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Gene: HBA2 (hemoglobin subunit alpha 2) Homo sapiens
Symbol: HBA2
Name: hemoglobin subunit alpha 2
Description: Contributes to haptoglobin binding activity and peroxidase activity. Involved in hydrogen peroxide catabolic process; positive regulation of cell death; and response to hydrogen peroxide. Localizes to several cellular components, including the cytosolic small ribosomal subunit; haptoglobin-hemoglobin complex; and hemoglobin complex. Implicated in alpha thalassemia; hemoglobin H disease; and primary polycythemia. Biomarker of alpha thalassemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha globin; alpha-2 globin; alpha-globin; ECYT7; HBA-T2; HBH; hemoglobin alpha chain; hemoglobin subunit alpha; hemoglobin, alpha 1; hemoglobin, alpha 2; mutant hemoglobin alpha 2 globin chain; truncated HbA2
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: We are aware that there is inconsistency among GenBank, RefSeq, and other browsers about the gene order in the alpha globin cluster. According to review by staff at HbVar (, the gene order, telomere to centromere, for these loci is ...HBZ(HBZ2)..HBZP(HBZ1)..HBA2..HBA1... [13 Feb 2013]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl16172,876 - 173,710 (+)Ensembl
GRCh3816172,876 - 173,710 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3716222,846 - 223,709 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3616162,875 - 163,708 (+)NCBINCBI36hg18NCBI36
Build 3416162,874 - 163,705NCBI
Celera16426,165 - 427,036 (+)NCBI
Cytogenetic Map16p13.3NCBI
HuRef16140,887 - 141,750 (+)NCBIHuRef
CHM1_116222,852 - 223,715 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HBA2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737064
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.