CYP2E1 (cytochrome P450 family 2 subfamily E member 1) - Rat Genome Database

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Gene: CYP2E1 (cytochrome P450 family 2 subfamily E member 1) Canis lupus familiaris
Analyze
Symbol: CYP2E1
Name: cytochrome P450 family 2 subfamily E member 1
RGD ID: 12058559
Description: ENCODES a protein that exhibits heme binding (ortholog); Hsp70 protein binding (ortholog); Hsp90 protein binding (ortholog); INVOLVED IN response to bacterium (ortholog); response to ethanol (ortholog); response to organonitrogen compound (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH acoustic neuroma (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN Golgi membrane (ortholog); intracellular membrane-bounded organelle (ortholog); intrinsic component of endoplasmic reticulum membrane (ortholog); INTERACTS WITH benzyl alcohol; clofibrate; diethyldithiocarbamic acid
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 4-nitrophenol 2-hydroxylase; CYPIIE1; cytochrome P450 2E1; cytochrome P450, family 2, subfamily E, polypeptide 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12841,079,164 - 41,089,188 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2841,035,025 - 41,122,754 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2841,171,673 - 41,181,706 (+)NCBI
ROS_Cfam_1.02841,754,551 - 41,764,586 (+)NCBI
ROS_Cfam_1.0 Ensembl2841,754,522 - 41,764,585 (+)Ensembl
UMICH_Zoey_3.12841,235,594 - 41,245,625 (+)NCBI
UNSW_CanFamBas_1.02841,224,985 - 41,235,013 (+)NCBI
UU_Cfam_GSD_1.02841,627,674 - 41,637,700 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
acute kidney failure  (ISO)
acute lymphoblastic leukemia  (ISO)
adenocarcinoma  (ISO)
alcohol use disorder  (ISO)
Alcoholic Fatty Liver  (ISO)
alcoholic liver cirrhosis  (ISO)
Alcoholic Liver Diseases  (ISO)
amenorrhea  (ISO)
asbestosis  (ISO)
asthma  (ISO)
Binge Drinking  (ISO)
Cardiomegaly  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon cancer  (ISO)
colorectal cancer  (ISO)
distal 10q deletion syndrome  (ISO)
Drug Eruptions  (ISO)
drug-induced hepatitis  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (ISO)
extrinsic allergic alveolitis  (ISO)
familial hyperlipidemia  (ISO)
fatty liver disease  (ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Human Viral Hepatitis  (ISO)
intrahepatic cholestasis  (ISO)
liver disease  (ISO)
Liver Injury  (ISO)
Liver Neoplasms  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
mental depression  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
middle cerebral artery infarction  (ISO)
morbid obesity  (ISO)
nasopharynx carcinoma  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (ISO)
oral cavity cancer  (ISO)
oral squamous cell carcinoma  (ISO)
Parkinson's disease  (ISO)
Patent Ductus Venosus  (ISO)
pneumonia  (ISO)
Prostatic Neoplasms  (ISO)
Reperfusion Injury  (ISO)
Sepsis  (ISO)
stomach cancer  (ISO)
Testicular Injury  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylsalicylic acid pharmacodynamics pathway  (ISO)
antipyrine drug pathway  (ISO)
arachidonic acid metabolic pathway  (ISO)
caffeine pharmacokinetics pathway  (ISO)
celecoxib pharmacodynamics pathway  (ISO)
diclofenac pharmacodynamics pathway  (ISO)
diflunisal pharmacodynamics pathway  (ISO)
disulfiram pharmacodynamics pathway  (ISO)
etodolac pharmacodynamics pathway  (ISO)
felbamate pharmacokinetics pathway  (ISO)
fenoprofen pharmacodynamics pathway  (ISO)
flurbiprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
ketoprofen pharmacodynamics pathway  (ISO)
ketorolac pharmacodynamics pathway  (ISO)
leukotriene C4 synthase deficiency pathway  (ISO)
lornoxicam pharmacodynamics pathway  (ISO)
magnesium salicylate pharmacodynamics pathway  (ISO)
mefenamic acid pharmacodynamics pathway  (ISO)
meloxicam pharmacodynamics pathway  (ISO)
nabumetone pharmacodynamics pathway  (ISO)
naproxen pharmacodynamics pathway  (ISO)
paracetamol drug pathway  (ISO)
paracetamol pharmacokinetics pathway  (ISO)
paracetamol response pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
piroxicam pharmacodynamics pathway  (ISO)
salicylic acid pharmacodynamics pathway  (ISO)
sodium salicylate pharmacodynamics pathway  (ISO)
sulindac pharmacodynamics pathway  (ISO)
tenoxicam pharmacodynamics pathway  (ISO)
tiaprofenic acid pharmacodynamics pathway  (ISO)
tolmetin pharmacodynamics pathway  (ISO)
valdecoxib pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:10901710   PMID:21833537  


Genomics

Comparative Map Data
CYP2E1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12841,079,164 - 41,089,188 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2841,035,025 - 41,122,754 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2841,171,673 - 41,181,706 (+)NCBI
ROS_Cfam_1.02841,754,551 - 41,764,586 (+)NCBI
ROS_Cfam_1.0 Ensembl2841,754,522 - 41,764,585 (+)Ensembl
UMICH_Zoey_3.12841,235,594 - 41,245,625 (+)NCBI
UNSW_CanFamBas_1.02841,224,985 - 41,235,013 (+)NCBI
UU_Cfam_GSD_1.02841,627,674 - 41,637,700 (+)NCBI
CYP2E1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810133,527,363 - 133,539,123 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl10133,520,406 - 133,561,220 (+)EnsemblGRCh38hg38GRCh38
GRCh3710135,340,867 - 135,352,627 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610135,190,857 - 135,202,610 (+)NCBINCBI36hg18NCBI36
Build 3410135,229,747 - 135,241,501NCBI
Celera10128,168,529 - 128,180,282 (-)NCBI
Cytogenetic Map10q26.3NCBI
HuRef10128,882,691 - 128,894,624 (+)NCBIHuRef
CHM1_110135,620,490 - 135,632,188 (+)NCBICHM1_1
T2T-CHM13v2.010134,478,949 - 134,490,654 (+)NCBI
Cyp2e1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,343,732 - 140,354,903 (+)NCBIGRCm39mm39
GRCm39 Ensembl7140,343,652 - 140,354,900 (+)Ensembl
GRCm387140,763,819 - 140,774,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7140,763,739 - 140,774,987 (+)EnsemblGRCm38mm10GRCm38
MGSCv377147,949,731 - 147,960,880 (+)NCBIGRCm37mm9NCBIm37
MGSCv367140,615,152 - 140,626,301 (+)NCBImm8
Celera7140,556,087 - 140,567,236 (+)NCBICelera
Cytogenetic Map7F4NCBI
cM Map785.94NCBI
Cyp2e1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21195,840,330 - 195,850,728 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1195,840,058 - 195,864,023 (+)Ensembl
Rnor_6.01213,511,892 - 213,522,195 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,511,874 - 213,535,542 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,405,975 - 220,416,727 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41200,918,521 - 200,928,919 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11201,068,525 - 201,078,911 (+)NCBI
Celera1193,484,404 - 193,494,772 (+)NCBICelera
Cytogenetic Map1q41NCBI
LOC102026028
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555076,289,576 - 6,304,193 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555076,293,162 - 6,303,255 (-)NCBIChiLan1.0ChiLan1.0
CYP2E1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110134,839,025 - 134,852,053 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10134,839,025 - 134,852,719 (+)Ensemblpanpan1.1panPan2
LOC101973029
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244072135,858,593 - 5,869,493 (-)NCBI
SpeTri2.0NW_00493648619,691,822 - 19,702,684 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP2E1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14141,690,426 - 141,736,817 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114141,690,737 - 141,703,078 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214153,478,051 - 153,490,404 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP2E1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12653,390,054 - 53,403,309 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2653,390,089 - 53,404,211 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605441,523,569 - 41,534,845 (+)NCBIVero_WHO_p1.0
LOC101722366
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473712,335,681 - 12,345,514 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473712,335,733 - 12,345,278 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000038789   ⟹   ENSCAFP00000034547
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2841,101,002 - 41,122,754 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000039127   ⟹   ENSCAFP00000034940
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2841,079,164 - 41,089,180 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000063996   ⟹   ENSCAFP00000056254
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2841,035,025 - 41,089,180 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000077318   ⟹   ENSCAFP00000063193
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2841,079,171 - 41,122,754 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845048334   ⟹   ENSCAFP00845037920
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2841,754,522 - 41,764,506 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845048390   ⟹   ENSCAFP00845037964
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2841,754,527 - 41,764,585 (+)Ensembl
RefSeq Acc Id: NM_001003339   ⟹   NP_001003339
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12841,079,164 - 41,089,188 (+)NCBI
Dog10K_Boxer_Tasha2841,171,673 - 41,181,706 (+)NCBI
ROS_Cfam_1.02841,754,551 - 41,764,586 (+)NCBI
UMICH_Zoey_3.12841,235,594 - 41,245,625 (+)NCBI
UNSW_CanFamBas_1.02841,224,985 - 41,235,013 (+)NCBI
UU_Cfam_GSD_1.02841,627,674 - 41,637,700 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001003339 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF88144 (Get FASTA)   NCBI Sequence Viewer  
  AAF88145 (Get FASTA)   NCBI Sequence Viewer  
  Q9MZY0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001003339   ⟸   NM_001003339
- UniProtKB: Q9MZY0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000034940   ⟸   ENSCAFT00000039127
RefSeq Acc Id: ENSCAFP00000063193   ⟸   ENSCAFT00000077318
RefSeq Acc Id: ENSCAFP00000034547   ⟸   ENSCAFT00000038789
RefSeq Acc Id: ENSCAFP00000056254   ⟸   ENSCAFT00000063996
RefSeq Acc Id: ENSCAFP00845037964   ⟸   ENSCAFT00845048390
RefSeq Acc Id: ENSCAFP00845037920   ⟸   ENSCAFT00845048334

Promoters
RGD ID:13688384
Promoter ID:EPDNEW_C6454
Type:multiple initiation site
Name:CYP2E1_1
Description:cytochrome P450 family 2 subfamily E member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12841,079,140 - 41,079,200EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013311 Ensembl
  ENSCAFG00030026254 UniProtKB/Swiss-Prot
  ENSCAFG00040018971 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00845027431 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030042533 UniProtKB/Swiss-Prot
  ENSCAFP00040030529 UniProtKB/TrEMBL
  ENSCAFP00040030554 UniProtKB/Swiss-Prot
  ENSCAFP00845037920.1 UniProtKB/TrEMBL
  ENSCAFP00845037964 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00030048596 UniProtKB/Swiss-Prot
  ENSCAFT00040035069 UniProtKB/TrEMBL
  ENSCAFT00040035095 UniProtKB/Swiss-Prot
  ENSCAFT00845048334.1 UniProtKB/TrEMBL
  ENSCAFT00845048390 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP2E-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:415128 UniProtKB/Swiss-Prot
NCBI Gene CYP2E1 ENTREZGENE
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450ICYP2E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0T4B0_CANLF UniProtKB/TrEMBL
  A0A8I3PU60_CANLF UniProtKB/TrEMBL
  CP2E1_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9MZY1 UniProtKB/Swiss-Prot
VGNC ID VGNC:50353 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-09 CYP2E1  cytochrome P450 family 2 subfamily E member 1    cytochrome P450, family 2, subfamily E, polypeptide 1  Symbol and/or name change 5135510 APPROVED