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Gene: Cyp2b2 (cytochrome P450, family 2, subfamily b, polypeptide 2) Rattus norvegicus
Symbol: Cyp2b2
Name: cytochrome P450, family 2, subfamily b, polypeptide 2
Description: Exhibits steroid hydroxylase activity. Involved in several processes, including aging; nicotine metabolic process; and response to calcium ion. Localizes to the intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6); PARTICIPATES IN arachidonic acid metabolic pathway; phase I biotransformation pathway via cytochrome P450; retinol metabolic pathway; INTERACTS WITH (2-trans,6-trans)-farnesol; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Cype; CYPIIB2; cytochrome P-450b type e; cytochrome P-450e-M; cytochrome P450 2B2; cytochrome P450 PB4; Cytochrome P450 subfamily IIB (phenobarbital-inducible)(b e); Cytochrome P450, subfamily IIB (phenobarbital-inducible) (b, e); Cytochrome P450, subfamily IIB (phenobarbital-inducible)(b, e); cytochrome P450E
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0183,103,925 - 83,119,578 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0184,361,236 - 84,376,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4181,345,425 - 81,359,415 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1181,421,142 - 81,423,532 (+)NCBI
Celera176,026,715 - 76,040,695 (+)NCBICelera
Cytogenetic Map1q21NCBI
RH 2.0 Map1513.2RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cyp2b2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2467
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.