CYP2E1 (cytochrome P450 family 2 subfamily E member 1)

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Gene: CYP2E1 (cytochrome P450 family 2 subfamily E member 1) Canis lupus familiaris

Analyze

Symbol:

CYP2E1

Name:

cytochrome P450 family 2 subfamily E member 1

RGD ID:

12058559

Description:

ENCODES a protein that exhibits heme binding (ortholog); Hsp70 protein binding (ortholog); Hsp90 protein binding (ortholog); INVOLVED IN response to bacterium (ortholog); response to ethanol (ortholog); response to organonitrogen compound (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH acoustic neuroma (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN Golgi membrane (ortholog); intracellular membrane-bounded organelle (ortholog); intrinsic component of endoplasmic reticulum membrane (ortholog); INTERACTS WITH benzyl alcohol; clofibrate; diethyldithiocarbamic acid

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

4-nitrophenol 2-hydroxylase; CYPIIE1; cytochrome P450 2E1; cytochrome P450, family 2, subfamily E, polypeptide 1

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	41,079,164 - 41,089,188 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	41,035,025 - 41,122,754 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	41,171,673 - 41,181,706 (+)	NCBI
ROS_Cfam_1.0	28	41,754,551 - 41,764,586 (+)	NCBI
ROS_Cfam_1.0 Ensembl	28	41,754,522 - 41,764,585 (+)	Ensembl
UMICH_Zoey_3.1	28	41,235,594 - 41,245,625 (+)	NCBI
UNSW_CanFamBas_1.0	28	41,224,985 - 41,235,013 (+)	NCBI
UU_Cfam_GSD_1.0	28	41,627,674 - 41,637,700 (+)	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acoustic neuroma (ISO)

acute kidney failure (ISO)

acute lymphoblastic leukemia (ISO)

adenocarcinoma (ISO)

alcohol use disorder (ISO)

Alcoholic Fatty Liver (ISO)

alcoholic liver cirrhosis (ISO)

Alcoholic Liver Diseases (ISO)

amenorrhea (ISO)

asbestosis (ISO)

asthma (ISO)

Binge Drinking (ISO)

Cardiomegaly (ISO)

Chemical and Drug Induced Liver Injury (ISO)

Chronic Bronchitis (ISO)

chronic obstructive pulmonary disease (ISO)

colon cancer (ISO)

colorectal cancer (ISO)

distal 10q deletion syndrome (ISO)

Drug Eruptions (ISO)

drug-induced hepatitis (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Liver Neoplasms (ISO)

extrinsic allergic alveolitis (ISO)

familial hyperlipidemia (ISO)

fatty liver disease (ISO)

hepatocellular adenoma (ISO)

hepatocellular carcinoma (ISO)

high grade glioma (ISO)

Human Viral Hepatitis (ISO)

intrahepatic cholestasis (ISO)

liver disease (ISO)

Liver Injury (ISO)

Liver Neoplasms (ISO)

lung disease (ISO)

Lung Neoplasms (ISO)

lung non-small cell carcinoma (ISO)

mental depression (ISO)

Micronuclei, Chromosome-Defective (ISO)

middle cerebral artery infarction (ISO)

morbid obesity (ISO)

nasopharynx carcinoma (ISO)

Necrosis (ISO)

Neoplasm Invasiveness (ISO)

non-alcoholic fatty liver disease (ISO)

non-Hodgkin lymphoma (ISO)

obesity (ISO)

oral cavity cancer (ISO)

oral squamous cell carcinoma (ISO)

Parkinson's disease (ISO)

Patent Ductus Venosus (ISO)

pneumonia (ISO)

Prostatic Neoplasms (ISO)

Reperfusion Injury (ISO)

Sepsis (ISO)

stomach cancer (ISO)

Testicular Injury (ISO)

type 1 diabetes mellitus (ISO)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

benzyl alcohol (EXP)

clofibrate (EXP)

diethyldithiocarbamic acid (EXP)

fomepizole (EXP)

o-cresol (EXP)

p-cresol (EXP)

phenobarbital (EXP)

toluene (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

4-nitrophenol metabolic process (IEA)

epoxygenase P450 pathway (IBA)

fatty acid metabolic process (IEA)

heterocycle metabolic process (IEA)

lipid hydroxylation (IEA)

lipid metabolic process (IEA)

long-chain fatty acid metabolic process (IEA)

monoterpenoid metabolic process (IEA)

organic acid metabolic process (IBA)

response to bacterium (IEA,ISO)

response to ethanol (ISO)

response to organonitrogen compound (ISO)

response to ozone (ISO)

response to xenobiotic stimulus (ISO)

steroid metabolic process (IEA)

triglyceride metabolic process (ISO)

xenobiotic metabolic process (IBA,IEA,ISO)

Cellular Component

cytoplasm (IBA)

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IEA)

Golgi membrane (ISO)

integral component of membrane (IEA)

intracellular membrane-bounded organelle (IBA,IEA,ISO)

intrinsic component of endoplasmic reticulum membrane (ISO)

membrane (IEA)

mitochondrial inner membrane (IEA,ISS)

mitochondrion (IEA,ISO)

Molecular Function

4-nitrophenol 2-monooxygenase activity (IEA)

arachidonic acid epoxygenase activity (IBA)

aromatase activity (IEA)

enzyme binding (IEA)

heme binding (IBA,IEA,ISS)

Hsp70 protein binding (IEA,ISS)

Hsp90 protein binding (IEA,ISS)

iron ion binding (IEA)

long-chain fatty acid omega-1 hydroxylase activity (IEA)

metal ion binding (IEA)

monooxygenase activity (IEA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (IEA)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (IBA,IEA)

steroid hydroxylase activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylsalicylic acid pharmacodynamics pathway (ISO)

antipyrine drug pathway (ISO)

arachidonic acid metabolic pathway (ISO)

caffeine pharmacokinetics pathway (ISO)

celecoxib pharmacodynamics pathway (ISO)

diclofenac pharmacodynamics pathway (ISO)

diflunisal pharmacodynamics pathway (ISO)

disulfiram pharmacodynamics pathway (ISO)

etodolac pharmacodynamics pathway (ISO)

felbamate pharmacokinetics pathway (ISO)

fenoprofen pharmacodynamics pathway (ISO)

flurbiprofen pharmacodynamics pathway (ISO)

ibuprofen pharmacodynamics pathway (ISO)

indometacin pharmacodynamics pathway (ISO)

ketoprofen pharmacodynamics pathway (ISO)

ketorolac pharmacodynamics pathway (ISO)

leukotriene C4 synthase deficiency pathway (ISO)

lornoxicam pharmacodynamics pathway (ISO)

magnesium salicylate pharmacodynamics pathway (ISO)

mefenamic acid pharmacodynamics pathway (ISO)

meloxicam pharmacodynamics pathway (ISO)

nabumetone pharmacodynamics pathway (ISO)

naproxen pharmacodynamics pathway (ISO)

paracetamol drug pathway (ISO)

paracetamol pharmacokinetics pathway (ISO)

paracetamol response pathway (ISO)

phenytoin pharmacodynamics pathway (ISO)

piroxicam pharmacodynamics pathway (ISO)

salicylic acid pharmacodynamics pathway (ISO)

sodium salicylate pharmacodynamics pathway (ISO)

sulindac pharmacodynamics pathway (ISO)

tenoxicam pharmacodynamics pathway (ISO)

tiaprofenic acid pharmacodynamics pathway (ISO)

tolmetin pharmacodynamics pathway (ISO)

valdecoxib pharmacodynamics pathway (ISO)

References

Additional References at PubMed

PMID:10901710	PMID:21833537

Genomics

Comparative Map Data

CYP2E1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	41,079,164 - 41,089,188 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	41,035,025 - 41,122,754 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	41,171,673 - 41,181,706 (+)	NCBI
ROS_Cfam_1.0	28	41,754,551 - 41,764,586 (+)	NCBI
ROS_Cfam_1.0 Ensembl	28	41,754,522 - 41,764,585 (+)	Ensembl
UMICH_Zoey_3.1	28	41,235,594 - 41,245,625 (+)	NCBI
UNSW_CanFamBas_1.0	28	41,224,985 - 41,235,013 (+)	NCBI
UU_Cfam_GSD_1.0	28	41,627,674 - 41,637,700 (+)	NCBI

CYP2E1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	133,527,363 - 133,539,123 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	10	133,520,406 - 133,561,220 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	135,340,867 - 135,352,627 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	135,190,857 - 135,202,610 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	10	135,229,747 - 135,241,501	NCBI
Celera	10	128,168,529 - 128,180,282 (-)	NCBI
Cytogenetic Map	10	q26.3	NCBI
HuRef	10	128,882,691 - 128,894,624 (+)	NCBI		HuRef
CHM1_1	10	135,620,490 - 135,632,188 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	134,478,949 - 134,490,654 (+)	NCBI

Cyp2e1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	140,343,732 - 140,354,903 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	7	140,343,652 - 140,354,900 (+)	Ensembl
GRCm38	7	140,763,819 - 140,774,990 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	140,763,739 - 140,774,987 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	147,949,731 - 147,960,880 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	7	140,615,152 - 140,626,301 (+)	NCBI			mm8
Celera	7	140,556,087 - 140,567,236 (+)	NCBI		Celera
Cytogenetic Map	7	F4	NCBI
cM Map	7	85.94	NCBI

Cyp2e1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	195,840,330 - 195,850,728 (+)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	1	195,840,058 - 195,864,023 (+)	Ensembl
Rnor_6.0	1	213,511,892 - 213,522,195 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	213,511,874 - 213,535,542 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	220,405,975 - 220,416,727 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	200,918,521 - 200,928,919 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	201,068,525 - 201,078,911 (+)	NCBI
Celera	1	193,484,404 - 193,494,772 (+)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI

LOC102026028
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955507	6,289,576 - 6,304,193 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955507	6,293,162 - 6,303,255 (-)	NCBI	ChiLan1.0	ChiLan1.0

CYP2E1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	10	134,839,025 - 134,852,053 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	134,839,025 - 134,852,719 (+)	Ensembl	panpan1.1		panPan2

LOC101973029
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	5,858,593 - 5,869,493 (-)	NCBI
SpeTri2.0	NW_004936486	19,691,822 - 19,702,684 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CYP2E1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	141,690,426 - 141,736,817 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	141,690,737 - 141,703,078 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	153,478,051 - 153,490,404 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CYP2E1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	53,390,054 - 53,403,309 (+)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	26	53,390,089 - 53,404,211 (+)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666054	41,523,569 - 41,534,845 (+)	NCBI	Vero_WHO_p1.0

LOC101722366
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624737	12,335,681 - 12,345,514 (-)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624737	12,335,733 - 12,345,278 (-)	NCBI	HetGla_female_1.0		hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001003339	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF029978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF029979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000301	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000071	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000374	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSCAFT00000038789 ⟹ ENSCAFP00000034547

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	28	41,101,002 - 41,122,754 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000039127 ⟹ ENSCAFP00000034940

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	28	41,079,164 - 41,089,180 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000063996 ⟹ ENSCAFP00000056254

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	28	41,035,025 - 41,089,180 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000077318 ⟹ ENSCAFP00000063193

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	28	41,079,171 - 41,122,754 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845048334 ⟹ ENSCAFP00845037920

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	28	41,754,522 - 41,764,506 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845048390 ⟹ ENSCAFP00845037964

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	28	41,754,527 - 41,764,585 (+)	Ensembl

RefSeq Acc Id:

NM_001003339 ⟹ NP_001003339

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	28	41,079,164 - 41,089,188 (+)	NCBI
Dog10K_Boxer_Tasha	28	41,171,673 - 41,181,706 (+)	NCBI
ROS_Cfam_1.0	28	41,754,551 - 41,764,586 (+)	NCBI
UMICH_Zoey_3.1	28	41,235,594 - 41,245,625 (+)	NCBI
UNSW_CanFamBas_1.0	28	41,224,985 - 41,235,013 (+)	NCBI
UU_Cfam_GSD_1.0	28	41,627,674 - 41,637,700 (+)	NCBI

Sequence:

show sequence

AGACACCATGGCCGCCTTGGGCATCACAGTGGCCCTGCTGGTGTGGATGGCCACCTTAATGCTT
ATCTCTATCTGGAAGCAGATCTACAGCCGCTGGAAACTGCCCCCTGGCCCTTTTCCACTGCCCA
TCATTGGGAATATTCTGCAGGTGGATATCAAGAATGTTCCCAAATCTCTCGCCAAGCTGGCAGA
GCAGTACGGGCCAGTGTTCACCTTGTACCTGGGCTCCCAGCGCACAGTGGTCCTGCATGGCTAC
AAGGCGGTGAAGGAAGTTCTGCTTGACCACAAGAATGACCTTTCTGGCAGAGGAGAAGTCTTCG
CATTCCAGTCGCACAAGGACAGAGGGATCACGTTCAACAATGGGCCCGGCTGGAAGGACACGCG
GCGACTCTCCCTGAGCACCCTCCGGGACTACGGCATGGGGAAGCGCGGCAACGAGGAGCGGATC
CAGAGGGAGATCCCCTTCCTGCTGGAGGCGCTCAGGGGCACCCGGGGCCAGCCCTTCGACCCCA
CCTTTCTCCTGGGCTTCGCCCCCTTCAACGTCATCGCTGACATCCTCTTCCACAAGCACTTTGA
CTACTCGGATCAGACTGGGCTGCGGATACAGAAGCTGTTCAACGAGAACTTCCACCTGCTCAGC
ACCGGCTGGCTCCAGCTTTATAACATTTTCCCAAGCTATCTGCACTACCTGCCCGGAAGCCATA
GAAAAGTCTTAAGAAATGTGGCTGAACTAAAGGATTACAGCTTAGAAAGGGTGAAGGAGCACCA
GGAGTCGCTGGACCCCACCTGCTCCCGGGACTTCACTGACTGCTTGCTCCAGGAGCTGCAGAAG
GAGAGATACGGTACGGAGCCTTGGTATACCTTGGACAACATTGCCGTGACCGTGGCTGACCTGT
TCTTTGCGGGCACGGAGACCACCAGCACCACCCTGAGATACGGGCTCCTGATTCTCATGAAATA
CCCAGAGGTCGAAGAGAAACTTCATGAAGAAATCGACAGGGTGATCGGCCCAAGCCGAGTCCCT
GCCATCAAGGACAGGCTGGAGATGCCCTACATGGATGCCGTGGTGCACGAGATTCAGCGATTCA
TCGACCTGCTGCCCTCCAACCTGCCCCATGTAGCAAACCAGGACACGATGTTCAGAGGATATGT
CATCCCCAAGGGCACAGTGGTAATTCCCACACTGGACTCCGTCTTGTTTGACAAACAAGAATTC
CCTGATCCAGAGAAGTTCAAGCCAGAGCACTTTCTGAATGAAAACGGAAAATTCAAATATAGTG
ACTACTTCAAGGCATTCTCCGCAGGAAAGCGGGTGTGTGTTGGAGAAGGCCTGGCTCGCATGGA
GCTCTTCCTGTTCTTGTCCGCCATTTTGCAGCACTTTAACCTGAAGTCTCTCGTCGACCCCAAG
GATATTGACCTCAGTCCCTGCACAATCGGGTTTGCCAAGATCCCCCCCCATTACAAACTCTGTG
TCGTTCCCCGCTCGGGCTGAAGACCCCCGGGCCCCAGGCTCTTTGGTGCAAACCTGGAGTCTTC
CTGCTTCCGCATATCCCTTTAATGCCTCCAGGAAGACCCTCCCTGCACAGTCTGGTGGAGGCAC
TCAGGGTTTCACAGGGAATAAATTGGTCCTGAGATGCTGCTTTTCAGAGTCACACTCATCAGAT
GAAATTTGACAGCAACGTCCAAAAAAGATTGTGCAAAACTAATTAAACAAATTGAAACAAACAA
AAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001003339	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF88144	(Get FASTA)	NCBI Sequence Viewer
	AAF88145	(Get FASTA)	NCBI Sequence Viewer
	Q9MZY0	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001003339 ⟸ NM_001003339

- UniProtKB:

Q9MZY0 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MAALGITVALLVWMATLMLISIWKQIYSRWKLPPGPFPLPIIGNILQVDIKNVPKSLAKLAEQY
GPVFTLYLGSQRTVVLHGYKAVKEVLLDHKNDLSGRGEVFAFQSHKDRGITFNNGPGWKDTRRL
SLSTLRDYGMGKRGNEERIQREIPFLLEALRGTRGQPFDPTFLLGFAPFNVIADILFHKHFDYS
DQTGLRIQKLFNENFHLLSTGWLQLYNIFPSYLHYLPGSHRKVLRNVAELKDYSLERVKEHQES
LDPTCSRDFTDCLLQELQKERYGTEPWYTLDNIAVTVADLFFAGTETTSTTLRYGLLILMKYPE
VEEKLHEEIDRVIGPSRVPAIKDRLEMPYMDAVVHEIQRFIDLLPSNLPHVANQDTMFRGYVIP
KGTVVIPTLDSVLFDKQEFPDPEKFKPEHFLNENGKFKYSDYFKAFSAGKRVCVGEGLARMELF
LFLSAILQHFNLKSLVDPKDIDLSPCTIGFAKIPPHYKLCVVPRSG

hide sequence

RefSeq Acc Id:

ENSCAFP00000034940 ⟸ ENSCAFT00000039127

RefSeq Acc Id:

ENSCAFP00000063193 ⟸ ENSCAFT00000077318

RefSeq Acc Id:

ENSCAFP00000034547 ⟸ ENSCAFT00000038789

RefSeq Acc Id:

ENSCAFP00000056254 ⟸ ENSCAFT00000063996

RefSeq Acc Id:

ENSCAFP00845037964 ⟸ ENSCAFT00845048390

RefSeq Acc Id:

ENSCAFP00845037920 ⟸ ENSCAFT00845048334

Promoters

RGD ID:

13688384

Promoter ID:

EPDNEW_C6454

Type:

multiple initiation site

Name:

CYP2E1_1

Description:

cytochrome P450 family 2 subfamily E member 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	28	41,079,140 - 41,079,200	EPDNEW

Damaging Variants

Assembly: CanFam3.1

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
28	41088922	41088923	T	C	snv	Australian Cattle dog (AC023), Tibetan Mastiff (TM8), Alpine Dachsbracke (AD009), Weimaraner (WE006), Basset (BH003), Basenji (BJ002), Basenji (BJ003), Basenji (BJ004), Basenji (BJ006), Bullterrier (BT012), Cavalier King Charles Spaniel (CK023), Great Dane (DD116), Dachshund (DH126), Chinese indigenous dogs (DQ10), Chinese indigenous dogs (DQ2), Chinese indigenous dogs (DQ3), Chinese indigenous dogs (DQ4), Chinese indigenous dogs (DQ5), Chinese indigenous dogs (DQ6), Chinese indigenous dogs (DQ7), Chinese indigenous dogs (DQ8), German Shepherd/Mixed breed (DS041), German Shepherd (DS053), Elo (EL565), Eurasier (EU035), German Shepherd (GS3), German Shepherd (GS4), German Shepherd (GS6), German Shepherd (GS7), Kromfohrländer (KF042), Kunming Dog (KM3), Labrador Retriever (LA1869), Labrador Retriever (LA2443), Labrador Retriever (LA882), Labrador Retriever (LA900), Chinese indigenous dogs (LJ6), Chinese indigenous dogs (LJ8), Chinese indigenous dogs (LJ9), Old English Sheepdog (OS001), Cavalier King Charles Spaniel (SID00101), Shetland Sheepdog (SRS932138), Standard Poodle (SRS932143), Alaskan Husky (SY018), Tibetan Mastiff (TM1), Tibetan Mastiff (TM10), Tibetan Mastiff (TM6), Australian Cattle dog (AC108)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000013311	Ensembl
	ENSCAFG00030026254	UniProtKB/Swiss-Prot
	ENSCAFG00040018971	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSCAFG00845027431	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSCAFP00030042533	UniProtKB/Swiss-Prot
	ENSCAFP00040030529	UniProtKB/TrEMBL
	ENSCAFP00040030554	UniProtKB/Swiss-Prot
	ENSCAFP00845037920.1	UniProtKB/TrEMBL
	ENSCAFP00845037964	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSCAFT00030048596	UniProtKB/Swiss-Prot
	ENSCAFT00040035069	UniProtKB/TrEMBL
	ENSCAFT00040035095	UniProtKB/Swiss-Prot
	ENSCAFT00845048334.1	UniProtKB/TrEMBL
	ENSCAFT00845048390	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.630.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Cyt_P450	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cyt_P450_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cyt_P450_E_grp-I	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cyt_P450_E_grp-I_CYP2E-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cyt_P450_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	cfa:415128	UniProtKB/Swiss-Prot
NCBI Gene	CYP2E1	ENTREZGENE
Pfam	p450	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	EP450I	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EP450ICYP2E	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P450	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	CYTOCHROME_P450	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48264	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8C0T4B0_CANLF	UniProtKB/TrEMBL
	A0A8I3PU60_CANLF	UniProtKB/TrEMBL
	CP2E1_CANLF	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	Q9MZY1	UniProtKB/Swiss-Prot
VGNC ID	VGNC:50353	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-01-09	CYP2E1	cytochrome P450 family 2 subfamily E member 1		cytochrome P450, family 2, subfamily E, polypeptide 1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

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Imported Annotations - SMPDB