Cyp2e1 (cytochrome P450, family 2, subfamily e, polypeptide 1) - Rat Genome Database

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Gene: Cyp2e1 (cytochrome P450, family 2, subfamily e, polypeptide 1) Rattus norvegicus
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Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
RGD ID: 2475
Description: Enables Hsp70 protein binding activity and Hsp90 protein binding activity. Involved in several processes, including response to ethanol; response to ozone; and triglyceride metabolic process. Located in Golgi membrane; endoplasmic reticulum membrane; and mitochondrial inner membrane. Used to study drug-induced hepatitis. Biomarker of several diseases, including alcohol use disorder; fatty liver disease (multiple); liver disease (multiple); middle cerebral artery infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; fatty liver disease; gastrointestinal system cancer (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human CYP2E1 (cytochrome P450 family 2 subfamily E member 1); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (R)-carnitine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 4-nitrophenol 2-hydroxylase; Cyp2e; CYPIIE1; cytochrome P450 2E1; Cytochrome P450 subfamily 2e1 (ethanol-inducible); cytochrome P450, subfamily 2E, polypeptide 1; cytochrome P450, subfamily 2e1 (ethanol-inducible); cytochrome P450-J; cytochrome P450RLM6; P450-J; P450RLM6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21195,840,330 - 195,850,728 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1195,840,058 - 195,864,023 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,182,795 - 204,193,148 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01211,309,700 - 211,320,053 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01203,983,553 - 203,993,906 (+)NCBIRnor_WKY
Rnor_6.01213,511,892 - 213,522,195 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,511,874 - 213,535,542 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,405,975 - 220,416,727 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41200,918,521 - 200,928,919 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,068,525 - 201,078,911 (+)NCBI
Celera1193,484,404 - 193,494,772 (+)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
acute kidney failure  (IEP)
acute lymphoblastic leukemia  (ISO)
adenocarcinoma  (ISO)
alcohol use disorder  (IEP,ISO)
Alcoholic Fatty Liver  (ISO)
alcoholic liver cirrhosis  (ISO)
Alcoholic Liver Diseases  (IEP,ISO)
amenorrhea  (ISO)
asbestosis  (ISO)
asthma  (ISO)
Binge Drinking  (IEP,ISO)
Cardiomegaly  (ISO)
Chemical and Drug Induced Liver Injury  (IEP,ISO)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon cancer  (IEP)
colorectal cancer  (ISO)
distal 10q deletion syndrome  (ISO)
Drug Eruptions  (ISO)
drug-induced hepatitis  (IDA)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Neoplasms  (ISO)
extrinsic allergic alveolitis  (ISO)
familial hyperlipidemia  (IEP)
fatty liver disease  (IEP,ISO)
hepatocellular adenoma  (IEP)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Human Viral Hepatitis  (ISO)
intrahepatic cholestasis  (ISO)
liver disease  (IEP,ISO)
Liver Injury  (IEP)
Liver Neoplasms  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
mental depression  (IEP)
Micronuclei, Chromosome-Defective  (ISO)
middle cerebral artery infarction  (IEP)
morbid obesity  (ISO)
nasopharynx carcinoma  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
non-alcoholic fatty liver disease  (IEP,ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (IEP,ISO)
oral cavity cancer  (ISO)
oral squamous cell carcinoma  (ISO)
Parkinson's disease  (ISO)
Patent Ductus Venosus  (ISO)
pneumonia  (ISO)
Prostatic Neoplasms  (ISO)
Reperfusion Injury  (IEP)
Sepsis  (IEP)
stomach cancer  (ISO)
Testicular Injury  (IEP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-schisandrin B  (EXP,ISO)
(+)-taxifolin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-trans-epsilon-viniferin  (ISO)
(2-hydroxyphenyl)acetic acid  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-mandelic acid  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (ISO)
1,1,1-trichloroethane  (ISO)
1,1-Dichloroethane  (EXP)
1,1-dichloroethene  (EXP,ISO)
1,2,3,5-tetrachlorobenzene  (ISO)
1,2,4,5-tetrachlorobenzene  (EXP)
1,2,4-trichlorobenzene  (ISO)
1,2-dibromoethane  (ISO)
1,2-dichlorobenzene  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dichloroethene  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
1,4-benzoquinone  (EXP)
1,4-dichlorobenzene  (EXP,ISO)
1,4-dioxane  (EXP)
1,4-naphthoquinone  (ISO)
1-benzylpiperazine  (EXP)
1-bromopropane  (EXP,ISO)
1-Methylpyrene  (ISO)
1-naphthol  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
19(S)-HETE  (EXP)
19-HETE  (EXP)
1H-imidazole  (EXP)
1H-pyrazole  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,5,6-tetrachlorophenol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,6-dimethylaniline  (ISO)
2,6-dimethylnaphthalene  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-chloroethanol  (EXP)
2-naphthol  (ISO)
2-nitroanisole  (EXP,ISO)
2-nitrophenol  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-(Methylthio)-1-propene  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-hydroxy-TEMPO  (EXP)
4-methylumbelliferone  (ISO)
4-nitrocatechol  (EXP,ISO)
4-nitrophenol  (EXP,ISO)
4-Vinylcyclohexene  (EXP,ISO)
4-vinylcyclohexene dioxide  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (EXP)
5-(2-chloroethyl)-4-methylthiazole  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
5-methoxy-N,N-diisopropyltryptamine  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-Hydroxychlorzoxazone  (EXP,ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-dihydroxycoumarin  (EXP)
7-ethoxycoumarin  (ISO)
8-Br-cAMP  (ISO)
8-Epidiosbulbin E acetate  (ISO)
abamectin  (EXP)
acadesine  (EXP)
acarbose  (EXP)
acephate  (ISO)
acetaldehyde  (EXP,ISO)
acetamide  (EXP)
acetic acid  (ISO)
acetone  (EXP,ISO)
acetonitrile  (EXP,ISO)
acetylsalicylic acid  (EXP)
acrylamide  (EXP,ISO)
acrylonitrile  (EXP,ISO)
acteoside  (EXP)
aflatoxin B1  (EXP,ISO)
alcohol  (ISO)
aldehydo-D-glucose  (ISO)
alizarin  (ISO)
alkaloid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (EXP)
allyl alcohol  (ISO)
allyl cyanide  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-linolenic acid  (ISO)
alpha-methyltryptamine  (ISO)
amiodarone  (ISO)
amitraz  (EXP)
amitrole  (ISO)
amlexanox  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
amphibole asbestos  (ISO)
ampicillin  (EXP)
angelicin  (ISO)
aniline  (EXP,ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
arachidonic acid  (EXP,ISO)
arecoline  (EXP)
Aroclor 1254  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
asiatic acid  (EXP)
aspartame  (EXP)
atrazine  (ISO)
baicalein  (ISO)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzylideneacetone  (EXP)
berberine  (ISO)
Besigomsin  (ISO)
beta-carboline  (ISO)
beta-naphthoflavone  (EXP,ISO)
bifenthrin  (ISO)
bilobalide  (EXP)
biotin  (ISO)
biphenyl-4-amine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Bromadiolone  (EXP)
bromobenzene  (EXP)
bromodichloromethane  (EXP,ISO)
bromoethene  (ISO)
brucine  (EXP)
bucladesine  (ISO)
buta-1,3-diene  (ISO)
butan-2-one  (ISO)
butane-1,3-diol  (EXP)
Butylbenzyl phthalate  (EXP)
Butylparaben  (EXP)
C.I. Natural Red 20  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cafestol  (ISO)
caffeine  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
canadine  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbamazepine  (EXP)
carbaryl  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (ISO)
carnosine  (ISO)
catechol  (EXP,ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chloral hydrate  (EXP)
chlordecone  (ISO)
chlorfluazuron  (ISO)
chlorobenzene  (EXP,ISO)
chloroethene  (EXP,ISO)
chloroform  (ISO)
chlorogenic acid  (ISO)
chloromethane  (ISO)
chloroprene  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chlorzoxazone  (EXP,ISO)
cholesterol  (ISO)
choline  (EXP,ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cimetidine  (ISO)
ciprofibrate  (EXP)
cis-caffeic acid  (EXP)
cisplatin  (EXP,ISO)
citral  (ISO)
clofibrate  (EXP,ISO)
clothianidin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corticosterone  (EXP,ISO)
cortisol  (EXP)
coumarin  (EXP,ISO)
crocidolite asbestos  (ISO)
crocin-1  (EXP)
curcumin  (EXP,ISO)
cyanides  (ISO)
cyanocob(III)alamin  (ISO)
cyclohexanols  (EXP)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cyfluthrin  (EXP)
cyhalothrin  (EXP)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
cyproconazole  (EXP,ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
daidzein  (EXP,ISO)
deoxycholic acid  (EXP)
desferrioxamine B  (EXP)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
dextromethorphan  (ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (EXP)
dibutyl phthalate  (EXP)
dichloromethane  (EXP,ISO)
diclofenac  (ISO)
dicofol  (EXP)
dicoumarol  (EXP,ISO)
diepoxybutane  (ISO)
diethyldithiocarbamic acid  (EXP,ISO)
diethylstilbestrol  (ISO)
dihydrocapsaicin  (EXP)
dihydroxyacetone  (ISO)
dimethyl sulfoxide  (EXP,ISO)
dimethylmercury  (EXP)
dioscin  (EXP,ISO)
diosmetin  (ISO)
diosmin  (EXP)
dioxygen  (EXP,ISO)
dipropyl disulfide  (ISO)
dipropyl phthalate  (EXP)
Dipropyl sulfide  (ISO)
diprotium oxide  (ISO)
disulfiram  (EXP,ISO)
dodecanoic acid  (ISO)
dopamine  (ISO)
doxorubicin  (ISO)
dronedarone  (ISO)
ebselen  (EXP)
elemental selenium  (EXP)
ellipticine  (ISO)
emamectin benzoate  (ISO)
endosulfan  (EXP,ISO)
enfuvirtide  (ISO)
enilconazole  (ISO)
epoxiconazole  (EXP)
erastin  (ISO)
Erionite  (ISO)
Estragole  (ISO)
ethambutol  (EXP,ISO)
ethanol  (EXP,ISO)
ethene  (EXP,ISO)
ethosuximide  (EXP)
ethyl methanesulfonate  (ISO)
ethylbenzene  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
ethylenediaminetetraacetic acid  (ISO)
ethylparaben  (EXP)
eugenol  (EXP,ISO)
farnesol  (EXP,ISO)
felbamate  (EXP,ISO)
fenarimol  (ISO)
fenitrothion  (ISO)
fenofibrate  (EXP)
fenvalerate  (ISO)
ferrostatin-1  (ISO)
fipronil  (EXP,ISO)
flavonoids  (ISO)
fluoranthene  (ISO)
fluoroethene  (EXP,ISO)
fluphenazine  (ISO)
folic acid  (ISO)
fomepizole  (EXP,ISO)
fructose  (ISO)
fucoxanthin  (ISO)
fulvestrant  (ISO)
fumaraldehyde  (EXP)
fumonisin B1  (ISO)
Furafylline  (EXP)
furan  (EXP,ISO)
gabapentin  (EXP)
gadolinium trichloride  (EXP)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
geranial  (ISO)
geraniol  (EXP,ISO)
ginsenoside Rg1  (ISO)
glafenine  (EXP)
glucose  (ISO)
glutathione  (EXP,ISO)
Glutathione ethyl ester  (ISO)
glycerol  (ISO)
glycine betaine  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glyphosate  (EXP)
GW 4064  (ISO)
halothane  (EXP,ISO)
hemin  (EXP,ISO)
hesperetin  (EXP)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP,ISO)
hexane  (EXP,ISO)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (EXP,ISO)
Hypaconitine  (ISO)
imidazoles  (EXP)
indole-3-methanol  (ISO)
indometacin  (EXP)
irbesartan  (ISO)
iron(III) citrate  (ISO)
iron(III) nitrilotriacetate  (ISO)
isatin  (ISO)
isobavachalcone  (EXP)
isobutyronitrile  (ISO)
isoliquiritigenin  (EXP)
isoniazide  (EXP,ISO)
isoprenaline  (EXP)
isoproturon  (ISO)
isoquinolines  (EXP)
ivermectin  (ISO)
kaempferol  (ISO)
kahweol  (ISO)
ketamine  (EXP)
ketoconazole  (ISO)
kojic acid  (EXP)
L-ascorbic acid  (EXP,ISO)
L-methionine  (EXP,ISO)
lamotrigine  (ISO)
Lasiocarpine  (ISO)
leupeptin  (ISO)
Licochalcone A  (ISO)
linoleic acid  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
liquiritin  (EXP)
lithocholic acid  (ISO)
luteolin  (ISO)
LY294002  (EXP)
lycopene  (ISO)
m-tolualdehyde  (EXP)
m-xylene  (EXP,ISO)
malathion  (ISO)
mancozeb  (ISO)
mandelic acid  (ISO)
maneb  (EXP,ISO)
mangiferin  (EXP)
melatonin  (EXP,ISO)
menadione  (ISO)
mephenytoin  (ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP,ISO)
methoxsalen  (EXP,ISO)
methoxychlor  (EXP,ISO)
methoxyflurane  (ISO)
methyltestosterone  (ISO)
metronidazole  (EXP)
microcystin-LR  (ISO)
midazolam  (ISO)
mirex  (EXP)
Monobutylphthalate  (EXP)
monocrotophos  (EXP,ISO)
monosodium L-glutamate  (ISO)
muconic acid  (ISO)
myricetin  (ISO)
myricitrin  (ISO)
N'-(2,4-dimethylphenyl)-N-methylformamidine  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N,N-diisopropyltryptamine  (ISO)
N,N-dimethylformamide  (EXP,ISO)
N-acetyl-1,4-benzoquinone imine  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methylformamide  (EXP,ISO)
N-Nitrosodi-n-butylamine  (ISO)
N-Nitrosodi-n-propylamine  (ISO)
N-Nitrosodiethanolamine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-Nitrosomethylethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N-nitrosopiperidine  (ISO)
N-Nitrosopyrrolidine  (ISO)
NADP zwitterion  (EXP,ISO)
NADP(+)  (EXP,ISO)
naphthalene  (ISO)
nefazodone  (EXP)
Neferine  (EXP)
neobavaisoflavone  (EXP)
neomycin  (EXP)
nicotinamide  (EXP)
nicotine  (EXP)
nifedipine  (ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
nitroglycerin  (EXP)
Notopterol  (ISO)
o-anisidine  (ISO)
O-methyleugenol  (ISO)
o-xylene  (EXP,ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
oleanolic acid  (EXP,ISO)
oleic acid  (EXP,ISO)
oltipraz  (ISO)
omeprazole  (ISO)
orphenadrine  (ISO)
oxirane  (ISO)
oxycodone  (EXP)
ozone  (ISO)
p-cresol  (ISO)
p-xylene  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
pentachlorobenzene  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenacetin  (EXP)
phenanthrene  (ISO)
phenethyl caffeate  (EXP,ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenol  (EXP,ISO)
phenthoate  (ISO)
phenylglyoxylic acid  (ISO)
phenytoin  (EXP,ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phthalaldehyde  (ISO)
pioglitazone  (ISO)
piperidin-2-one  (ISO)
Pipermethystine  (EXP)
potassium dichromate  (ISO)
primaquine  (ISO)
prochloraz  (ISO)
procymidone  (ISO)