Cyp2b2 (cytochrome P450, family 2, subfamily b, polypeptide 2) - Rat Genome Database

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Gene: Cyp2b2 (cytochrome P450, family 2, subfamily b, polypeptide 2) Rattus norvegicus
Analyze
Symbol: Cyp2b2
Name: cytochrome P450, family 2, subfamily b, polypeptide 2
RGD ID: 2467
Description: Enables steroid hydroxylase activity. Involved in several processes, including aging; nicotine metabolic process; and response to calcium ion. Located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in acute myeloid leukemia; human immunodeficiency virus infectious disease; and tuberculosis. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6); PARTICIPATES IN arachidonic acid metabolic pathway; phase I biotransformation pathway via cytochrome P450; retinol metabolic pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dichloroethene; 1,4-dioxane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cype; CYPIIB2; cytochrome P-450b type e; cytochrome P-450e-M; cytochrome P450 2B2; cytochrome P450 PB4; Cytochrome P450 subfamily IIB (phenobarbital-inducible)(b e); Cytochrome P450, subfamily IIB (phenobarbital-inducible) (b, e); Cytochrome P450, subfamily IIB (phenobarbital-inducible)(b, e); cytochrome P450E
RGD Orthologs
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2181,594,534 - 81,608,567 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,594,555 - 81,608,566 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx187,015,246 - 87,029,282 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0195,513,596 - 95,527,589 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0188,771,080 - 88,785,114 (+)NCBIRnor_WKY
Rnor_6.0183,103,925 - 83,119,578 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,103,925 - 83,119,193 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0184,361,236 - 84,376,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4181,345,425 - 81,359,415 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1181,421,142 - 81,423,532 (+)NCBI
Celera176,026,715 - 76,040,695 (+)NCBICelera
RH 2.0 Map1513.2RGD
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Inflammation  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-dioxane  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
19-Nor-17alpha-pregn-5(10)-en-20-yne-3alpha,17beta-diol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-acetamidofluorene  (EXP)
2-nitroanisole  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3'-diindolylmethane  (EXP)
3-methylcholanthrene  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acephate  (ISO)
aflatoxin B1  (EXP)
alachlor  (EXP)
alpha-hexachlorocyclohexane  (EXP)
amiodarone  (EXP)
amitraz  (EXP)
amitriptyline  (EXP)
Aroclor 1254  (EXP)
aspartame  (EXP)
benzbromarone  (EXP)
benzene  (EXP)
benzo[b]fluoranthene  (ISO)
benzophenone  (EXP)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bilobalide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP)
bitertanol  (EXP)
bromobenzene  (EXP)
bromodichloromethane  (EXP)
brucine  (EXP)
C60 fullerene  (EXP)
carbamazepine  (EXP)
chloral hydrate  (EXP)
chlordecone  (EXP)
chlorohydrocarbon  (EXP)
cholic acid  (ISO)
choline  (EXP,ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (EXP)
clofibrate  (EXP)
clofibric acid  (EXP)
clothianidin  (EXP)
clotrimazole  (EXP)
cyclophosphamide  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproconazole  (EXP)
DDT  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
dextran sulfate  (ISO)
Diallyl sulfide  (EXP)
diazepam  (EXP)
dichloroacetic acid  (ISO)
dicofol  (EXP)
diethyldithiocarbamic acid  (EXP)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP)
disulfiram  (EXP)
enilconazole  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ethylbenzene  (EXP)
etofenprox  (EXP)
farnesol  (EXP)
fenarimol  (ISO)
fipronil  (EXP)
fipronil-sulfone  (EXP)
folic acid  (ISO)
gadolinium trichloride  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gliotoxin  (EXP)
griseofulvin  (ISO)
indole-3-methanol  (EXP)
L-ascorbic acid  (EXP)
L-ethionine  (EXP)
L-methionine  (ISO)
lansoprazole  (EXP)
linuron  (EXP)
m-xylene  (EXP)
melatonin  (EXP)
metazachlor  (EXP)
methoxychlor  (EXP)
methylarsonic acid  (EXP)
methylmercury chloride  (EXP)
metyrapone  (EXP)
mifepristone  (EXP)
mirex  (EXP)
Mitotane  (EXP)
monocrotophos  (EXP)
Muraglitazar  (EXP)
musk xylene  (EXP)
N'-(2,4-dimethylphenyl)-N-methylformamidine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
o-anisidine  (EXP)
octamethylcyclotetrasiloxane  (EXP)
oltipraz  (EXP)
omeprazole  (EXP)
orphenadrine  (EXP)
oxazepam  (EXP)
oxfendazole  (EXP)
oxycodone  (EXP)
p-xylene  (EXP)
pantoprazole  (EXP)
paracetamol  (EXP)
paraquat  (EXP)
parathion-methyl  (EXP)
PCB138  (EXP)
pentobarbital  (EXP)
perfluorobutyric acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenethyl caffeate  (EXP)
phenobarbital  (EXP,ISO)
phenytoin  (EXP)
PhIP  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prochloraz  (EXP)
propiconazole  (EXP)
propylbenzene  (EXP)
pyrazinecarboxamide  (EXP)
pyrene  (EXP)
pyrethrins  (EXP)
pyridine  (EXP)
pyrrolidines  (EXP)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
Retrorsine  (EXP)
rotenone  (EXP)
sevoflurane  (EXP)
silicon dioxide  (EXP)
sodium dodecyl sulfate  (EXP)
stilbene oxide  (EXP)
streptozocin  (ISO)
strychnine  (EXP)
styrene  (EXP)
Sudan III  (EXP)
tamoxifen  (EXP)
tebuconazole  (EXP)
tert-butyl ethyl ether  (EXP)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP)
Tetramethylthiourea  (EXP)
thiabendazole  (EXP)
thiacloprid  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
trans-1,2-dichloroethene  (EXP)
triadimefon  (EXP)
Tributyltin oxide  (ISO)
triclosan  (EXP)
trimethylarsine oxide  (EXP)
triptonide  (ISO)
troglitazone  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP,ISO)
zileuton  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Sequence requirements for cytochrome P-450IIB1 catalytic activity. Alteration of the stereospecificity and regioselectivity of steroid hydroxylation by a simultaneous change of two hydrophobic amino acid residues to phenylalanine. Aoyama T, etal., J Biol Chem. 1989 Dec 15;264(35):21327-33.
2. Association of CYP2B6 G15631T polymorphism with acute leukemia susceptibility. Berkoz M and Yalin S, Leuk Res. 2009 Jul;33(7):919-23. Epub 2009 Jan 13.
3. Expression of cytochrome CYP2B1/2 in nonpregnant, pregnant and fetal rats exposed to tobacco smoke. Czekaj P, etal., Acta Biochim Pol 2000;47(4):1115-27.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Interaction of bisphenol A with rat hepatic cytochrome P450 enzymes. Hanioka N, etal., Chemosphere 2000 Oct;41(7):973-8.
6. Molecular basis for the differences in lidocaine binding and regioselectivity of oxidation by cytochromes P450 2B1 and 2B2. Hanna IH, etal., Biochemistry. 1998 Jan 6;37(1):311-8.
7. Gadolinium chloride suppresses styrene-induced cytochrome P450s expression in rat liver. Hirasawa F, etal., Biomed Res. 2008 Dec;28(6):323-30.
8. Analysis of the promoter of the cytochrome P-450 2B2 gene in the rat. Hoffmann M, etal., Gene Expr 1992;2(4):353-63.
9. Coordinated changes in xenobiotic metabolizing enzyme gene expression in aging male rats. Lee JS, etal., Toxicol Sci. 2008 Nov;106(1):263-83. Epub 2008 Jul 24.
10. Blood coagulation-related parameter changes in Sprague-Dawley (SD) rats treated with phenobarbital (PB) and PB plus vitamin K. Mochizuki M, etal., J Toxicol Sci. 2008 Aug;33(3):307-14.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Phenobarbitone-mediated translocation of the cytosolic proteins interacting with the 5'-proximal region of rat liver CYP2B1/B2 gene into the nucleus. Samudre KR, etal., Biochem Biophys Res Commun 2002 Mar 29;292(2):312-7.
16. The effect of aspartame on rat brain xenobiotic-metabolizing enzymes. Vences-Mejia A, etal., Hum Exp Toxicol. 2006 Aug;25(8):453-9.
17. Effect of calcium channel antagonists nifedipine and nicardipine on rat cytochrome P-450 2B and 3A forms. Zangar RC, etal., J Pharmacol Exp Ther. 1999 Sep;290(3):1436-41.
Additional References at PubMed
PMID:2323573   PMID:2539047   PMID:2583091   PMID:2839467   PMID:3013548   PMID:3041969   PMID:3458196   PMID:3877725   PMID:3928374   PMID:6306654   PMID:6322758   PMID:6688421  
PMID:6689485   PMID:17646928   PMID:18782568   PMID:19285975   PMID:19702544   PMID:19737542   PMID:20208394   PMID:22612225   PMID:22905390   PMID:25036135  


Genomics

Comparative Map Data
Cyp2b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2181,594,534 - 81,608,567 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,594,555 - 81,608,566 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx187,015,246 - 87,029,282 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0195,513,596 - 95,527,589 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0188,771,080 - 88,785,114 (+)NCBIRnor_WKY
Rnor_6.0183,103,925 - 83,119,578 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,103,925 - 83,119,193 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0184,361,236 - 84,376,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4181,345,425 - 81,359,415 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1181,421,142 - 81,423,532 (+)NCBI
Celera176,026,715 - 76,040,695 (+)NCBICelera
RH 2.0 Map1513.2RGD
Cytogenetic Map1q21NCBI
Cyp2b13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,760,813 - 25,795,622 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl725,760,922 - 25,795,622 (+)EnsemblGRCm39 Ensembl
GRCm38726,061,388 - 26,096,197 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl726,061,497 - 26,096,197 (+)EnsemblGRCm38mm10GRCm38
MGSCv37726,846,514 - 26,881,215 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36725,770,255 - 25,804,956 (+)NCBIMGSCv36mm8
Celera720,663,633 - 20,698,699 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map714.11NCBI

Variants

.
Variants in Cyp2b2
99 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:90
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000028196, ENSRNOT00000047540
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat

Markers in Region
D1Wox17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,594,226 - 81,594,309 (+)MAPPERmRatBN7.2
Rnor_6.0183,103,580 - 83,103,662NCBIRnor6.0
Rnor_5.0184,360,890 - 84,360,973NCBIRnor5.0
Rnor_5.0184,360,891 - 84,360,973UniSTSRnor5.0
Rnor_5.0184,360,889 - 84,360,973NCBIRnor5.0
RGSC_v3.4181,345,080 - 81,345,162UniSTSRGSC3.4
RGSC_v3.4181,345,079 - 81,345,162RGDRGSC3.4
RGSC_v3.1181,423,190 - 81,423,273RGD
Celera176,026,370 - 76,026,452UniSTS
RH 3.4 Map1825.0RGD
RH 3.4 Map1825.0UniSTS
RH 2.0 Map1508.5RGD
Cytogenetic Map1q21UniSTS
D1Mco21  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0184,360,891 - 84,360,973UniSTSRnor5.0
RGSC_v3.4181,345,080 - 81,345,162UniSTSRGSC3.4
RGSC_v3.1181,423,190 - 81,423,273RGD
Celera176,026,370 - 76,026,452UniSTS
RH 3.4 Map1825.0UniSTS
Cytogenetic Map1q21UniSTS
D1Hmgc4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,518,043 - 81,518,167 (+)MAPPERmRatBN7.2
mRatBN7.2181,594,162 - 81,594,314 (+)MAPPERmRatBN7.2
Rnor_6.0183,103,516 - 83,103,667NCBIRnor6.0
Rnor_6.0799,142,086 - 99,142,209NCBIRnor6.0
Rnor_5.0184,360,827 - 84,360,978UniSTSRnor5.0
Rnor_5.0799,736,092 - 99,736,215UniSTSRnor5.0
RGSC_v3.4181,345,016 - 81,345,167UniSTSRGSC3.4
RGSC_v3.4181,342,475 - 81,345,421RGDRGSC3.4
RGSC_v3.4181,266,464 - 81,266,587UniSTSRGSC3.4
Celera176,026,306 - 76,026,457UniSTS
Celera175,950,295 - 75,950,418UniSTS
RH 3.4 Map1827.8UniSTS
RH 3.4 Map1827.8RGD
Cytogenetic Map1q21UniSTS
D1Wox48  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,594,189 - 81,594,416 (+)MAPPERmRatBN7.2
mRatBN7.2181,518,070 - 81,518,269 (+)MAPPERmRatBN7.2
Rnor_6.0799,142,113 - 99,142,311NCBIRnor6.0
Rnor_6.0183,103,543 - 83,103,769NCBIRnor6.0
Rnor_5.0799,736,119 - 99,736,317UniSTSRnor5.0
Rnor_5.0184,360,854 - 84,361,080UniSTSRnor5.0
RGSC_v3.4181,266,491 - 81,266,689UniSTSRGSC3.4
RGSC_v3.4181,345,043 - 81,345,269UniSTSRGSC3.4
Celera176,026,333 - 76,026,559UniSTS
Celera175,950,322 - 75,950,520UniSTS
Cytogenetic Map1q21UniSTS
D1Wox70  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,608,815 - 81,608,910 (+)MAPPERmRatBN7.2
Rnor_6.0799,183,784 - 99,183,878NCBIRnor6.0
Rnor_6.0183,119,828 - 83,119,922NCBIRnor6.0
Rnor_5.0184,377,139 - 84,377,233UniSTSRnor5.0
Rnor_5.0799,777,790 - 99,777,884UniSTSRnor5.0
RGSC_v3.4181,359,665 - 81,359,759UniSTSRGSC3.4
Celera176,040,945 - 76,041,039UniSTS
Cytogenetic Map1q21UniSTS
AU046371  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,602,813 - 81,603,096 (+)MAPPERmRatBN7.2
Rnor_6.0183,113,837 - 83,114,119NCBIRnor6.0
Rnor_5.0184,371,148 - 84,371,430UniSTSRnor5.0
RGSC_v3.4181,353,667 - 81,353,949UniSTSRGSC3.4
Celera176,034,957 - 76,035,239UniSTS
Cytogenetic Map1q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 23 23
Low 4 2 2 2 1 2
Below cutoff 1 1 9 6 3 6 4 4 1 5 2 8 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028196   ⟹   ENSRNOP00000028196
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl183,103,925 - 83,119,193 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000047540   ⟹   ENSRNOP00000045196
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl183,103,925 - 83,119,190 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102544   ⟹   ENSRNOP00000088265
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl181,594,555 - 81,608,566 (+)Ensembl
RefSeq Acc Id: NM_001198676   ⟹   NP_001185605
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2181,594,572 - 81,608,566 (+)NCBI
Rnor_6.0183,103,925 - 83,119,578 (+)NCBI
Rnor_5.0184,361,236 - 84,376,889 (+)NCBI
Celera176,026,715 - 76,040,695 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039081823   ⟹   XP_038937751
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2181,594,534 - 81,608,567 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001185605   ⟸   NM_001198676
- Peptide Label: precursor
- UniProtKB: P04167 (UniProtKB/Swiss-Prot),   A0A8I6GGX5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028196   ⟸   ENSRNOT00000028196
RefSeq Acc Id: ENSRNOP00000045196   ⟸   ENSRNOT00000047540
RefSeq Acc Id: XP_038937751   ⟸   XM_039081823
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000088265   ⟸   ENSRNOT00000102544

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04167-F1-model_v2 AlphaFold P04167 1-491 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689840
Promoter ID:EPDNEW_R360
Type:initiation region
Name:Cyp2b2_1
Description:cytochrome P450, family 2, subfamily b, polypeptide 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0183,103,860 - 83,103,920EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2467 AgrOrtholog
BioCyc Gene G2FUF-60347 BioCyc
Ensembl Genes ENSRNOG00000020775 Ensembl
  ENSRNOG00000062471 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000088265 ENTREZGENE
  ENSRNOP00000088265.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000102544 ENTREZGENE
  ENSRNOT00000102544.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP2B-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361523 UniProtKB/Swiss-Prot
NCBI Gene 361523 ENTREZGENE
PANTHER CYTOCHROME P450 2B6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CYP2B6 RGD
PhenoGen Cyp2b2 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450ICYP2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GGX5 ENTREZGENE, UniProtKB/TrEMBL
  CP2B2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q64579 UniProtKB/Swiss-Prot
  Q64582 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-09-27 Cyp2j5-ps  cytochrome P450, family 2, subfamily b, polypeptide 2  Cyp2b2  Cytochrome P450, family 2, subfamily b, polypeptide 2  Name updated 1299863 APPROVED
2005-10-12 Cyp2b2        Symbol and Name status set to provisional 70820 PROVISIONAL
2005-05-03   Cytochrome P450, family 2, subfamily b, polypeptide 2  Cyp2b2  Cytochrome P450, subfamily IIB (phenobarbital-inducible) (b, e)  Name updated 1299863 APPROVED
2002-06-10 Cyp2b2  Cytochrome P450, subfamily IIB (phenobarbital-inducible) (b, e)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed after nictotine exposure in liver and lung by time- and tissue-specific mechanisms 1298852
gene_expression protein expressed in fetal liver after tobacco smoke exposure 1298848
gene_expression protein expressed in liver and lung tissues of day 1 newborns after exposure to tobacco smoke 1298848
gene_expression protein expressed in liver, lung and heart of tobacco-exposed pregnant and non-pregnant rats 1298848
gene_process metabolizes nicotine and some drugs and activates carcinogens 1298848
gene_regulation interaction with the positive response element is essential for the PB-mediated translocation of cytosolic protein complexes into the nucleus 625556
gene_regulation promoter contains a basic regulatory element (BRE; -103 to -66) that serves as a cis-acting site for transcription regulation 1298852
gene_transcript promoter region contains both positive (-69 to -98 bp) and negative response elements for phenobarbital (PB) 625556