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Gene: CYP2E1 (cytochrome P450 family 2 subfamily E member 1) Homo sapiens
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Symbol: CYP2E1
Name: cytochrome P450 family 2 subfamily E member 1
Description: Exhibits 4-nitrophenol 2-monooxygenase activity; enzyme binding activity; and heme binding activity. Involved in several processes, including 4-nitrophenol metabolic process; lipid hydroxylation; and monoterpenoid metabolic process. Predicted to localize to the mitochondrial inner membrane. Implicated in several diseases, including acoustic neuroma; fatty liver disease; gastrointestinal system cancer (multiple); liver disease (multiple); and lung disease (multiple). Biomarker of alcohol use disorder; asthma; diabetes mellitus (multiple); interstitial lung disease (multiple); and morbid obesity.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 4-nitrophenol 2-hydroxylase; CPE1; CYP2E; CYPIIE1; cytochrome P450 2E1; cytochrome P450, family 2, subfamily E, polypeptide 1; cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1; cytochrome P450-J; flavoprotein-linked monooxygenase; microsomal monooxygenase; P450-J; P450C2E; xenobiotic monooxygenase
Orthologs:
Mus musculus (house mouse) : Cyp2e1 (cytochrome P450, family 2, subfamily e, polypeptide 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cyp2e1 (cytochrome P450, family 2, subfamily e, polypeptide 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102026028 (cytochrome P450 2E1)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100981327 (cytochrome P450 2E1)
Canis lupus familiaris (dog) : CYP2E1 (cytochrome P450 family 2 subfamily E member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101973029 (cytochrome P450 2E1)
Sus scrofa (pig) : CYP2E1 (cytochrome P450, family 2, subfamily E, polypeptide 1)
Chlorocebus sabaeus (African green monkey) : CYP2E1 (cytochrome P450 family 2 subfamily E member 1)
Heterocephalus glaber (naked mole-rat) : LOC101722366 (cytochrome P450 2E1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl10133,520,406 - 133,561,220 (+)Ensembl
GRCh3810133,527,363 - 133,539,123 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710135,340,300 - 135,352,627 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610135,190,857 - 135,202,610 (+)NCBINCBI36hg18NCBI36
Build 3410135,229,747 - 135,241,501NCBI
Celera10128,168,529 - 128,180,282 (-)NCBI
Cytogenetic Map10q26.3NCBI
HuRef10128,882,691 - 128,894,624 (+)NCBIHuRef
CHM1_110135,620,490 - 135,632,188 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated