PARACETAMOL DRUG PATHWAY (PW:0001524)

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Description

Paracetamol or N-acetyl-p-aminophenol (APAP), also known as acetaminophen or by its trade name in the USA as Tylenol, is a widely used analgesic and antipyretic drug. However, overdose of paracetamol - accidental or intentional - is associated with hepatotoxicity and a leading cause of liver failure. APAP metabolism occurs mostly in the liver where it is primarily subject to glucuronidation and sulfation by members of phase II biotransformation enzymes. To a lesser extent, it is also metaboliz

Pathway Diagram:

Elsevier Inc. Ptgs2 Ptgs1 prostanoid biosynthetic pathway ---> various responses elicited by signaling via prostanoids various responses elicited by signaling via prostanoids prostanoid biosynthetic pathway arachidonic acid PGH2 PGG2 cyclooxygenase mediated pathway of arachidonic acid metabolism paracetamol pharmacokinetics pathway arachidonic acid metabolic pathway paracetamol response pathway paracetamol paracetamol ---> paracetamol pharmacokinetics pathway arachidonic acid ---> PGG2 paracetamol --+> paracetamol response pathway PGG2 ---> PGH2 paracetamol ---| Ptgs1 paracetamol ---| Ptgs2 paracetamol ---| prostanoid biosynthetic pathway PGH2 --+> prostanoid biosynthetic pathway Pain Fever paracetamol ---| Fever paracetamol ---| Pain
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Genes in Pathway:

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paracetamol drug pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:10402751
G Alox12 arachidonate 12-lipoxygenase, 12S type JBrowse link 10 56,851,734 56,864,049 RGD:10402751
G Alox12b arachidonate 12-lipoxygenase, 12R type JBrowse link 10 55,744,646 55,756,524 RGD:10402751
G Alox15 arachidonate 15-lipoxygenase JBrowse link 10 56,953,692 56,962,145 RGD:10402751
G Alox15b arachidonate 15-lipoxygenase, type B JBrowse link 10 55,773,748 55,783,489 RGD:10402751
G Alox5 arachidonate 5-lipoxygenase JBrowse link 4 148,398,004 148,446,308 RGD:10402751
G Cbr1 carbonyl reductase 1 JBrowse link 11 33,813,041 33,815,418 RGD:10402751
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:10402751
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 JBrowse link 1 147,236,480 147,307,988 RGD:10402751
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:10402751
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 JBrowse link 5 119,546,458 119,564,843 RGD:10402751
G Cyp2u1 cytochrome P450, family 2, subfamily u, polypeptide 1 JBrowse link 2 236,414,131 236,431,650 RGD:10402751
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 JBrowse link 16 19,501,680 19,528,935 RGD:10402751
G Ephx2 epoxide hydrolase 2 JBrowse link 15 42,757,241 42,794,211 RGD:10402751
G Fam213b family with sequence similarity 213, member B JBrowse link 5 172,304,799 172,307,402 RGD:10402751
G Ggt1 gamma-glutamyltransferase 1 JBrowse link 20 14,019,723 14,045,781 RGD:10402751
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:10402751
G Lta4h leukotriene A4 hydrolase JBrowse link 7 34,288,333 34,320,243 RGD:10402751
G Ltc4s leukotriene C4 synthase JBrowse link 10 35,736,486 35,743,088 RGD:10402751
G Pla2g4b phospholipase A2 group IVB JBrowse link 3 111,824,919 111,833,526 RGD:10402751
G Ptgds prostaglandin D2 synthase JBrowse link 3 2,686,125 2,689,059 RGD:10402751
G Ptges prostaglandin E synthase JBrowse link 3 9,727,408 9,738,752 RGD:10402751
G Ptgis prostaglandin I2 synthase JBrowse link 3 163,950,746 163,986,129 RGD:10402751
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:8552695
RGD:10402751
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:8552695
RGD:10402751
G Tbxas1 thromboxane A synthase 1 JBrowse link 4 66,624,181 66,846,745 RGD:10402751
paracetamol pharmacokinetics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:10402751
G Abcc1 ATP binding cassette subfamily C member 1 JBrowse link 10 549,537 672,235 RGD:10402751
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:8552693
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:8552693
G Abcc4 ATP binding cassette subfamily C member 4 JBrowse link 15 103,695,415 103,927,980 RGD:8552693
RGD:10402751
G Abcc5 ATP binding cassette subfamily C member 5 JBrowse link 11 84,395,982 84,490,215 RGD:10402751
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:8552693
RGD:10402751
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:10402751
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:10402751
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:8552693
RGD:10402751
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 JBrowse link 11 81,741,342 81,757,806 RGD:10402751
G Erp29 endoplasmic reticulum protein 29 JBrowse link 12 40,619,377 40,625,884 RGD:10402751
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:10402751
G Gstt1 glutathione S-transferase theta 1 JBrowse link 20 13,799,102 13,816,527 RGD:10402751
G Hsp90b1 heat shock protein 90 beta family member 1 JBrowse link 7 27,226,570 27,240,533 RGD:10402751
G Hspa5 heat shock protein family A member 5 JBrowse link 3 13,838,304 13,842,763 RGD:10402751
G Hyou1 hypoxia up-regulated 1 JBrowse link 8 48,699,796 48,711,912 RGD:10402751
G Pdia2 protein disulfide isomerase family A, member 2 RGD:10402751
G Pdia4 protein disulfide isomerase family A, member 4 JBrowse link 4 77,470,636 77,489,535 RGD:10402751
G Pdia6 protein disulfide isomerase family A, member 6 JBrowse link 6 42,568,269 42,585,654 RGD:10402751
G Ppib peptidylprolyl isomerase B JBrowse link 8 71,719,681 71,725,538 RGD:10402751
G Sdf2l1 stromal cell-derived factor 2-like 1 JBrowse link 11 88,122,271 88,124,513 RGD:10402751
G Sult1a1 sulfotransferase family 1A member 1 JBrowse link 1 198,100,586 198,104,106 RGD:10402751
G Sult1e1 sulfotransferase family 1E member 1 JBrowse link 14 22,070,861 22,089,264 RGD:8552693
RGD:10402751
G Sult2a1 sulfotransferase family 2A member 1 JBrowse link 1 76,558,721 76,614,315 RGD:10402751
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:8552693
RGD:10402751
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 JBrowse link 9 95,241,609 95,302,822 RGD:8552693
RGD:10402751
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 JBrowse link 9 95,161,157 95,302,822 RGD:10402751

Pathway Gene Annotations

Disease Annotations Associated with Genes in the paracetamol drug pathway
Disease TermsGene Symbols
abdominal aortic aneurysmPtgs2
Abortion, SpontaneousPtgis
acoustic neuromaCyp2e1
acute kidney failureAlox5 , Ephx2 , Ptgs2
Acute Liver FailureLtc4s , Ptgs2
Acute Lung InjuryAlox15 , Ephx2 , Ptgs2
acute myeloid leukemiaGpx1
adenocarcinomaCyp2e1 , Lta4h , Ptgs2
adenomaAlox5
Adrenal Gland NeoplasmsPtgs2
AlbuminuriaAlox12 , Ggt1 , Ptgs2
alcohol use disorderCyp2e1 , Ggt1
Alcohol Withdrawal DeliriumPtgs2
Alcoholic Fatty LiverCyp2e1
alcoholic liver cirrhosisCyp2e1
Alcoholic Liver DiseasesTbxas1
alpha thalassemiaGpx1
Alzheimer's diseaseAlox15 , Ptgs1 , Ptgs2
amyotrophic lateral sclerosisPtgs2
AnaphylaxisPtgs1 , Ptgs2
anemiaGpx1
AnorexiaGpx1
aortic aneurysmAlox5
Aortic Valve, Calcification ofPtgs2
ARC syndromeCyp2b3
arteriosclerosisAlox5 , Gpx1 , Ptgds , Ptgs2 , Tbxas1
asbestosisCyp2e1
asphyxia neonatorumPtgs2
Aspirin-Induced AsthmaLtc4s , Ptgs2
asthmaAlox15 , Alox5 , Cyp2e1 , Lta4h , Ltc4s , Ptgs2
Asthma, Exercise-InducedAlox5
Asthma, OccupationalPtgs1 , Ptgs2
atherosclerosisAlox15 , Alox5 , Ephx2 , Lta4h , Ptgs2
autistic disorderGpx1 , Ptgs2
autosomal recessive congenital ichthyosis 1Alox12b
autosomal recessive congenital ichthyosis 2Alox12b
avian influenzaPtgs2
B-cell lymphomaPtgs2
bacterial pneumoniaCyp2j4
Barrett's esophagusPtges , Ptgs2
bipolar disorderPtgs1 , Ptgs2
bladder neck obstructionPtgs2
Bone FracturesAlox5 , Ptgs2
Bone MetastasisAlox12
Bone NeoplasmsPtgs2
brain infarctionTbxas1
Brain InjuriesEphx2 , Gpx1 , Ptgs1 , Ptgs2
brain ischemiaAlox15 , Alox5 , Gpx1 , Ptgis , Ptgs1 , Ptgs2
breast ductal carcinomaAlox5
Breast NeoplasmsAlox12 , Gpx1 , Ptges , Ptgs1 , Ptgs2
Bronchial HyperreactivityPtgs1
Bronchitis, ChronicCyp2e1
BurnsPtgs2
Burns, ChemicalAlox12
CachexiaPtgs2
Cadmium PoisoningGpx1
calcinosisGpx1
carcinomaGgt1 , Ptgs1 , Ptgs2
cardiac arrestEphx2
Cardiac ArrhythmiasPtgs2
CardiomegalyCyp2e1
cardiomyopathyCbr1 , Ptgs2
Cardiovascular AbnormalitiesGpx1
cardiovascular system diseaseGpx1 , Ptgs2
carotid artery diseasePtgds
Carotid Artery InjuriesAlox12
carotid stenosisGpx1
Castration-Resistant Prostatic NeoplasmsAkr1c3
cataractGpx1
Cell Transformation, NeoplasticAkr1c3
Cerebral HemorrhagePtgs2
cerebral infarctionEphx2 , Tbxas1
cervix uteri carcinoma in situPtgs2
Chemical and Drug Induced Liver InjuryCyp2b3 , Cyp2e1 , Ptgs2
Childhood SchizophreniaPtgis
cholangiocarcinomaAlox5 , Ptgs2
chronic kidney diseaseCbr1 , Gpx1
Chronic Lymphocytic Leukemia, B-CellPtgs2
chronic myeloid leukemiaAlox5 , Gpx1
chronic obstructive pulmonary diseaseCyp2e1 , Ptgs2
Cognition DisordersPtgs2
colitisAlox5 , Ptgs2
Colonic NeoplasmsAlox5 , Cbr1 , Ptgs2
Colonic PolypsAlox5
Colorectal NeoplasmsPtgs2
common coldAlox5
congenital ichthyosiform erythrodermaAlox12b
congestive heart failureAlox12 , Alox15 , Ephx2 , Ptgs1 , Ptgs2
coronary artery diseaseEphx2 , Gpx1 , Ptgs2
Coronary DiseaseCyp2j4 , Ephx2 , Ggt1
CoughPtgs2
Creutzfeldt-Jakob diseasePtgs1 , Ptgs2
Crohn's diseaseAlox12 , Gpx1 , Ptgs2
cryptorchidismPtgs2
cystic fibrosisPtgs2
cystitisPtgs2
demyelinating diseasePtgs2
Developmental DisabilitiesCyp2u1
diabetes mellitusGgt1 , Ptgs2
diabetic angiopathyGpx1
Diabetic NephropathiesCyp2j4 , Ephx2 , Gpx1 , Ptgds , Ptgs2
diabetic neuropathyAlox15 , Ggt1 , Ptgs2
diabetic retinopathyGgt1
Diamond-Blackfan anemiaAlox12b , Alox15b
dilated cardiomyopathyGpx1
disease of cellular proliferationPtgs2
drug allergyLtc4s , Ptgs1 , Tbxas1
Drug EruptionsAlox5 , Cyp2e1
Drug-Induced LeukopeniaCyp2c79
Drug-induced NeutropeniaCyp2c79
Drug-Related Side Effects and Adverse ReactionsCyp2b3 , Cyp2c79 , Cyp2e1 , Ephx2 , Ptgs2
ductal carcinoma in situAkr1c3 , Ptges , Ptgs2
duodenal ulcerPtgs2
EdemaPtgs2
EFAVIRENZ, POOR METABOLISM OFCyp2b3
end stage renal failureCbr1 , Cyp2b3 , Cyp2c79 , Ephx2 , Ptgs1 , Ptgs2
Endometrial NeoplasmsAkr1c3 , Ptges , Ptgs1 , Ptgs2
endometriosisAkr1c3 , Ptges , Ptgs2
EndotoxemiaAlox5 , Ephx2 , Ptgs2 , Tbxas1
epilepsyGpx1
Esophageal NeoplasmsAlox15 , Ptgs1 , Ptgs2
esophagitisPtgs2
esophagus adenocarcinomaPtgs2
esophagus squamous cell carcinomaPtgs2
essential hypertensionPtgis
Experimental ArthritisAlox15 , Ptges , Ptgs1 , Ptgs2
Experimental Autoimmune EncephalomyelitisAlox15 , Ptgs1 , Ptgs2
Experimental Autoimmune NeuritisPtgs1 , Ptgs2
Experimental Diabetes MellitusCbr1 , Cyp2b3 , Cyp2e1 , Ggt1 , Gpx1 , Ptgs1 , Ptgs2
Experimental Liver CirrhosisAkr1c3 , Lta4h , Ptgs1 , Ptgs2
extrinsic allergic alveolitisCyp2e1
familial adenomatous polyposisPtgs2
familial hypercholesterolemiaEphx2
fatty liver diseaseCyp2e1 , Gpx1 , Ptgs2
Fetal Growth RetardationPtgs2
FeverCbr1 , Ptges , Ptgs2
FibrosisPtgs2
FlushingPtgs1
Fractures, ClosedAlox5
Gallbladder NeoplasmsPtgs2
gastric ulcerPtgs1 , Ptgs2
gastritisPtgs2
gastroesophageal reflux diseasePtgs2
gestational diabetesGgt1 , Gpx1
Ghosal Hematodiaphyseal DysplasiaTbxas1
glaucomaPtgs1
glioblastoma multiformePtgs1 , Ptgs2
gliosarcomaCyp2b3 , Ptgs1 , Ptgs2
glomerulonephritisAlox15 , Ltc4s , Tbxas1
Glutathione Peroxidase Deficiency, Hemolytic Anemia possibly due toGpx1
GlutathionuriaGgt1
granulosa cell tumorPtgs2
Graves OphthalmopathyPtgs2
growth hormone secreting pituitary adenomaPtgs2
hairy cell leukemiaGpx1
Head and Neck NeoplasmsGpx1
head and neck squamous cell carcinomaPtgs2
HemolysisGpx1
hepatic encephalopathyPtgs1
Hepatitis, ChronicGpx1
hepatocellular carcinomaCbr1 , Cyp2e1 , Ptgs2
hereditary spastic paraplegia 56Cyp2u1
hereditary spastic paraplegia 5ACyp2u1
human immunodeficiency virus infectious diseasePtgs2
Human InfluenzaPtgs2
Huntington's diseaseGpx1 , Ptgs2
hydronephrosisPtges , Ptgs2 , Tbxas1
HyperalgesiaAlox12 , Alox5 , Ephx2 , Ptgs1 , Ptgs2
HyperemiaPtgs2
hyperglycemiaGpx1 , Ptgs2
hyperhomocysteinemiaGpx1
hyperinsulinismGpx1
HyperoxiaAlox5
HyperplasiaPtgs2
hypertensionAlox12 , Alox15 , Alox5 , Cyp2j4 , Ephx2 , Gpx1 , Ptgds , Ptgis , Ptgs2 , Tbxas1
hyperthyroidismGpx1
Hypertrophy, Left VentricularPtgs2
hypothyroidismGpx1
HypoxiaPtgs2
ichthyosisAlox12b
idiopathic pulmonary fibrosisPtgs2
in situ carcinomaAlox5 , Ptges , Ptgs2
InflammationAlox15 , Alox5 , Ptges , Ptgs2
inflammatory bowel diseasePtgs2
Insulin ResistanceAlox15 , Ptgds
intestinal obstructionPtgs2
Intestinal PolypsPtgs1 , Ptgs2
invasive ductal carcinomaPtgs2
iron deficiency anemiaGpx1
Iron OverloadGpx1
irritant dermatitisCbr1
ischemiaPtges
juvenile rheumatoid arthritisAlox12
Keshan diseaseGpx1
kidney diseaseCyp2c79 , Ptgs2
Kidney NeoplasmsPtgs2
Laryngeal NeoplasmsPtgs2
Laryngeal PapillomatosisPtgs2
leiomyosarcomaPtgs2
leukemiaAkr1c3 , Gpx1
Leukotriene C4 Synthase DeficiencyLtc4s
liver diseaseCyp2e1 , Ggt1
Liver InjuryGpx1
liver neoplasmCyp2e1
Liver Neoplasms, ExperimentalCyp2c79 , Cyp2e1
lung diseaseAlox5 , Cyp2e1 , Ptgs2
Lung NeoplasmsAlox12 , Cyp2e1 , Gpx1 , Ptgis , Ptgs2
Lymphatic MetastasisPtgs2
malignant gliomaCyp2e1 , Ptgs2
Mammary Neoplasms, AnimalGgt1
Mammary Neoplasms, ExperimentalGgt1 , Ptgs2
melanomaPtgs2
membranous glomerulonephritisTbxas1
mental depressionCyp2e1 , Gpx1 , Ptgs2
Mercury PoisoningGpx1
Metabolic SyndromeEphx2 , Ggt1 , Ptgs2
Micronuclei, Chromosome-DefectiveCyp2e1
middle cerebral artery infarctionAlox5
morbid obesityCyp2e1
mouth diseasePtgs2
Mouth NeoplasmsPtgs2
multiple myelomaGpx1
Multiple Organ FailureAlox5
myeloid neoplasmAkr1c3 , Gpx1
myocardial infarctionCyp2j4 , Ephx2 , Ggt1 , Gpx1 , Ptgs2
Myocardial Reperfusion InjuryAlox5 , Ephx2 , Ptgs2
myocarditisPtgs2
Nasal PolypsAlox12 , Alox15 , Ptgs1 , Ptgs2
NecrosisCyp2e1
Neoplasm InvasivenessAlox5 , Cyp2e1
Neoplasm MetastasisAlox5 , Ptgs2
Neoplasm Recurrence, LocalPtgs2
Neoplasms, Hormone-DependentAkr1c3
nephritisCyp2j4
nephroblastomaPtgs2
nephrosclerosisPtgds
nephrosisGpx1
nephrotic syndromeAlox5 , Ptgs2
nervous system diseaseCyp2c79 , Ptgs2
Neurogenic InflammationPtgs2
non-Hodgkin lymphomaCyp2e1 , Gpx1
non-small cell lung carcinomaCyp2e1 , Ptges , Ptgs2
nonalcoholic fatty liver diseaseAlox15 , Cyp2e1 , Gpx1
obesityAkr1c3 , Alox12 , Cyp2e1 , Gpx1 , Ptgs2
obstructive sleep apneaPtgs2
open-angle glaucomaPtgs2
oral mucosa leukoplakiaPtgs2
oral submucous fibrosisPtgs2
osteoarthritisPtgs2
Osteoarthritis, KneePtges
osteoporosisGpx1
ovarian cystPtgs1
Ovarian NeoplasmsPtges , Ptgs1 , Ptgs2
PainAlox5 , Ptgs1 , Ptgs2
pancreatic cancerAlox5 , Ptgs2
pancreatic ductal carcinomaPtgs2
pancreatitisPtgs2
Pancreatitis, Acute NecrotizingTbxas1
papillomaPtges , Ptgs2
paraplegiaCyp2u1
Parkinson's diseaseCyp2e1 , Ephx2 , Gpx1
Parkinsonian DisordersPtgs2
patent ductus arteriosusPtgis
penile neoplasmPtges
peptic esophagitisPtges
Perennial Allergic RhinitisPtgs1
pericardial effusionPtgs2
periodontitisGgt1
Peripheral Nerve InjuriesPtgs1 , Ptgs2
peripheral nervous system diseaseAlox12 , Cyp2c79 , Ltc4s
peritonitisAlox15
Plaque, AtheroscleroticEphx2
platelet-type bleeding disorder 14Tbxas1
pleomorphic xanthoastrocytomaTbxas1
pleurisyAlox5 , Ptgs2
pleuropneumoniaAlox5
Pneumococcal PneumoniaAlox5
pneumoniaCyp2e1
PoisoningCyp4f18
Polycystic Kidney DiseasesPtgs1 , Ptgs2
polycystic ovary syndromeAkr1c3
PolyuriaPtges
portal hypertensionAlox5 , Ptgs2
pre-eclampsiaAkr1c3 , Cyp2j4 , Ptgs1
pre-malignant neoplasmPtgs2
precursor B lymphoblastic lymphoma/leukemiaAkr1c3
precursor lymphoblastic lymphoma/leukemiaCyp2c79 , Gpx1
precursor T-lymphoblastic lymphoma/leukemiaAkr1c3
Premature BirthPtgs2
prolactinomaPtgs2
prostate cancerAkr1c3 , Ptgs2
prostate carcinoma in situPtgs2
prostatic hypertrophyPtgs2
Prostatic NeoplasmsAkr1c3 , Alox12 , Cbr1 , Cyp2e1 , Ggt1 , Ptgs2 , Tbxas1
prostatitisPtgs2
proteinuriaPtgs2
pseudoxanthoma elasticumGpx1
psoriasisAlox12
Puberty, PrecociousPtgs2
pulmonary edemaAlox5
pulmonary embolismTbxas1
pulmonary emphysemaPtgs2
pulmonary fibrosisAlox5 , Ptgs2
pulmonary hypertensionAlox5 , Cyp2j4 , Ephx2 , Ptgis , Ptgs2
pulmonary tuberculosisAlox5
Radiation Injuries, ExperimentalPtgs1 , Ptgs2
Radiation PneumonitisAlox5
renal cell carcinomaAlox12 , Ptgs1 , Ptgs2
renal fibrosisCyp2j4
renal hypertensionCyp2c79 , Cyp2j4
renovascular hypertensionPtgs1
Reperfusion InjuryAlox12 , Alox15 , Alox5 , Cyp2e1 , Ephx2 , Gpx1 , Ptges , Ptgs1 , Ptgs2 , Tbxas1
ReticulocytosisGpx1
retrograde amnesiaPtgs2
RhabdomyolysisCyp2c79
Rhabdomyolysis, Cerivastatin-InducedCyp2c79
rheumatoid arthritisAlox5 , Ptgs1 , Ptgs2
sarcoidosisPtgs2
schizophreniaGgt1 , Ptgs2
Seasonal Allergic RhinitisAlox5 , Ptgs1
secondary hyperparathyroidismPtgs2
senile cataractGpx1
sensorineural hearing lossPtgds
SepsisCyp2e1 , Cyp2j4
sex differentiation diseaseAkr1c3
sickle cell anemiaGpx1
skin diseaseAlox12 , Ptgs2
Skin NeoplasmsPtgs2
Sleep DeprivationPtgs1 , Ptgs2
Spinal Cord InjuriesPtgs1 , Ptgs2
squamous cell carcinomaGpx1 , Lta4h , Ptgs2
status epilepticusPtgs2
Stevens-Johnson syndromePtgis
Stomach NeoplasmsAkr1c3 , Alox5 , Ptgs2
StrokeEphx2 , Ptgs2
Subarachnoid HemorrhagePtgs2
systemic lupus erythematosusPtgs2
systemic sclerodermaPtgs2
Testicular NeoplasmsAlox12
thrombosisPtgs2 , Tbxas1
Thyroid NeoplasmsPtgs2
Tobacco Addiction, Susceptibility ToCyp2b3
Tongue NeoplasmsPtgs2
transitional cell carcinomaGpx1 , Ptges , Ptgs2
type 1 diabetes mellitusAlox15 , Cyp2e1
type 2 diabetes mellitusAlox12 , Cyp2e1 , Ggt1 , Gpx1 , Ptgds , Ptgs2
ulcerative colitisAlox12 , Gpx1
ureteral obstructionCyp2j4
urinary bladder cancerAlox12 , Gpx1 , Ptgs2
Urologic NeoplasmsPtgs2
urticariaAlox5
Uterine Cervical NeoplasmsPtgs1 , Ptgs2
vascular dementiaGpx1
Venous ThrombosisGpx1
Ventilator-Induced Lung InjuryPtgs2
Ventricular Dysfunction, LeftEphx2
visual epilepsyPtgs2
Wernicke encephalopathyPtgs2
Wounds and InjuriesAlox15
Pathway Annotations Associated with Genes in the paracetamol drug pathway
Pathway TermsGene Symbols
acetylsalicylic acid pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
alpha-linoleic acid metabolic pathwayPla2g4b
amyotrophic lateral sclerosis pathwayGpx1
antipyrine drug pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
arachidonic acid metabolic pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
atherosclerosis pathwayAlox15
caffeine pharmacokinetics pathwayCyp2c79 , Cyp2e1
carbamazepine pharmacokinetics pathwayCyp2b3 , Cyp2c79
celecoxib pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
celecoxib pharmacokinetics pathwayPtgs1 , Ptgs2
clopidogrel pharmacodynamics pathwayCyp2b3
clopidogrel pharmacokinetics pathwayCyp2b3
cyanoamino acid metabolic pathwayGgt1
cyclooxygenase mediated pathway of arachidonic acid metabolismPtgs1 , Ptgs2
cyclophosphamide pharmacodynamics pathwayCyp2b3 , Cyp2c79
cyclophosphamide pharmacokinetics pathwayCyp2b3 , Cyp2c79
diclofenac pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
diflunisal pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
disulfiram pharmacodynamics pathwayCyp2e1
dopa responsive dystonia pathwayCbr1
doxorubicin pharmacokinetics pathwayAkr1c3 , Cbr1
ether lipid metabolic pathwayPla2g4b
ether lipid metabolic pathwayPla2g4b
etodolac pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
etoposide pharmacodynamics pathwayPtgs1 , Ptgs2
etoposide pharmacokinetics pathwayPtgs1 , Ptgs2
Fc epsilon receptor mediated signaling pathwayPla2g4b
felbamate pharmacokinetics pathwayCyp2e1
fenoprofen pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
flurbiprofen pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
glutamate signaling pathwayPla2g4b
glutathione metabolic pathwayGgt1 , Gpx1
glutathione synthase deficiency pathwayGpx1
glutathionuria disease pathwayGpx1
glycerophospholipid metabolic pathwayPla2g4b
gonadotropin-releasing hormone signaling pathwayPla2g4b
Huntington's disease pathwayGpx1
ibuprofen pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
ibuprofen pharmacokinetics pathwayCyp2c79 , Ptgs1 , Ptgs2
ifosfamide pharmacodynamics pathwayCyp2b3 , Cyp2c79
ifosfamide pharmacokinetics pathwayCyp2b3 , Cyp2c79
indometacin pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
indometacin pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
interleukin-23 signaling pathwayAlox12b
interleukin-4 signaling pathwayAlox15
isoprenoid metabolic pathwayAkr1c3
ketoprofen pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
ketorolac pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
Leishmaniasis pathwayPtgs2
leukotriene C4 synthase deficiency pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
leukotriene metabolic pathwayAlox5 , Lta4h , Ltc4s
linoleic acid metabolic pathwayAlox15 , Cyp2e1 , Cyp2j4 , Pla2g4b
lipoxygenase mediated pathway of arachidonic acid metabolismAlox12 , Alox12b , Alox15 , Alox15b , Alox5 , Lta4h , Ltc4s
long term depressionPla2g4b
lornoxicam pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
magnesium salicylate pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
mefenamic acid pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
meloxicam pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
methadone pharmacodynamics pathwayCyp2b3 , Cyp2c79
methadone pharmacokinetics pathwayCyp2b3 , Cyp2c79
mitogen activated protein kinase signaling pathwayPla2g4b
mycophenolic acid pharmacokinetics pathwayCyp2c79
nabumetone pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
naproxen pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
neviparine pharmacokinetics pathwayCyp2b3
nicotine pharmacodynamics pathwayCyp2b3
nicotine pharmacokinetics pathwayCyp2b3
paracetamol drug pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
paracetamol pharmacokinetics pathwayCyp2e1
paracetamol response pathwayCyp2e1
phase I biotransformation pathway via cytochrome P450Cyp2b3 , Cyp2e1
phenytoin pharmacodynamics pathwayCyp2e1
piroxicam pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
prostacyclin biosynthetic pathwayPtgis
prostaglandin biosynthetic pathwayAkr1c3 , Cbr1 , Fam213b , Ptgds , Ptges
prostanoid biosynthetic pathwayPtgs1 , Ptgs2
retinol metabolic pathwayCyp2b3
rosiglitazone pharmacokinetics pathwayCyp2c79
salicylic acid pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
Segawa syndrome pathwayCbr1
selenoamino acid metabolic pathwayGgt1
small cell lung carcinoma pathwayPtgs2
sodium salicylate pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
sorafenib pharmacokinetics pathwayCyp2b3 , Cyp2c79
sphingosine 1-phosphate signaling pathwayPtgs2
sulindac pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
tamoxifen pharmacodynamics pathwayCyp2b3
tamoxifen pharmacokinetics pathwayCyp2b3
taurine and hypotaurine metabolic pathwayGgt1
tenoxicam pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
thromboxane biosynthetic pathwayTbxas1
tiaprofenic acid pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
tolmetin pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
toxoplasmosis pathwayAlox5 , Pla2g4b
tramadol pharmacokinetics pathwayCyp2b3
type 1 diabetes mellitus pathwayAlox15
valdecoxib pharmacodynamics pathwayAkr1c3 , Alox12 , Alox12b , Alox15 , Alox15b , Alox5 , Cbr1 , Cyp2b3 , Cyp2c79 , Cyp2e1 , Cyp2j4 , Cyp2u1 , Cyp4f18 , Ephx2 , Fam213b , Ggt1 , Gpx1 , Lta4h , Ltc4s , Pla2g4b , Ptgds , Ptges , Ptgis , Ptgs1 , Ptgs2 , Tbxas1
valproic acid pharmacokinetics pathwayCyp2b3
vascular endothelial growth factor signaling pathwayPla2g4b , Ptgs2
vitamin A deficiency pathwayCyp2b3

References Associated with the paracetamol drug pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: