Cyp2d26 (cytochrome P450, family 2, subfamily d, polypeptide 26) - Rat Genome Database

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Gene: Cyp2d26 (cytochrome P450, family 2, subfamily d, polypeptide 26) Mus musculus
Analyze
No known orthologs.
Symbol: Cyp2d26
Name: cytochrome P450, family 2, subfamily d, polypeptide 26
RGD ID: 1550436
MGI Page MGI
Description: Predicted to enable anandamide epoxidase activity; heme binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in arachidonic acid metabolic process and xenobiotic metabolic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including genitourinary system; liver; lung; and skeletal muscle. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to human CYP2D6 (cytochrome P450 family 2 subfamily D member 6) and CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1300006E06Rik; CYPIID26; cytochrome P450 2D26; cytochrome P450, 2d26
RGD Orthologs
Alliance Genes
More Info homologs ...
Related Pseudogenes: Cyp2d32-ps   Cyp2d33-ps   Cyp2d34-ps   Cyp2d36-ps   Cyp2d39-ps  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391582,674,308 - 82,678,653 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1582,674,302 - 82,678,495 (-)EnsemblGRCm39 Ensembl
GRCm381582,790,107 - 82,794,452 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1582,790,101 - 82,794,294 (-)EnsemblGRCm38mm10GRCm38
MGSCv371582,620,537 - 82,624,675 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361582,617,873 - 82,622,011 (-)NCBIMGSCv36mm8
Celera1584,923,097 - 84,927,223 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12745259   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16618389   PMID:17208939   PMID:21873635   PMID:32179912  


Genomics

Variants

.
Variants in Cyp2d26
87 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:168
Count of miRNA genes:156
Interacting mature miRNAs:168
Transcripts:ENSMUST00000006094
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15612948186684201Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15692948184584201Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800024486684201Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154216339695497881Mouse
26884397Humsd5_mhumerus midshaft diameter 5, 10 week (mouse)154836339698397881Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
4142198Hbtq_mhabituation QTL (mouse)Not determined155116070885160833Mouse
10045637Heal27_mwound healing/regeneration 29 (mouse)Not determined155141836185418511Mouse
10412067Pain2_mpain 2 (mouse)Not determined155164533985645626Mouse
1302080Szs13_mseizure susceptibility 13 (mouse)Not determined155168583285694449Mouse
1301708Cocrb14_mcocaine related behavior 14 (mouse)Not determined155180651585806651Mouse
38501067Tip3_mtuberculosis immunophenotype 3, IFN-g level (mouse)155356339689584203Mouse
13504731Cath5_mcarotid atherosclerosis 5 (mouse)155478912988789129Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
27095936Ulnl4_mulna length 4, 5 week (mouse)155676339687684201Mouse
1300800Ses3_msalmonella enteritidis susceptibility 3 (mouse)Not determined155711700591117153Mouse
1357407Pfat4_mpredicted fat percentage 4 (mouse)8.6Body fat amountpredicted fat percentage155711700591117153Mouse
12880420V25Dq8_mvitamin D inactive form serum level QTL 8 (mouse)156158420095584200Mouse
1301601Faq9_mfluctuating asymmetry QTL 9 (mouse)Not determined156316390397163995Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
4141135Cia35_mcollagen induced arthritis 35 (mouse)Not determined156481182698811946Mouse
1301119Drb7_mdopamine receptor binding 7 (mouse)Not determined156533657899341028Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156552537699525499Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567270698101270847Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
1301472Pain1_mpain 1 (mouse)Not determined157532084690813185Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577527592104073951Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78601103102901704Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578601103102901704Mouse
14928306Manh79_mmandible shape 79 (mouse)1578847557104073951Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1578897881104073951Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579163411104073951Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined79908940104073951Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580313634104073951Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580884933104073951Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580884933104073951Mouse
4141511Gdcr1_mglycerolphosphate dehydrogenase regulator 1 (mouse)Not determined82615474104073951Mouse

Markers in Region
Cyp2d26  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15E1UniSTS
cM Map15 UniSTS
PMC291882P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381582,793,229 - 82,794,160UniSTSGRCm38
MGSCv371582,623,659 - 82,624,590UniSTSGRCm37
Celera1584,926,219 - 84,927,138UniSTS
Cytogenetic Map15E1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000006094   ⟹   ENSMUSP00000006094
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1582,674,302 - 82,678,495 (-)Ensembl
GRCm38.p6 Ensembl1582,790,101 - 82,794,294 (-)Ensembl
RefSeq Acc Id: ENSMUST00000229387   ⟹   ENSMUSP00000155717
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1582,674,302 - 82,678,495 (-)Ensembl
GRCm38.p6 Ensembl1582,790,101 - 82,794,294 (-)Ensembl
RefSeq Acc Id: ENSMUST00000229512   ⟹   ENSMUSP00000155850
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1582,675,860 - 82,678,423 (-)Ensembl
GRCm38.p6 Ensembl1582,791,659 - 82,794,222 (-)Ensembl
RefSeq Acc Id: ENSMUST00000230125
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1582,677,235 - 82,678,446 (-)Ensembl
GRCm38.p6 Ensembl1582,793,034 - 82,794,245 (-)Ensembl
RefSeq Acc Id: NM_029562   ⟹   NP_083838
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391582,674,308 - 82,678,446 (-)NCBI
GRCm381582,790,107 - 82,794,245 (-)NCBI
MGSCv371582,620,537 - 82,624,675 (-)RGD
Celera1584,923,097 - 84,927,223 (-)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006521524   ⟹   XP_006521587
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391582,674,839 - 82,678,653 (-)NCBI
GRCm381582,790,638 - 82,794,452 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_083838   ⟸   NM_029562
- UniProtKB: Q9DBJ5 (UniProtKB/Swiss-Prot),   Q8CIM7 (UniProtKB/Swiss-Prot),   A0A0R4IZY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006521587   ⟸   XM_006521524
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000006094   ⟸   ENSMUST00000006094
RefSeq Acc Id: ENSMUSP00000155717   ⟸   ENSMUST00000229387
RefSeq Acc Id: ENSMUSP00000155850   ⟸   ENSMUST00000229512

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CIM7-F1-model_v2 AlphaFold Q8CIM7 1-500 view protein structure

Promoters
RGD ID:6825896
Promoter ID:MM_KWN:19222
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:NM_029562
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361582,624,506 - 82,625,006 (-)MPROMDB
RGD ID:8684534
Promoter ID:EPDNEW_M20298
Type:initiation region
Name:Cyp2d26_1
Description:Mus musculus cytochrome P450, family 2, subfamily d, polypeptide26 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381582,794,247 - 82,794,307EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1923529 AgrOrtholog
Ensembl Genes ENSMUSG00000022445 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000006094 ENTREZGENE
  ENSMUST00000006094.6 UniProtKB/TrEMBL
  ENSMUST00000229387.2 UniProtKB/TrEMBL
  ENSMUST00000229512.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP2D-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:76279 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1923529 ENTREZGENE
NCBI Gene 76279 ENTREZGENE
PANTHER CYTOCHROME P450 1A UniProtKB/TrEMBL
  CYTOCHROME P450 2D26 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 1 UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp2d26 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450ICYP2D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4IZY2 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8VI97_MOUSE UniProtKB/TrEMBL
  A0A2R8W716_MOUSE UniProtKB/TrEMBL
  CP2DQ_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q9DBJ5 ENTREZGENE
UniProt Secondary Q9DBJ5 UniProtKB/Swiss-Prot