Cyp2e1 (cytochrome P450, family 2, subfamily e, polypeptide 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cyp2e1 (cytochrome P450, family 2, subfamily e, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
RGD ID: 2475
Description: Enables Hsp70 protein binding activity and Hsp90 protein binding activity. Involved in several processes, including response to 3-methylcholanthrene; response to ethanol; and response to ozone. Located in Golgi membrane; endoplasmic reticulum membrane; and mitochondrial inner membrane. Used to study alcohol dependence and drug-induced hepatitis. Biomarker of several diseases, including alcohol use disorder; liver disease (multiple); middle cerebral artery infarction; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in acoustic neuroma; gastrointestinal system cancer (multiple); high grade glioma; liver disease (multiple); and lung disease (multiple). Orthologous to human CYP2E1 (cytochrome P450 family 2 subfamily E member 1); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (R)-carnitine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 4-nitrophenol 2-hydroxylase; Cyp2e; CYPIIE1; cytochrome P450 2E1; Cytochrome P450 subfamily 2e1 (ethanol-inducible); cytochrome P450, subfamily 2E, polypeptide 1; cytochrome P450, subfamily 2e1 (ethanol-inducible); cytochrome P450-J; cytochrome P450RLM6; P450-J; P450RLM6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,269,967 - 205,280,365 (+)NCBIGRCr8
mRatBN7.21195,840,330 - 195,850,728 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1195,840,058 - 195,864,023 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,182,795 - 204,193,148 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,309,700 - 211,320,053 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01203,983,553 - 203,993,906 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,511,892 - 213,522,195 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,511,874 - 213,535,542 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,405,975 - 220,416,727 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41200,918,521 - 200,928,919 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,068,525 - 201,078,911 (+)NCBI
Celera1193,484,404 - 193,494,772 (+)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
acute kidney failure  (IEP)
acute lymphoblastic leukemia  (ISO)
adenocarcinoma  (ISO)
alcohol dependence  (IDA)
alcohol use disorder  (IEP,ISO)
alcoholic liver cirrhosis  (ISO)
Alcoholic Liver Diseases  (IEP,ISO)
amenorrhea  (ISO)
asbestosis  (ISO)
asthma  (ISO)
Binge Drinking  (IEP,ISO)
Cardiomegaly  (ISO)
Chemical and Drug Induced Liver Injury  (IEP,ISO)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon cancer  (IEP)
colorectal cancer  (ISO)
depressive disorder  (IEP)
distal 10q deletion syndrome  (ISO)
Drug Eruptions  (ISO)
drug-induced hepatitis  (IDA)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Neoplasms  (ISO)
extrinsic allergic alveolitis  (ISO)
familial hyperlipidemia  (IEP)
hepatocellular adenoma  (IEP)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Human Viral Hepatitis  (ISO)
hypertrophic cardiomyopathy  (IEP)
intrahepatic cholestasis  (ISO)
liver disease  (IEP,ISO)
Liver Injury  (IEP)
Liver Neoplasms  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
metabolic dysfunction and alcohol associated liver disease  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP,ISO)
Micronuclei, Chromosome-Defective  (ISO)
middle cerebral artery infarction  (IEP)
morbid obesity  (ISO)
nasopharynx carcinoma  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (IEP,ISO)
oral cavity cancer  (ISO)
oral squamous cell carcinoma  (ISO)
Parkinson's disease  (ISO)
Patent Ductus Venosus  (ISO)
pneumonia  (ISO)
Prenatal Exposure Delayed Effects  (IEP)
Prostatic Neoplasms  (ISO)
Reperfusion Injury  (IEP)
Sepsis  (IEP)
steatotic liver disease  (IEP,ISO)
stomach cancer  (ISO)
Testicular Injury  (IEP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-schisandrin B  (EXP,ISO)
(+)-taxifolin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-trans-epsilon-viniferin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(2-hydroxyphenyl)acetic acid  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-mandelic acid  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (ISO)
1,1,1-trichloroethane  (ISO)
1,1-Dichloroethane  (EXP)
1,1-dichloroethene  (EXP,ISO)
1,2,3,5-tetrachlorobenzene  (ISO)
1,2,4,5-tetrachlorobenzene  (EXP)
1,2,4-trichlorobenzene  (ISO)
1,2-dibromoethane  (ISO)
1,2-dichlorobenzene  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dichloroethene  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
1,3,5-trimethylbenzene  (ISO)
1,4-benzoquinone  (EXP)
1,4-dichlorobenzene  (EXP,ISO)
1,4-dioxane  (EXP)
1,4-naphthoquinone  (ISO)
1-benzylpiperazine  (EXP)
1-bromopropane  (EXP,ISO)
1-Methylpyrene  (ISO)
1-naphthol  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
19(S)-HETE  (EXP)
19-HETE  (EXP)
1H-imidazole  (EXP)
1H-pyrazole  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,5,6-tetrachlorophenol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-D  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethylaniline  (ISO)
2,6-dimethylnaphthalene  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-chloroethanol  (EXP)
2-naphthol  (ISO)
2-nitroanisole  (EXP,ISO)
2-nitrophenol  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-(Methylthio)-1-propene  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-hydroxy-TEMPO  (EXP)
4-methylumbelliferone  (ISO)
4-nitrocatechol  (EXP,ISO)
4-nitrophenol  (EXP,ISO)
4-Vinylcyclohexene  (EXP,ISO)
4-vinylcyclohexene dioxide  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (EXP)
5-(2-chloroethyl)-4-methylthiazole  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
5-methoxy-N,N-diisopropyltryptamine  (ISO)
5-methyltryptamine  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-Hydroxychlorzoxazone  (EXP,ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-dihydroxycoumarin  (EXP)
7-ethoxycoumarin  (ISO)
8-Br-cAMP  (ISO)
8-Epidiosbulbin E acetate  (ISO)
abamectin  (EXP)
acadesine  (EXP)
acarbose  (EXP)
acephate  (ISO)
acetaldehyde  (EXP,ISO)
acetamide  (EXP)
acetic acid  (ISO)
acetone  (EXP,ISO)
acetonitrile  (EXP,ISO)
acetylsalicylic acid  (EXP)
acrylamide  (EXP,ISO)
acrylonitrile  (EXP,ISO)
acteoside  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin G1  (ISO)
alcohol  (ISO)
aldehydo-D-glucose  (ISO)
alizarin  (ISO)
alkaloid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (EXP)
allyl alcohol  (ISO)
allyl cyanide  (ISO)
allyl methyl disulfide  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-linolenic acid  (ISO)
alpha-methyltryptamine  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
amitraz  (EXP)
amitrole  (ISO)
amlexanox  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
amphibole asbestos  (ISO)
ampicillin  (EXP)
angelicin  (ISO)
aniline  (EXP,ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
arachidonic acid  (EXP,ISO)
arecoline  (EXP)
Aroclor 1254  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
asiatic acid  (EXP)
aspartame  (EXP)
atrazine  (ISO)
baicalein  (ISO)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzylideneacetone  (EXP)
berberine  (ISO)
Besigomsin  (ISO)
beta-carboline  (ISO)
beta-naphthoflavone  (EXP,ISO)
bifenthrin  (ISO)
bilobalide  (EXP)
biotin  (ISO)
biphenyl-4-amine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Bromadiolone  (EXP)
bromobenzene  (EXP)
bromodichloromethane  (EXP,ISO)
bromoethene  (ISO)
brucine  (EXP)
bucladesine  (ISO)
buta-1,3-diene  (ISO)
butan-2-one  (ISO)
butane-1,3-diol  (EXP)
Butylbenzyl phthalate  (EXP)
Butylparaben  (EXP)
C.I. Natural Red 20  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cafestol  (ISO)
caffeine  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
canadine  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbamazepine  (EXP)
carbaryl  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (ISO)
carnosine  (ISO)
catechol  (EXP,ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chloral hydrate  (EXP)
chlordecone  (ISO)
chlorfluazuron  (ISO)
chlorobenzene  (EXP,ISO)
chloroethene  (EXP,ISO)
chloroform  (ISO)
chlorogenic acid  (ISO)
chloromethane  (ISO)
chloroprene  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chlorzoxazone  (EXP,ISO)
cholesterol  (ISO)
choline  (EXP,ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cimetidine  (ISO)
ciprofibrate  (EXP)
cis-caffeic acid  (EXP)
cisplatin  (EXP,ISO)
citral  (ISO)
clofibrate  (EXP,ISO)
clothianidin  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corticosterone  (EXP,ISO)
cortisol  (EXP)
coumarin  (EXP,ISO)
crocidolite asbestos  (ISO)
crocin-1  (EXP)
curcumin  (EXP,ISO)
cyanides  (ISO)
cyanocob(III)alamin  (ISO)
cyclohexanols  (EXP)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cyfluthrin  (EXP)
cyhalothrin  (EXP)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
cyproconazole  (EXP,ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
daidzein  (EXP,ISO)
Dendrobine  (ISO)
deoxycholic acid  (EXP)
desferrioxamine B  (EXP)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
dextromethorphan  (ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (EXP)
dibutyl phthalate  (EXP)
dichloromethane  (EXP,ISO)
diclofenac  (ISO)
dicofol  (EXP)
dicoumarol  (EXP,ISO)
diepoxybutane  (ISO)
diethyldithiocarbamic acid  (EXP,ISO)
diethylstilbestrol  (ISO)
dihydrocapsaicin  (EXP)
dihydroxyacetone  (ISO)
dimethyl sulfoxide  (EXP,ISO)
dimethylmercury  (EXP)
dioscin  (EXP,ISO)
diosmetin  (ISO)
diosmin  (EXP)
dioxygen  (EXP,ISO)
dipropyl disulfide  (ISO)
dipropyl phthalate  (EXP)
Dipropyl sulfide  (ISO)
diprotium oxide  (ISO)
disulfiram  (EXP,ISO)
dodecanoic acid  (ISO)
dopamine  (ISO)
doxorubicin  (ISO)
dronedarone  (ISO)
ebselen  (EXP)
elemental selenium  (EXP)
ellipticine  (ISO)
emamectin benzoate  (ISO)
endosulfan  (EXP,ISO)
enfuvirtide  (ISO)
enilconazole  (ISO)
epoxiconazole  (EXP)
erastin  (ISO)
Erionite  (ISO)
estragole  (ISO)
ethambutol  (EXP,ISO)
ethanol  (EXP,ISO)
ethene  (EXP,ISO)
ethosuximide  (EXP)
ethyl methanesulfonate  (ISO)
ethylbenzene  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
ethylenediaminetetraacetic acid  (ISO)
ethylparaben  (EXP)
eugenol  (EXP,ISO)
farnesol  (EXP,ISO)
felbamate  (EXP,ISO)
fenarimol  (ISO)
fenitrothion  (ISO)
fenofibrate  (EXP)
fentin chloride  (EXP)
fenvalerate  (ISO)
ferrostatin-1  (ISO)
fipronil  (EXP,ISO)
flavonoids  (ISO)
fluoranthene  (ISO)
fluoroethene  (EXP,ISO)
fluphenazine  (ISO)
flutriafol  (ISO)
folic acid  (ISO)
fomepizole  (EXP,ISO)
fructose  (ISO)
fucoxanthin  (ISO)
fulvestrant  (ISO)
fumaraldehyde  (EXP)
fumonisin B1  (ISO)
Furafylline  (EXP)
furan  (EXP,ISO)
gabapentin  (EXP)
gadolinium trichloride  (EXP)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
geranial  (ISO)
geraniol  (EXP,ISO)
ginsenoside Rg1  (ISO)
glafenine  (EXP)
glucose  (ISO)
glutathione  (EXP,ISO)
Glutathione ethyl ester  (ISO)
glycerol  (ISO)
glycine betaine  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (ISO)
halothane  (EXP,ISO)
hemin  (EXP,ISO)
hesperetin  (EXP)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP,ISO)
hexane  (EXP,ISO)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (EXP,ISO)
Hypaconitine  (ISO)
icariin  (ISO)
imidacloprid  (EXP)
imidazoles  (EXP)
indole-3-methanol  (EXP,ISO)
indometacin  (EXP)
irbesartan  (ISO)
iron(III) citrate  (ISO)
iron(III) nitrilotriacetate  (ISO)
isatin  (ISO)
isobavachalcone  (EXP)
isobutyronitrile  (ISO)
isoliquiritigenin  (EXP)
isoniazide  (EXP,ISO)
isoprenaline  (EXP)
isoproturon  (ISO)
isoquinolines  (EXP)
ivermectin  (ISO)
kaempferol  (ISO)
kahweol  (ISO)
ketamine  (EXP)
ketoconazole  (ISO)
kojic acid  (EXP)
L-ascorbic acid  (EXP,ISO)
L-methionine  (EXP,ISO)
lamotrigine  (ISO)
lansoprazole  (ISO)
Lasiocarpine  (ISO)
leupeptin  (ISO)
Licochalcone A  (ISO)
linoleic acid  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
liquiritin  (EXP)
lithocholic acid  (ISO)
luteolin  (ISO)
LY294002  (EXP)
lycopene  (ISO)
m-tolualdehyde  (EXP)
m-xylene  (EXP,ISO)
malathion  (ISO)
mancozeb  (ISO)
mandelic acid  (ISO)
maneb  (EXP,ISO)
mangiferin  (EXP)
melatonin  (EXP,ISO)
menadione  (ISO)
mephenytoin  (ISO)
mercury dichloride  (EXP,ISO)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP,ISO)
methoxsalen  (EXP,ISO)
methoxychlor  (EXP,ISO)
methoxyflurane  (ISO)
Methylacrylonitrile  (EXP,ISO)
methyltestosterone  (ISO)
metronidazole  (EXP)
microcystin-LR  (ISO)
midazolam  (ISO)
mirex  (EXP)
Monobutylphthalate  (EXP)
monocrotophos  (EXP,ISO)
monosodium L-glutamate  (ISO)
muconic acid  (ISO)
myricetin  (ISO)
myricitrin  (ISO)
N'-(2,4-dimethylphenyl)-N-methylformamidine  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N,N-diisopropyltryptamine  (ISO)
N,N-dimethylformamide  (EXP,ISO)
N-acetyl-1,4-benzoquinone imine  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetyl-S-phenyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methylformamide  (EXP,ISO)
N-Nitrosodi-n-butylamine  (ISO)
N-Nitrosodi-n-propylamine  (ISO)
N-Nitrosodiethanolamine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-Nitrosomethylethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N-nitrosopiperidine  (ISO)
N-Nitrosopyrrolidine  (ISO)
NADP zwitterion  (EXP,ISO)
NADP(+)  (EXP,ISO)
naphthalene  (ISO)
nefazodone  (EXP)
Neferine  (EXP)
neobavaisoflavone  (EXP)
neomycin  (EXP)
nicotinamide  (EXP)
nicotine  (EXP)
nifedipine  (ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
nitroglycerin  (EXP)
Notopterol  (ISO)
o-anisidine  (ISO)
O-methyleugenol  (ISO)
o-xylene  (EXP,ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
oleanolic acid  (EXP,ISO)
oleic acid  (EXP,ISO)
oltipraz  (ISO)
omeprazole  (ISO)
orphenadrine  (ISO)
oxirane  (ISO)
oxycodone  (EXP)
ozone  (ISO)
p-cresol  (ISO)
p-xylene  (ISO)
paclitaxel  (EXP)
pantoprazole  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
pentachlorobenzene  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenacetin  (EXP)
phenanthrene  (ISO)
phenethyl caffeate  (EXP,ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenol  (EXP,ISO)
phenthoate  (ISO)
phenylglyoxylic acid  (ISO)
phenytoin  (EXP,ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phthalaldehyde  (ISO)
pioglitazone  (ISO)
piperidin-2-one  (ISO)
Pipermethystine  (EXP)
potassium dichromate  (ISO)
primaquine  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
profenofos  (ISO)
progesterone  (EXP,ISO)
prop-2-yn-1-ol  (EXP)
propacetamol  (ISO)
propan-2-ol  (EXP)
propetamphos  (EXP)
propiconazole  (EXP,ISO)
propylparaben  (EXP)
psoralen  (ISO)
psoralidin  (EXP)
puerarin  (ISO)
purpurogallin  (EXP)
pyrazinecarboxamide  (EXP)
pyrazines  (EXP)
pyrene  (EXP)
pyridine  (EXP,ISO)
pyridine N-oxide  (EXP)
pyridines  (EXP)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quinacrine  (EXP)
quinidine  (ISO)
quinoline  (EXP,ISO)
quinolines  (EXP)
rac-1,2-dichloropropane  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
Retrorsine  (EXP)
riddelliine  (EXP)
rifampicin  (EXP,ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (EXP,ISO)
S-adenosyl-L-methionine  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
safrole  (ISO)
Salidroside  (ISO)
salvianolic acid B  (EXP)
sanguinarine  (EXP)
satraplatin  (ISO)
SB 203580  (ISO)
SCH772984  (EXP)
selenium atom  (EXP)
senecionine  (ISO)
sevoflurane  (ISO)
Shikonin  (EXP,ISO)
silicon dioxide  (EXP,ISO)
sirolimus  (ISO)
skatole  (ISO)
sodium arsenite  (ISO)
sodium chromate  (EXP)
staurosporine  (EXP)
streptozocin  (EXP,ISO)
styrene  (EXP,ISO)
styrene oxide  (ISO)
Sudan I  (ISO)
sulforaphane  (ISO)
sunitinib  (EXP)
tamoxifen  (ISO)
taurine  (EXP,ISO)
tebuconazole  (EXP,ISO)
tenofovir disoproxil fumarate  (ISO)
tert-butyl ethyl ether  (EXP)
testosterone  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloroethene  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetrachlorophenol  (ISO)
tetracycline  (ISO)
tetrahydrocurcumin  (ISO)
tetraphene  (ISO)
thallium  (EXP)
theobromine  (ISO)
theophylline  (EXP,ISO)
thiacloprid  (ISO)
thiamine(1+) chloride  (EXP)
thiazoles  (EXP)
thioacetamide  (EXP,ISO)
thiophanate-methyl  (EXP)
thioridazine  (ISO)
thiostrepton  (ISO)
thiram  (EXP)
thymoquinone  (EXP)
Tiopronin  (EXP)
tirapazamine  (EXP)
titanium dioxide  (EXP,ISO)
toluene  (EXP,ISO)
trabectedin  (EXP)
trans-1,2-dichloroethene  (EXP,ISO)
trans-caffeic acid  (EXP)
trans-cinnamic acid  (ISO)
transfluthrin  (EXP)
tranylcypromine  (ISO)
triadimefon  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (EXP,ISO)
tryptamines  (ISO)
umbelliferone  (ISO)
uranium atom  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vanoxerine dihydrochloride  (ISO)
vinclozolin  (EXP,ISO)
vinyl carbamate  (EXP,ISO)
vitamin D  (ISO)
vitamin E  (EXP,ISO)
water  (ISO)
wortmannin  (EXP,ISO)
Wuweizisu C  (ISO)
XL147  (ISO)
zearalenone  (EXP)
zinc atom  (EXP,ISO)
zinc protoporphyrin  (EXP,ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylsalicylic acid pharmacodynamics pathway  (ISO)
antipyrine drug pathway  (ISO)
arachidonic acid metabolic pathway  (IEA,ISO)
caffeine pharmacokinetics pathway  (ISO)
celecoxib pharmacodynamics pathway  (ISO)
diclofenac pharmacodynamics pathway  (ISO)
diflunisal pharmacodynamics pathway  (ISO)
disulfiram pharmacodynamics pathway  (ISO)
etodolac pharmacodynamics pathway  (ISO)
felbamate pharmacokinetics pathway  (ISO)
fenoprofen pharmacodynamics pathway  (ISO)
flurbiprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
ketoprofen pharmacodynamics pathway  (ISO)
ketorolac pharmacodynamics pathway  (ISO)
leukotriene C4 synthase deficiency pathway  (ISO)
linoleic acid metabolic pathway  (IEA)
lornoxicam pharmacodynamics pathway  (ISO)
magnesium salicylate pharmacodynamics pathway  (ISO)
mefenamic acid pharmacodynamics pathway  (ISO)
meloxicam pharmacodynamics pathway  (ISO)
nabumetone pharmacodynamics pathway  (ISO)
naproxen pharmacodynamics pathway   (ISO)
paracetamol drug pathway   (ISO)
paracetamol pharmacokinetics pathway   (ISO)
paracetamol response pathway  (ISO)
phase I biotransformation pathway via cytochrome P450  (IEA)
phenytoin pharmacodynamics pathway  (ISO)
piroxicam pharmacodynamics pathway  (ISO)
salicylic acid pharmacodynamics pathway  (ISO)
sodium salicylate pharmacodynamics pathway  (ISO)
sulindac pharmacodynamics pathway  (ISO)
tenoxicam pharmacodynamics pathway  (ISO)
tiaprofenic acid pharmacodynamics pathway  (ISO)
tolmetin pharmacodynamics pathway  (ISO)
valdecoxib pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis. Abdelmegeed MA, etal., Free Radic Biol Med. 2013 Dec;65:1238-1245. doi: 10.1016/j.freeradbiomed.2013.09.009. Epub 2013 Sep 21.
2. Cytochrome P450-2E1 promotes aging-related hepatic steatosis, apoptosis and fibrosis through increased nitroxidative stress. Abdelmegeed MA, etal., Free Radic Biol Med. 2016 Feb;91:188-202. doi: 10.1016/j.freeradbiomed.2015.12.016. Epub 2015 Dec 17.
3. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Aboutabl ME, etal., Br J Pharmacol. 2009 Dec;158(7):1808-19. doi: 10.1111/j.1476-5381.2009.00461.x.
4. Date fruits inhibit hepatocyte apoptosis and modulate the expression of hepatocyte growth factor, cytochrome P450 2E1 and heme oxygenase-1 in carbon tetrachloride-induced liver fibrosis. Al-Rasheed NM, etal., Arch Physiol Biochem. 2017 May;123(2):78-92. doi: 10.1080/13813455.2016.1251945. Epub 2016 Dec 14.
5. Dilinoleoylphosphatidylcholine decreases ethanol-induced cytochrome P4502E1. Aleynik MK and Lieber CS, Biochem Biophys Res Commun 2001 Nov 9;288(4):1047-51.
6. Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism. Anandatheerthavarada HK, etal., J Biol Chem. 2009 Jun 19;284(25):17352-63. doi: 10.1074/jbc.M109.007492. Epub 2009 Apr 28.
7. Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary disease. Arif E, etal., Clin Chim Acta. 2007 Jul;382(1-2):37-42. Epub 2007 Mar 24.
8. [Genetic polymorphism of cytochrome P450 2E1 and the risk of nasopharyngeal carcinoma]. Ben Chaaben A, etal., Bull Cancer. 2015 Dec;102(12):967-72. doi: 10.1016/j.bulcan.2015.09.013. Epub 2015 Nov 12.
9. Genetic polymorphisms of NAT2 and CYP2E1 associated with antituberculosis drug-induced hepatotoxicity in Korean patients with pulmonary tuberculosis. Cho HJ, etal., Tuberculosis (Edinb). 2007 Nov;87(6):551-6.
10. Increased ethanol-inducible cytochrome P450-2E1 and cytochrome P450 isoforms in exosomes of alcohol-exposed rodents and patients with alcoholism through oxidative and endoplasmic reticulum stress. Cho YE, etal., Hepatol Commun. 2017 Jul 13;1(7):675-690. doi: 10.1002/hep4.1066. eCollection 2017 Sep.
11. Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumors. De Roos AJ, etal., Cancer Epidemiol Biomarkers Prev 2003 Jan;12(1):14-22.
12. Role of CYP2E1 gene polymorphisms association with hepatitis risk in Northeast India. Deka M, etal., World J Gastroenterol. 2010 Oct 14;16(38):4800-8. doi: 10.3748/wjg.v16.i38.4800.
13. Protective role of garlic oil against oxidative damage induced by furan exposure from weaning through adulthood in adult rat testis. El-Akabawy G and El-Sherif NM, Acta Histochem. 2016 Jun;118(5):456-63. doi: 10.1016/j.acthis.2016.04.008. Epub 2016 Apr 26.
14. Taurine is more effective than melatonin on cytochrome P450 2E1 and some oxidative stress markers in streptozotocin-induced diabetic rats. El-Batch M, etal., J Agric Food Chem. 2011 May 11;59(9):4995-5000. doi: 10.1021/jf1049547. Epub 2011 Mar 22.
15. CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease. Emery MG, etal., Hepatology. 2003 Aug;38(2):428-35.
16. Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats. Enriquez A, etal., Biochem Biophys Res Commun. 1999 Feb 16;255(2):300-6.
17. Functional PstI/RsaI polymorphism in CYP2E1 is associated with the development, progression and poor outcome of gastric cancer. Feng J, etal., PLoS One. 2012;7(9):e44478. doi: 10.1371/journal.pone.0044478. Epub 2012 Sep 5.
18. Protection from 1,1-dichloroethylene-induced Clara cell injury by diallyl sulfone, a derivative of garlic. Forkert PG, etal., J Pharmacol Exp Ther. 1996 Jun;277(3):1665-71.
19. Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability. Forsyth CB, etal., Am J Physiol Gastrointest Liver Physiol. 2013 Jul 15;305(2):G185-95. doi: 10.1152/ajpgi.00354.2012. Epub 2013 May 9.
20. Chemopreventive efficacy zingerone (4-[4-hydroxy-3-methylphenyl] butan-2-one) in experimental colon carcinogenesis in Wistar rats. Ganaie MA, etal., Environ Toxicol. 2019 May;34(5):610-625. doi: 10.1002/tox.22727. Epub 2019 Feb 5.
21. Genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 associated with head and neck cancer. Gattás GJ, etal., Head Neck. 2006 Sep;28(9):819-26. doi: 10.1002/hed.20410.
22. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
23. Aplysin Protects Against Alcohol-Induced Liver Injury Via Alleviating Oxidative Damage and Modulating Endogenous Apoptosis-Related Genes Expression in Rats. Ge N, etal., J Food Sci. 2018 Oct;83(10):2612-2621. doi: 10.1111/1750-3841.14320. Epub 2018 Sep 7.
24. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
25. Coexistence of hyperlipidemia and acute cerebral ischemia/reperfusion induces severe liver damage in a rat model. Gong WH, etal., World J Gastroenterol. 2012 Sep 21;18(35):4934-43. doi: 10.3748/wjg.v18.i35.4934.
26. Association of genetic polymorphisms of aldehyde dehydrogenase-2 and cytochrome P450 2E1-RsaI and alcohol consumption with oral squamous cell carcinoma. Guo LK, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2012 Aug;34(4):390-5. doi: 10.3881/j.issn.1000-503X.2012.04.015.
27. Role of Inflammatory and Oxidative Stress, Cytochrome P450 2E1, and Bile Acid Disturbance in Rat Liver Injury Induced by Isoniazid and Lipopolysaccharide Cotreatment. Hassan HM, etal., Antimicrob Agents Chemother. 2016 Aug 22;60(9):5285-93. doi: 10.1128/AAC.00854-16. Print 2016 Sep.
28. Cytochrome P4502E1 (CYP2E1) expression in peripheral blood lymphocytes: evaluation in hepatitis C and diabetes. Haufroid V, etal., Eur J Clin Pharmacol. 2003 May;59(1):29-33. Epub 2003 Mar 22.
29. Decreased Cyp2E1 mRNA expression in human leucocytes in patients with fibrotic and inflammatory lung diseases. Helmig S, etal., Int J Mol Med. 2010 Jul;26(1):143-9.
30. A review of acetaminophen poisoning. Hodgman MJ and Garrard AR, Crit Care Clin. 2012 Oct;28(4):499-516. doi: 10.1016/j.ccc.2012.07.006.
31. Total sesquiterpene glycosides from Loquat (Eriobotrya japonica) leaf alleviate high-fat diet induced non-alcoholic fatty liver disease through cytochrome P450 2E1 inhibition. Jian T, etal., Biomed Pharmacother. 2017 Jul;91:229-237. doi: 10.1016/j.biopha.2017.04.056. Epub 2017 Apr 28.
32. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
33. Obesity-induced increase of CYP2E1 activity and its effect on disposition kinetics of chlorzoxazone in Zucker rats. Khemawoot P, etal., Biochem Pharmacol. 2007 Jan 1;73(1):155-62. Epub 2006 Sep 14.
34. Red meat intake, CYP2E1 and PPARγ polymorphisms, and colorectal cancer risk. Kim NH, etal., Eur J Cancer Prev. 2019 Jul;28(4):304-310. doi: 10.1097/CEJ.0000000000000462.
35. Genetic polymorphisms in the cytochromes P-450 (1A1, 2E1), microsomal epoxide hydrolase and glutathione S-transferase M1, T1, and P1 genes, and their relationship with chronic bronchitis and relapsing pneumonia in children. Korytina GF, etal., J Mol Med. 2005 Sep;83(9):700-10. Epub 2005 Jun 1.
36. [Role of polymorphic variants of cytochrome P450 genes (CYP1A1, CYP2E1) and microsomal epoxide hydrolase (mEPHX) in pathogenesis of cystic fibrosis and chronic respiratory tract diseases] Korytina GF, etal., Mol Biol (Mosk). 2003 Sep-Oct;37(5):784-92.
37. Hepatic drug metabolizing profile of Flinders Sensitive Line rat model of depression. Kotsovolou O, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1075-84. Epub 2010 Jun 4.
38. Chronic ethanol ingestion induces oxidative kidney injury through taurine-inhibitable inflammation. Latchoumycandane C, etal., Free Radic Biol Med. 2014 Apr;69:403-16. doi: 10.1016/j.freeradbiomed.2014.01.001. Epub 2014 Jan 8.
39. Constitutive and inducible expression of hepatic CYP2E1 in leptin-deficient ob/ob mice. Leclercq IA, etal., Biochem Biophys Res Commun. 2000 Feb 16;268(2):337-44.
40. Interleukin-32γ attenuates ethanol-induced liver injury by the inhibition of cytochrome P450 2E1 expression and inflammatory responses. Lee DH, etal., Clin Sci (Lond). 2015 May 1;128(10):695-706. doi: 10.1042/CS20140576.
41. Suppression of hepatic cytochrome p450-mediated drug metabolism during the late stage of sepsis in rats. Lee SH and Lee SM, Shock. 2005 Feb;23(2):144-9.
42. NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-tuberculosis drug-induced hepatitis. Lee SW, etal., Int J Tuberc Lung Dis. 2010 May;14(5):622-6.
43. Increased cytochrome P-450 2E1 expression sensitizes hepatocytes to c-Jun-mediated cell death from TNF-alpha. Liu H, etal., Am J Physiol Gastrointest Liver Physiol 2002 Feb;282(2):G257-66.
44. Autoantibodies against cytochromes P-4502E1 and P-4503A in alcoholics. Lytton SD, etal., Mol Pharmacol. 1999 Feb;55(2):223-33. doi: 10.1124/mol.55.2.223.
45. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. McGill MR and Jaeschke H, Pharm Res. 2013 Sep;30(9):2174-87. doi: 10.1007/s11095-013-1007-6. Epub 2013 Mar 6.
46. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
47. Identification of rat cytochromes P450 metabolizing N-(2-methoxyphenyl)hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole. Naiman K, etal., Neuro Endocrinol Lett. 2010 Dec 28;31(Suppl2).
48. Effect of nanoformulated copper/zinc superoxide dismutase on chronic ethanol-induced alterations in liver and adipose tissue. Natarajan G, etal., Alcohol. 2019 Sep;79:71-79. doi: 10.1016/j.alcohol.2018.12.005. Epub 2019 Jan 3.
49. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
50. Enzyme-specific transport of rat liver cytochrome P450 to the Golgi apparatus. Neve EP, etal., Arch Biochem Biophys. 1996 Sep 15;333(2):459-65.
51. Identification of sequences responsible for intracellular targeting and membrane binding of rat CYP2E1 in yeast. Neve EP, etal., Biochemistry. 2003 Dec 16;42(49):14566-75.
52. Cytochrome P450 2E1-derived reactive oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells. Nieto N, etal., J Biol Chem 2002 Mar 22;277(12):9853-64. Epub 2002 Jan 8.
53. Relationship between genetic polymorphism of cytochrome P450IIE1 and fatty liver. Piao YF, etal., World J Gastroenterol. 2003 Nov;9(11):2612-5.
54. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
55. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
56. Influence of acetaminophen and trichloroethylene on liver cytochrome P450-dependent monooxygenase system. Plewka A, etal., Acta Biochim Pol 2000;47(4):1129-36.
57. Acetaminophen induces apoptosis in rat cortical neurons. Posadas I, etal., PLoS One. 2010 Dec 10;5(12):e15360.
58. A rodent model of low- to moderate-dose ethanol consumption during pregnancy: patterns of ethanol consumption and effects on fetal and offspring growth. Probyn ME, etal., Reprod Fertil Dev. 2012;24(6):859-70. doi: 10.1071/RD11200.
59. Effect of ammonium pyrrolidine dithiocarbamate (PDTC) on NF-κB activation and CYP2E1 content of rats with immunological liver injury. Qin JD, etal., Pharm Biol. 2014 Nov;52(11):1460-6. doi: 10.3109/13880209.2014.898075. Epub 2014 Jun 25.
60. Protective effect of iridoid glucosides from Boschniakia rossica on acute liver injury induced by carbon tetrachloride in rats. Quan J, etal., Biosci Biotechnol Biochem. 2009 Apr 23;73(4):849-54. Epub 2009 Apr 7.
61. GOA pipeline RGD automated data pipeline
62. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
63. Ethanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytes. Robin MA, etal., FEBS Lett. 2005 Dec 19;579(30):6895-902. Epub 2005 Dec 1.
64. The role of ethanol metabolism in development of alcoholic steatohepatitis in the rat. Ronis MJ, etal., Alcohol. 2010 Mar;44(2):157-69. Epub 2010 Jan 29.
65. Ethanol concentration-dependent alterations in gene expression during acute binge drinking in the HIV-1 transgenic rat. Sarkar S and Chang SL, Alcohol Clin Exp Res. 2013 Jul;37(7):1082-90. doi: 10.1111/acer.12077. Epub 2013 Feb 15.
66. Type 1 diabetic mice are protected from acetaminophen hepatotoxicity. Shankar K, etal., Toxicol Sci. 2003 Jun;73(2):220-34. Epub 2003 Apr 15.
67. CYP2E1 testis expression and alcohol-mediated changes of rat spermatogenesis indices and type I collagen. Shayakhmetova GM, etal., Arh Hig Rada Toksikol. 2013 Jun;64(2):51-60. doi: 10.2478/10004-1254-64-2013-2313.
68. Methylation of cytochrome p450 2E1 promoter induced by low dosage of isoniazid. Shen L, etal., Environ Toxicol Pharmacol. 2013 Jul;36(1):149-51. doi: 10.1016/j.etap.2013.03.016. Epub 2013 Apr 2.
69. Loss of Nrf2 in mice evokes a congenital intrahepatic shunt that alters hepatic oxygen and protein expression gradients and toxicity. Skoko JJ, etal., Toxicol Sci. 2014 Sep;141(1):112-9. doi: 10.1093/toxsci/kfu109. Epub 2014 Jun 12.
70. Dietary tomato powder inhibits alcohol-induced hepatic injury by suppressing cytochrome p450 2E1 induction in rodent models. Stice CP, etal., Arch Biochem Biophys. 2015 Apr 15;572:81-88. doi: 10.1016/j.abb.2015.01.004. Epub 2015 Jan 12.
71. The cytochromes P450 (CYP) response to allergic inflammation of the lung. Stoilov I, etal., Arch Biochem Biophys. 2006 Dec 1;456(1):30-8. Epub 2006 Oct 16.
72. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
73. Pioglitazone, quercetin and hydroxy citric acid effect on cytochrome P450 2E1 (CYP2E1) enzyme levels in experimentally induced non alcoholic steatohepatitis (NASH). Surapaneni KM, etal., Eur Rev Med Pharmacol Sci. 2014;18(18):2736-41.
74. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
75. Beneficial effects of Vitis coignetiae Pulliat leaves on nonalcoholic steatohepatitis in a rat model. Takayama F, etal., Acta Med Okayama. 2009 Apr;63(2):105-11.
76. SUMOylation regulates cytochrome P450 2E1 expression and activity in alcoholic liver disease. Tomasi ML, etal., FASEB J. 2018 Jun;32(6):3278-3288. doi: 10.1096/fj.201701124R. Epub 2018 Jan 18.
77. Liver injury following renal ischemia reperfusion in rats. Wang B, etal., Transplant Proc. 2010 Nov;42(9):3422-6.
78. Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans. Wang Z, etal., Br J Clin Pharmacol. 2003 Jan;55(1):77-85.
79. Inhibition of cytochrome P450 2E1 and activation of transcription factor Nrf2 are renoprotective in myoglobinuric acute kidney injury. Wang Z, etal., Kidney Int. 2014 Aug;86(2):338-49. doi: 10.1038/ki.2014.65. Epub 2014 Apr 9.
80. Cytochrome P450 2E1 in rat tracheobronchial airways: response to ozone exposure. Watt KC, etal., Toxicol Appl Pharmacol. 1998 Apr;149(2):195-202.
81. Cyclosporine A protects against arachidonic acid toxicity in rat hepatocytes: role of CYP2E1 and mitochondria. Wu D and Cederbaum AI, Hepatology 2002 Jun;35(6):1420-30.
82. Role of p38 MAPK in CYP2E1-dependent arachidonic acid toxicity. Wu D and Cederbaum AI, J Biol Chem 2003 Jan 10;278(2):1115-24.
83. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. Xu J, etal., Hepatol Commun. 2017 Oct 30;1(10):1043-1057. doi: 10.1002/hep4.1115. eCollection 2017 Dec.
84. Cytochrome P450 2E1 is responsible for the initiation of 1,2-dichloropropane-induced liver damage. Yanagiba Y, etal., Toxicol Ind Health. 2016 Sep;32(9):1589-97. doi: 10.1177/0748233714568801. Epub 2015 Feb 13.
85. Effect of taurine supplementation on cytochrome P450 2E1 and oxidative stress in the liver and kidneys of rats with streptozotocin-induced diabetes. Yao HT, etal., Food Chem Toxicol. 2009 Jul;47(7):1703-9. Epub 2009 May 3.
86. Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats. Ye Q, etal., Hepatobiliary Surg Nutr. 2012 Dec;1(1):5-18. doi: 10.3978/j.issn.2304-3881.2012.11.05. Epub 2012 Nov 30.
87. Genetic variants of ALDH2-rs671 and CYP2E1-rs2031920 contributed to risk of hepatocellular carcinoma susceptibility in a Chinese population. Ye X, etal., Cancer Manag Res. 2018 May 4;10:1037-1050. doi: 10.2147/CMAR.S162105. eCollection 2018.
88. [Association between aldehyde dehydrogenase-2/cytochrome P450 2E1 genetic polymorphism and habit of alcohol drinking and the susceptibility of hepatocellular carcinoma]. Ye X, etal., Wei Sheng Yan Jiu. 2010 Jan;39(1):42-5.
89. Exacerbation of benzene pneumotoxicity in connexin 32 knockout mice: enhanced proliferation of CYP2E1-immunoreactive alveolar epithelial cells. Yoon BI, etal., Toxicology. 2004 Jan 15;195(1):19-29.
90. Protective effect of acidic polysaccharide from Schisandra chinensis on acute ethanol-induced liver injury through reducing CYP2E1-dependent oxidative stress. Yuan R, etal., Biomed Pharmacother. 2018 Mar;99:537-542. doi: 10.1016/j.biopha.2018.01.079. Epub 2018 Feb 20.
91. Binge alcohol promotes hypoxic liver injury through a CYP2E1-HIF-1α-dependent apoptosis pathway in mice and humans. Yun JW, etal., Free Radic Biol Med. 2014 Dec;77:183-94. doi: 10.1016/j.freeradbiomed.2014.08.030. Epub 2014 Sep 16.
92. Correlation of CpG Island Methylation of the Cytochrome P450 2E1/2D6 Genes with Liver Injury Induced by Anti-Tuberculosis Drugs: A Nested Case-Control Study. Zhang J, etal., Int J Environ Res Public Health. 2016 Aug 1;13(8). pii: ijerph13080776. doi: 10.3390/ijerph13080776.
93. Altered ethylbenzene-mediated hepatic CYP2E1 expression in growth hormone-deficient dwarf rats. Zhang S, etal., Toxicol Appl Pharmacol 2002 Mar 1;179(2):74-82.
94. Expression of P450 enzymes in rat whole skin and cultured epidermal keratinocytes. Zhu Z, etal., Biochem Biophys Res Commun 2002 Sep 13;297(1):65.
Additional References at PubMed
PMID:1441586   PMID:2321956   PMID:2832413   PMID:3308889   PMID:3782137   PMID:9348445   PMID:10553002   PMID:12191992   PMID:12270935   PMID:12470497   PMID:12529372   PMID:12604681  
PMID:12777398   PMID:14642533   PMID:14693714   PMID:14767997   PMID:15162526   PMID:15189336   PMID:15489334   PMID:15632182   PMID:15680923   PMID:15763544   PMID:15797236   PMID:16223484  
PMID:16306132   PMID:16331994   PMID:16374848   PMID:16380384   PMID:16401082   PMID:16878272   PMID:16904701   PMID:16962935   PMID:17058263   PMID:17366540   PMID:17431589   PMID:17587688  
PMID:17681033   PMID:17697118   PMID:17881659   PMID:17949244   PMID:18071271   PMID:18288650   PMID:18326880   PMID:18356043   PMID:18652256   PMID:18818195   PMID:18990514   PMID:19219744  
PMID:19285975   PMID:19336974   PMID:19651758   PMID:19848203   PMID:20522591   PMID:20529841   PMID:21224420   PMID:21813270   PMID:22357518   PMID:22396533   PMID:22885143   PMID:23012479  
PMID:23044233   PMID:23235327   PMID:23892269   PMID:23920219   PMID:24021170   PMID:24500986   PMID:24771067   PMID:25038063   PMID:25323755   PMID:25330250   PMID:25683034   PMID:26463279  
PMID:27314315   PMID:28385499   PMID:28555194   PMID:28803882   PMID:28864499   PMID:31116889   PMID:31881060   PMID:32093091   PMID:32777474   PMID:34830430   PMID:35523980   PMID:35780828  
PMID:37195324   PMID:37499993   PMID:37657698  


Genomics

Comparative Map Data
Cyp2e1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,269,967 - 205,280,365 (+)NCBIGRCr8
mRatBN7.21195,840,330 - 195,850,728 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1195,840,058 - 195,864,023 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,182,795 - 204,193,148 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,309,700 - 211,320,053 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01203,983,553 - 203,993,906 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,511,892 - 213,522,195 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,511,874 - 213,535,542 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,405,975 - 220,416,727 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41200,918,521 - 200,928,919 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,068,525 - 201,078,911 (+)NCBI
Celera1193,484,404 - 193,494,772 (+)NCBICelera
Cytogenetic Map1q41NCBI
CYP2E1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810133,527,363 - 133,539,123 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10133,520,406 - 133,561,220 (+)EnsemblGRCh38hg38GRCh38
GRCh3710135,340,867 - 135,352,627 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610135,190,857 - 135,202,610 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410135,229,747 - 135,241,501NCBI
Celera10128,168,529 - 128,180,282 (-)NCBICelera
Cytogenetic Map10q26.3NCBI
HuRef10128,882,691 - 128,894,624 (+)NCBIHuRef
CHM1_110135,620,490 - 135,632,188 (+)NCBICHM1_1
T2T-CHM13v2.010134,478,949 - 134,490,654 (+)NCBIT2T-CHM13v2.0
Cyp2e1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,343,732 - 140,354,903 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7140,343,652 - 140,354,900 (+)EnsemblGRCm39 Ensembl
GRCm387140,763,819 - 140,774,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7140,763,739 - 140,774,987 (+)EnsemblGRCm38mm10GRCm38
MGSCv377147,949,731 - 147,960,880 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367140,615,152 - 140,626,301 (+)NCBIMGSCv36mm8
Celera7140,556,087 - 140,567,236 (+)NCBICelera
Cytogenetic Map7F4NCBI
cM Map785.94NCBI
LOC102026028
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555076,289,576 - 6,304,193 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555076,293,162 - 6,303,255 (-)NCBIChiLan1.0ChiLan1.0
CYP2E1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28145,644,624 - 145,686,410 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110145,649,978 - 145,691,767 (+)NCBINHGRI_mPanPan1
PanPan1.110134,839,025 - 134,852,053 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10134,839,025 - 134,852,719 (+)Ensemblpanpan1.1panPan2
CYP2E1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12841,079,164 - 41,089,188 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2841,035,025 - 41,122,754 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2841,171,673 - 41,181,706 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02841,754,551 - 41,764,586 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2841,754,522 - 41,764,585 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12841,235,594 - 41,245,625 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02841,224,985 - 41,235,013 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02841,627,674 - 41,637,700 (+)NCBIUU_Cfam_GSD_1.0
LOC101973029
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244072135,858,593 - 5,869,493 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648619,691,822 - 19,702,102 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648619,691,822 - 19,702,684 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP2E1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14141,690,426 - 141,736,817 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114141,690,737 - 141,703,078 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214153,478,051 - 153,490,404 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP2E1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12653,390,054 - 53,403,309 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2653,390,089 - 53,404,211 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605441,523,569 - 41,534,845 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101722366
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473712,335,681 - 12,345,514 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473712,335,733 - 12,345,278 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cyp2e1
28 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:9
Count of miRNA genes:9
Interacting mature miRNAs:9
Transcripts:ENSRNOT00000016883
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1117917486196963478Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1181746937196383668Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1192485903199050587Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1189607473200611765Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1123556856196963478Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat

Markers in Region
D1Smu4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21195,841,852 - 195,842,092 (+)MAPPERmRatBN7.2
Rnor_6.01213,513,415 - 213,513,654NCBIRnor6.0
Rnor_5.01220,407,852 - 220,408,091UniSTSRnor5.0
RGSC_v3.41200,920,044 - 200,920,283UniSTSRGSC3.4
Celera1193,485,927 - 193,486,166UniSTS
Cytogenetic Map1q41-q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 11 49 60 91 90 59 25 59 6 217 97 40 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF045572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF056333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF061442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M20131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000016883   ⟹   ENSRNOP00000016883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1195,840,058 - 195,850,728 (+)Ensembl
Rnor_6.0 Ensembl1213,511,892 - 213,522,195 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078080   ⟹   ENSRNOP00000073600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1195,840,311 - 195,864,023 (+)Ensembl
Rnor_6.0 Ensembl1213,511,874 - 213,535,542 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098359   ⟹   ENSRNOP00000083600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1195,840,311 - 195,850,728 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101512   ⟹   ENSRNOP00000081291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1195,840,311 - 195,850,728 (+)Ensembl
RefSeq Acc Id: NM_031543   ⟹   NP_113731
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,269,967 - 205,280,365 (+)NCBI
mRatBN7.21195,840,330 - 195,850,728 (+)NCBI
Rnor_6.01213,511,892 - 213,522,195 (+)NCBI
Rnor_5.01220,405,975 - 220,416,727 (+)NCBI
RGSC_v3.41200,918,521 - 200,928,919 (+)RGD
Celera1193,484,404 - 193,494,772 (+)RGD
Sequence:
RefSeq Acc Id: NP_113731   ⟸   NM_031543
- UniProtKB: P05182 (UniProtKB/Swiss-Prot),   A6HXJ0 (UniProtKB/TrEMBL),   A0A8L2Q8J4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016883   ⟸   ENSRNOT00000016883
Ensembl Acc Id: ENSRNOP00000073600   ⟸   ENSRNOT00000078080
Ensembl Acc Id: ENSRNOP00000083600   ⟸   ENSRNOT00000098359
Ensembl Acc Id: ENSRNOP00000081291   ⟸   ENSRNOT00000101512

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05182-F1-model_v2 AlphaFold P05182 1-493 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690527
Promoter ID:EPDNEW_R1038
Type:multiple initiation site
Name:Cyp2e1_1
Description:cytochrome P450, family 2, subfamily e, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01213,511,874 - 213,511,934EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2475 AgrOrtholog
BioCyc Gene G2FUF-57017 BioCyc
Ensembl Genes ENSRNOG00000012458 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016883.7 UniProtKB/TrEMBL
  ENSRNOT00000078080.2 UniProtKB/TrEMBL
  ENSRNOT00000098359.1 UniProtKB/TrEMBL
  ENSRNOT00000101512.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110096 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP2E-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cytochrome_P450_fam2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25086 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93361 IMAGE-MGC_LOAD
NCBI Gene 25086 ENTREZGENE
PANTHER CYTOCHROME P450 2E1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CYP2E1 RGD
PhenoGen Cyp2e1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450ICYP2E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012458 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K5X9_RAT UniProtKB/TrEMBL
  A0A8I5ZS79_RAT UniProtKB/TrEMBL
  A0A8I5ZXI6_RAT UniProtKB/TrEMBL
  A0A8L2Q8J4 ENTREZGENE, UniProtKB/TrEMBL
  A6HXJ0 ENTREZGENE, UniProtKB/TrEMBL
  A6HXJ1_RAT UniProtKB/TrEMBL
  A6HXJ2_RAT UniProtKB/TrEMBL
  A6HXJ3_RAT UniProtKB/TrEMBL
  A6HXJ4_RAT UniProtKB/TrEMBL
  CP2E1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q71US7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cyp2e1  cytochrome P450, family 2, subfamily e, polypeptide 1    cytochrome P450, subfamily 2E, polypeptide 1  Name updated 1299863 APPROVED
2002-11-06 Cyp2e1  cytochrome P450, subfamily 2E, polypeptide 1    cytochrome P450, subfamily 2e1 (ethanol-inducible)  Name updated 625702 APPROVED
2002-06-10 Cyp2e1  cytochrome P450, subfamily 2e1 (ethanol-inducible)      Symbol and Name status set to approved 70586 APPROVED
2002-02-15 Cyp2e  Cytochrome P450, IIE (ethanol inducible)      Object retired and merged with RGD:2475 68913 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_disease overexpression correlates with alcoholic liver disease and nonalcoholic steatohepatitis 70809
gene_expression expressed in liver and skin 625597
gene_mutations_overexpression overexpression results in changing the hepatocyte TNF- response from proliferation to apoptotic and necrotic cell death, and this is blocked by antioxidants or adenoviral expression of a dominant-negative c-Jun 70809
gene_process mediates oxidative metabolism of endogenous and foreign compounds, including ethanol 61490
gene_process mediates oxidative metabolism of endogenous and foreign compounds, including ethanol 70809