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Gene: HBA2 (hemoglobin subunit alpha 2) Homo sapiens
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Symbol: HBA2
Name: hemoglobin subunit alpha 2
Description: Contributes to haptoglobin binding activity and peroxidase activity. Involved in hydrogen peroxide catabolic process; positive regulation of cell death; and response to hydrogen peroxide. Localizes to several cellular components, including the cytosolic small ribosomal subunit; haptoglobin-hemoglobin complex; and hemoglobin complex. Implicated in alpha thalassemia; hemoglobin H disease; and primary polycythemia. Biomarker of alpha thalassemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha globin; alpha-2 globin; alpha-globin; ECYT7; HBA-T2; HBH; hemoglobin alpha chain; hemoglobin subunit alpha; hemoglobin, alpha 1; hemoglobin, alpha 2; mutant hemoglobin alpha 2 globin chain; truncated HbA2
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: We are aware that there is inconsistency among GenBank, RefSeq, and other browsers about the gene order in the alpha globin cluster. According to review by staff at HbVar (http://globin.bx.psu.edu/hbvar/menu.html), the gene order, telomere to centromere, for these loci is ...HBZ(HBZ2)..HBZP(HBZ1)..HBA2..HBA1... [13 Feb 2013]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl16172,876 - 173,710 (+)Ensembl
GRCh3816172,876 - 173,710 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3716222,846 - 223,709 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3616162,875 - 163,708 (+)NCBINCBI36hg18NCBI36
Build 3416162,874 - 163,705NCBI
Celera16426,165 - 427,036 (+)NCBI
Cytogenetic Map16p13.3NCBI
HuRef16140,887 - 141,750 (+)NCBIHuRef
CHM1_116222,852 - 223,715 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on HBA2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737064
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-01-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.