 82,264,458 (-)Ensembl
GRCm38.p6 Ensembl1582,370,527 - 82,380,257 (-)Ensembl
Ensembl Acc Id: ENSMUST00000228986   ⟹   ENSMUSP00000155368
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1582,255,816 - 82,260,101 (-)Ensembl
GRCm38.p6 Ensembl1582,371,615 - 82,375,900 (-)Ensembl
Ensembl Acc Id: ENSMUST00000229438
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1582,259,520 - 82,264,444 (-)Ensembl
GRCm38.p6 Ensembl1582,375,319 - 82,380,243 (-)Ensembl
Ensembl Acc Id: ENSMUST00000229599
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1582,256,023 - 82,257,647 (-)Ensembl
GRCm38.p6 Ensembl1582,371,822 - 82,373,446 (-)Ensembl
Ensembl Acc Id: ENSMUST00000230370
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1582,257,280 - 82,258,039 (-)Ensembl
GRCm38.p6 Ensembl1582,373,079 - 82,373,838 (-)Ensembl
Ensembl Acc Id: ENSMUST00000230663
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1582,254,728 - 82,264,461 (-)Ensembl
GRCm38.p6 Ensembl1582,370,527 - 82,380,260 (-)Ensembl
RefSeq Acc Id: NM_001163472   ⟹   NP_001156944
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391582,254,728 - 82,264,461 (-)NCBI
GRCm381582,370,527 - 82,380,260 (-)ENTREZGENE
MGSCv371582,200,957 - 82,210,690 (-)RGD
Celera1584,494,227 - 84,513,082 (-)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_019823   ⟹   NP_062797
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391582,254,728 - 82,264,461 (-)NCBI
GRCm381582,370,527 - 82,380,260 (-)ENTREZGENE
MGSCv371582,200,957 - 82,210,690 (-)RGD
Celera1584,494,227 - 84,513,082 (-)RGD
cM Map15 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001156944 (Get FASTA)   NCBI Sequence Viewer  
  NP_062797 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF34652 (Get FASTA)   NCBI Sequence Viewer  
  AAH16256 (Get FASTA)   NCBI Sequence Viewer  
  EDL04505 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000023083
  ENSMUSP00000023083.8
  ENSMUSP00000155368.2
RefSeq Acc Id: NP_062797   ⟸   NM_019823
- UniProtKB: Q9JKY7 (UniProtKB/TrEMBL),   Q91W87 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001156944   ⟸   NM_001163472
- UniProtKB: Q9JKY7 (UniProtKB/TrEMBL),   Q91W87 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000023083   ⟸   ENSMUST00000023083
Ensembl Acc Id: ENSMUSP00000155368   ⟸   ENSMUST00000228986

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JKY7-F1-model_v2 AlphaFold Q9JKY7 1-500 view protein structure

Promoters
RGD ID:6825895
Promoter ID:MM_KWN:19208
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver,   Lung
Transcripts:UC007WZD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361582,206,851 - 82,207,351 (-)MPROMDB
RGD ID:6825894
Promoter ID:MM_KWN:19209
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver,   Lung
Transcripts:NM_001163472,   NM_019823
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361582,210,211 - 82,210,962 (-)MPROMDB
RGD ID:8684518
Promoter ID:EPDNEW_M20290
Type:initiation region
Name:Cyp2d22_1
Description:Mus musculus cytochrome P450, family 2, subfamily d, polypeptide22 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381582,380,221 - 82,380,281EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1929474 AgrOrtholog
Ensembl Genes ENSMUSG00000061740 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000023083 ENTREZGENE
  ENSMUST00000023083.9 UniProtKB/TrEMBL
  ENSMUST00000228986.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_B UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP2D-like UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
  Cytochrome_P450_fam2 UniProtKB/TrEMBL
KEGG Report mmu:56448 UniProtKB/TrEMBL
MGD MGI:1929474 ENTREZGENE
NCBI Gene 56448 ENTREZGENE
PANTHER CYTOCHROME P450 2D6-RELATED UniProtKB/TrEMBL
  CYTOCHROME P450 508A4-RELATED UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PharmGKB CYP2D6 RGD
PhenoGen Cyp2d22 PhenoGen
PRINTS BP450 UniProtKB/TrEMBL
  EP450I UniProtKB/TrEMBL
  EP450ICYP2D UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP Cytochrome_P450 UniProtKB/TrEMBL
UniProt A0A2R8VKC7_MOUSE UniProtKB/TrEMBL
  Q91W87 ENTREZGENE, UniProtKB/TrEMBL
  Q9JKY7 ENTREZGENE, UniProtKB/TrEMBL