RGD Reference Report - Relationship between genetic polymorphism of cytochrome P450IIE1 and fatty liver. - Rat Genome Database

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Relationship between genetic polymorphism of cytochrome P450IIE1 and fatty liver.

Authors: Piao, YF  Li, JT  Shi, Y 
Citation: Piao YF, etal., World J Gastroenterol. 2003 Nov;9(11):2612-5.
RGD ID: 1626302
Pubmed: PMID:14606109   (View Abstract at PubMed)
PMCID: PMC4656553   (View Article at PubMed Central)

AIM: To study the correlation between genetic polymorphism of cytochrome P450IIE1 (CYPIIE1) and fatty liver. METHODS: Peripheral blood mononuclear cells were collected in 56 patients with fatty liver, 26 patients without fatty liver and 20 normal controls. Then PCR-RFLP was used to analyze genetic polymorphism of CYPIIE1 in monocytes on the region of Pst I and Rsa I. RESULTS: The frequency of homozygotic C1 gene in patients with alcoholic fatty liver (28.6%), obese fatty liver (38.5%), or diabetic fatty liver (33.3%) was significantly lower than that of the corresponding patients without fatty liver (100%, 100% and 80% respectively), while the frequency of C2 genes, including C1/C2 and C2/C2, was significantly higher (71.4%/0%, 61.5%/0%, and 66.7%/20%) (P<0.01). The frequency distribution of the above genes of non-fatty liver patients (100%/0, 100%/0, and 80%/20%) was not significantly different from that of the normal controls (85%/15%) (P>0.05). CONCLUSION: The genetic polymorphism of CYPIIE1 on the position of Pst I and Rsa I is related to the susceptibility of fatty liver. Besides, C2 gene may play a key role in the pathogenesis of fatty liver.




  
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Species
Term
Qualifier
Evidence
With
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Source
Original Reference(s)
CYP2E1Humansteatotic liver disease  IAGP DNA:polymorphism:5' utr:reduced frequency of homozygotic C1 RFLP (PstI+, RsaI-) and increased frequency of C2 RFLP (PstI- and RsaI+) in Chinese patientsRGD 
Cyp2e1Ratsteatotic liver disease  ISOCYP2E1 (Homo sapiens) RGD 
Cyp2e1Mousesteatotic liver disease  ISOCYP2E1 (Homo sapiens) RGD 


Genes (Rattus norvegicus)
Cyp2e1  (cytochrome P450, family 2, subfamily e, polypeptide 1)

Genes (Mus musculus)
Cyp2e1  (cytochrome P450, family 2, subfamily e, polypeptide 1)

Genes (Homo sapiens)
CYP2E1  (cytochrome P450 family 2 subfamily E member 1)