Cyp2d11 (cytochrome P450, family 2, subfamily d, polypeptide 11) - Rat Genome Database

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Gene: Cyp2d11 (cytochrome P450, family 2, subfamily d, polypeptide 11) Mus musculus
Analyze
No known orthologs.
Symbol: Cyp2d11
Name: cytochrome P450, family 2, subfamily d, polypeptide 11
RGD ID: 1613206
MGI Page MGI
Description: Predicted to enable anandamide epoxidase activity; aromatase activity; and heme binding activity. Predicted to be involved in arachidonate metabolic process and xenobiotic metabolic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to human CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)) and CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cyp2; Cyp2d; CYPIID11; cytochrome P450 2D11; cytochrome P450, 2d11; cytochrome P450-16-alpha; cytochrome P450CC; P450-2; P450-2D; testosterone 16-alpha hydroxylase
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391582,273,355 - 82,278,223 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1582,273,355 - 82,278,223 (-)EnsemblGRCm39 Ensembl
GRCm381582,389,154 - 82,394,022 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1582,389,154 - 82,394,022 (-)EnsemblGRCm38mm10GRCm38
MGSCv371582,219,584 - 82,224,452 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361582,219,584 - 82,224,452 (-)NCBIMGSCv36mm8
Celera1584,521,989 - 84,526,868 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.58NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2914938   PMID:21873635  


Genomics

Variants

.
Variants in Cyp2d11
100 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:190
Count of miRNA genes:176
Interacting mature miRNAs:186
Transcripts:ENSMUST00000170255
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
38501067Tip3_mtuberculosis immunophenotype 3, IFN-g level (mouse)155356339689584203Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15692948184584201Mouse
4142198Hbtq_mhabituation QTL (mouse)Not determined155116070885160833Mouse
15092079Igly6_mIgG glycosylation 6, GP6 (mouse)157410054082674156Mouse
1357407Pfat4_mpredicted fat percentage 4 (mouse)8.6Body fat amountpredicted fat percentage155711700591117153Mouse
14928306Manh79_mmandible shape 79 (mouse)1578847557104073951Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578601103102901704Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
1302080Szs13_mseizure susceptibility 13 (mouse)Not determined155168583285694449Mouse
1300800Ses3_msalmonella enteritidis susceptibility 3 (mouse)Not determined155711700591117153Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78601103102901704Mouse
13504731Cath5_mcarotid atherosclerosis 5 (mouse)155478912988789129Mouse
15092080Igly7_mIgG glycosylation 7, GP10 (mouse)157779491982674156Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
10045637Heal27_mwound healing/regeneration 29 (mouse)Not determined155141836185418511Mouse
27095936Ulnl4_mulna length 4, 5 week (mouse)155676339687684201Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567270698101270847Mouse
1301708Cocrb14_mcocaine related behavior 14 (mouse)Not determined155180651585806651Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1578897881104073951Mouse
12880420V25Dq8_mvitamin D inactive form serum level QTL 8 (mouse)156158420095584200Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156552537699525499Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577527592104073951Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579163411104073951Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
1301429Pcir3_mperiosteal circumference 3 (mouse)Not determined154846536282465496Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154216339695497881Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
1301119Drb7_mdopamine receptor binding 7 (mouse)Not determined156533657899341028Mouse
4141135Cia35_mcollagen induced arthritis 35 (mouse)Not determined156481182698811946Mouse
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15612948186684201Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580884933104073951Mouse
1301601Faq9_mfluctuating asymmetry QTL 9 (mouse)Not determined156316390397163995Mouse
1301472Pain1_mpain 1 (mouse)Not determined157532084690813185Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800024486684201Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined79908940104073951Mouse
26884397Humsd5_mhumerus midshaft diameter 5, 10 week (mouse)154836339698397881Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580313634104073951Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
10412067Pain2_mpain 2 (mouse)Not determined155164533985645626Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580884933104073951Mouse

Markers in Region
Cyp2d9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15E1UniSTS
cM Map1547.2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000170255   ⟹   ENSMUSP00000130338
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1582,273,355 - 82,278,223 (-)Ensembl
GRCm38.p6 Ensembl1582,389,154 - 82,394,022 (-)Ensembl
RefSeq Acc Id: NM_001104531   ⟹   NP_001098001
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391582,273,355 - 82,278,223 (-)NCBI
GRCm381582,389,154 - 82,394,022 (-)ENTREZGENE
MGSCv371582,219,584 - 82,224,452 (-)RGD
Celera1584,521,989 - 84,526,868 (-)RGD
cM Map15 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001098001 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA37514 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000130338
  ENSMUSP00000130338.2
GenBank Protein P24457 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001098001   ⟸   NM_001104531
- UniProtKB: P24457 (UniProtKB/Swiss-Prot),   E9Q750 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000130338   ⟸   ENSMUST00000170255

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24457-F1-model_v2 AlphaFold P24457 1-504 view protein structure

Promoters
RGD ID:8684520
Promoter ID:EPDNEW_M20291
Type:multiple initiation site
Name:Cyp2d11_1
Description:Mus musculus cytochrome P450, family 2, subfamily d, polypeptide11 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381582,394,021 - 82,394,081EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88603 AgrOrtholog
Ensembl Genes ENSMUSG00000068085 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000170255 ENTREZGENE
  ENSMUST00000170255.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I_CYP2D-like UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_fam2 UniProtKB/Swiss-Prot
KEGG Report mmu:545123 UniProtKB/Swiss-Prot
MGD MGI:88603 ENTREZGENE
NCBI Gene Cyp2d11 ENTREZGENE
PANTHER CYTOCHROME P450 2D10-RELATED UniProtKB/Swiss-Prot
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp2d11 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  EP450ICYP2D UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt CP2DB_MOUSE UniProtKB/Swiss-Prot
  E9Q750 ENTREZGENE
  P24457 ENTREZGENE
UniProt Secondary E9Q750 UniProtKB/Swiss-Prot