Cyp2b2 (cytochrome P450, family 2, subfamily b, polypeptide 2) - Rat Genome Database

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Gene: Cyp2b2 (cytochrome P450, family 2, subfamily b, polypeptide 2) Rattus norvegicus
Analyze
Symbol: Cyp2b2
Name: cytochrome P450, family 2, subfamily b, polypeptide 2
RGD ID: 2467
Description: Exhibits steroid hydroxylase activity. Involved in several processes, including aging; nicotine metabolic process; and response to calcium ion. Localizes to intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6); PARTICIPATES IN arachidonic acid metabolic pathway; phase I biotransformation pathway via cytochrome P450; retinol metabolic pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dichloroethene; 1,4-dioxane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Cype; CYPIIB2; cytochrome P-450b type e; cytochrome P-450e-M; cytochrome P450 2B2; cytochrome P450 PB4; Cytochrome P450 subfamily IIB (phenobarbital-inducible)(b e); Cytochrome P450, subfamily IIB (phenobarbital-inducible) (b, e); Cytochrome P450, subfamily IIB (phenobarbital-inducible)(b, e); cytochrome P450E
RGD Orthologs
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2181,594,534 - 81,608,567 (+)NCBI
Rnor_6.0 Ensembl183,103,925 - 83,119,193 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0183,103,925 - 83,119,578 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0184,361,236 - 84,376,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4181,345,425 - 81,359,415 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1181,421,142 - 81,423,532 (+)NCBI
Celera176,026,715 - 76,040,695 (+)NCBICelera
RH 2.0 Map1513.2RGD
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Inflammation  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-dioxane  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
19-Nor-17alpha-pregn-5(10)-en-20-yne-3alpha,17beta-diol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-acetamidofluorene  (EXP)
2-nitroanisole  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3'-diindolylmethane  (EXP)
3-methylcholanthrene  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acephate  (ISO)
aflatoxin B1  (EXP)
alachlor  (EXP)
alpha-hexachlorocyclohexane  (EXP)
amiodarone  (EXP)
amitraz  (EXP)
amitriptyline  (EXP)
Aroclor 1254  (EXP)
aspartame  (EXP)
benzbromarone  (EXP)
benzene  (EXP)
benzo[b]fluoranthene  (ISO)
benzophenone  (EXP)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bilobalide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP)
bitertanol  (EXP)
bromobenzene  (EXP)
bromodichloromethane  (EXP)
brucine  (EXP)
C60 fullerene  (EXP)
carbamazepine  (EXP)
chloral hydrate  (EXP)
chlordecone  (EXP)
chlorohydrocarbon  (EXP)
cholic acid  (ISO)
choline  (EXP,ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (EXP)
clofibrate  (EXP)
clofibric acid  (EXP)
clotrimazole  (EXP)
cyclophosphamide  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproconazole  (EXP)
DDT  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
dextran sulfate  (ISO)
Diallyl sulfide  (EXP)
diazepam  (EXP)
dichloroacetic acid  (ISO)
dicofol  (EXP)
diethyldithiocarbamic acid  (EXP)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP)
disulfiram  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ethylbenzene  (EXP)
etofenprox  (EXP)
farnesol  (EXP)
fenarimol  (ISO)
fipronil  (EXP)
fipronil-sulfone  (EXP)
folic acid  (ISO)
gadolinium trichloride  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gliotoxin  (EXP)
griseofulvin  (ISO)
indole-3-methanol  (EXP)
L-ascorbic acid  (EXP)
L-ethionine  (EXP)
L-methionine  (ISO)
lansoprazole  (EXP)
linuron  (EXP)
m-xylene  (EXP)
melatonin  (EXP)
metazachlor  (EXP)
methoxychlor  (EXP)
methylarsonic acid  (EXP)
methylmercury chloride  (EXP)
metyrapone  (EXP)
mifepristone  (EXP)
mirex  (EXP)
Mitotane  (EXP)
monocrotophos  (EXP)
musk xylene  (EXP)
N'-(2,4-dimethylphenyl)-N-methylformamidine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
o-anisidine  (EXP)
octamethylcyclotetrasiloxane  (EXP)
oltipraz  (EXP)
omeprazole  (EXP)
orphenadrine  (EXP)
oxazepam  (EXP)
oxfendazole  (EXP)
oxycodone  (EXP)
p-xylene  (EXP)
pantoprazole  (EXP)
paracetamol  (EXP)
parathion-methyl  (EXP)
PCB138  (EXP)
pentobarbital  (EXP)
perfluorobutyric acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenethyl caffeate  (EXP)
phenobarbital  (EXP,ISO)
phenytoin  (EXP)
PhIP  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prochloraz  (EXP)
propiconazole  (EXP)
propylbenzene  (EXP)
pyrazinecarboxamide  (EXP)
pyrene  (EXP)
pyrethrins  (EXP)
pyridine  (EXP)
pyrrolidines  (EXP)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
Retrorsine  (EXP)
rotenone  (EXP)
sevoflurane  (EXP)
sodium dodecyl sulfate  (EXP)
stilbene oxide  (EXP)
streptozocin  (ISO)
strychnine  (EXP)
styrene  (EXP)
Sudan III  (EXP)
tamoxifen  (EXP)
tebuconazole  (EXP)
tert-butyl ethyl ether  (EXP)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
trans-1,2-dichloroethene  (EXP)
triadimefon  (EXP)
Tributyltin oxide  (ISO)
triclosan  (EXP)
trimethylarsine oxide  (EXP)
triptonide  (ISO)
troglitazone  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP,ISO)
zileuton  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:2323573   PMID:2539047   PMID:2583091   PMID:2839467   PMID:3013548   PMID:3041969   PMID:3458196   PMID:3877725   PMID:3928374   PMID:6306654   PMID:6322758   PMID:6688421  
PMID:6689485   PMID:17646928   PMID:18782568   PMID:19285975   PMID:19702544   PMID:19737542   PMID:20208394   PMID:22612225   PMID:22905390   PMID:25036135  


Genomics

Comparative Map Data
Cyp2b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2181,594,534 - 81,608,567 (+)NCBI
Rnor_6.0 Ensembl183,103,925 - 83,119,193 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0183,103,925 - 83,119,578 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0184,361,236 - 84,376,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4181,345,425 - 81,359,415 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1181,421,142 - 81,423,532 (+)NCBI
Celera176,026,715 - 76,040,695 (+)NCBICelera
RH 2.0 Map1513.2RGD
Cytogenetic Map1q21NCBI
Cyp2b13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,760,813 - 25,795,622 (+)NCBIGRCm39mm39
GRCm39 Ensembl725,760,922 - 25,795,622 (+)Ensembl
GRCm38726,061,388 - 26,096,197 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl726,061,497 - 26,096,197 (+)EnsemblGRCm38mm10GRCm38
MGSCv37726,846,514 - 26,881,215 (+)NCBIGRCm37mm9NCBIm37
MGSCv36725,770,255 - 25,804,956 (+)NCBImm8
Celera720,663,633 - 20,698,699 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map714.11NCBI

Position Markers
D1Wox17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,594,226 - 81,594,309 (+)MAPPER
Rnor_6.0183,103,580 - 83,103,662NCBIRnor6.0
Rnor_5.0184,360,890 - 84,360,973NCBIRnor5.0
Rnor_5.0184,360,891 - 84,360,973UniSTSRnor5.0
Rnor_5.0184,360,889 - 84,360,973NCBIRnor5.0
RGSC_v3.4181,345,080 - 81,345,162UniSTSRGSC3.4
RGSC_v3.4181,345,079 - 81,345,162RGDRGSC3.4
RGSC_v3.1181,423,190 - 81,423,273RGD
Celera176,026,370 - 76,026,452UniSTS
RH 3.4 Map1825.0RGD
RH 3.4 Map1825.0UniSTS
RH 2.0 Map1508.5RGD
Cytogenetic Map1q21UniSTS
D1Mco21  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0184,360,891 - 84,360,973UniSTSRnor5.0
RGSC_v3.4181,345,080 - 81,345,162UniSTSRGSC3.4
RGSC_v3.1181,423,190 - 81,423,273RGD
Celera176,026,370 - 76,026,452UniSTS
RH 3.4 Map1825.0UniSTS
Cytogenetic Map1q21UniSTS
D1Hmgc4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,518,043 - 81,518,167 (+)MAPPER
mRatBN7.2181,594,162 - 81,594,314 (+)MAPPER
Rnor_6.0183,103,516 - 83,103,667NCBIRnor6.0
Rnor_6.0799,142,086 - 99,142,209NCBIRnor6.0
Rnor_5.0184,360,827 - 84,360,978UniSTSRnor5.0
Rnor_5.0799,736,092 - 99,736,215UniSTSRnor5.0
RGSC_v3.4181,345,016 - 81,345,167UniSTSRGSC3.4
RGSC_v3.4181,342,475 - 81,345,421RGDRGSC3.4
RGSC_v3.4181,266,464 - 81,266,587UniSTSRGSC3.4
Celera176,026,306 - 76,026,457UniSTS
Celera175,950,295 - 75,950,418UniSTS
RH 3.4 Map1827.8UniSTS
RH 3.4 Map1827.8RGD
Cytogenetic Map1q21UniSTS
D1Wox48  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,594,189 - 81,594,416 (+)MAPPER
mRatBN7.2181,518,070 - 81,518,269 (+)MAPPER
Rnor_6.0799,142,113 - 99,142,311NCBIRnor6.0
Rnor_6.0183,103,543 - 83,103,769NCBIRnor6.0
Rnor_5.0799,736,119 - 99,736,317UniSTSRnor5.0
Rnor_5.0184,360,854 - 84,361,080UniSTSRnor5.0
RGSC_v3.4181,266,491 - 81,266,689UniSTSRGSC3.4
RGSC_v3.4181,345,043 - 81,345,269UniSTSRGSC3.4
Celera176,026,333 - 76,026,559UniSTS
Celera175,950,322 - 75,950,520UniSTS
Cytogenetic Map1q21UniSTS
D1Wox70  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,608,815 - 81,608,910 (+)MAPPER
Rnor_6.0799,183,784 - 99,183,878NCBIRnor6.0
Rnor_6.0183,119,828 - 83,119,922NCBIRnor6.0
Rnor_5.0184,377,139 - 84,377,233UniSTSRnor5.0
Rnor_5.0799,777,790 - 99,777,884UniSTSRnor5.0
RGSC_v3.4181,359,665 - 81,359,759UniSTSRGSC3.4
Celera176,040,945 - 76,041,039UniSTS
Cytogenetic Map1q21UniSTS
AU046371  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,602,813 - 81,603,096 (+)MAPPER
Rnor_6.0183,113,837 - 83,114,119NCBIRnor6.0
Rnor_5.0184,371,148 - 84,371,430UniSTSRnor5.0
RGSC_v3.4181,353,667 - 81,353,949UniSTSRGSC3.4
Celera176,034,957 - 76,035,239UniSTS
Cytogenetic Map1q21UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)125439386904217Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15655769122614963Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1565577285706974Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11131448983657083Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11131448983657083Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11131448983657083Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11131448983657083Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11131448983657083Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123406428108057505Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)125951907130917265Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134993530173445086Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13537750894364229Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135377692217372257Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14190724986907249Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143579208126240667Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143579208126240667Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143579208126240667Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143579208126240667Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143579208126240667Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143579208126240667Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143579208126240667Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)149147799156446783Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14954732883657083Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14957857794578577Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149578577169852184Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149578693217054291Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15052271494225616Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15385134883657083Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15385134883657083Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)157761301104391981Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)158209327103209327Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)158354072161711996Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)164588516125875986Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)166113339122614963Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)16722768394201552Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)179134941113593716Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)179689548124689548Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17968976594909507Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)182788437239853971Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:90
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000028196, ENSRNOT00000047540
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 23 23
Low 4 2 2 2 1 2
Below cutoff 1 1 9 6 3 6 4 4 1 5 2 8 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028196   ⟹   ENSRNOP00000028196
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl183,103,925 - 83,119,193 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000047540   ⟹   ENSRNOP00000045196
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl183,103,925 - 83,119,190 (+)Ensembl
RefSeq Acc Id: NM_001198676   ⟹   NP_001185605
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2181,594,572 - 81,608,566 (+)NCBI
Rnor_6.0183,103,925 - 83,119,578 (+)NCBI
Rnor_5.0184,361,236 - 84,376,889 (+)NCBI
Celera176,026,715 - 76,040,695 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039081823   ⟹   XP_038937751
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2181,594,534 - 81,608,567 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001185605   ⟸   NM_001198676
- Peptide Label: precursor
- UniProtKB: P04167 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028196   ⟸   ENSRNOT00000028196
RefSeq Acc Id: ENSRNOP00000045196   ⟸   ENSRNOT00000047540
RefSeq Acc Id: XP_038937751   ⟸   XM_039081823
- Peptide Label: isoform X1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689840
Promoter ID:EPDNEW_R360
Type:initiation region
Name:Cyp2b2_1
Description:cytochrome P450, family 2, subfamily b, polypeptide 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0183,103,860 - 83,103,920EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2467 AgrOrtholog
Ensembl Genes ENSRNOG00000020775 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000028196 UniProtKB/TrEMBL
  ENSRNOP00000045196 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028196 UniProtKB/TrEMBL
  ENSRNOT00000047540 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP2B-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361523 UniProtKB/Swiss-Prot
NCBI Gene 361523 ENTREZGENE
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CYP2B6 RGD
PhenoGen Cyp2b2 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450ICYP2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CP2B2_RAT UniProtKB/Swiss-Prot
  F1LSA2_RAT UniProtKB/TrEMBL
  F7FBM8_RAT UniProtKB/TrEMBL
  P04167 ENTREZGENE
UniProt Secondary Q64579 UniProtKB/Swiss-Prot
  Q64582 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-09-27 Cyp2j5-ps  cytochrome P450, family 2, subfamily b, polypeptide 2  Cyp2b2  Cytochrome P450, family 2, subfamily b, polypeptide 2  Name updated 1299863 APPROVED
2005-10-12 Cyp2b2        Symbol and Name status set to provisional 70820 PROVISIONAL
2005-05-03   Cytochrome P450, family 2, subfamily b, polypeptide 2  Cyp2b2  Cytochrome P450, subfamily IIB (phenobarbital-inducible) (b, e)  Name updated 1299863 APPROVED
2002-06-10 Cyp2b2  Cytochrome P450, subfamily IIB (phenobarbital-inducible) (b, e)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed after nictotine exposure in liver and lung by time- and tissue-specific mechanisms 1298852
gene_expression protein expressed in fetal liver after tobacco smoke exposure 1298848
gene_expression protein expressed in liver and lung tissues of day 1 newborns after exposure to tobacco smoke 1298848
gene_expression protein expressed in liver, lung and heart of tobacco-exposed pregnant and non-pregnant rats 1298848
gene_process metabolizes nicotine and some drugs and activates carcinogens 1298848
gene_regulation interaction with the positive response element is essential for the PB-mediated translocation of cytosolic protein complexes into the nucleus 625556
gene_regulation promoter contains a basic regulatory element (BRE; -103 to -66) that serves as a cis-acting site for transcription regulation 1298852
gene_transcript promoter region contains both positive (-69 to -98 bp) and negative response elements for phenobarbital (PB) 625556