Cyp2e1 (cytochrome P450, family 2, subfamily e, polypeptide 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Cyp2e1 (cytochrome P450, family 2, subfamily e, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
RGD ID: 2475
Description: Enables Hsp70 protein binding activity and Hsp90 protein binding activity. Involved in several processes, including response to ethanol; response to ozone; and triglyceride metabolic process. Located in Golgi membrane; endoplasmic reticulum membrane; and mitochondrial inner membrane. Is intrinsic component of endoplasmic reticulum membrane. Used to study drug-induced hepatitis. Biomarker of several diseases, including alcohol use disorder; fatty liver disease (multiple); liver disease (multiple); middle cerebral artery infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; fatty liver disease; gastrointestinal system cancer (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human CYP2E1 (cytochrome P450 family 2 subfamily E member 1); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (R)-carnitine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 4-nitrophenol 2-hydroxylase; Cyp2e; CYPIIE1; cytochrome P450 2E1; Cytochrome P450 subfamily 2e1 (ethanol-inducible); cytochrome P450, subfamily 2E, polypeptide 1; cytochrome P450, subfamily 2e1 (ethanol-inducible); cytochrome P450-J; cytochrome P450RLM6; P450-J; P450RLM6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21195,840,330 - 195,850,728 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1195,840,058 - 195,864,023 (+)Ensembl
Rnor_6.01213,511,892 - 213,522,195 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,511,874 - 213,535,542 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,405,975 - 220,416,727 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41200,918,521 - 200,928,919 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11201,068,525 - 201,078,911 (+)NCBI
Celera1193,484,404 - 193,494,772 (+)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
acute kidney failure  (IEP)
acute lymphoblastic leukemia  (ISO)
adenocarcinoma  (ISO)
alcohol use disorder  (IEP,ISO)
Alcoholic Fatty Liver  (ISO)
alcoholic liver cirrhosis  (ISO)
Alcoholic Liver Diseases  (IEP,ISO)
amenorrhea  (ISO)
asbestosis  (ISO)
asthma  (ISO)
Binge Drinking  (IEP,ISO)
Cardiomegaly  (ISO)
Chemical and Drug Induced Liver Injury  (IEP,ISO)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon cancer  (IEP)
colorectal cancer  (ISO)
distal 10q deletion syndrome  (ISO)
Drug Eruptions  (ISO)
drug-induced hepatitis  (IDA)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Neoplasms  (ISO)
extrinsic allergic alveolitis  (ISO)
familial hyperlipidemia  (IEP)
fatty liver disease  (IEP,ISO)
hepatocellular adenoma  (IEP)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Human Viral Hepatitis  (ISO)
intrahepatic cholestasis  (ISO)
liver disease  (IEP,ISO)
Liver Injury  (IEP)
Liver Neoplasms  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
mental depression  (IEP)
Micronuclei, Chromosome-Defective  (ISO)
middle cerebral artery infarction  (IEP)
morbid obesity  (ISO)
nasopharynx carcinoma  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
non-alcoholic fatty liver disease  (IEP,ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (IEP,ISO)
oral cavity cancer  (ISO)
oral squamous cell carcinoma  (ISO)
Parkinson's disease  (ISO)
Patent Ductus Venosus  (ISO)
pneumonia  (ISO)
Prostatic Neoplasms  (ISO)
Reperfusion Injury  (IEP)
Sepsis  (IEP)
stomach cancer  (ISO)
Testicular Injury  (IEP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-schisandrin B  (EXP,ISO)
(+)-taxifolin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-trans-epsilon-viniferin  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-mandelic acid  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (ISO)
1,1,1-trichloroethane  (ISO)
1,1-Dichloroethane  (EXP)
1,1-dichloroethene  (EXP,ISO)
1,2,3,5-tetrachlorobenzene  (ISO)
1,2,4,5-tetrachlorobenzene  (EXP)
1,2,4-trichlorobenzene  (ISO)
1,2-dibromoethane  (ISO)
1,2-dichlorobenzene  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dichloroethene  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
1,4-benzoquinone  (EXP)
1,4-dichlorobenzene  (EXP,ISO)
1,4-dioxane  (EXP)
1,4-naphthoquinone  (ISO)
1-benzylpiperazine  (EXP)
1-bromopropane  (EXP,ISO)
1-naphthol  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
19(S)-HETE  (EXP)
19-HETE  (EXP)
1H-imidazole  (EXP)
1H-pyrazole  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,5,6-tetrachlorophenol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,6-dimethylaniline  (ISO)
2,6-dimethylnaphthalene  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-chloroethanol  (EXP)
2-naphthol  (ISO)
2-nitroanisole  (EXP,ISO)
2-nitrophenol  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-dihydroxybenzoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-(Methylthio)-1-propene  (EXP)
3-methylcholanthrene  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-Hydroxy-TEMPO  (EXP)
4-methylumbelliferone  (ISO)
4-nitrocatechol  (EXP,ISO)
4-nitrophenol  (EXP,ISO)
4-Vinylcyclohexene  (EXP,ISO)
4-vinylcyclohexene dioxide  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (EXP)
5-(2-chloroethyl)-4-methylthiazole  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
5-methoxy-N,N-diisopropyltryptamine  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-dihydroxycoumarin  (EXP)
7-ethoxycoumarin  (ISO)
8-Br-cAMP  (ISO)
8-Epidiosbulbin E acetate  (ISO)
abamectin  (EXP)
acarbose  (EXP)
acephate  (ISO)
acetaldehyde  (EXP,ISO)
acetamide  (EXP)
acetic acid  (ISO)
acetone  (EXP,ISO)
acetonitrile  (EXP,ISO)
acetylsalicylic acid  (EXP)
acrylamide  (EXP,ISO)
acrylonitrile  (EXP,ISO)
acteoside  (EXP)
aflatoxin B1  (EXP,ISO)
alcohol  (ISO)
aldehydo-D-glucose  (ISO)
alizarin  (ISO)
alkaloid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (EXP)
allyl alcohol  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-linolenic acid  (ISO)
alpha-methyltryptamine  (ISO)
amiodarone  (ISO)
amitraz  (EXP)
amitrole  (ISO)
amlexanox  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
amphibole asbestos  (ISO)
ampicillin  (EXP)
angelicin  (ISO)
aniline  (EXP,ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
arachidonic acid  (EXP,ISO)
arecoline  (EXP)
Aroclor 1254  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
asiatic acid  (EXP)
aspartame  (EXP)
atrazine  (ISO)
baicalein  (ISO)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzylideneacetone  (EXP)
berberine  (ISO)
Besigomsin  (ISO)
beta-carboline  (ISO)
beta-naphthoflavone  (EXP,ISO)
bifenthrin  (ISO)
bilobalide  (EXP)
biotin  (ISO)
biphenyl-4-amine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Bromadiolone  (EXP)
bromobenzene  (EXP)
bromodichloromethane  (EXP,ISO)
bromoethene  (ISO)
brucine  (EXP)
bucladesine  (ISO)
buta-1,3-diene  (ISO)
butan-2-one  (ISO)
butane-1,3-diol  (EXP)
Butylbenzyl phthalate  (EXP)
Butylparaben  (EXP)
C.I. Natural Red 20  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cafestol  (ISO)
caffeine  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
canadine  (ISO)
capsaicin  (EXP)
carbamazepine  (EXP)
carbaryl  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (ISO)
carnosine  (ISO)
catechol  (EXP,ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chloral hydrate  (EXP)
chlordecone  (ISO)
chlorfluazuron  (ISO)
chlorobenzene  (EXP,ISO)
chloroethene  (EXP,ISO)
chloroform  (ISO)
chlorogenic acid  (ISO)
chloromethane  (ISO)
chloroprene  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chlorzoxazone  (EXP,ISO)
cholesterol  (ISO)
choline  (EXP,ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cimetidine  (ISO)
ciprofibrate  (EXP)
cis-caffeic acid  (EXP)
cisplatin  (EXP,ISO)
citral  (ISO)
clofibrate  (EXP,ISO)
clothianidin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cortisol  (EXP)
coumarin  (EXP)
crocidolite asbestos  (ISO)
crocin-1  (EXP)
curcumin  (EXP,ISO)
cyanides  (ISO)
cyanocob(III)alamin  (ISO)
cyclohexanols  (EXP)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cyfluthrin  (EXP)
cyhalothrin  (EXP)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
cyproconazole  (EXP,ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
daidzein  (EXP,ISO)
deoxycholic acid  (EXP)
desferrioxamine B  (EXP)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
dextromethorphan  (ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (EXP)
dibutyl phthalate  (EXP)
dichloromethane  (EXP,ISO)
diclofenac  (ISO)
dicofol  (EXP)
dicoumarol  (EXP,ISO)
diepoxybutane  (ISO)
diethyldithiocarbamic acid  (EXP,ISO)
diethylstilbestrol  (ISO)
dihydrocapsaicin  (EXP)
dihydroxyacetone  (ISO)
dimethyl sulfoxide  (EXP,ISO)
dimethylmercury  (EXP)
dioscin  (EXP,ISO)
diosmetin  (ISO)
diosmin  (EXP)
dioxygen  (EXP,ISO)
dipropyl disulfide  (ISO)
dipropyl phthalate  (EXP)
Dipropyl sulfide  (ISO)
diprotium oxide  (ISO)
disulfiram  (EXP,ISO)
dodecanoic acid  (ISO)
dopamine  (ISO)
doxorubicin  (ISO)
dronedarone  (ISO)
ebselen  (EXP)
elemental selenium  (EXP)
ellipticine  (ISO)
emamectin benzoate  (ISO)
endosulfan  (EXP,ISO)
enfuvirtide  (ISO)
enilconazole  (ISO)
epoxiconazole  (EXP)
erastin  (ISO)
Erionite  (ISO)
Estragole  (ISO)
ethambutol  (EXP,ISO)
ethanol  (EXP,ISO)
ethene  (EXP,ISO)
ethosuximide  (EXP)
ethyl methanesulfonate  (ISO)
ethylbenzene  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
ethylenediaminetetraacetic acid  (ISO)
ethylparaben  (EXP)
eugenol  (EXP,ISO)
farnesol  (EXP,ISO)
felbamate  (EXP)
fenarimol  (ISO)
fenitrothion  (ISO)
fenofibrate  (EXP)
fenvalerate  (ISO)
ferrostatin-1  (ISO)
fipronil  (EXP,ISO)
flavonoids  (ISO)
fluoranthene  (ISO)
fluoroethene  (EXP,ISO)
fluphenazine  (ISO)
folic acid  (ISO)
fomepizole  (EXP,ISO)
fructose  (ISO)
fucoxanthin  (ISO)
fulvestrant  (ISO)
fumaraldehyde  (EXP)
fumonisin B1  (ISO)
Furafylline  (EXP)
furan  (EXP)
gabapentin  (EXP)
gadolinium trichloride  (EXP)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
geranial  (ISO)
geraniol  (EXP,ISO)
ginsenoside Rg1  (ISO)
glafenine  (EXP)
glucose  (ISO)
glutathione  (EXP,ISO)
glycerol  (ISO)
glycine betaine  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glyphosate  (EXP)
GW 4064  (ISO)
halothane  (EXP,ISO)
hemin  (EXP,ISO)
hesperetin  (EXP)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP,ISO)
hexane  (EXP,ISO)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (EXP,ISO)
Hypaconitine  (ISO)
imidazoles  (EXP)
indole-3-methanol  (ISO)
indometacin  (EXP)
irbesartan  (ISO)
iron(III) citrate  (ISO)
iron(III) nitrilotriacetate  (ISO)
isatin  (ISO)
isobavachalcone  (EXP)
isobutyronitrile  (ISO)
isoliquiritigenin  (EXP)
isoniazide  (EXP,ISO)
isoprenaline  (EXP)
isoproturon  (ISO)
isoquinolines  (EXP)
ivermectin  (ISO)
kaempferol  (ISO)
kahweol  (ISO)
ketamine  (EXP)
ketoconazole  (ISO)
kojic acid  (EXP)
L-ascorbic acid  (EXP,ISO)
L-methionine  (EXP,ISO)
lamotrigine  (ISO)
Lasiocarpine  (ISO)
leupeptin  (ISO)
Licochalcone A  (ISO)
linoleic acid  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
liquiritin  (EXP)
lithocholic acid  (ISO)
luteolin  (ISO)
LY 364947  (ISO)
LY294002  (EXP)
lycopene  (ISO)
m-tolualdehyde  (EXP)
m-xylene  (EXP,ISO)
malathion  (ISO)
mancozeb  (ISO)
mandelic acid  (ISO)
maneb  (EXP,ISO)
mangiferin  (EXP)
melatonin  (EXP,ISO)
menadione  (ISO)
mephenytoin  (ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP,ISO)
methoxsalen  (EXP,ISO)
methoxychlor  (EXP,ISO)
methoxyflurane  (ISO)
methyltestosterone  (ISO)
metronidazole  (EXP)
microcystin-LR  (ISO)
midazolam  (ISO)
mirex  (EXP)
Monobutylphthalate  (EXP)
monocrotophos  (EXP,ISO)
monosodium L-glutamate  (ISO)
muconic acid  (ISO)
myricetin  (ISO)
myricitrin  (ISO)
N'-(2,4-dimethylphenyl)-N-methylformamidine  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N,N-diisopropyltryptamine  (ISO)
N,N-dimethylformamide  (EXP,ISO)
N-acetyl-1,4-benzoquinone imine  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methylformamide  (EXP,ISO)
N-Nitrosodi-n-butylamine  (ISO)
N-Nitrosodi-n-propylamine  (ISO)
N-Nitrosodiethanolamine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-Nitrosomethylethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N-nitrosopiperidine  (ISO)
N-Nitrosopyrrolidine  (ISO)
NADP zwitterion  (EXP,ISO)
NADP(+)  (EXP,ISO)
naphthalene  (ISO)
nefazodone  (EXP)
Neferine  (EXP)
neobavaisoflavone  (EXP)
neomycin  (EXP)
nicotinamide  (EXP)
nicotine  (EXP)
nifedipine  (ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
nitroglycerin  (EXP)
Notopterol  (ISO)
o-anisidine  (ISO)
O-methyleugenol  (ISO)
o-xylene  (EXP,ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
oleanolic acid  (EXP,ISO)
oleic acid  (EXP,ISO)
oltipraz  (ISO)
omeprazole  (ISO)
orphenadrine  (ISO)
oxirane  (ISO)
oxycodone  (EXP)
ozone  (ISO)
p-cresol  (ISO)
p-xylene  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
pentachlorobenzene  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenacetin  (EXP)
phenanthrene  (ISO)
phenethyl caffeate  (EXP,ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenol  (EXP,ISO)
phenthoate  (ISO)
phenylglyoxylic acid  (ISO)
phenytoin  (EXP,ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phthalaldehyde  (ISO)
pioglitazone  (ISO)
piperidin-2-one  (ISO)
Pipermethystine  (EXP)
potassium dichromate  (ISO)
primaquine  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
profenofos  (ISO)
progesterone  (EXP,ISO)
prop-2-yn-1-ol  (EXP)
propacetamol  (ISO)
propan-2-ol  (EXP)
propetamphos  (EXP)
propiconazole  (EXP)
propylparaben  (EXP)
psoralen  (ISO)
psoralidin  (EXP)
puerarin  (ISO)
purpurin  (ISO)
purpurogallin  (EXP)
pyrazinecarboxamide  (EXP)
pyrazines  (EXP)
pyrene  (EXP)
pyridine  (EXP,ISO)
pyridine N-oxide  (EXP)
pyridines  (EXP)
pyrogallol  (ISO)
quartz  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quinacrine  (EXP)
quinidine  (ISO)
quinoline  (EXP,ISO)
quinolines  (EXP)
rac-1,2-dichloropropane  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
Retrorsine  (EXP)
riddelliine  (EXP)
rifampicin  (EXP,ISO)
rotenone  (EXP)
S-adenosyl-L-methioninate  (EXP,ISO)
S-adenosyl-L-methionine  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
safrole  (ISO)
salvianolic acid B  (EXP)
satraplatin  (ISO)
SB 203580  (ISO)
SCH772984  (EXP)
selenium atom  (EXP)
senecionine  (ISO)
sevoflurane  (ISO)
Shikonin  (EXP,ISO)
silicon dioxide  (EXP,ISO)
sirolimus  (ISO)
skatole  (ISO)
sodium arsenite  (ISO)
sodium chromate  (EXP)
staurosporine  (EXP)
streptozocin  (EXP,ISO)
styrene  (EXP,ISO)
styrene oxide  (ISO)
Sudan I  (ISO)
sulforaphane  (ISO)
sunitinib  (EXP)
tamoxifen  (ISO)
taurine  (ISO)
tebuconazole  (EXP,ISO)
tenofovir disoproxil fumarate  (ISO)
tert-butyl ethyl ether  (EXP)
testosterone  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloroethene  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetrachlorophenol  (ISO)
tetracycline  (ISO)
tetrahydrocurcumin  (ISO)
tetraphene  (ISO)
thallium  (EXP)
theobromine  (ISO)
theophylline  (EXP,ISO)
thiacloprid  (ISO)
thiamine(1+) chloride  (EXP)
thiazoles  (EXP)
thioacetamide  (EXP,ISO)
thiophanate-methyl  (EXP)
thioridazine  (ISO)
thiostrepton  (ISO)
thiram  (EXP)
Tiopronin  (EXP)
tirapazamine  (EXP)
titanium dioxide  (EXP,ISO)
toluene  (EXP,ISO)
trabectedin  (EXP)
trans-1,2-dichloroethene  (EXP,ISO)
trans-caffeic acid  (EXP)
trans-cinnamic acid  (ISO)
transfluthrin  (EXP)
tranylcypromine  (ISO)
triadimefon  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (EXP,ISO)
troglitazone  (EXP,ISO)
tryptamines  (ISO)
umbelliferone  (ISO)
uranium atom  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vanoxerine dihydrochloride  (ISO)
vinclozolin  (EXP,ISO)
vinyl carbamate  (EXP,ISO)
vitamin E  (EXP,ISO)
water  (ISO)
wortmannin  (EXP,ISO)
Wuweizisu C  (ISO)
XL147  (ISO)
zearalenone  (EXP)
zinc atom  (EXP,ISO)
zinc protoporphyrin  (EXP,ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylsalicylic acid pharmacodynamics pathway  (ISO)
antipyrine drug pathway  (ISO)
arachidonic acid metabolic pathway  (IEA,ISO)
caffeine pharmacokinetics pathway  (ISO)
celecoxib pharmacodynamics pathway  (ISO)
diclofenac pharmacodynamics pathway  (ISO)
diflunisal pharmacodynamics pathway  (ISO)
disulfiram pharmacodynamics pathway  (ISO)
etodolac pharmacodynamics pathway  (ISO)
felbamate pharmacokinetics pathway  (ISO)
fenoprofen pharmacodynamics pathway  (ISO)
flurbiprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
ketoprofen pharmacodynamics pathway  (ISO)
ketorolac pharmacodynamics pathway  (ISO)
leukotriene C4 synthase deficiency pathway  (ISO)
linoleic acid metabolic pathway  (IEA)
lornoxicam pharmacodynamics pathway  (ISO)
magnesium salicylate pharmacodynamics pathway  (ISO)
mefenamic acid pharmacodynamics pathway  (ISO)
meloxicam pharmacodynamics pathway  (ISO)
nabumetone pharmacodynamics pathway  (ISO)
naproxen pharmacodynamics pathway  (ISO)
paracetamol drug pathway  (ISO)
paracetamol pharmacokinetics pathway  (ISO)
paracetamol response pathway  (ISO)
phase I biotransformation pathway via cytochrome P450  (IEA)
phenytoin pharmacodynamics pathway  (ISO)
piroxicam pharmacodynamics pathway  (ISO)
salicylic acid pharmacodynamics pathway  (ISO)
sodium salicylate pharmacodynamics pathway  (ISO)
sulindac pharmacodynamics pathway  (ISO)
tenoxicam pharmacodynamics pathway  (ISO)
tiaprofenic acid pharmacodynamics pathway  (ISO)
tolmetin pharmacodynamics pathway  (ISO)
valdecoxib pharmacodynamics pathway  (ISO)

References

References - curated
1. Abdelmegeed MA, etal., Free Radic Biol Med. 2013 Dec;65:1238-1245. doi: 10.1016/j.freeradbiomed.2013.09.009. Epub 2013 Sep 21.
2. Abdelmegeed MA, etal., Free Radic Biol Med. 2016 Feb;91:188-202. doi: 10.1016/j.freeradbiomed.2015.12.016. Epub 2015 Dec 17.
3. Al-Rasheed NM, etal., Arch Physiol Biochem. 2017 May;123(2):78-92. doi: 10.1080/13813455.2016.1251945. Epub 2016 Dec 14.
4. Aleynik MK and Lieber CS, Biochem Biophys Res Commun 2001 Nov 9;288(4):1047-51.
5. Anandatheerthavarada HK, etal., J Biol Chem. 2009 Jun 19;284(25):17352-63. doi: 10.1074/jbc.M109.007492. Epub 2009 Apr 28.
6. Arif E, etal., Clin Chim Acta. 2007 Jul;382(1-2):37-42. Epub 2007 Mar 24.
7. Ben Chaaben A, etal., Bull Cancer. 2015 Dec;102(12):967-72. doi: 10.1016/j.bulcan.2015.09.013. Epub 2015 Nov 12.
8. Cho HJ, etal., Tuberculosis (Edinb). 2007 Nov;87(6):551-6.
9. Cho YE, etal., Hepatol Commun. 2017 Jul 13;1(7):675-690. doi: 10.1002/hep4.1066. eCollection 2017 Sep.
10. De Roos AJ, etal., Cancer Epidemiol Biomarkers Prev 2003 Jan;12(1):14-22.
11. Deka M, etal., World J Gastroenterol. 2010 Oct 14;16(38):4800-8. doi: 10.3748/wjg.v16.i38.4800.
12. El-Akabawy G and El-Sherif NM, Acta Histochem. 2016 Jun;118(5):456-63. doi: 10.1016/j.acthis.2016.04.008. Epub 2016 Apr 26.
13. El-Batch M, etal., J Agric Food Chem. 2011 May 11;59(9):4995-5000. doi: 10.1021/jf1049547. Epub 2011 Mar 22.
14. Emery MG, etal., Hepatology. 2003 Aug;38(2):428-35.
15. Enriquez A, etal., Biochem Biophys Res Commun. 1999 Feb 16;255(2):300-6.
16. Feng J, etal., PLoS One. 2012;7(9):e44478. doi: 10.1371/journal.pone.0044478. Epub 2012 Sep 5.
17. Forkert PG, etal., J Pharmacol Exp Ther. 1996 Jun;277(3):1665-71.
18. Ganaie MA, etal., Environ Toxicol. 2019 May;34(5):610-625. doi: 10.1002/tox.22727. Epub 2019 Feb 5.
19. Gattás GJ, etal., Head Neck. 2006 Sep;28(9):819-26. doi: 10.1002/hed.20410.
20. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
21. Ge N, etal., J Food Sci. 2018 Oct;83(10):2612-2621. doi: 10.1111/1750-3841.14320. Epub 2018 Sep 7.
22. GOA data from the GO Consortium
23. Gong WH, etal., World J Gastroenterol. 2012 Sep 21;18(35):4934-43. doi: 10.3748/wjg.v18.i35.4934.
24. Guo LK, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2012 Aug;34(4):390-5. doi: 10.3881/j.issn.1000-503X.2012.04.015.
25. Hassan HM, etal., Antimicrob Agents Chemother. 2016 Aug 22;60(9):5285-93. doi: 10.1128/AAC.00854-16. Print 2016 Sep.
26. Haufroid V, etal., Eur J Clin Pharmacol. 2003 May;59(1):29-33. Epub 2003 Mar 22.
27. Helmig S, etal., Int J Mol Med. 2010 Jul;26(1):143-9.
28. Hodgman MJ and Garrard AR, Crit Care Clin. 2012 Oct;28(4):499-516. doi: 10.1016/j.ccc.2012.07.006.
29. Jian T, etal., Biomed Pharmacother. 2017 Jul;91:229-237. doi: 10.1016/j.biopha.2017.04.056. Epub 2017 Apr 28.
30. KEGG
31. Khemawoot P, etal., Biochem Pharmacol. 2007 Jan 1;73(1):155-62. Epub 2006 Sep 14.
32. Kim NH, etal., Eur J Cancer Prev. 2019 Jul;28(4):304-310. doi: 10.1097/CEJ.0000000000000462.
33. Korytina GF, etal., J Mol Med. 2005 Sep;83(9):700-10. Epub 2005 Jun 1.
34. Korytina GF, etal., Mol Biol (Mosk). 2003 Sep-Oct;37(5):784-92.
35. Kotsovolou O, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1075-84. Epub 2010 Jun 4.
36. Latchoumycandane C, etal., Free Radic Biol Med. 2014 Apr;69:403-16. doi: 10.1016/j.freeradbiomed.2014.01.001. Epub 2014 Jan 8.
37. Leclercq IA, etal., Biochem Biophys Res Commun. 2000 Feb 16;268(2):337-44.
38. Lee DH, etal., Clin Sci (Lond). 2015 May 1;128(10):695-706. doi: 10.1042/CS20140576.
39. Lee SH and Lee SM, Shock. 2005 Feb;23(2):144-9.
40. Lee SW, etal., Int J Tuberc Lung Dis. 2010 May;14(5):622-6.
41. Liu H, etal., Am J Physiol Gastrointest Liver Physiol 2002 Feb;282(2):G257-66.
42. McGill MR and Jaeschke H, Pharm Res. 2013 Sep;30(9):2174-87. doi: 10.1007/s11095-013-1007-6. Epub 2013 Mar 6.
43. MGD data from the GO Consortium
44. Naiman K, etal., Neuro Endocrinol Lett. 2010 Dec 28;31(Suppl2).
45. NCBI rat LocusLink and RefSeq merged data July 26, 2002
46. Neve EP, etal., Arch Biochem Biophys. 1996 Sep 15;333(2):459-65.
47. Neve EP, etal., Biochemistry. 2003 Dec 16;42(49):14566-75.
48. Nieto N, etal., J Biol Chem 2002 Mar 22;277(12):9853-64. Epub 2002 Jan 8.
49. Piao YF, etal., World J Gastroenterol. 2003 Nov;9(11):2612-5.
50. Pipeline to import KEGG annotations from KEGG into RGD
51. Pipeline to import SMPDB annotations from SMPDB into RGD
52. Plewka A, etal., Acta Biochim Pol 2000;47(4):1129-36.
53. Posadas I, etal., PLoS One. 2010 Dec 10;5(12):e15360.
54. Qin JD, etal., Pharm Biol. 2014 Nov;52(11):1460-6. doi: 10.3109/13880209.2014.898075. Epub 2014 Jun 25.
55. Quan J, etal., Biosci Biotechnol Biochem. 2009 Apr 23;73(4):849-54. Epub 2009 Apr 7.
56. RGD automated data pipeline
57. RGD automated import pipeline for gene-chemical interactions
58. Robin MA, etal., FEBS Lett. 2005 Dec 19;579(30):6895-902. Epub 2005 Dec 1.
59. Ronis MJ, etal., Alcohol. 2010 Mar;44(2):157-69. Epub 2010 Jan 29.
60. Shankar K, etal., Toxicol Sci. 2003 Jun;73(2):220-34. Epub 2003 Apr 15.
61. Shayakhmetova GM, etal., Arh Hig Rada Toksikol. 2013 Jun;64(2):51-60. doi: 10.2478/10004-1254-64-2013-2313.
62. Shen L, etal., Environ Toxicol Pharmacol. 2013 Jul;36(1):149-51. doi: 10.1016/j.etap.2013.03.016. Epub 2013 Apr 2.
63. Skoko JJ, etal., Toxicol Sci. 2014 Sep;141(1):112-9. doi: 10.1093/tox