Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

PARACETAMOL DRUG PATHWAY (PW:0001524)

View Ontology Report

Description

Paracetamol or N-acetyl-p-aminophenol (APAP), also known as acetaminophen or by its trade name in the USA as Tylenol, is a widely used analgesic and antipyretic drug. However, overdose of paracetamol - accidental or intentional - is associated with hepatotoxicity and a leading cause of liver failure. APAP metabolism occurs mostly in the liver where it is primarily subject to glucuronidation and sulfation by members of phase II biotransformation enzymes. To a lesser extent, it is also metaboliz

Pathway Diagram:

Elsevier Inc. Ptgs2 Ptgs1 prostanoid biosynthetic pathway ---> various responses elicited by signaling via prostanoids various responses elicited by signaling via prostanoids prostanoid biosynthetic pathway arachidonic acid PGH2 PGG2 cyclooxygenase mediated pathway of arachidonic acid metabolism paracetamol pharmacokinetics pathway arachidonic acid metabolic pathway paracetamol response pathway paracetamol paracetamol ---> paracetamol pharmacokinetics pathway arachidonic acid ---> PGG2 paracetamol --+> paracetamol response pathway PGG2 ---> PGH2 paracetamol ---| Ptgs1 paracetamol ---| Ptgs2 paracetamol ---| prostanoid biosynthetic pathway PGH2 --+> prostanoid biosynthetic pathway Pain Fever paracetamol ---| Fever paracetamol ---| Pain
GO TO:

Genes in Pathway:


show annotations for term's descendants           Sort by:
paracetamol drug pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 ISO SMPDB SMP:00710 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type ISO SMPDB SMP:00710 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type ISO SMPDB SMP:00710 NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938
JBrowse link
G Alox15 arachidonate 15-lipoxygenase ISO SMPDB SMP:00710 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
JBrowse link
G Alox15b arachidonate 15-lipoxygenase, type B ISO SMPDB SMP:00710 NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812
JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO SMPDB SMP:00710 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Cbr1 carbonyl reductase 1 ISO SMPDB SMP:00710 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 ISO SMPDB SMP:00710 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 ISO SMPDB SMP:00710
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO SMPDB SMP:00710 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 ISO SMPDB SMP:00710 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp2u1 cytochrome P450, family 2, subfamily u, polypeptide 1 ISO SMPDB SMP:00710 NCBI chr 2:219,849,403...219,866,959
Ensembl chr 2:219,849,407...219,866,882
JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 ISO SMPDB SMP:00710 NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940
JBrowse link
G Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 ISO SMPDB SMP:00710 NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782
JBrowse link
G Ephx2 epoxide hydrolase 2 ISO SMPDB SMP:00710 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO SMPDB SMP:00710 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Gpx1 glutathione peroxidase 1 ISO SMPDB SMP:00710 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Lta4h leukotriene A4 hydrolase ISO SMPDB SMP:00710 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
JBrowse link
G Ltc4s leukotriene C4 synthase ISO SMPDB SMP:00710 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
JBrowse link
G Pla2g4b phospholipase A2 group IVB ISO SMPDB SMP:00710 NCBI chr 3:107,004,238...107,013,853
Ensembl chr 3:107,005,489...107,013,853
JBrowse link
G Prxl2b peroxiredoxin like 2B ISO SMPDB SMP:00710 NCBI chr 5:165,462,610...165,465,213 JBrowse link
G Ptgds prostaglandin D2 synthase ISO SMPDB SMP:00710 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
JBrowse link
G Ptges prostaglandin E synthase ISO SMPDB SMP:00710 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptgis prostaglandin I2 synthase ISO SMPDB SMP:00710 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO SMPDB
RGD
PMID:23719833 SMP:00710, RGD:8552695 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO SMPDB
RGD
PMID:23719833 SMP:00710, RGD:8552695 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tbxas1 thromboxane A synthase 1 ISO SMPDB SMP:00710 NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096
JBrowse link
paracetamol pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO SMPDB SMP:00640 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00640 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 TAS RGD PMID:23462933 RGD:8552693 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 TAS RGD PMID:23462933 RGD:8552693 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 TAS
ISO
SMPDB
RGD
PMID:23462933 SMP:00640, RGD:8552693 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 ISO SMPDB SMP:00640 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 TAS
ISO
SMPDB
RGD
PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 ISO SMPDB SMP:00640 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 ISO SMPDB SMP:00640 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO SMPDB
RGD
PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 ISO SMPDB SMP:00640 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00640 NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407
JBrowse link
G Erp29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00640 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376
JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO SMPDB SMP:00640 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstt1 glutathione S-transferase theta 1 ISO SMPDB SMP:00640 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00640 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00640 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hyou1 hypoxia up-regulated 1 ISO SMPDB SMP:00640 NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186
JBrowse link
G Pdia2 protein disulfide isomerase family A, member 2 ISO SMPDB SMP:00640 NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 ISO SMPDB SMP:00640 NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 ISO SMPDB SMP:00640 NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613
JBrowse link
G Ppib peptidylprolyl isomerase B ISO SMPDB SMP:00640 NCBI chr 8:66,603,877...66,609,734
Ensembl chr 8:66,603,861...66,630,428
JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 ISO SMPDB SMP:00640 NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 ISO SMPDB SMP:00640 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 ISO SMPDB
RGD
PMID:23462933 SMP:00640, RGD:8552693 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 ISO SMPDB SMP:00640 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 ISO SMPDB
RGD
PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 ISO SMPDB
RGD
PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 ISO SMPDB SMP:00640 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link

Pathway Gene Annotations

Disease Annotations Associated with Genes in the paracetamol drug pathway
Disease TermsGene Symbols
3-Hydroxyacyl-CoA Dehydrogenase DeficiencyCyp2u1
abdominal aortic aneurysmGpx1 , Ptgs2
acoustic neuromaCyp2e1
Acute Coronary SyndromeGpx1
acute kidney failureAlox5 , Cyp2e1 , Ephx2 , Ptgs2
Acute Liver FailureLtc4s , Ptgs2
Acute Lung InjuryAlox15 , Ephx2 , Ptgs2
acute lymphoblastic leukemiaCyp2c79 , Cyp2e1 , Gpx1
Acute Lymphoblastic Leukemia, with Lymphomatous FeaturesCyp2b3
acute myeloid leukemiaCyp2b3 , Gpx1
acute necrotizing pancreatitisTbxas1
acute promyelocytic leukemiaLtc4s
Adams-Oliver Syndrome 5Ptgds
adenocarcinomaAlox12b , Alox5 , Cyp2e1 , Lta4h , Ptgs2
adenomaAlox5
Adrenal Gland NeoplasmsPtgs2
aflatoxins-related hepatocellular carcinomaGgt1
Aicardi-Goutieres Syndrome 1Gpx1
AlbuminuriaAlox12 , Ggt1 , Ptgs2
alcohol dependenceCyp2e1 , Ggt1
alcohol use disorderCyp2e1 , Ggt1
Alcohol Withdrawal DeliriumPtgs2
Alcoholic Fatty LiverCyp2e1
alcoholic liver cirrhosisCyp2e1
Alcoholic Liver DiseasesCyp2e1 , Tbxas1
allergic rhinitisPtgs2
alpha thalassemiaGpx1
Alzheimer's diseaseAlox15 , Ptgs1 , Ptgs2
amenorrheaCyp2e1
amyotrophic lateral sclerosisPtgs2
amyotrophic lateral sclerosis type 1Cbr1
AnaphylaxisPtgs1 , Ptgs2
anemiaGpx1
Animal Mammary NeoplasmsGgt1
AnorexiaGpx1 , Ptgs2
aortic aneurysmAlox5
Arterial Occlusive DiseasesPtgis
arteriosclerosisAlox5 , Gpx1 , Ptgds , Ptgs2 , Tbxas1
asbestosisCyp2e1
asphyxia neonatorumPtgs2
aspirin-induced respiratory diseaseLtc4s , Ptgs2
asthmaAlox15 , Alox5 , Cyp2e1 , Lta4h , Ptgs2
asthma, nasal polyps, and aspirin intoleranceAlox15 , Ltc4s
atherosclerosisAlox15 , Alox5 , Ephx2 , Lta4h , Ptgis , Ptgs2
autism spectrum disorderAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2j4 , Cyp2u1 , Cyp4f6 , Ephx2 , Ptges , Ptgis , Ptgs1
autistic disorderGpx1 , Ptgs2
autosomal dominant intellectual developmental disorder 7Cbr1
autosomal dominant intellectual developmental disorder 8Ptgds
autosomal dominant nocturnal frontal lobe epilepsyEphx2
autosomal dominant nocturnal frontal lobe epilepsy 5Ptgds
autosomal recessive congenital ichthyosisAlox12b
autosomal recessive congenital ichthyosis 1Alox12b
autosomal recessive congenital ichthyosis 2Alox12b
autosomal recessive limb-girdle muscular dystrophy type 2PGpx1
avian influenzaPtgs2
B-Cell Chronic Lymphocytic LeukemiaPtgs2
B-cell lymphomaPtgs2
B-lymphoblastic leukemia/lymphomaAkr1c3
bacterial pneumoniaCyp2j4
Barrett's esophagusPtges , Ptgs2
benign familial infantile seizures 6Ephx2
biliary atresiaGgt1
Binge DrinkingCyp2e1 , Gpx1
bipolar disorderPtgs1 , Ptgs2
bladder neck obstructionPtgs2
Bloom syndromePla2g4b
Bone FracturesAlox5 , Ptgs2
Bone MetastasisAlox12
Bone NeoplasmsPtgs2
brain infarctionTbxas1
Brain InjuriesEphx2 , Gpx1 , Ptgs1 , Ptgs2
brain ischemiaAlox15 , Alox5 , Gpx1 , Ptgis , Ptgs1 , Ptgs2
breast cancerAlox12 , Gpx1 , Ptgs1
breast ductal carcinomaAlox5
Breast NeoplasmsGpx1 , Ptges , Ptgs1 , Ptgs2
Bronchial HyperreactivityPtgs1
BurnsPtgs2
CachexiaPtgs2
Cadmium PoisoningGpx1
Calcification of Aortic ValvePtgs2
calcinosisGpx1
Carbon Tetrachloride PoisoningGpx1
carcinomaGgt1 , Ptgs1 , Ptgs2
cardiac arrestEphx2
Cardiac ArrhythmiasPtgs2
CardiomegalyCyp2e1
cardiomyopathyCbr1 , Ptgs2
Cardiovascular AbnormalitiesGpx1
cardiovascular system diseaseGpx1 , Ptgs2
carotid artery diseasePtgds
Carotid Artery InjuriesAlox12 , Ptgis
carotid stenosisGpx1 , Ptgis
Carpenter Syndrome 2Cyp2b3
castration-resistant prostate carcinomaAkr1c3
cataractGpx1
cerebral cavernous malformation 1Ptgis
Cerebral HemorrhagePtgs2
cerebral infarctionEphx2 , Ptgis , Tbxas1
cervix carcinomaPtgs1
cervix uteri carcinoma in situPtgs2
Chemical and Drug Induced Liver InjuryCyp2b3 , Cyp2e1 , Ggt1 , Ptgs2
Chemical BurnsAlox12
Childhood SchizophreniaPtgis
cholangiocarcinomaAlox5 , Ptgs2
cholestasisCyp2b3
chromosome 1p36 deletion syndromePrxl2b
Chronic BronchitisCyp2e1
Chronic HepatitisGpx1
Chronic Hepatitis CGgt1
chronic kidney diseaseCbr1 , Gpx1
chronic myeloid leukemiaAlox5 , Gpx1
chronic obstructive pulmonary diseaseCyp2c79 , Cyp2e1 , Cyp2j4 , Ptgs2
Closed FracturesAlox5
cognitive disorderPtgs2
colitisAlox5 , Ptgs2
colon cancerCyp2e1 , Gpx1 , Ptgis
Colonic NeoplasmsAlox12b , Alox5 , Cbr1 , Ptgs2
Colonic PolypsAlox5
colorectal adenocarcinomaCyp4f6
colorectal adenomaPtgis
colorectal cancerCyp2e1 , Gpx1 , Pla2g4b
Colorectal NeoplasmsPtgs2
common coldAlox5
common variable immunodeficiencyAlox12 , Alox12b , Alox15b
cone-rod dystrophy 6Alox12b , Alox15b
congenital hypoplastic anemiaCyp2b3
congenital myasthenic syndrome 2AAlox12
congestive heart failureAlox12 , Alox15 , Ephx2 , Ptgis , Ptgs1 , Ptgs2
coronary artery diseaseEphx2 , Gpx1 , Ptgs2
Coronary DiseaseCyp2j4 , Ephx2 , Ggt1
CoughPtgs2
COVID-19Akr1c3 , Alox15b , Cbr1 , Gpx1 , Lta4h , Ptgs2
craniosynostosisCyp2b3
Creutzfeldt-Jakob diseasePtgs1 , Ptgs2
Crohn's diseaseAlox12 , Gpx1 , Ptgs2
cryptorchidismPtgs2
cystic fibrosisPtgs2
cystitisPtgs2
demyelinating diseasePtgs2
depressive disorderCyp2e1 , Gpx1 , Ptgs2
developmental and epileptic encephalopathyPtges
developmental and epileptic encephalopathy 14Ptgds
developmental and epileptic encephalopathy 25Alox12
Developmental DisabilitiesCyp2u1
diabetes mellitusGgt1 , Ptgs2
diabetic angiopathyGpx1
Diabetic NephropathiesCyp2j4 , Ephx2 , Gpx1 , Ptgds , Ptgs2
diabetic neuropathyAlox15 , Ggt1 , Ptgs2
diabetic retinopathyGgt1
Diamond-Blackfan anemiaAlox12b , Alox15b , Cyp2b3
diastolic heart failureAlox15
dilated cardiomyopathyGpx1
dilated cardiomyopathy 1LLPrxl2b
disease of cellular proliferationPtgs2
disorder of sexual developmentAkr1c3
distal 10q deletion syndromeCyp2e1
drug allergyLtc4s , Ptgs1 , Tbxas1
drug dependenceCyp2b3
Drug EruptionsAlox5 , Cyp2e1
Drug OverdoseCyp2b3
drug-induced hepatitisCyp2e1
Drug-Induced LeukopeniaCyp2c79
Drug-induced NeutropeniaCyp2c79
Drug-Related Side Effects and Adverse ReactionsCyp2c79 , Cyp2e1 , Ephx2 , Ptgs2
ductal carcinoma in situAkr1c3 , Ptges , Ptgs2
duodenal ulcerPtgs2
dyskeratosis congenitaAlox12 , Alox12b , Alox15b
dystoniaPtges
early infantile epileptic encephalopathyPtges
EdemaPtgs2
Efavirenz, Poor Metabolism ofCyp2b3
Ehlers-Danlos syndrome dermatosparaxis typeLtc4s
Ehlers-Danlos syndrome spondylodysplastic type 2Prxl2b
end stage renal diseaseCbr1 , Cyp2b3 , Cyp2c79 , Ephx2 , Ptgs1 , Ptgs2
endometrial adenocarcinomaPtges
endometrial carcinomaPtgs1
Endometrial NeoplasmsAkr1c3 , Ptgs2
endometriosisAkr1c3 , Ptges , Ptgs2
EndotoxemiaAlox5 , Ephx2 , Ptgis , Ptgs2 , Tbxas1
epilepsyCyp2u1 , Ggt1 , Gpx1 , Ptgds
Esophageal NeoplasmsAlox15 , Ptgs1 , Ptgs2
esophagitisPtgs2
esophagus adenocarcinomaPtgs1 , Ptgs2
esophagus squamous cell carcinomaPtgs2
essential hypertensionPtgis
exercise-induced bronchoconstrictionAlox5
Experimental ArthritisAlox15 , Ptges , Ptgs1 , Ptgs2
Experimental Autoimmune EncephalomyelitisAlox15 , Ptgs1 , Ptgs2
Experimental Autoimmune NeuritisPtgs1 , Ptgs2
Experimental Diabetes MellitusCbr1 , Cyp2b3 , Cyp2e1 , Ggt1 , Gpx1 , Ptgis , Ptgs1 , Ptgs2
Experimental Liver CirrhosisAkr1c3 , Lta4h , Ptgs1 , Ptgs2
Experimental Liver NeoplasmsCyp2e1
Experimental Mammary NeoplasmsGgt1 , Ptgs2
Experimental Radiation InjuriesPtgs1 , Ptgs2
extrinsic allergic alveolitisCyp2e1
familial adenomatous polyposisPtgs2
familial hypercholesterolemiaEphx2
familial hyperlipidemiaCyp2e1
Familial Platelet Disorder with Associated Myeloid MalignancyCbr1
Fetal Growth RetardationPtgs2
FeverCbr1 , Ptges , Ptgs2
FibrosisPtgs2
FlushingPtgs1
frontotemporal dementia and/or amyotrophic lateral sclerosis 1Ltc4s
Gallbladder NeoplasmsPtgs2
gamma-glutamyl transpeptidase deficiencyGgt1
gastric adenocarcinomaGpx1
gastric ulcerPtgs1 , Ptgs2
gastritisPtgs2
gastroesophageal reflux diseasePtgs2
gastrointestinal stromal tumorPtgs2
genetic diseaseAlox12b , Alox5 , Cyp2u1 , Tbxas1
Genetic Predisposition to DiseaseGpx1
gestational diabetesGgt1 , Gpx1
Ghosal hematodiaphyseal syndromeTbxas1
glaucomaPtgs1
glioblastomaPtgs1 , Ptgs2
gliosarcomaCyp2b3 , Ptgs1 , Ptgs2
glomerulonephritisAlox15 , Ltc4s , Tbxas1
Glutathione Peroxidase Deficiency, Hemolytic Anemia possibly due toGpx1
glycine encephalopathyGpx1
Goldberg-Shprintzen syndromePrxl2b
granulosa cell tumorPtgs2
Graves ophthalmopathyPtgs2
growth hormone secreting pituitary adenomaPtgs2
hairy cell leukemiaGpx1
Head and Neck NeoplasmsGpx1
head and neck squamous cell carcinomaPtgs2
HemolysisGpx1
HemorrhagePtgs1
hemorrhagic diseaseTbxas1
hepatic encephalopathyPtgs1
hepatocellular adenomaCyp2e1
hepatocellular carcinomaCbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Ggt1 , Gpx1 , Ptgs2
hereditary spastic paraplegiaCyp2u1
hereditary spastic paraplegia 56Cyp2u1
hereditary spastic paraplegia 5ACyp2u1
heroin dependenceCyp2b3
high grade gliomaCyp2e1 , Ptgs2
holocarboxylase synthetase deficiencyCbr1
human immunodeficiency virus infectious diseaseCyp2b3 , Ptgs2
Human InfluenzaPtgs2
Human Viral HepatitisCyp2e1
Huntington's diseaseGpx1 , Ptgs2
hydronephrosisPtges , Ptgs2 , Tbxas1
HyperalgesiaAlox12 , Alox5 , Ephx2 , Ptgs1 , Ptgs2
HyperemiaPtgs2
hyperglycemiaGpx1 , Ptgs2
hyperhomocysteinemiaGpx1
hyperinsulinismGpx1
HyperoxiaAlox5
HyperplasiaPtgs2
hypertensionAlox12 , Alox15 , Alox5 , Cyp2j4 , Ephx2 , Gpx1 , Ptgds , Ptgis , Ptgs2 , Tbxas1
HyperthermiaGpx1
hyperthyroidismGpx1
hypertrophic cardiomyopathyCyp2e1 , Ephx2
hypoparathyroidism-deafness-renal disease syndromeAkr1c3
hypothyroidismGpx1
HypoxiaPtgs2
ichthyosisAlox12b
idiopathic pulmonary fibrosisPtgs2
immunodeficiency 16Prxl2b
immunodeficiency 28Cbr1
immunodeficiency 38Prxl2b
in situ carcinomaAlox5 , Ptges , Ptgs2
InflammationAlox15 , Alox5 , Ptges , Ptgs2
inflammatory bowel diseasePtgs2
Insulin ResistanceAlox15 , Ptgds , Ptgis
intellectual disabilityCyp2j4
intestinal obstructionPtgs2
Intestinal PolypsPtgs1 , Ptgs2
intrahepatic cholestasisCyp2e1
invasive ductal carcinomaAlox5 , Ptgs2
iron deficiency anemiaGpx1
Iron OverloadGgt1 , Gpx1
irritant dermatitisCbr1
ischemiaPtges
Joubert syndrome 1Ptgds
Joubert syndrome 25Prxl2b
juvenile rheumatoid arthritisAlox12
Keshan diseaseGpx1
kidney diseaseCyp2c79 , Ptgs2
Kidney NeoplasmsPtgs2
Kidney Reperfusion InjuryPtgis
Kleefstra syndrome 1Ptgds
Knee OsteoarthritisPtges
Labrune SyndromeAlox12b
Laryngeal NeoplasmsPtgs2
Laryngeal PapillomatosisPtgs2
laryngeal squamous cell carcinomaGpx1
larynx cancerGpx1
Left Ventricular HypertrophyPtgs2
Leigh diseasePtgds
leiomyosarcomaPtgs2
leukemiaAkr1c3 , Gpx1
Leukotriene C4 Synthase DeficiencyLtc4s
Li-Fraumeni syndromeAlox12b , Alox15b
limb ischemiaPtgis
liver cirrhosisGgt1 , Ptgs2
liver diseaseCyp2e1 , Ggt1
Liver InjuryCyp2e1 , Gpx1
Liver NeoplasmsCyp2e1 , Gpx1
lung adenocarcinomaAlox12b , Alox5
lung cancerGpx1 , Ptgs2
lung diseaseAlox5 , Cyp2e1 , Ptgs2
Lung NeoplasmsAlox12 , Cyp2e1 , Gpx1 , Ptgis
lung non-small cell carcinomaCyp2e1 , Gpx1 , Ptges , Ptgis , Ptgs2
lung squamous cell carcinomaGpx1
Lymphatic MetastasisPtgs2
maple syrup urine diseaseCyp2b3
melanomaGgt1 , Ptgs2
membranous glomerulonephritisTbxas1
Mercury PoisoningGpx1
metabolic dysfunction-associated steatotic liver diseaseAlox15 , Cyp2e1 , Gpx1 , Ptgs2
Metabolic Side Effects of Drugs and SubstancesCyp2b3
Metabolic SyndromeEphx2 , Ggt1 , Ptgs2
Micronuclei, Chromosome-DefectiveCyp2e1
middle cerebral artery infarctionAlox5 , Cyp2e1
morbid obesityCyp2e1
mouth diseasePtgs2
Mouth NeoplasmsPtgs2
Multibacillary LeprosyGgt1
multiple myelomaGpx1
Multiple Organ FailureAlox5
myeloid neoplasmAkr1c3 , Gpx1
myocardial infarctionCyp2j4 , Ephx2 , Ggt1 , Gpx1 , Ptgis , Ptgs2
Myocardial IschemiaEphx2
Myocardial Reperfusion InjuryAlox5 , Ephx2 , Ptgs2
myocarditisPtgs2
Nasal PolypsAlox12 , Alox15 , Ptgs1 , Ptgs2
nasopharynx carcinomaCyp2e1 , Gpx1
NecrosisCyp2e1
neonatal abstinence syndromeCyp2b3
Neoplasm InvasivenessAlox5 , Cyp2e1
Neoplasm MetastasisAlox5 , Ptgis , Ptgs2
Neoplasm Recurrence, LocalPtgs2
Neoplasms, Hormone-DependentAkr1c3
Neoplastic Cell TransformationAkr1c3
nephritisCyp2j4
nephroblastomaPtgs2
nephrosclerosisAlox5 , Ptgds
nephrosisGpx1
nephrotic syndromeAlox5 , Gpx1 , Ptgs2
nervous system diseaseCyp2c79 , Ptgs2
Nervous System MalformationsCyp2u1
Neurodevelopmental DisordersPla2g4b , Prxl2b
Neurogenic InflammationPtgs2
nicotine dependenceCyp2b3
Nociceptive PainPtgis
non-alcoholic fatty liverGgt1
non-Hodgkin lymphomaCyp2e1 , Gpx1
obesityAkr1c3 , Alox12 , Cyp2e1 , Gpx1 , Ptgs2
obstructive sleep apneaPtgs2
occupational asthmaPtgs1 , Ptgs2
open-angle glaucomaPtgs2
oral cavity cancerCyp2e1
oral mucosa leukoplakiaPtgs2
oral squamous cell carcinomaCyp2e1 , Gpx1 , Ptgis
oral submucous fibrosisPtgs2
osteoarthritisPtgs2
osteoporosisGpx1
otitis mediaLta4h , Ltc4s
ovarian cancerPtgs1
ovarian cystPtgs1
Ovarian NeoplasmsAlox12b , Alox5 , Ptgs1 , Ptgs2
ovary epithelial cancerPtges
PainAlox5 , Ptgs1 , Ptgs2
pancreatic cancerAlox12b , Alox5 , Ptgs2
pancreatic ductal carcinomaPtgs2
pancreatitisPtgs2
papillomaPtges , Ptgs2
paraplegiaCyp2u1
parathyroid carcinomaPtgs2
Parkinson's diseaseCyp2e1 , Ephx2 , Gpx1 , Ptgis
ParkinsonismPtgs2
patent ductus arteriosusPtgis
Patent Ductus VenosusCyp2e1
Paucibacillary LeprosyGgt1
penile benign neoplasmPtges
peptic esophagitisPtges
Perennial Allergic RhinitisPtgs1
pericardial effusionPtgs2
periodontitisGgt1
Peripheral Nerve InjuriesPtgs1 , Ptgs2
peripheral nervous system diseaseAlox12 , Cyp2c79 , Ltc4s
peritonitisAlox15 , Ptgis
Peroxisome Biogenesis Disorder, Complementation Group 7Prxl2b
Pierson syndromeGpx1
Plaque, AtheroscleroticEphx2
platelet-type bleeding disorder 14Tbxas1
pleomorphic xanthoastrocytomaTbxas1
pleurisyAlox5 , Ptgs2
pleuropneumoniaAlox5
Pneumococcal PneumoniaAlox5
pneumoconiosisPrxl2b
pneumoniaCyp2e1
PoisoningCyp4f18
polycystic kidney diseasePtgs1 , Ptgs2
polycystic ovary syndromeAkr1c3
PolyuriaPtges
portal hypertensionAlox5 , Ptgs2
pre-eclampsiaAkr1c3 , Cyp2j4 , Gpx1 , Ptgs1
pre-malignant neoplasmPtgs2
Precocious PubertyPtgs2
Premature BirthPtgs2
Prenatal Exposure Delayed EffectsCyp2e1
primary coenzyme Q10 deficiency 7Ptgds , Ptges
primary pulmonary hypertensionPtgis
prolactinomaPtgs2
prostate cancerAkr1c3 , Alox12 , Ptgs2
prostate carcinoma in situPtgs2
prostatic hypertrophyPtgs2
Prostatic NeoplasmsAkr1c3 , Alox12b , Alox5 , Cbr1 , Cyp2e1 , Ggt1 , Ptgs2 , Tbxas1
prostatitisPtgs2
proteinuriaPtgs2
pseudoxanthoma elasticumGpx1
psoriasisAlox12
Pulmonary Arterial HypertensionPtgis
pulmonary edemaAlox5
pulmonary embolismTbxas1
pulmonary emphysemaPtgs2
pulmonary fibrosisAlox5 , Ptgs2
pulmonary hypertensionAlox5 , Cyp2j4 , Ephx2 , Ptgis , Ptgs2
Pulmonary Hypertension, Hypoxia-Induced Ptgis
pulmonary tuberculosisAlox5
Radiation PneumonitisAlox5
Rafiq syndromePtgds
RASopathyTbxas1
renal cell carcinomaAlox12 , Alox12b , Alox5 , Ptgs1 , Ptgs2
renal fibrosisCyp2j4
renal hypertensionCyp2c79 , Cyp2j4
renovascular hypertensionPtgs1
Reperfusion InjuryAlox12 , Alox15 , Alox5 , Cyp2e1 , Ephx2 , Gpx1 , Ptges , Ptgs1 , Ptgs2 , Tbxas1
ReticulocytosisGpx1
retrograde amnesiaPtgs2
RhabdomyolysisCyp2c79
Rhabdomyolysis, Cerivastatin-InducedCyp2c79
rheumatoid arthritisAlox5 , Ptgs1 , Ptgs2
salivary gland carcinomaPtgs1
sarcoidosisPtgs2
schizophreniaAkr1c3 , Ephx2 , Ggt1 , Ptgs2
Seasonal Allergic RhinitisAlox5 , Ptgs1
secondary hyperparathyroidismPtgs2
senile cataractGpx1
sensorineural hearing lossPtgds
SepsisCyp2e1 , Cyp2j4
Shprintzen-Goldberg CraniosynostosisPrxl2b
sickle cell anemiaGpx1
skin diseaseAlox12 , Ptgs2
skin melanomaGpx1
Skin NeoplasmsPtgs2
Sleep DeprivationPtgs1 , Ptgs2
Sotos syndromeLtc4s
Spinal Cord InjuriesPtgs1 , Ptgs2
Spontaneous AbortionsPtgis
squamous cell carcinomaGpx1 , Lta4h , Ptgs2
status epilepticusPtgs2
steatotic liver diseaseCyp2e1 , Ggt1 , Gpx1 , Ptgs2
Stevens-Johnson syndromePtgis
stomach cancerCyp2e1 , Gpx1
stomach carcinomaGpx1
Stomach NeoplasmsAkr1c3 , Alox5 , Ptgs2
StrokeEphx2 , Ptgs2
Subarachnoid HemorrhagePtgs2
systemic lupus erythematosusPtgs2
systemic sclerodermaPtgs2
T-cell acute lymphoblastic leukemiaAkr1c3
Testicular Germ Cell TumorAlox12b , Alox5
Testicular InjuryCyp2e1
Testicular NeoplasmsAlox12
thrombocytopeniaCbr1
thrombosisPtgs2 , Tbxas1
Thyroid NeoplasmsPtgs2
Tobacco Use DisorderCyp2b3
Tongue NeoplasmsPtgs2
transient cerebral ischemiaPtgis
transitional cell carcinomaGpx1 , Ptges , Ptgs2
traumatic brain injuryPtgs2
tuberculosisCyp2b3
tuberous sclerosis 1Ptgds
type 1 diabetes mellitusAlox15 , Cyp2e1
type 2 diabetes mellitusAlox12 , Cyp2e1 , Ggt1 , Gpx1 , Ptgds , Ptgis , Ptgs2
ulcerative colitisAlox12 , Gpx1 , Ptgs1 , Ptgs2
ureteral obstructionCyp2j4
urinary bladder cancerAlox12 , Gpx1 , Ptgs2
Urologic NeoplasmsPtgs2
urticariaAlox5
Uterine Cervical NeoplasmsPtgs2
vascular dementiaGpx1
Venous ThrombosisGpx1
Ventilator-Induced Lung InjuryPtgs2
Ventricular Dysfunction, LeftEphx2
very long chain acyl-CoA dehydrogenase deficiencyAlox12 , Alox12b , Alox15b
visual epilepsyPtgs2
Wernicke encephalopathyPtgs2
Wounds and InjuriesAlox15
Pathway Annotations Associated with Genes in the paracetamol drug pathway
Pathway TermsGene Symbols
acetylsalicylic acid pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
alpha-linolenic acid metabolic pathwayPla2g4b
amyotrophic lateral sclerosis pathwayGpx1
antipyrine drug pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
arachidonic acid metabolic pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
atherosclerosis pathwayAlox15
caffeine pharmacokinetics pathwayCyp2c79 , Cyp2e1
carbamazepine pharmacokinetics pathwayCyp2b3 , Cyp2c79
celecoxib pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
celecoxib pharmacokinetics pathwayPtgs1 , Ptgs2
clopidogrel pharmacodynamics pathwayCyp2b3
clopidogrel pharmacokinetics pathwayCyp2b3
cyanoamino acid metabolic pathwayGgt1
cyclooxygenase mediated pathway of arachidonic acid metabolismPtgs1 , Ptgs2
cyclophosphamide pharmacodynamics pathwayCyp2b3 , Cyp2c79
cyclophosphamide pharmacokinetics pathwayCyp2b3 , Cyp2c79
diclofenac pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
diflunisal pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
disulfiram pharmacodynamics pathwayCyp2e1
dopa responsive dystonia pathwayCbr1
doxorubicin pharmacokinetics pathwayAkr1c3 , Cbr1
ether lipid metabolic pathwayPla2g4b
ether lipid metabolic pathwayPla2g4b
etodolac pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
etoposide pharmacodynamics pathwayPtgs1 , Ptgs2
etoposide pharmacokinetics pathwayPtgs1 , Ptgs2
Fc epsilon receptor mediated signaling pathwayPla2g4b
felbamate pharmacokinetics pathwayCyp2e1
fenoprofen pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
flurbiprofen pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
glutamate signaling pathwayPla2g4b
glutathione metabolic pathwayGgt1 , Gpx1
glutathione synthase deficiency pathwayGpx1
glutathionuria disease pathwayGpx1
glycerophospholipid metabolic pathwayPla2g4b
gonadotropin-releasing hormone signaling pathwayPla2g4b
Huntington's disease pathwayGpx1
ibuprofen pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
ibuprofen pharmacokinetics pathwayCyp2c79 , Ptgs1 , Ptgs2
ifosfamide pharmacodynamics pathwayCyp2b3 , Cyp2c79
ifosfamide pharmacokinetics pathwayCyp2b3 , Cyp2c79
indometacin pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
indometacin pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
interleukin-23 signaling pathwayAlox12b
interleukin-4 signaling pathwayAlox15
isoprenoid metabolic pathwayAkr1c3
ketoprofen pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
ketorolac pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
Leishmaniasis pathwayPtgs2
leukotriene C4 synthase deficiency pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
leukotriene metabolic pathwayAlox5 , Lta4h , Ltc4s
linoleic acid metabolic pathwayAlox15 , Cyp2e1 , Cyp2j4 , Pla2g4b
lipoxygenase mediated pathway of arachidonic acid metabolismAlox12 , Alox12b , Alox15 , Alox15b , Alox5 , Lta4h , Ltc4s
long term depressionPla2g4b
lornoxicam pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
losartan pharmacokinetics pathwayCyp2c79
magnesium salicylate pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
mefenamic acid pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
meloxicam pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
methadone pharmacodynamics pathwayCyp2b3 , Cyp2c79
methadone pharmacokinetics pathwayCyp2b3 , Cyp2c79
mitogen activated protein kinase signaling pathwayPla2g4b
mycophenolic acid pharmacokinetics pathwayCyp2c79
nabumetone pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
naproxen pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
neviparine pharmacokinetics pathwayCyp2b3
nicotine pharmacodynamics pathwayCyp2b3
nicotine pharmacokinetics pathwayCyp2b3
organophosphate response pathwayCyp2b3
paracetamol drug pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
paracetamol pharmacokinetics pathwayCyp2e1
paracetamol response pathwayCyp2e1
phase I biotransformation pathway via cytochrome P450Cyp2b3 , Cyp2e1
phenytoin pharmacodynamics pathwayCyp2e1
piroxicam pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
pro-inflammatory cytokine mediated pathwayPtgs2
prostacyclin biosynthetic pathwayPtgis
prostaglandin biosynthetic pathwayAkr1c3 , Cbr1 , Prxl2b , Ptgds , Ptges
prostanoid biosynthetic pathwayPtgs1 , Ptgs2
repaglinide pharmacokinetics pathwayCyp2c79
retinol metabolic pathwayCyp2b3
rosiglitazone pharmacokinetics pathwayCyp2c79
salicylic acid pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
Segawa syndrome pathwayCbr1
selenoamino acid metabolic pathwayGgt1
small cell lung carcinoma pathwayPtgs2
sodium salicylate pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
sorafenib pharmacokinetics pathwayCyp2b3 , Cyp2c79
sphingosine 1-phosphate signaling pathwayPtgs2
statin pharmacokinetics pathwayCyp2c79
sulindac pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
tamoxifen pharmacodynamics pathwayCyp2b3
tamoxifen pharmacokinetics pathwayCyp2b3 , Cyp2c79
taurine and hypotaurine metabolic pathwayGgt1
tenoxicam pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
thromboxane biosynthetic pathwayTbxas1
tiaprofenic acid pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
tolmetin pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
toxoplasmosis pathwayAlox5 , Pla2g4b
tramadol pharmacokinetics pathwayCyp2b3
type 1 diabetes mellitus pathwayAlox15
valdecoxib pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Cyp4f6 , Ephx2 , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Prxl2b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
valproic acid pharmacokinetics pathwayCyp2b3
vascular endothelial growth factor signaling pathwayPla2g4b , Ptgs2
vitamin A deficiency pathwayCyp2b3
warfarin pharmacokinetics pathwayCyp2c79
Phenotype Annotations Associated with Genes in the paracetamol drug pathway

References Associated with the paracetamol drug pathway:

Ontology Path Diagram:

paths to the root
paths to the root

Import into Pathway Studio: