Cyp2e1 (cytochrome P450, family 2, subfamily e, polypeptide 1) - Rat Genome Database

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Gene: Cyp2e1 (cytochrome P450, family 2, subfamily e, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
RGD ID: 2475
Description: Enables Hsp70 protein binding activity and Hsp90 protein binding activity. Involved in several processes, including response to 3-methylcholanthrene; response to ethanol; and response to ozone. Located in Golgi membrane; endoplasmic reticulum membrane; and mitochondrial inner membrane. Used to study alcohol dependence and drug-induced hepatitis. Biomarker of several diseases, including alcohol use disorder; liver disease (multiple); middle cerebral artery infarction; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in acoustic neuroma; gastrointestinal system cancer (multiple); high grade glioma; liver disease (multiple); and lung disease (multiple). Orthologous to human CYP2E1 (cytochrome P450 family 2 subfamily E member 1); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (R)-carnitine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 4-nitrophenol 2-hydroxylase; Cyp2e; CYPIIE1; cytochrome P450 2E1; Cytochrome P450 subfamily 2e1 (ethanol-inducible); cytochrome P450, subfamily 2E, polypeptide 1; cytochrome P450, subfamily 2e1 (ethanol-inducible); cytochrome P450-J; cytochrome P450RLM6; P450-J; P450RLM6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,269,967 - 205,280,365 (+)NCBIGRCr8
mRatBN7.21195,840,330 - 195,850,728 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1195,840,058 - 195,864,023 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,182,795 - 204,193,148 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,309,700 - 211,320,053 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01203,983,553 - 203,993,906 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,511,892 - 213,522,195 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,511,874 - 213,535,542 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,405,975 - 220,416,727 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41200,918,521 - 200,928,919 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,068,525 - 201,078,911 (+)NCBI
Celera1193,484,404 - 193,494,772 (+)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Cyp2e1Ratacoustic neuroma  ISOCYP2E1 (Homo sapiens)1358568DNA:snp:promoter:c.-1053C>T (human)RGD 
Cyp2e1Ratacute kidney failure treatmentIEP 14700914 RGD 
Cyp2e1Ratacute kidney failure treatmentIEP 14700920 RGD 
Cyp2e1Ratalcohol dependence  IDA 405650696 RGD 
Cyp2e1Ratalcohol use disorder  IEP 14700915 RGD 
Cyp2e1Ratalcohol use disorder  ISOCYP2E1 (Homo sapiens)14700911protein:increased expression:plasma and extracellular exosomeRGD 
Cyp2e1Ratalcohol use disorder  ISOCyp2e1 (Mus musculus)14700911 RGD 
Cyp2e1Ratalcoholic liver cirrhosis  ISOCYP2E1 (Homo sapiens)14700873 RGD 
Cyp2e1RatAlcoholic Liver Diseases  ISOCyp2e1 (Mus musculus) and CYP2E1 (Homo sapiens)14700887 RGD 
Cyp2e1RatAlcoholic Liver Diseases treatmentISOCyp2e1 (Mus musculus)14700893 RGD 
Cyp2e1RatAlcoholic Liver Diseases treatmentIEP 14700906 RGD 
Cyp2e1RatAlcoholic Liver Diseases treatmentISOCyp2e1 (Mus musculus)14700894 RGD 
Cyp2e1RatAlcoholic Liver Diseases  ISOCYP2E1 (Homo sapiens)405650696 RGD 
Cyp2e1Ratasbestosis  ISOCYP2E1 (Homo sapiens)4892076mRNA:decreased expression:leukocyteRGD 
Cyp2e1Ratasthma  ISOCYP2E1 (Homo sapiens)4892076mRNA:decreased expression:leukocyteRGD 
Cyp2e1Ratasthma  ISOCyp2e1 (Mus musculus)4892220 RGD 
Cyp2e1RatBinge Drinking  IEP 14700911 RGD 
Cyp2e1RatBinge Drinking  IEP 405100715mRNA:altered exxpression:liver (rat)RGD 
Cyp2e1RatBinge Drinking  IEP 7495839associated with Alcoholic Liver Diseases and protein:increased expression:liverRGD 
Cyp2e1RatBinge Drinking  ISOCYP2E1 (Homo sapiens)14700891protein:increased expression and increased nitration RGD 
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Original Reference(s)
Cyp2e1Ratamenorrhea  ISOCYP2E1 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary amenorrheaClinVarPMID:21681106
Cyp2e1Ratdistal 10q deletion syndrome  ISOCYP2E1 (Homo sapiens)8554872ClinVar Annotator: match by term: Distal 10q deletion syndromeClinVarPMID:31690835
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Cyp2e1Ratacute lymphoblastic leukemia  ISOCYP2E1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11774269
Cyp2e1Ratadenocarcinoma  ISOCYP2E1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16142352
Cyp2e1Ratalcohol use disorder  ISOCYP2E1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20843640
Cyp2e1Ratalcoholic liver cirrhosis  ISOCYP2E1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20843640
Cyp2e1Ratasthma  ISOCYP2E1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28807506
Cyp2e1RatCardiomegaly  ISOCYP2E1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18725507
Cyp2e1RatChemical and Drug Induced Liver Injury  ISOCYP2E1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12668988 more ...
Cyp2e1RatDrug Eruptions  ISOCYP2E1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19351467
Cyp2e1RatDrug-Related Side Effects and Adverse Reactions  ISOCYP2E1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18990727
Cyp2e1RatExperimental Liver Neoplasms  ISOCYP2E1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18056438
Cyp2e1Rathepatocellular carcinoma  ISOCYP2E1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15162526
Cyp2e1RatLiver Neoplasms  ISOCYP2E1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17093202
Cyp2e1RatLung Neoplasms  ISOCYP2E1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:1673675 and PMID:17093202
Cyp2e1Ratlung non-small cell carcinoma  ISOCYP2E1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16142352
Cyp2e1Ratmetabolic dysfunction and alcohol associated liver disease  ISOCYP2E1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26428356
Cyp2e1Ratmetabolic dysfunction-associated steatotic liver disease  ISOCYP2E1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26428356
Cyp2e1RatMicronuclei, Chromosome-Defective  ISOCYP2E1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22156006
Cyp2e1RatNecrosis  ISOCYP2E1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12086689 and PMID:12566070
Cyp2e1RatNeoplasm Invasiveness  ISOCYP2E1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26213588
Cyp2e1Ratnon-Hodgkin lymphoma  ISOCYP2E1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11406608
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Cyp2e1Rat(+)-artemisinin increases expressionISOCyp2e1 (Mus musculus)6480464artemisinin results in increased expression of CYP2E1 mRNACTDPMID:17962186
Cyp2e1Rat(+)-catechin multiple interactionsISOCYP2E1 (Homo sapiens)6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of CYP2E1 mRNA and Catechin inhibits the reaction [Ethanol results in increased expression of CYP2E1]CTDPMID:21352821 and PMID:24763279
Cyp2e1Rat(+)-catechin multiple interactionsISOCyp2e1 (Mus musculus)6480464[Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP2E1 mRNACTDPMID:25663641
Cyp2e1Rat(+)-epicatechin-3-O-gallate multiple interactionsISOCyp2e1 (Mus musculus)6480464[Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP2E1 mRNACTDPMID:25663641
Cyp2e1Rat(+)-schisandrin B decreases activityISOCyp2e1 (Mus musculus)6480464schizandrin B results in decreased activity of CYP2E1 proteinCTDPMID:25753323
Cyp2e1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]CTDPMID:31150632
Cyp2e1Rat(+)-taxifolin decreases expressionISOCYP2E1 (Homo sapiens)6480464taxifolin results in decreased expression of CYP2E1 mRNACTDPMID:17541156
Cyp2e1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOCyp2e1 (Mus musculus)6480464[Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP2E1 mRNA and epigallocatechin gallate results in increased expression of and results in increased activity of CYP2E1 proteinCTDPMID:14600287 and PMID:25663641
Cyp2e1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOCYP2E1 (Homo sapiens)6480464epigallocatechin gallate inhibits the reaction [Acrylamide results in increased expression of CYP2E1 protein]CTDPMID:24508477
Cyp2e1Rat(-)-epigallocatechin 3-gallate affects bindingEXP 6480464epigallocatechin gallate binds to CYP2E1 proteinCTDPMID:23010222
Cyp2e1Rat(-)-trans-epsilon-viniferin decreases activityISOCYP2E1 (Homo sapiens)6480464epsilon-viniferin results in decreased activity of CYP2E1 proteinCTDPMID:12818727
Cyp2e1Rat(1->4)-beta-D-glucan multiple interactionsISOCyp2e1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CYP2E1 mRNACTDPMID:36331819
Cyp2e1Rat(2-hydroxyphenyl)acetic acid multiple interactionsISOCYP2E1 (Homo sapiens)6480464[CYP2E1 protein results in increased metabolism of coumarin] which results in increased abundance of 2-hydroxyphenylacetic acidCTDPMID:34334558
Cyp2e1Rat(R)-carnitine multiple interactionsEXP 6480464Carnitine promotes the reaction [Ethanol results in increased expression of CYP2E1 protein]CTDPMID:8130774
Cyp2e1Rat(R)-lipoic acid multiple interactionsISOCyp2e1 (Mus musculus)6480464Thioctic Acid affects the reaction [cyanoginosin LR affects the expression of CYP2E1 protein]CTDPMID:32061150
Cyp2e1Rat(R,R,R)-alpha-tocopherol multiple interactionsEXP 6480464[Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein] more ...CTDPMID:26332274 and PMID:27919644
Cyp2e1Rat(R,R,R)-alpha-tocopherol increases expressionISOCYP2E1 (Homo sapiens)6480464alpha-Tocopherol results in increased expression of CYP2E1 mRNACTDPMID:28062356
Cyp2e1Rat(R,R,R)-alpha-tocopherol increases expressionEXP 6480464alpha-Tocopherol results in increased expression of CYP2E1 mRNACTDPMID:26332274
Cyp2e1Rat(S)-mandelic acid multiple interactionsISOCYP2E1 (Homo sapiens)6480464CYP2E1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid]CTDPMID:25562543
Cyp2e1Rat(S)-naringenin decreases activityISOCYP2E1 (Homo sapiens)6480464naringenin results in decreased activity of CYP2E1 proteinCTDPMID:33007396

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Biological Process
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Original Reference(s)
Cyp2e1Rat4-nitrophenol metabolic process involved_inISOCYP2E1 (Homo sapiens)1624291 PMID:9348445RGDPMID:9348445
Cyp2e1Ratepoxygenase P450 pathway involved_inIBAPANTHER:PTN002549507 and Cyp2b12 (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp2e1Ratfatty acid metabolic process involved_inIEAUniPathway:UPA001991600115GO_REF:0000041UniProtGO_REF:0000041
Cyp2e1Ratfatty acid metabolic process involved_inIEAUniProtKB-KW:KW-02761600115GO_REF:0000043UniProtGO_REF:0000043
Cyp2e1Ratlipid hydroxylation involved_inISOCYP2E1 (Homo sapiens)1624291 PMID:10553002RGDPMID:10553002
Cyp2e1Ratlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Cyp2e1Ratlong-chain fatty acid metabolic process involved_inISOCYP2E1 (Homo sapiens)1624291 PMID:18577768RGDPMID:18577768
Cyp2e1Ratmonoterpenoid metabolic process involved_inISOCYP2E1 (Homo sapiens)1624291 PMID:16401082RGDPMID:16401082
Cyp2e1Ratresponse to 3-methylcholanthrene  IEP 401794453 RGD 
Cyp2e1Ratresponse to bacterium acts_upstream_of_or_withinISOCyp2e1 (Mus musculus)1624291 PMID:23012479RGDPMID:23012479
Cyp2e1Ratresponse to ethanol  IEP 1626309 RGD 
Cyp2e1Ratresponse to ethanol  IEP 405100715 RGD 
Cyp2e1Ratresponse to ozone  IEP 4892221 RGD 
Cyp2e1Ratresponse to xenobiotic stimulus  IEP 4892234acetaminophenRGD 
Cyp2e1Ratsteroid metabolic process involved_inISOCYP2E1 (Homo sapiens)1624291 PMID:18356043RGDPMID:18356043
Cyp2e1Rattriglyceride metabolic process  IMP 2317269 RGD 
Cyp2e1Ratxenobiotic metabolic process  IMP 4892233 RGD 
Cyp2e1Ratxenobiotic metabolic process  NAS 625597 RGD 
Cyp2e1Ratxenobiotic metabolic process involved_inIBAPANTHER:PTN000670347 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp2e1Ratxenobiotic metabolic process involved_inISOCYP2E1 (Homo sapiens)1624291 PMID:18356043 and PMID:19219744RGDPMID:18356043 and PMID:19219744
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Cellular Component
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Original Reference(s)
Cyp2e1Ratcytoplasm is_active_inIBAFB:FBgn0004959 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp2e1Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Cyp2e1Ratendoplasmic reticulum located_inISOCyp2e1 (Mus musculus)1624291 PMID:16223484RGDPMID:16223484
Cyp2e1Ratendoplasmic reticulum membrane located_inIDA 13838795PMID:19401463UniProt 
Cyp2e1Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Cyp2e1Ratendoplasmic reticulum membrane located_inIEAUniRule:UR0015287621600115GO_REF:0000104UniProtGO_REF:0000104
Cyp2e1RatGolgi membrane  IDA 1626303 RGD 
Cyp2e1Ratintracellular membrane-bounded organelle is_active_inIBAFB:FBgn0004959 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp2e1Ratintracellular membrane-bounded organelle located_inIEAUniProtKB-KW:KW-04921600115GO_REF:0000043UniProtGO_REF:0000043
Cyp2e1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Cyp2e1Ratmitochondrial inner membrane located_inIDA 13838795PMID:19401463UniProt 
Cyp2e1Ratmitochondrial inner membrane located_inIEAUniProtKB-KW:KW-09991600115GO_REF:0000043UniProtGO_REF:0000043
Cyp2e1Ratmitochondrial inner membrane located_inIEAUniRule:UR0015287621600115GO_REF:0000104UniProtGO_REF:0000104
Cyp2e1Ratmitochondrial inner membrane located_inIEAUniProtKB-SubCell:SL-01681600115GO_REF:0000044UniProtGO_REF:0000044
Cyp2e1Ratmitochondrion located_inIEAUniProtKB-KW:KW-04961600115GO_REF:0000043UniProtGO_REF:0000043
Cyp2e1Ratmitochondrion located_inIEAUniProtKB-SubCell:SL-01731600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function
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Cyp2e1Rat4-nitrophenol 2-monooxygenase activity enablesISOCYP2E1 (Homo sapiens)1624291 PMID:9348445RGDPMID:9348445
Cyp2e1Ratarachidonate epoxygenase activity enablesIBAPANTHER:PTN002549507 and Cyp2b12 (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp2e1Ratenzyme binding enablesISOCYP2E1 (Homo sapiens)1624291UniProtKB:P00167 more ...RGDPMID:15680923
Cyp2e1Ratheme binding enablesISSUniProtKB:P051811600115GO_REF:0000024UniProtGO_REF:0000024
Cyp2e1Ratheme binding enablesIBAPANTHER:PTN000670347 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cyp2e1Ratheme binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp2e1Ratheme binding enablesISOCYP2E1 (Homo sapiens)1624291 PMID:18818195RGDPMID:18818195
Cyp2e1Ratheme binding enablesIEAUniRule:UR0015287621600115GO_REF:0000104UniProtGO_REF:0000104
Cyp2e1RatHsp70 protein binding enablesIDA 13838795PMID:19401463UniProt 
Cyp2e1RatHsp70 protein binding enablesIEAUniRule:UR0015287621600115GO_REF:0000104UniProtGO_REF:0000104
Cyp2e1RatHsp90 protein binding enablesIDA 13838795PMID:19401463UniProt 
Cyp2e1RatHsp90 protein binding enablesIEAUniRule:UR0015287621600115GO_REF:0000104UniProtGO_REF:0000104
Cyp2e1Ratiron ion binding enablesIEAUniRule:UR0015287621600115GO_REF:0000104UniProtGO_REF:0000104
Cyp2e1Ratiron ion binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp2e1Ratiron ion binding enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cyp2e1Ratlong-chain fatty acid omega-1 hydroxylase activity enablesISOCYP2E1 (Homo sapiens)1624291 PMID:18577768RGDPMID:18577768
Cyp2e1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Cyp2e1Ratmonooxygenase activity  TAS 70809 RGD 
Cyp2e1Ratmonooxygenase activity enablesISOCyp2e1 (Mus musculus)1624291 PMID:14642533RGDPMID:14642533
Cyp2e1Ratmonooxygenase activity enablesIEAInterPro:IPR001128 more ...1600115GO_REF:0000002InterProGO_REF:0000002
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RGD Manual Annotations


  
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Original Reference(s)
Cyp2e1Ratparacetamol pharmacokinetics pathway   ISOCyp2e1 (Mus musculus)8552693 RGD 
Cyp2e1Ratparacetamol response pathway   ISOCYP2E1 (Homo sapiens)8552696 RGD 

Imported Annotations - SMPDB

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Cyp2e1Ratacetylsalicylic acid pharmacodynamics pathway  ISOCYP2E1 (Homo sapiens)10402751 SMPDBSMP:00083
Cyp2e1Ratantipyrine drug pathway  ISOCYP2E1 (Homo sapiens)10402751 SMPDBSMP:00692
Cyp2e1Ratarachidonic acid metabolic pathway  ISOCYP2E1 (Homo sapiens)10402751 SMPDBSMP:00075
Cyp2e1Ratcaffeine pharmacokinetics pathway  ISOCYP2E1 (Homo sapiens)10402751 SMPDBSMP:00028
Cyp2e1Ratcelecoxib pharmacodynamics pathway  ISOCYP2E1 (Homo sapiens)10402751 SMPDBSMP:00096
Cyp2e1Ratdiclofenac pharmacodynamics pathway  ISOCYP2E1 (Homo sapiens)10402751 SMPDBSMP:00093
Cyp2e1Ratdiflunisal pharmacodynamics pathway  ISOCYP2E1 (Homo sapiens)10402751 SMPDBSMP:00289
Cyp2e1Ratdisulfiram pharmacodynamics pathway  ISOCYP2E1 (Homo sapiens)10402751 SMPDBSMP:00429
Cyp2e1Ratetodolac pharmacodynamics pathway  ISOCYP2E1 (Homo sapiens)10402751 SMPDBSMP:00084
Cyp2e1Ratfelbamate pharmacokinetics pathway  ISOCYP2E1 (Homo sapiens)10402751 SMPDBSMP:00633
Cyp2e1Ratfenoprofen pharmacodynamics pathway  ISOCYP2E1 (Homo sapiens)10402751 SMPDBSMP:00696
Cyp2e1Ratflurbiprofen pharmacodynamics pathway  ISOCYP2E1 (Homo sapiens)10402751 SMPDBSMP:00697
Cyp2e1Ratibuprofen pharmacodynamics pathway  ISOCYP2E1 (Homo sapiens)10402751 SMPDBSMP:00086
Cyp2e1Ratindometacin pharmacodynamics pathway  ISOCYP2E1 (Homo sapiens)10402751 SMPDBSMP:00104
Cyp2e1Ratindometacin pharmacodynamics pathway  ISOCYP2E1 (Homo sapiens)10402751 SMPDBSMP:00104
Cyp2e1Ratketoprofen pharmacodynamics pathway  ISOCYP2E1 (Homo sapiens)10402751 SMPDBSMP:00085
Cyp2e1Ratketorolac pharmacodynamics pathway  ISOCYP2E1 (Homo sapiens)10402751 SMPDBSMP:00098
Cyp2e1Ratleukotriene C4 synthase deficiency pathway  ISOCYP2E1 (Homo sapiens)10402751 SMPDBSMP:00353
Cyp2e1Ratlornoxicam pharmacodynamics pathway  ISOCYP2E1 (Homo sapiens)10402751 SMPDBSMP:00700
Cyp2e1Ratmagnesium salicylate pharmacodynamics pathway  ISOCYP2E1 (Homo sapiens)10402751 SMPDBSMP:00698
1 to 20 of 35 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cyp2e1Ratarachidonic acid metabolic pathway  IEA 6907045 KEGGrno:00590
Cyp2e1Ratlinoleic acid metabolic pathway  IEA 6907045 KEGGrno:00591
Cyp2e1Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00980
Cyp2e1Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00982

1 to 20 of 95 rows
#
Reference Title
Reference Citation
1. CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis. Abdelmegeed MA, etal., Free Radic Biol Med. 2013 Dec;65:1238-1245. doi: 10.1016/j.freeradbiomed.2013.09.009. Epub 2013 Sep 21.
2. Cytochrome P450-2E1 promotes aging-related hepatic steatosis, apoptosis and fibrosis through increased nitroxidative stress. Abdelmegeed MA, etal., Free Radic Biol Med. 2016 Feb;91:188-202. doi: 10.1016/j.freeradbiomed.2015.12.016. Epub 2015 Dec 17.
3. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Aboutabl ME, etal., Br J Pharmacol. 2009 Dec;158(7):1808-19. doi: 10.1111/j.1476-5381.2009.00461.x.
4. Date fruits inhibit hepatocyte apoptosis and modulate the expression of hepatocyte growth factor, cytochrome P450 2E1 and heme oxygenase-1 in carbon tetrachloride-induced liver fibrosis. Al-Rasheed NM, etal., Arch Physiol Biochem. 2017 May;123(2):78-92. doi: 10.1080/13813455.2016.1251945. Epub 2016 Dec 14.
5. Dilinoleoylphosphatidylcholine decreases ethanol-induced cytochrome P4502E1. Aleynik MK and Lieber CS, Biochem Biophys Res Commun 2001 Nov 9;288(4):1047-51.
6. Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism. Anandatheerthavarada HK, etal., J Biol Chem. 2009 Jun 19;284(25):17352-63. doi: 10.1074/jbc.M109.007492. Epub 2009 Apr 28.
7. Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary disease. Arif E, etal., Clin Chim Acta. 2007 Jul;382(1-2):37-42. Epub 2007 Mar 24.
8. A proteomic analysis of liver after ethanol binge in chronically ethanol treated rats. Aroor AR, etal., Proteome Sci. 2012 Apr 30;10(1):29. doi: 10.1186/1477-5956-10-29.
9. [Genetic polymorphism of cytochrome P450 2E1 and the risk of nasopharyngeal carcinoma]. Ben Chaaben A, etal., Bull Cancer. 2015 Dec;102(12):967-72. doi: 10.1016/j.bulcan.2015.09.013. Epub 2015 Nov 12.
10. Genetic polymorphisms of NAT2 and CYP2E1 associated with antituberculosis drug-induced hepatotoxicity in Korean patients with pulmonary tuberculosis. Cho HJ, etal., Tuberculosis (Edinb). 2007 Nov;87(6):551-6.
11. Increased ethanol-inducible cytochrome P450-2E1 and cytochrome P450 isoforms in exosomes of alcohol-exposed rodents and patients with alcoholism through oxidative and endoplasmic reticulum stress. Cho YE, etal., Hepatol Commun. 2017 Jul 13;1(7):675-690. doi: 10.1002/hep4.1066. eCollection 2017 Sep.
12. Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumors. De Roos AJ, etal., Cancer Epidemiol Biomarkers Prev 2003 Jan;12(1):14-22.
13. Role of CYP2E1 gene polymorphisms association with hepatitis risk in Northeast India. Deka M, etal., World J Gastroenterol. 2010 Oct 14;16(38):4800-8. doi: 10.3748/wjg.v16.i38.4800.
14. Protective role of garlic oil against oxidative damage induced by furan exposure from weaning through adulthood in adult rat testis. El-Akabawy G and El-Sherif NM, Acta Histochem. 2016 Jun;118(5):456-63. doi: 10.1016/j.acthis.2016.04.008. Epub 2016 Apr 26.
15. Taurine is more effective than melatonin on cytochrome P450 2E1 and some oxidative stress markers in streptozotocin-induced diabetic rats. El-Batch M, etal., J Agric Food Chem. 2011 May 11;59(9):4995-5000. doi: 10.1021/jf1049547. Epub 2011 Mar 22.
16. CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease. Emery MG, etal., Hepatology. 2003 Aug;38(2):428-35.
17. Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats. Enriquez A, etal., Biochem Biophys Res Commun. 1999 Feb 16;255(2):300-6.
18. Functional PstI/RsaI polymorphism in CYP2E1 is associated with the development, progression and poor outcome of gastric cancer. Feng J, etal., PLoS One. 2012;7(9):e44478. doi: 10.1371/journal.pone.0044478. Epub 2012 Sep 5.
19. Protection from 1,1-dichloroethylene-induced Clara cell injury by diallyl sulfone, a derivative of garlic. Forkert PG, etal., J Pharmacol Exp Ther. 1996 Jun;277(3):1665-71.
20. Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability. Forsyth CB, etal., Am J Physiol Gastrointest Liver Physiol. 2013 Jul 15;305(2):G185-95. doi: 10.1152/ajpgi.00354.2012. Epub 2013 May 9.
1 to 20 of 95 rows
PMID:1441586   PMID:2321956   PMID:2832413   PMID:3308889   PMID:3782137   PMID:9348445   PMID:10553002   PMID:12191992   PMID:12270935   PMID:12470497   PMID:12529372   PMID:12604681  
PMID:12777398   PMID:14642533   PMID:14693714   PMID:14767997   PMID:15162526   PMID:15189336   PMID:15489334   PMID:15632182   PMID:15680923   PMID:15763544   PMID:15797236   PMID:16223484  
PMID:16306132   PMID:16331994   PMID:16374848   PMID:16380384   PMID:16401082   PMID:16878272   PMID:16904701   PMID:16962935   PMID:17058263   PMID:17366540   PMID:17431589   PMID:17587688  
PMID:17681033   PMID:17697118   PMID:17881659   PMID:17949244   PMID:18071271   PMID:18288650   PMID:18326880   PMID:18356043   PMID:18652256   PMID:18818195   PMID:18990514   PMID:19219744  
PMID:19285975   PMID:19336974   PMID:19651758   PMID:19848203   PMID:20522591   PMID:20529841   PMID:21224420   PMID:21813270   PMID:22357518   PMID:22396533   PMID:22885143   PMID:23012479  
PMID:23044233   PMID:23235327   PMID:23892269   PMID:23920219   PMID:24021170   PMID:24500986   PMID:24771067   PMID:25038063   PMID:25323755   PMID:25330250   PMID:25683034   PMID:26463279  
PMID:27314315   PMID:28385499   PMID:28555194   PMID:28803882   PMID:28864499   PMID:31116889   PMID:31881060   PMID:32093091   PMID:32777474   PMID:34830430   PMID:35523980   PMID:35780828  
PMID:37195324   PMID:37499993   PMID:37657698  



Cyp2e1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,269,967 - 205,280,365 (+)NCBIGRCr8
mRatBN7.21195,840,330 - 195,850,728 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1195,840,058 - 195,864,023 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,182,795 - 204,193,148 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,309,700 - 211,320,053 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01203,983,553 - 203,993,906 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,511,892 - 213,522,195 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,511,874 - 213,535,542 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,405,975 - 220,416,727 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41200,918,521 - 200,928,919 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,068,525 - 201,078,911 (+)NCBI
Celera1193,484,404 - 193,494,772 (+)NCBICelera
Cytogenetic Map1q41NCBI
CYP2E1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810133,527,363 - 133,539,123 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10133,520,406 - 133,561,220 (+)EnsemblGRCh38hg38GRCh38
GRCh3710135,340,867 - 135,352,627 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610135,190,857 - 135,202,610 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410135,229,747 - 135,241,501NCBI
Celera10128,168,529 - 128,180,282 (-)NCBICelera
Cytogenetic Map10q26.3NCBI
HuRef10128,882,691 - 128,894,624 (+)NCBIHuRef
CHM1_110135,620,490 - 135,632,188 (+)NCBICHM1_1
T2T-CHM13v2.010134,478,949 - 134,490,654 (+)NCBIT2T-CHM13v2.0
Cyp2e1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,343,732 - 140,354,903 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7140,343,652 - 140,354,900 (+)EnsemblGRCm39 Ensembl
GRCm387140,763,819 - 140,774,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7140,763,739 - 140,774,987 (+)EnsemblGRCm38mm10GRCm38
MGSCv377147,949,731 - 147,960,880 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367140,615,152 - 140,626,301 (+)NCBIMGSCv36mm8
Celera7140,556,087 - 140,567,236 (+)NCBICelera
Cytogenetic Map7F4NCBI
cM Map785.94NCBI
LOC102026028
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555076,289,576 - 6,304,193 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555076,293,162 - 6,303,255 (-)NCBIChiLan1.0ChiLan1.0
CYP2E1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28145,644,624 - 145,686,410 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110145,649,978 - 145,691,767 (+)NCBINHGRI_mPanPan1
PanPan1.110134,839,025 - 134,852,053 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10134,839,025 - 134,852,719 (+)Ensemblpanpan1.1panPan2
CYP2E1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12841,079,164 - 41,089,188 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2841,035,025 - 41,122,754 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2841,171,673 - 41,181,706 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02841,754,551 - 41,764,586 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2841,754,522 - 41,764,585 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12841,235,594 - 41,245,625 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02841,224,985 - 41,235,013 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02841,627,674 - 41,637,700 (+)NCBIUU_Cfam_GSD_1.0
LOC101973029
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244072135,858,593 - 5,869,493 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648619,691,822 - 19,702,102 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648619,691,822 - 19,702,684 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP2E1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14141,690,426 - 141,736,817 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114141,690,737 - 141,703,078 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214153,478,051 - 153,490,404 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP2E1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12653,390,054 - 53,403,309 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2653,390,089 - 53,404,211 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605441,523,569 - 41,534,845 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101722366
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473712,335,681 - 12,345,514 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473712,335,733 - 12,345,278 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Cyp2e1
28 total Variants

Predicted Target Of
Summary Value
Count of predictions:9
Count of miRNA genes:9
Interacting mature miRNAs:9
Transcripts:ENSRNOT00000016883
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 93 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat

1 to 10 of 93 rows
D1Smu4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21195,841,852 - 195,842,092 (+)MAPPERmRatBN7.2
Rnor_6.01213,513,415 - 213,513,654NCBIRnor6.0
Rnor_5.01220,407,852 - 220,408,091UniSTSRnor5.0
RGSC_v3.41200,920,044 - 200,920,283UniSTSRGSC3.4
Celera1193,485,927 - 193,486,166UniSTS
Cytogenetic Map1q41-q42UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 11 49 60 91 90 59 25 59 6 217 97 40 45 60 31


1 to 30 of 36 rows
RefSeq Transcripts NM_031543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF045572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF056333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF061442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 36 rows

Ensembl Acc Id: ENSRNOT00000016883   ⟹   ENSRNOP00000016883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1195,840,058 - 195,850,728 (+)Ensembl
Rnor_6.0 Ensembl1213,511,892 - 213,522,195 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078080   ⟹   ENSRNOP00000073600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1195,840,311 - 195,864,023 (+)Ensembl
Rnor_6.0 Ensembl1213,511,874 - 213,535,542 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098359   ⟹   ENSRNOP00000083600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1195,840,311 - 195,850,728 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101512   ⟹   ENSRNOP00000081291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1195,840,311 - 195,850,728 (+)Ensembl
RefSeq Acc Id: NM_031543   ⟹   NP_113731
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,269,967 - 205,280,365 (+)NCBI
mRatBN7.21195,840,330 - 195,850,728 (+)NCBI
Rnor_6.01213,511,892 - 213,522,195 (+)NCBI
Rnor_5.01220,405,975 - 220,416,727 (+)NCBI
RGSC_v3.41200,918,521 - 200,928,919 (+)RGD
Celera1193,484,404 - 193,494,772 (+)RGD
Sequence:
RefSeq Acc Id: NP_113731   ⟸   NM_031543
- UniProtKB: P05182 (UniProtKB/Swiss-Prot),   A6HXJ0 (UniProtKB/TrEMBL),   A0A8L2Q8J4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016883   ⟸   ENSRNOT00000016883
Ensembl Acc Id: ENSRNOP00000073600   ⟸   ENSRNOT00000078080
Ensembl Acc Id: ENSRNOP00000083600   ⟸   ENSRNOT00000098359
Ensembl Acc Id: ENSRNOP00000081291   ⟸   ENSRNOT00000101512

Name Modeler Protein Id AA Range Protein Structure
AF-P05182-F1-model_v2 AlphaFold P05182 1-493 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690527
Promoter ID:EPDNEW_R1038
Type:multiple initiation site
Name:Cyp2e1_1
Description:cytochrome P450, family 2, subfamily e, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01213,511,874 - 213,511,934EPDNEW


1 to 36 of 36 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-57017 BioCyc
Ensembl Genes ENSRNOG00000012458 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000016883 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7110096 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I_CYP2E-like UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_fam2 UniProtKB/Swiss-Prot
KEGG Report rno:25086 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93361 IMAGE-MGC_LOAD
NCBI Gene 25086 ENTREZGENE
PANTHER CYTOCHROME P450 2E1 UniProtKB/Swiss-Prot
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PharmGKB CYP2E1 RGD
PhenoGen Cyp2e1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  EP450ICYP2E UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012458 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0A0G2K5X9_RAT UniProtKB/TrEMBL
  A0A8I5ZS79_RAT UniProtKB/TrEMBL
  A0A8I5ZXI6_RAT UniProtKB/TrEMBL
  A0A8L2Q8J4 ENTREZGENE, UniProtKB/TrEMBL
  A6HXJ0 ENTREZGENE, UniProtKB/TrEMBL
  A6HXJ1_RAT UniProtKB/TrEMBL
  A6HXJ2_RAT UniProtKB/TrEMBL
  A6HXJ3_RAT UniProtKB/TrEMBL
  A6HXJ4_RAT UniProtKB/TrEMBL
  CP2E1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q71US7_RAT UniProtKB/TrEMBL
1 to 36 of 36 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cyp2e1  cytochrome P450, family 2, subfamily e, polypeptide 1    cytochrome P450, subfamily 2E, polypeptide 1  Name updated 1299863 APPROVED
2002-11-06 Cyp2e1  cytochrome P450, subfamily 2E, polypeptide 1    cytochrome P450, subfamily 2e1 (ethanol-inducible)  Name updated 625702 APPROVED
2002-06-10 Cyp2e1  cytochrome P450, subfamily 2e1 (ethanol-inducible)      Symbol and Name status set to approved 70586 APPROVED
2002-02-15 Cyp2e  Cytochrome P450, IIE (ethanol inducible)      Object retired and merged with RGD:2475 68913 WITHDRAWN

Note Type Note Reference
gene_disease overexpression correlates with alcoholic liver disease and nonalcoholic steatohepatitis 70809
gene_expression expressed in liver and skin 625597
gene_mutations_overexpression overexpression results in changing the hepatocyte TNF- response from proliferation to apoptotic and necrotic cell death, and this is blocked by antioxidants or adenoviral expression of a dominant-negative c-Jun 70809
gene_process mediates oxidative metabolism of endogenous and foreign compounds, including ethanol 61490
gene_process mediates oxidative metabolism of endogenous and foreign compounds, including ethanol 70809