Cyp2e1 (cytochrome P450, family 2, subfamily e, polypeptide 1)

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Gene: Cyp2e1 (cytochrome P450, family 2, subfamily e, polypeptide 1) Rattus norvegicus

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Symbol:

Cyp2e1

Name:

cytochrome P450, family 2, subfamily e, polypeptide 1

RGD ID:

2475

Description:

Enables Hsp70 protein binding activity and Hsp90 protein binding activity. Involved in several processes, including response to 3-methylcholanthrene; response to ethanol; and response to ozone. Located in Golgi membrane; endoplasmic reticulum membrane; and mitochondrial inner membrane. Used to study alcohol dependence and drug-induced hepatitis. Biomarker of several diseases, including alcohol use disorder; liver disease (multiple); middle cerebral artery infarction; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in acoustic neuroma; gastrointestinal system cancer (multiple); high grade glioma; liver disease (multiple); and lung disease (multiple). Orthologous to human CYP2E1 (cytochrome P450 family 2 subfamily E member 1); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (R)-carnitine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

4-nitrophenol 2-hydroxylase; Cyp2e; CYPIIE1; cytochrome P450 2E1; Cytochrome P450 subfamily 2e1 (ethanol-inducible); cytochrome P450, subfamily 2E, polypeptide 1; cytochrome P450, subfamily 2e1 (ethanol-inducible); cytochrome P450-J; cytochrome P450RLM6; P450-J; P450RLM6

RGD Orthologs

Alliance Orthologs

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CYP2E1 (cytochrome P450 family 2 subfamily E member 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Cyp2e1 (cytochrome P450, family 2, subfamily e, polypeptide 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	LOC102026028 (cytochrome P450 2E1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CYP2E1 (cytochrome P450 family 2 subfamily E member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CYP2E1 (cytochrome P450 family 2 subfamily E member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101973029 (cytochrome P450 2E1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CYP2E1 (cytochrome P450 family 2 subfamily E member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CYP2E1 (cytochrome P450 family 2 subfamily E member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	LOC101722366 (cytochrome P450 2E1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	HBA2 (hemoglobin subunit alpha 2)	HGNC	OMA
Homo sapiens (human):	KRT13 (keratin 13)	HGNC	OMA
Homo sapiens (human):	HBA1 (hemoglobin subunit alpha 1)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Cyp2e1 (cytochrome P450, family 2, subfamily e, polypeptide 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CYP2E1 (cytochrome P450 family 2 subfamily E member 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cyp2y3 (cytochrome P450, family 2, subfamily Y, polypeptide 3)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	phm	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA)
Drosophila melanogaster (fruit fly):	phm	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA)
Caenorhabditis elegans (roundworm):	cyp-33A1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-33C9	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-33D1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-33D3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-33B1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-33C11	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-33C12	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-33C3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-33C4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-33C5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-33C6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-33C7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-33C8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-33C1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-33C2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-33E1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-33E2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	cyp-34A7	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	cyp-34A1	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	cyp-34A5	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	cyp-34A6	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	cyp-34A8	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	cyp-35A3	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	cyp-35B1	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	cyp-35B2	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	cyp-34A10	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	cyp-34A2	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	cyp-34A9	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	cyp-35A5	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	cyp-35A4	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	cyp-35A2	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	cyp-35C1	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	Cyp305a1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA)
Drosophila melanogaster (fruit fly):	Cyp303a1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA)
Xenopus tropicalis (tropical clawed frog):	cyp2a6.7	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	cyp2a6.2	Alliance	DIOPT (OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	205,269,967 - 205,280,365 (+)	NCBI		GRCr8
mRatBN7.2	1	195,840,330 - 195,850,728 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	195,840,058 - 195,864,023 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	204,182,795 - 204,193,148 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	211,309,700 - 211,320,053 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	203,983,553 - 203,993,906 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	213,511,892 - 213,522,195 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	213,511,874 - 213,535,542 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	220,405,975 - 220,416,727 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	200,918,521 - 200,928,919 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	201,068,525 - 201,078,911 (+)	NCBI
Celera	1	193,484,404 - 193,494,772 (+)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD