(+)-catechin multiple interactions ISO RGD:736218 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP2D22 mRNA CTD PMID:25663641 (+)-epicatechin-3-O-gallate multiple interactions ISO RGD:736218 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP2D22 mRNA CTD PMID:25663641 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:736218 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP2D22 mRNA CTD PMID:25663641 (R)-lipoic acid multiple interactions EXP 6480464 Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 (R,R)-tramadol decreases response to substance EXP 6480464 CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol CTD PMID:16960721 (R,R)-tramadol affects methylation ISO RGD:736218 6480464 CYP2D6 protein affects the methylation of Tramadol CTD PMID:12893130 (R,R)-tramadol multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol more ... CTD PMID:18204346 , PMID:29555325 (R,R)-tramadol decreases methylation EXP 6480464 CYP2D6 protein results in decreased methylation of Tramadol CTD PMID:14624403 more ... (R,R)-tramadol affects response to substance EXP 6480464 CYP2D6 gene polymorphism affects the susceptibility to Tramadol, CYP2D6 protein affects the susceptibility to Tramadol CTD PMID:16497087 , PMID:16960721 (R,R)-tramadol affects metabolic processing EXP 6480464 CYP2D6 gene mutant form affects the metabolism of Tramadol, CYP2D6 gene polymorphism affects the metabolism of Tramadol CTD PMID:12191703 more ... (R,R)-tramadol increases response to substance EXP 6480464 CYP2D6 gene mutant form results in increased susceptibility to Tramadol CTD PMID:18204346 (R,R)-tramadol increases metabolic processing EXP 6480464 CYP2D6 gene mutant form results in increased metabolism of Tramadol, CYP2D6 protein results in increased metabolism of Tramadol CTD PMID:18204346 more ... (S)-duloxetine hydrochloride multiple interactions ISO RGD:620640 6480464 [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride, CYP2D6 protein results in increased activity of and results in increased glutathionylation of Duloxetine Hydrochloride CTD PMID:20669986 (S)-nicotine multiple interactions ISO RGD:736218 6480464 Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:19594327 (S)-nicotine increases expression ISO RGD:736218 6480464 Nicotine results in increased expression of CYP2D22 mRNA, Nicotine results in increased expression of CYP2D22 protein CTD PMID:19594327 (S)-timolol (anhydrous) affects response to substance EXP 6480464 CYP2D6 gene SNP affects the susceptibility to Timolol CTD PMID:19284319 , PMID:20925579 1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane increases hydroxylation EXP 6480464 CYP2D6 protein results in increased hydroxylation of 1 more ... CTD PMID:9047321 1,4-naphthoquinone increases abundance EXP 6480464 CYP2D6 protein results in increased abundance of 1, 4-naphthoquinone CTD PMID:16243959 1-(3-chlorophenyl)piperazine affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of 1-(3-chlorophenyl)piperazine CTD PMID:18238857 1-(3-chlorophenyl)piperazine multiple interactions EXP 6480464 Quinidine inhibits the reaction [CYP2D6 protein affects the metabolism of 1-(3-chlorophenyl)piperazine] CTD PMID:18238857 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile decreases methylation EXP 6480464 CYP2D6 protein results in decreased methylation of Citalopram analog CTD PMID:9110356 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of 1-Methyl-4-phenyl-1 more ... CTD PMID:12464242 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO RGD:736218 6480464 Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:19594327 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression ISO RGD:736218 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:19594327 1-naphthol increases abundance EXP 6480464 CYP2D6 protein results in increased abundance of 1-naphthol CTD PMID:16243959 1-naphthyl isothiocyanate decreases expression ISO RGD:620640 6480464 1-Naphthylisothiocyanate results in decreased expression of CYP2D4 mRNA CTD PMID:25380136 17alpha-ethynylestradiol decreases expression ISO RGD:620640 6480464 Ethinyl Estradiol results in decreased expression of CYP2D22 mRNA, Ethinyl Estradiol results in decreased expression of CYP2D4 mRNA CTD PMID:16174780 , PMID:17108234 17alpha-ethynylestradiol multiple interactions ISO RGD:736218 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYP2D22 mRNA CTD PMID:17942748 1H-pyrazole decreases expression ISO RGD:736218 6480464 pyrazole results in decreased expression of CYP2D22 mRNA CTD PMID:17945193 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:620640 6480464 Tetrachlorodibenzodioxin results in decreased expression of CYP2D4 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:736218 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYP2D22 mRNA, Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP2D22 gene] CTD PMID:17942748 , PMID:28213091 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:736218 6480464 Tetrachlorodibenzodioxin affects the expression of CYP2D22 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:736218 6480464 Tetrachlorodibenzodioxin results in decreased expression of CYP2D22 mRNA CTD PMID:19770486 , PMID:28213091 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:620640 6480464 Tetrachlorodibenzodioxin results in increased expression of CYP2D4 protein CTD PMID:12361703 2,4-dinitrotoluene affects expression ISO RGD:620640 6480464 2, 4-dinitrotoluene affects the expression of CYP2D22 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:620640 6480464 2, 6-dinitrotoluene affects the expression of CYP2D22 mRNA CTD PMID:21346803 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile decreases activity ISO RGD:736218 6480464 Verapamil results in decreased activity of CYP2D22 protein, Verapamil results in decreased activity of CYP2D6 protein CTD PMID:18420780 3,4-methylenedioxymethamphetamine increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of N-Methyl-3, 4-methylenedioxyamphetamine CTD PMID:12464242 3,4-methylenedioxymethamphetamine increases expression ISO RGD:736218 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of CYP2D22 mRNA CTD PMID:20188158 3,4-methylenedioxymethamphetamine decreases activity EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased activity of CYP2D6 protein CTD PMID:16049126 , PMID:24211539 3,4-methylenedioxymethamphetamine multiple interactions EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine inhibits the reaction [CYP2D6 protein results in increased metabolism of bufuralol] CTD PMID:16049126 3,5-xylenol multiple interactions EXP 6480464 [CYP2D6 protein results in increased oxidation of 3, 5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog CTD PMID:27665777 3,5-xylenol increases oxidation EXP 6480464 CYP2D6 protein results in increased oxidation of 3, 5-xylenol analog CTD PMID:27665777 3-methylcholanthrene increases expression ISO RGD:620640 6480464 Methylcholanthrene results in increased expression of CYP2D4 mRNA CTD PMID:11328961 3-methylthiopropanal multiple interactions EXP 6480464 methional inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol] CTD PMID:15576237 4'-hydroxydiclofenac multiple interactions EXP 6480464 [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac, [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac CTD PMID:24246759 4,4'-diaminodiphenylmethane decreases expression ISO RGD:620640 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of CYP2D4 mRNA CTD PMID:25380136 4,4'-sulfonyldiphenol increases expression ISO RGD:620640 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of CYP2D4 mRNA CTD PMID:26186136 4-(methylsulfinyl)phenol increases abundance EXP 6480464 CYP2D6 protein results in increased abundance of 4-(methylsulfinyl)phenol analog CTD PMID:27665777 4-(methylsulfinyl)phenol multiple interactions EXP 6480464 [CYP2D6 protein results in increased oxidation of 3, 5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog CTD PMID:27665777 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CTD PMID:2070484 4-Hydroxy-N-desmethyltamoxifen multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of 4-hydroxy-N-desmethyltamoxifen] which results in increased abundance of 4-hydroxy-N-desmethyltamoxifen metabolite more ... CTD PMID:14652237 , PMID:29285606 4-Hydroxy-N-desmethyltamoxifen increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of 4-hydroxy-N-desmethyltamoxifen CTD PMID:29285606 4-Hydroxy-N-desmethyltamoxifen affects abundance EXP 6480464 CYP2D6 gene polymorphism affects the abundance of 4-hydroxy-N-desmethyltamoxifen CTD PMID:14652237 4-hydroxyphenyl retinamide increases expression ISO RGD:736218 6480464 Fenretinide results in increased expression of CYP2D22 mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine increases expression ISO RGD:736218 6480464 Decitabine results in increased expression of CYP2D22 mRNA CTD PMID:30503582 5-hydroxydiclofenac multiple interactions EXP 6480464 [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expression ISO RGD:620640 6480464 Omeprazole affects the expression of CYP2D4 mRNA CTD PMID:19483382 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole decreases activity ISO RGD:736218 6480464 Omeprazole results in decreased activity of CYP2D6 protein CTD PMID:18420780 5-methoxy-N,N-diisopropyltryptamine multiple interactions EXP 6480464 [5-methoxy-N, N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan CTD PMID:26599973 5-methoxy-N,N-diisopropyltryptamine decreases activity EXP 6480464 5-methoxy-N, N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein CTD PMID:26599973 6-propyl-2-thiouracil affects expression ISO RGD:620640 6480464 Propylthiouracil affects the expression of CYP2D4 mRNA CTD PMID:19483382 6-propyl-2-thiouracil decreases expression ISO RGD:620640 6480464 Propylthiouracil results in decreased expression of CYP2D4 mRNA CTD PMID:24780913 7,12-dimethyltetraphene increases response to substance EXP 6480464 CYP2D6 protein results in increased susceptibility to 9 more ... CTD PMID:20507880 8-hydroxy-2'-deoxyguanosine multiple interactions EXP 6480464 [Eugenol co-treated with Copper co-treated with CYP2D6 protein] results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:15576237 aconitine increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Aconitine CTD PMID:21277363 aconitine multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of Aconitine] which results in increased chemical synthesis of 16-O-demethylaconitine, [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of Aconitine metabolite CTD PMID:21277363 afimoxifene multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite CTD PMID:29285606 afimoxifene increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of afimoxifene CTD PMID:29285606 aflatoxin B1 multiple interactions EXP 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Aflatoxin B1 CTD PMID:23397584 aflatoxin B1 increases methylation EXP 6480464 Aflatoxin B1 results in increased methylation of CYP2D6 gene CTD PMID:27153756 aflatoxin B1 decreases expression ISO RGD:736218 6480464 Aflatoxin B1 results in decreased expression of CYP2D22 mRNA CTD PMID:19770486 ajmalicine multiple interactions EXP 6480464 raubasine inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan] CTD PMID:15930738 ajmalicine decreases activity EXP 6480464 raubasine results in decreased activity of CYP2D6 protein CTD PMID:15930738 all-trans-retinoic acid decreases activity EXP 6480464 Tretinoin results in decreased activity of CYP2D6 protein CTD PMID:18420780 all-trans-retinoic acid decreases activity ISO RGD:736218 6480464 Tretinoin results in decreased activity of CYP2D22 protein CTD PMID:18420780 almotriptan decreases methylation EXP 6480464 CYP2D6 protein results in decreased methylation of almotriptan CTD PMID:12642466 almotriptan increases hydroxylation EXP 6480464 CYP2D6 protein results in increased hydroxylation of almotriptan CTD PMID:12642466 alpha-methyltryptamine decreases activity EXP 6480464 indopan analog results in decreased activity of CYP2D6 protein, indopan results in decreased activity of CYP2D6 protein CTD PMID:26599973 alpha-methyltryptamine multiple interactions EXP 6480464 [indopan analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan, [indopan results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan CTD PMID:26599973 amiodarone decreases activity EXP 6480464 Amiodarone results in decreased activity of CYP2D6 protein CTD PMID:16449812 amiodarone affects expression ISO RGD:620640 6480464 Amiodarone affects the expression of CYP2D4 mRNA CTD PMID:19483382 amiodarone multiple interactions EXP 6480464 CYP2D6 gene polymorphism affects the reaction [Amiodarone results in increased abundance of Metoprolol] CTD PMID:15541258 amiodarone increases expression EXP 6480464 Amiodarone results in increased expression of CYP2D6 mRNA CTD PMID:19774075 amitriptyline decreases activity EXP 6480464 Amitriptyline results in decreased activity of CYP2D6 protein CTD PMID:18359183 amitriptyline multiple interactions EXP 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline CTD PMID:23397584 amitriptyline increases metabolic processing EXP 6480464 Amitriptyline results in increased metabolism of CYP2D6 protein, CYP2D6 protein results in increased metabolism of Amitriptyline CTD PMID:16044105 more ... amitriptylinoxide increases abundance EXP 6480464 CYP2D6 protein results in increased abundance of amitriptyline N-oxide CTD PMID:27320963 ammonium chloride affects expression ISO RGD:620640 6480464 Ammonium Chloride affects the expression of CYP2D4 mRNA CTD PMID:16483693 amodiaquine multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine, [CYP2D6 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine CTD PMID:28478157 , PMID:31629065 amodiaquine increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Amodiaquine CTD PMID:28478157 , PMID:31629065 amphetamine decreases methylation EXP 6480464 CYP2D6 protein results in decreased methylation of Amphetamine analog CTD PMID:29277574 amphetamine increases oxidation EXP 6480464 CYP2D6 protein results in increased oxidation of Amphetamine analog CTD PMID:29277574 amphetamine increases hydroxylation EXP 6480464 CYP2D6 protein results in increased hydroxylation of Amphetamine analog CTD PMID:29277574 amphetamine affects chemical synthesis EXP 6480464 CYP2D6 protein affects the chemical synthesis of Amphetamine CTD PMID:15294457 amphetamines increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Amphetamines CTD PMID:10911933 aniline multiple interactions EXP 6480464 CYP2D6 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 arachidonic acid increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Arachidonic Acid CTD PMID:12675279 arsenous acid multiple interactions EXP 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CYP2D6 protein] CTD PMID:26598702 atomoxetine hydrochloride increases hydroxylation EXP 6480464 CYP2D6 protein results in increased hydroxylation of Atomoxetine Hydrochloride CTD PMID:17470523 bacitracin decreases expression ISO RGD:620640 6480464 Bacitracin results in decreased expression of CYP2D22 mRNA CTD PMID:18289764 barnidipine decreases activity EXP 6480464 mepirodipine results in decreased activity of CYP2D6 protein CTD PMID:10805063 benidipine decreases activity EXP 6480464 benidipine results in decreased activity of CYP2D6 protein CTD PMID:10805063 benzbromarone affects expression ISO RGD:620640 6480464 Benzbromarone affects the expression of CYP2D4 mRNA CTD PMID:19483382 benzene increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Benzene CTD PMID:17479406 benzene increases response to substance EXP 6480464 CYP2D6 gene polymorphism results in increased susceptibility to Benzene CTD PMID:16737584 , PMID:17479406 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of CYP2D6 mRNA CTD PMID:16269432 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of CYP2D6 mRNA CTD PMID:32234424 benzo[a]pyrene decreases expression ISO RGD:736218 6480464 Benzo(a)pyrene results in decreased expression of CYP2D22 mRNA CTD PMID:19770486 benzo[b]fluoranthene increases expression EXP 6480464 benzo(b)fluoranthene results in increased expression of CYP2D6 mRNA CTD PMID:16269432 beta-carboline multiple interactions EXP 6480464 CYP2D6 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 beta-naphthoflavone decreases expression EXP 6480464 beta-Naphthoflavone results in decreased expression of CYP2D6 mRNA CTD PMID:22258563 bisphenol A increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of bisphenol A CTD PMID:21402134 bisphenol A decreases expression ISO RGD:620640 6480464 bisphenol A results in decreased expression of CYP2D4 mRNA, bisphenol A results in decreased expression of CYP2D6 mRNA CTD PMID:25181051 , PMID:30816183 bisphenol A increases expression ISO RGD:620640 6480464 bisphenol A results in increased expression of CYP2D4 mRNA CTD PMID:26186136 bisphenol A multiple interactions ISO RGD:736218 6480464 [potassium bromate co-treated with bisphenol A] affects the expression of CYP2D22 mRNA, [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of CYP2D22 mRNA] CTD PMID:27082013 bisphenol A multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of bisphenol A] which results in increased chemical synthesis of hydroquinone CTD PMID:21402134 bisphenol F increases expression ISO RGD:620640 6480464 4, 4'-bisphenol F results in increased expression of CYP2D4 mRNA CTD PMID:26186136 bortezomib affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of Bortezomib CTD PMID:15764713 Bufuralol multiple interactions EXP 6480464 1-aminobenzotriazole inhibits the reaction [CYP2D6 protein results in increased hydroxylation of bufuralol] more ... CTD PMID:11377097 more ... Bufuralol increases hydroxylation ISO RGD:736218 6480464 CYP2D4 protein results in increased hydroxylation of bufuralol CTD PMID:15742976 Bufuralol affects metabolic processing ISO RGD:620640 6480464 CYP2D6 protein affects the metabolism of bufuralol CTD PMID:15801540 Bufuralol increases oxidation EXP 6480464 CYP2D6 protein results in increased oxidation of bufuralol CTD PMID:21964418 Bufuralol increases hydroxylation EXP 6480464 CYP2D6 protein results in increased hydroxylation of bufuralol CTD PMID:10933885 more ... Bufuralol affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of bufuralol CTD PMID:15801540 Bufuralol increases hydrolysis EXP 6480464 CYP2D6 protein results in increased hydrolysis of bufuralol CTD PMID:11377097 Bufuralol increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of bufuralol CTD PMID:12401345 more ... buprenorphine decreases activity EXP 6480464 Buprenorphine results in decreased activity of CYP2D6 protein CTD PMID:12756210 buprenorphine increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Buprenorphine CTD PMID:12756210 buspirone increases oxidation EXP 6480464 CYP2D6 protein results in increased oxidation of Buspirone CTD PMID:15640381 buspirone increases expression ISO RGD:620640 6480464 Buspirone results in increased expression of CYP2D4 mRNA CTD PMID:24136188 butyric acid increases expression EXP 6480464 Butyric Acid results in increased expression of CYP2D6 mRNA CTD PMID:30439556 cadmium dichloride decreases expression ISO RGD:620640 6480464 Cadmium Chloride results in decreased expression of CYP2D4 mRNA CTD PMID:25993096 caffeine affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of Caffeine CTD PMID:15199075 calciol decreases activity EXP 6480464 Cholecalciferol results in decreased activity of CYP2D6 protein CTD PMID:18420780 cannabidiol decreases activity EXP 6480464 Cannabidiol results in decreased activity of CYP2D6 protein CTD PMID:24667653 capsaicin decreases activity EXP 6480464 Capsaicin results in decreased activity of CYP2D6 protein CTD PMID:22375877 carbamazepine multiple interactions EXP 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Carbamazepine CTD PMID:23397584 carbendazim decreases activity EXP 6480464 carbendazim results in decreased activity of CYP2D6 protein CTD PMID:20183062 carbon nanotube increases expression ISO RGD:736218 6480464 Nanotubes, Carbon results in increased expression of CYP2D22 mRNA CTD PMID:25554681 carvedilol affects glucuronidation EXP 6480464 CYP2D6 gene polymorphism affects the glucuronidation of carvedilol CTD PMID:16849011 carvedilol affects metabolic processing EXP 6480464 CYP2D6 gene polymorphism affects the metabolism of carvedilol, CYP2D6 protein polymorphism affects the metabolism of carvedilol CTD PMID:15001973 more ... carvedilol affects response to substance EXP 6480464 CYP2D6 gene polymorphism affects the susceptibility to carvedilol CTD PMID:20643254 chelidonine increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of chelidonine CTD PMID:31102647 chelidonine multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog CTD PMID:31102647 chloroquine affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of Chloroquine CTD PMID:12920490 chloroquine decreases activity EXP 6480464 Chloroquine results in decreased activity of CYP2D6 protein CTD PMID:12756207 chloroquine multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine CTD PMID:12756207 chlorphenamine increases response to substance EXP 6480464 CYP2D6 mutant form results in increased susceptibility to Chlorpheniramine CTD PMID:17089107 chlorpromazine multiple interactions EXP 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine, CYP2D6 protein results in increased metabolism of and results in increased activity of Chlorpromazine CTD PMID:19482014 , PMID:23397584 chlorpromazine decreases response to substance EXP 6480464 CYP2D6 protein results in decreased susceptibility to Chlorpromazine CTD PMID:26477383 chlorpyrifos increases expression EXP 6480464 Chlorpyrifos results in increased expression of CYP2D6 mRNA CTD PMID:16757081 chlorpyrifos decreases activity EXP 6480464 Chlorpyrifos results in decreased activity of CYP2D6 protein CTD PMID:20183062 chlorpyrifos multiple interactions ISO RGD:620640 6480464 Quinine inhibits the reaction [CYP2D6 protein results in increased oxidation of Chlorpyrifos] CTD PMID:14979094 chlorpyrifos increases oxidation ISO RGD:620640 6480464 CYP2D6 protein results in increased oxidation of Chlorpyrifos CTD PMID:14979094 choline multiple interactions ISO RGD:736218 6480464 [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP2D22 protein CTD PMID:27712037 cimetidine decreases activity EXP 6480464 Cimetidine results in decreased activity of CYP2D6 protein CTD PMID:19909766 cimetidine multiple interactions ISO RGD:620640 6480464 Cimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan] CTD PMID:17651725 cimetidine decreases activity ISO RGD:620640 6480464 Cimetidine results in decreased activity of CYP2D6 protein CTD PMID:17651725 cimetidine multiple interactions EXP 6480464 styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP2D6 protein] CTD PMID:19909766 cinacalcet decreases activity EXP 6480464 Cinacalcet results in decreased activity of CYP2D6 protein CTD PMID:16680561 cinnamic acid decreases activity EXP 6480464 cinnamic acid analog results in decreased activity of CYP2D6 protein CTD PMID:15072549 cisplatin decreases expression ISO RGD:620640 6480464 Cisplatin results in decreased expression of CYP2D22 mRNA CTD PMID:18289764 citalopram decreases methylation EXP 6480464 CYP2D6 protein results in decreased methylation of Citalopram analog CTD PMID:9110356 clofibrate affects expression ISO RGD:620640 6480464 Clofibrate affects the expression of CYP2D4 mRNA CTD PMID:19483382 clofibric acid affects expression ISO RGD:620640 6480464 Clofibric Acid affects the expression of CYP2D22 mRNA CTD PMID:17602206 clonidine increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Clonidine CTD PMID:31585114 clonidine multiple interactions EXP 6480464 [[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine more ... CTD PMID:31585114 clonidine (amino form) increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Clonidine CTD PMID:31585114 clonidine (amino form) multiple interactions EXP 6480464 [[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine more ... CTD PMID:31585114 clonidine (imino form) increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Clonidine CTD PMID:31585114 clonidine (imino form) multiple interactions EXP 6480464 [[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine more ... CTD PMID:31585114 clopidogrel multiple interactions EXP 6480464 CYP2D6 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite CTD PMID:19170597 clozapine affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of Clozapine CTD PMID:15286053 clozapine increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Clozapine CTD PMID:18809730 , PMID:27320963 clozapine multiple interactions EXP 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine CTD PMID:23397584 codeine affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of Codeine, CYP2D6 protein polymorphism affects the metabolism of Codeine CTD PMID:11823760 more ... codeine multiple interactions EXP 6480464 [CYP2D6 gene mutant form results in increased activity of CYP2D6 protein] which results in increased susceptibility to Codeine, [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine CTD PMID:16595712 , PMID:21241245 codeine multiple interactions ISO RGD:736218 6480464 [CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine CTD PMID:16595712 codeine increases metabolic processing ISO RGD:736218 6480464 CYP2D22 protein results in increased metabolism of Codeine CTD PMID:16595712 codeine decreases methylation EXP 6480464 CYP2D6 protein results in decreased methylation of Codeine CTD PMID:17470523 codeine affects response to substance EXP 6480464 CYP2D6 protein polymorphism affects the susceptibility to Codeine CTD PMID:9696456 codeine increases metabolic processing EXP 6480464 CYP2D6 gene polymorphism results in increased metabolism of Codeine, CYP2D6 protein results in increased metabolism of Codeine CTD PMID:10911933 more ... copper atom decreases expression ISO RGD:620640 6480464 Copper results in decreased expression of CYP2D22 mRNA CTD PMID:22465980 copper atom multiple interactions EXP 6480464 [CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol more ... CTD PMID:15576237 copper(0) decreases expression ISO RGD:620640 6480464 Copper results in decreased expression of CYP2D22 mRNA CTD PMID:22465980 copper(0) multiple interactions EXP 6480464 [CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol more ... CTD PMID:15576237 corticosterone increases expression ISO RGD:620640 6480464 Corticosterone results in increased expression of CYP2D4 mRNA CTD PMID:15755911 coumarins multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins, Quinidine inhibits the reaction [[CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins] CTD PMID:23850985 cyclophosphamide increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Cyclophosphamide CTD PMID:11377097 cyhalothrin decreases activity EXP 6480464 cyhalothrin results in decreased activity of CYP2D6 protein CTD PMID:20183062 cyhalothrin increases expression ISO RGD:620640 6480464 cyhalothrin results in increased expression of CYP2D4 mRNA CTD PMID:29727961 cypermethrin decreases activity EXP 6480464 cypermethrin results in decreased activity of CYP2D6 protein CTD PMID:18420780 daidzein decreases activity EXP 6480464 daidzein results in decreased activity of CYP2D6 protein CTD PMID:18420780 daidzein decreases activity ISO RGD:736218 6480464 daidzein results in decreased activity of CYP2D22 protein CTD PMID:18420780 dapsone multiple interactions EXP 6480464 CYP2D6 protein results in increased metabolism of and results in increased susceptibility to Dapsone CTD PMID:19998329 debrisoquin decreases response to substance EXP 6480464 CYP2D6 gene mutant form results in decreased susceptibility to Debrisoquin CTD PMID:11673748 debrisoquin increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Debrisoquin CTD PMID:12464242 debrisoquin increases hydroxylation EXP 6480464 CYP2D6 protein results in increased hydroxylation of Debrisoquin CTD PMID:17470523 debrisoquin affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of Debrisoquin, CYP2D6 protein polymorphism affects the metabolism of Debrisoquin CTD PMID:11823760 , PMID:3577206 debrisoquin increases abundance EXP 6480464 CYP2D6 gene mutant form results in increased abundance of Debrisoquin metabolite CTD PMID:11673748 debrisoquin multiple interactions EXP 6480464 CYP2D6 gene mutant form affects the metabolism of and affects the hydroxylation of Debrisoquin more ... CTD PMID:11673748 debrisoquin decreases metabolic processing EXP 6480464 CYP2D6 gene mutant form results in decreased metabolism of Debrisoquin, CYP2D6 gene polymorphism results in decreased metabolism of Debrisoquin CTD PMID:6603386 , PMID:8946814 desipramine affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of Desipramine CTD PMID:15286053 desloratadine affects chemical synthesis EXP 6480464 CYP2D6 protein affects the chemical synthesis of desloratadine CTD PMID:15932952 dexamethasone increases expression ISO RGD:620640 6480464 Dexamethasone results in increased expression of CYP2D4 mRNA CTD PMID:11328961 dexamethasone increases expression ISO RGD:736218 6480464 Dexamethasone results in increased expression of CYP2D22 mRNA CTD PMID:22733784 dextromethorphan increases response to substance EXP 6480464 CYP2D6 gene polymorphism results in increased susceptibility to Dextromethorphan CTD PMID:21228393 dextromethorphan decreases activity ISO RGD:736218 6480464 Dextromethorphan results in decreased activity of CYP2D6 protein CTD PMID:18420780 dextromethorphan multiple interactions ISO RGD:620640 6480464 Cimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan], ozagrel promotes the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan] CTD PMID:17651725 dextromethorphan increases metabolic processing ISO RGD:620640 6480464 CYP2D6 protein results in increased metabolism of Dextromethorphan CTD PMID:17651725 dextromethorphan decreases methylation EXP 6480464 CYP2D6 protein results in decreased methylation of Dextromethorphan CTD PMID:12433797 more ... dextromethorphan increases metabolic processing EXP 6480464 CYP2D6 mRNA results in increased metabolism of Dextromethorphan, CYP2D6 protein results in increased metabolism of Dextromethorphan CTD PMID:10911933 more ... dextromethorphan multiple interactions ISO RGD:736218 6480464 [CYP2D22 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan, Ketoconazole inhibits the reaction [CYP2D22 protein results in increased metabolism of Dextromethorphan] CTD PMID:16595712 , PMID:30503582 dextromethorphan increases metabolic processing ISO RGD:736218 6480464 CYP2D22 protein results in increased metabolism of Dextromethorphan CTD PMID:16595712 , PMID:30503582 dextromethorphan affects metabolic processing EXP 6480464 CYP2D6 polymorphism affects the metabolism of Dextromethorphan more ... CTD PMID:11823760 more ... dextromethorphan multiple interactions EXP 6480464 [5-bromotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan more ... CTD PMID:15863898 more ... dextrorphan affects chemical synthesis EXP 6480464 CYP2D6 protein affects the chemical synthesis of Dextrorphan CTD PMID:15988119 dextrorphan multiple interactions ISO RGD:736218 6480464 [CYP2D22 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan CTD PMID:30503582 dextrorphan multiple interactions EXP 6480464 [CYP2D6 mRNA results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan more ... CTD PMID:21915887 more ... dextrorphan increases chemical synthesis EXP 6480464 CYP2D6 protein results in increased chemical synthesis of Dextrorphan CTD PMID:15155557 more ... diarsenic trioxide multiple interactions EXP 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CYP2D6 protein] CTD PMID:26598702 diarylheptanoid decreases activity EXP 6480464 Diarylheptanoids results in decreased activity of CYP2D6 protein CTD PMID:23850985 diazinon increases expression EXP 6480464 Diazinon results in increased expression of CYP2D6 mRNA CTD PMID:16757081 dibenz[a,h]anthracene increases expression EXP 6480464 1 more ... CTD PMID:16269432 diclofenac multiple interactions EXP 6480464 [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac more ... CTD PMID:23397584 , PMID:24246759 dihydrocapsaicin decreases activity EXP 6480464 dihydrocapsaicin results in decreased activity of CYP2D6 protein CTD PMID:22375877 Dihydrocorynantheine decreases activity EXP 6480464 hirsutine results in decreased activity of CYP2D6 protein CTD PMID:31707106 dihydroergotamine decreases activity EXP 6480464 Dihydroergotamine results in decreased activity of CYP2D6 protein CTD PMID:18420780 dihydroergotamine decreases activity ISO RGD:736218 6480464 Dihydroergotamine results in decreased activity of CYP2D22 protein CTD PMID:18420780 dimemorfan increases oxidation EXP 6480464 CYP2D6 protein results in increased oxidation of dimemorfan CTD PMID:19593786 dimemorfan multiple interactions EXP 6480464 Paroxetine inhibits the reaction [CYP2D6 protein results in increased oxidation of dimemorfan] CTD PMID:19593786 dimethocaine increases hydroxylation EXP 6480464 CYP2D6 protein results in increased hydroxylation of dimethocaine CTD PMID:24309420 dimethyl sulfoxide multiple interactions EXP 6480464 Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein] more ... CTD PMID:11368792 dioxygen multiple interactions EXP 6480464 CYP2D6 protein inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA], CYP2D6 protein inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA] CTD PMID:21566342 domperidone increases hydroxylation EXP 6480464 CYP2D6 protein results in increased hydroxylation of Domperidone CTD PMID:15327587 dopamine decreases activity EXP 6480464 Dopamine results in decreased activity of CYP2D6 protein CTD PMID:18420780 dopamine multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of Tyramine] which results in increased abundance of Dopamine CTD PMID:26763401 dopamine increases abundance EXP 6480464 CYP2D6 protein results in increased abundance of Dopamine CTD PMID:26763401 dronedarone increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of dronedarone CTD PMID:29616291 dronedarone multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of Dronedarone] which results in decreased abundance of N-desbutyldronedarone more ... CTD PMID:29616291 dronedarone decreases response to substance EXP 6480464 CYP2D6 protein results in decreased susceptibility to dronedarone CTD PMID:29616291 ellipticine increases metabolic processing EXP 6480464 CYP2D6 protein mutant form results in increased metabolism of ellipticine CTD PMID:22917556 endosulfan decreases expression ISO RGD:620640 6480464 Endosulfan results in decreased expression of CYP2D4 mRNA CTD PMID:29391264 erythromycin A decreases activity ISO RGD:736218 6480464 Erythromycin results in decreased activity of CYP2D22 protein CTD PMID:18420780 ethambutol decreases activity EXP 6480464 Ethambutol results in decreased activity of CYP2D6 protein CTD PMID:24910189 ethanol increases expression EXP 6480464 Ethanol results in increased expression of CYP2D6 mRNA, Ethanol results in increased expression of CYP2D6 protein CTD PMID:30373287 ethanol increases expression ISO RGD:736218 6480464 Ethanol results in increased expression of CYP2D22 mRNA CTD PMID:30319688 eugenol multiple interactions EXP 6480464 [CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol more ... CTD PMID:15576237 eugenol increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Eugenol CTD PMID:15576237 eupatorin decreases activity EXP 6480464 eupatorin results in decreased activity of CYP2D6 protein CTD PMID:21276781 fenofibrate multiple interactions ISO RGD:620640 6480464 [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP2D22 mRNA CTD PMID:18253720 fenproporex decreases alkylation EXP 6480464 CYP2D6 protein results in decreased alkylation of fenproporex CTD PMID:15294457 fenvalerate decreases activity EXP 6480464 fenvalerate results in decreased activity of CYP2D6 protein CTD PMID:20183062 fipronil decreases activity EXP 6480464 fipronil results in decreased activity of CYP2D6 protein CTD PMID:31278966 fipronil-sulfone decreases activity EXP 6480464 fipronil sulfone results in decreased activity of CYP2D6 protein CTD PMID:31278966 flavonoids decreases expression ISO RGD:620640 6480464 Flavonoids results in decreased expression of CYP2D4 mRNA CTD PMID:18035473 fluoxetine affects response to substance EXP 6480464 CYP2D6 protein affects the susceptibility to Fluoxetine CTD PMID:15172931 fluoxetine decreases activity EXP 6480464 Fluoxetine results in decreased activity of CYP2D6 protein CTD PMID:12173784 more ... fluoxetine increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Fluoxetine CTD PMID:10755579 more ... fluoxetine increases metabolic processing ISO RGD:736218 6480464 CYP2D22 protein results in increased metabolism of Fluoxetine CTD PMID:16595712 fluoxetine multiple interactions EXP 6480464 [Fluoxetine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan, Fluoxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Tolterodine Tartrate] CTD PMID:10583026 , PMID:26599973 fluoxetine decreases metabolic processing EXP 6480464 CYP2D6 gene mutant form results in decreased metabolism of Fluoxetine CTD PMID:10755579 fluoxetine affects metabolic processing EXP 6480464 CYP2D6 gene polymorphism affects the metabolism of Fluoxetine, CYP2D6 protein affects the metabolism of Fluoxetine CTD PMID:14639062 more ... fluoxetine affects abundance EXP 6480464 CYP2D6 gene polymorphism affects the abundance of Fluoxetine, CYP2D6 protein affects the abundance of Fluoxetine CTD PMID:14726986 , PMID:15094477 fluoxetine decreases methylation EXP 6480464 CYP2D6 protein results in decreased methylation of Fluoxetine CTD PMID:17470523 flutamide multiple interactions EXP 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Flutamide CTD PMID:23397584 flutamide decreases expression ISO RGD:620640 6480464 Flutamide results in decreased expression of CYP2D4 mRNA CTD PMID:24793618 folic acid decreases expression ISO RGD:736218 6480464 Folic Acid results in decreased expression of CYP2D22 mRNA CTD PMID:25006883 formononetin decreases activity EXP 6480464 formononetin results in decreased activity of CYP2D6 protein CTD PMID:26278343 furan decreases expression ISO RGD:620640 6480464 furan results in decreased expression of CYP2D4 mRNA CTD PMID:15120968 gallocatechin multiple interactions ISO RGD:736218 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP2D22 mRNA CTD PMID:25663641 gamma-hexachlorocyclohexane decreases expression EXP 6480464 Hexachlorocyclohexane results in decreased expression of CYP2D6 mRNA CTD PMID:20035023 gefitinib affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of gefitinib CTD PMID:15788367 Germacrone decreases activity EXP 6480464 germacrone results in decreased activity of CYP2D6 protein CTD PMID:23850985 glafenine decreases expression ISO RGD:620640 6480464 Glafenine results in decreased expression of CYP2D4 mRNA CTD PMID:24136188 glutathione multiple interactions EXP 6480464 [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac more ... CTD PMID:20825217 more ... gold atom multiple interactions EXP 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of CYP2D6 mRNA CTD PMID:28433809 gold(0) multiple interactions EXP 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of CYP2D6 mRNA CTD PMID:28433809 haloperidol affects response to substance EXP 6480464 CYP2D6 protein polymorphism affects the susceptibility to Haloperidol CTD PMID:15538130 hemin multiple interactions EXP 6480464 Dimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]] more ... CTD PMID:11368792 hydrogen peroxide increases abundance EXP 6480464 CYP2D6 protein results in increased abundance of Hydrogen Peroxide CTD PMID:25061110 hydroquinone multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of bisphenol A] which results in increased chemical synthesis of hydroquinone CTD PMID:21402134 hydroxychloroquine decreases activity EXP 6480464 Hydroxychloroquine results in decreased activity of CYP2D6 protein CTD PMID:10848718 hydroxychloroquine multiple interactions EXP 6480464 Hydroxychloroquine inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol] CTD PMID:10848718 hyodeoxycholic acid multiple interactions ISO RGD:620640 6480464 [CYP2D6 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of hyodeoxycholic acid CTD PMID:18039809 Hypaconitine increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of hypaconitine CTD PMID:21550385 ifosfamide increases response to substance EXP 6480464 CYP2D6 protein results in increased susceptibility to Ifosfamide CTD PMID:20507880 imipramine affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of Imipramine CTD PMID:15286053 imipramine oxide increases abundance EXP 6480464 CYP2D6 protein results in increased abundance of imipramine N-oxide CTD PMID:27320963 imiquimod increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Imiquimod CTD PMID:31111189 isatin increases expression EXP 6480464 Isatin results in increased expression of CYP2D6 mRNA CTD PMID:15056799 isocarbophos multiple interactions EXP 6480464 CYP2D6 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos CTD PMID:24752505 isoimperatorin increases oxidation EXP 6480464 CYP2D6 protein results in increased oxidation of isoimperatorin CTD PMID:25500267 isoproturon decreases activity EXP 6480464 isoproturon results in decreased activity of CYP2D6 protein CTD PMID:18420780 ivermectin decreases activity EXP 6480464 Ivermectin results in decreased activity of CYP2D6 protein CTD PMID:11124226 , PMID:18420780 ivermectin decreases activity ISO RGD:736218 6480464 Ivermectin results in decreased activity of CYP2D22 protein CTD PMID:18420780 ketoconazole decreases activity EXP 6480464 Ketoconazole results in decreased activity of CYP2D6 protein CTD PMID:15618748 ketoconazole decreases activity ISO RGD:736218 6480464 Ketoconazole results in decreased activity of CYP2D22 protein, Ketoconazole results in decreased activity of CYP2D6 protein CTD PMID:18420780 , PMID:22334051 ketoconazole decreases expression ISO RGD:736218 6480464 Ketoconazole results in decreased expression of CYP2D22 mRNA, Ketoconazole results in decreased expression of CYP2D22 protein CTD PMID:19594327 ketoconazole multiple interactions ISO RGD:736218 6480464 Ketoconazole inhibits the reaction [CYP2D22 protein results in increased metabolism of Dextromethorphan] more ... CTD PMID:16595712 more ... ketoconazole multiple interactions EXP 6480464 Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid], Ketoconazole inhibits the reaction [CYP2D6 protein results in increased metabolism of YM 758] CTD PMID:19230594 , PMID:24120545 kojic acid multiple interactions ISO RGD:620640 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2D22 mRNA, [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP2D22 mRNA CTD PMID:18544905 L-ethionine affects expression ISO RGD:620640 6480464 Ethionine affects the expression of CYP2D4 mRNA CTD PMID:19483382 L-methionine multiple interactions ISO RGD:736218 6480464 [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP2D22 protein CTD PMID:27712037 lamotrigine increases glutathionylation EXP 6480464 CYP2D6 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 lefetamine decreases alkylation EXP 6480464 CYP2D6 protein results in decreased alkylation of lephetamine CTD PMID:26276083 lipoic acid multiple interactions EXP 6480464 Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 lithocholic acid increases metabolic processing ISO RGD:620640 6480464 CYP2D6 protein results in increased metabolism of Lithocholic Acid CTD PMID:18039809 lithocholic acid decreases activity ISO RGD:736218 6480464 Lithocholic Acid results in decreased activity of CYP2D22 protein CTD PMID:18420780 lithocholic acid multiple interactions ISO RGD:620640 6480464 [CYP2D6 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of hyodeoxycholic acid CTD PMID:18039809 Loratadine affects metabolic processing EXP 6480464 CYP2D6 gene polymorphism affects the metabolism of Loratadine, CYP2D6 protein affects the metabolism of Loratadine CTD PMID:15932952 loxapine increases metabolic processing EXP 6480464 CYP2D6 results in increased metabolism of Loxapine CTD PMID:21826677 maneb multiple interactions ISO RGD:736218 6480464 Ketoconazole inhibits the reaction [Maneb results in decreased expression of CYP2D22 protein] CTD PMID:22334051 maneb decreases expression ISO RGD:736218 6480464 Maneb results in decreased expression of CYP2D22 protein CTD PMID:22334051 manganese atom decreases response to substance EXP 6480464 CYP2D6 gene polymorphism results in decreased susceptibility to Manganese CTD PMID:12171760 manganese(0) decreases response to substance EXP 6480464 CYP2D6 gene polymorphism results in decreased susceptibility to Manganese CTD PMID:12171760 mangiferin decreases activity EXP 6480464 mangiferin results in decreased activity of CYP2D6 protein CTD PMID:22815239 manidipine decreases activity EXP 6480464 manidipine results in decreased activity of CYP2D6 protein CTD PMID:10805063 Melarsoprol decreases activity EXP 6480464 Melarsoprol results in decreased activity of CYP2D6 protein CTD PMID:11124226 Mequitazine increases hydroxylation EXP 6480464 CYP2D6 protein results in increased hydroxylation of mequitazine CTD PMID:15863898 Mequitazine multiple interactions EXP 6480464 Nicardipine inhibits the reaction [CYP2D6 protein results in increased hydroxylation of mequitazine] CTD PMID:15863898 methadone increases metabolic processing ISO RGD:736218 6480464 CYP2D22 protein results in increased metabolism of Methadone CTD PMID:16595712 methadone decreases activity EXP 6480464 Methadone results in decreased activity of CYP2D6 protein CTD PMID:16595712 methamphetamine affects response to substance EXP 6480464 CYP2D4 gene polymorphism affects the susceptibility to Methamphetamine, CYP2D6 protein affects the susceptibility to Methamphetamine CTD PMID:18280655 , PMID:20727252 methamphetamine increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Methamphetamine CTD PMID:27320963 methapyrilene decreases expression ISO RGD:620640 6480464 Methapyrilene results in decreased expression of CYP2D4 mRNA CTD PMID:15120968 methiocarb multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide CTD PMID:27665777 methiocarb increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Methiocarb CTD PMID:27665777 methiocarb-sulfoxide multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide CTD PMID:27665777 methiocarb-sulfoxide increases abundance EXP 6480464 CYP2D6 protein results in increased abundance of methiocarb sulfoxide CTD PMID:27665777 methoxsalen decreases activity EXP 6480464 Methoxsalen results in decreased activity of CYP2D6 protein CTD PMID:18420780 methoxychlor decreases activity EXP 6480464 Methoxychlor results in decreased activity of CYP2D6 protein CTD PMID:18420780 methoxychlor decreases methylation EXP 6480464 CYP2D6 protein results in decreased methylation of Methoxychlor CTD PMID:12167570 , PMID:12433799 metoclopramide affects metabolic processing EXP 6480464 CYP2D6 gene polymorphism affects the metabolism of Metoclopramide CTD PMID:16702617 metoprolol affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of Metoprolol, CYP2D6 protein polymorphism affects the metabolism of Metoprolol CTD PMID:11823760 more ... metoprolol increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Metoprolol CTD PMID:10848718 more ... metoprolol affects response to substance EXP 6480464 CYP2D6 gene affects the susceptibility to Metoprolol, CYP2D6 gene polymorphism affects the susceptibility to Metoprolol CTD PMID:12172215 more ... metoprolol multiple interactions EXP 6480464 [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased degradation of Metoprolol more ... CTD PMID:10470702 more ... midazolam decreases activity ISO RGD:736218 6480464 Midazolam results in decreased activity of CYP2D6 protein CTD PMID:18420780 Mitragynine increases expression EXP 6480464 mitragynine results in increased expression of CYP2D6 protein CTD PMID:23274770 Mitragynine decreases activity EXP 6480464 mitragynine results in decreased activity of CYP2D6 protein CTD PMID:31707106 monosodium L-glutamate multiple interactions ISO RGD:736218 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP2D22 mRNA, [Sodium Glutamate co-treated with Tea] affects the expression of CYP2D22 mRNA CTD PMID:25663641 morphine affects chemical synthesis EXP 6480464 CYP2D6 protein affects the chemical synthesis of Morphine CTD PMID:15625333 morphine multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine CTD PMID:16595712 , PMID:21241245 myricetin decreases activity EXP 6480464 myricetin results in decreased activity of CYP2D6 protein CTD PMID:29753067 N,N-Didesmethyltamoxifen multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of N more ... CTD PMID:29285606 N,N-Didesmethyltamoxifen increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of N, N-didesmethyltamoxifen CTD PMID:29285606 N,N-diethyl-m-toluamide increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of DEET CTD PMID:11854147 N,N-diisopropyltryptamine multiple interactions EXP 6480464 [N, N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan CTD PMID:26599973 N,N-diisopropyltryptamine decreases activity EXP 6480464 N, N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein CTD PMID:26599973 N-acetyl-1,4-benzoquinone imine increases abundance EXP 6480464 CYP2D6 protein results in increased abundance of N-acetyl-4-benzoquinoneimine CTD PMID:24661219 N-desmethylclozapine increases chemical synthesis EXP 6480464 CYP2D6 protein results in increased chemical synthesis of norclozapine CTD PMID:18809730 N-Desmethyltamoxifen multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of N-desmethyltamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1 more ... CTD PMID:14652237 , PMID:29285606 N-Desmethyltamoxifen increases abundance EXP 6480464 CYP2D6 protein results in increased abundance of N-desmethyltamoxifen CTD PMID:29285606 N-Desmethyltamoxifen increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of N-desmethyltamoxifen CTD PMID:29285606 N-nitrosodiethylamine multiple interactions ISO RGD:620640 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2D22 mRNA more ... CTD PMID:18253720 more ... N-nitrosodiethylamine increases expression ISO RGD:736218 6480464 Diethylnitrosamine results in increased expression of CYP2D22 mRNA CTD PMID:17942915 N-nitrosodiethylamine multiple interactions ISO RGD:736218 6480464 MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of CYP2D22 mRNA] CTD PMID:17942915 N-nitrosodimethylamine decreases expression ISO RGD:620640 6480464 Dimethylnitrosamine results in decreased expression of CYP2D4 mRNA CTD PMID:25380136 N-Nitrosopyrrolidine decreases expression EXP 6480464 N-Nitrosopyrrolidine results in decreased expression of CYP2D6 mRNA CTD PMID:32234424 NADP zwitterion multiple interactions EXP 6480464 [CYP2D6 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1 more ... CTD PMID:20825217 more ... NADP(+) multiple interactions EXP 6480464 [CYP2D6 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1 more ... CTD PMID:20825217 more ... naphthalene increases expression EXP 6480464 naphthalene results in increased expression of CYP2D6 mRNA CTD PMID:20500019 Nicardipine decreases activity EXP 6480464 Nicardipine results in decreased activity of CYP2D6 protein CTD PMID:10805063 , PMID:15863898 Nicardipine multiple interactions EXP 6480464 Nicardipine inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan], Nicardipine inhibits the reaction [CYP2D6 protein results in increased hydroxylation of mequitazine] CTD PMID:15863898 Nicardipine affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of Nicardipine CTD PMID:15863898 Niclosamide decreases activity EXP 6480464 Niclosamide results in decreased activity of CYP2D6 protein CTD PMID:11124226 nicotine multiple interactions ISO RGD:736218 6480464 Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:19594327 nicotine increases expression ISO RGD:736218 6480464 Nicotine results in increased expression of CYP2D22 mRNA, Nicotine results in increased expression of CYP2D22 protein CTD PMID:19594327 nifedipine decreases activity ISO RGD:736218 6480464 Nifedipine results in decreased activity of CYP2D6 protein CTD PMID:18420780 nimesulide increases glutathionylation EXP 6480464 CYP2D6 protein results in increased glutathionylation of nimesulide CTD PMID:26524229 norcodeine multiple interactions ISO RGD:736218 6480464 [CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine CTD PMID:16595712 nortriptyline decreases response to substance EXP 6480464 CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline CTD PMID:11673748 nortriptyline increases metabolic processing EXP 6480464 Nortriptyline results in increased metabolism of CYP2D6 protein CTD PMID:18359012 nortriptyline multiple interactions EXP 6480464 Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline] CTD PMID:11673748 nortriptyline increases hydroxylation EXP 6480464 CYP2D6 protein results in increased hydroxylation of Nortriptyline CTD PMID:17470523 Notopterol increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of notopterol CTD PMID:32198085 Notopterol multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol] more ... CTD PMID:32198085 Notopterol decreases activity EXP 6480464 notopterol results in decreased activity of CYP2D6 protein CTD PMID:32198085 o-anisidine increases oxidation EXP 6480464 CYP2D6 protein results in increased oxidation of 2-anisidine CTD PMID:15828049 O-methyleugenol decreases expression EXP 6480464 methyleugenol results in decreased expression of CYP2D6 mRNA CTD PMID:32234424 O-methylserotonin multiple interactions EXP 6480464 CYP2D6 protein binds to and results in decreased methylation of 5-Methoxytryptamine CTD PMID:12777961 obeticholic acid increases expression EXP 6480464 obeticholic acid results in increased expression of CYP2D6 mRNA CTD PMID:27939613 ochratoxin A decreases expression ISO RGD:620640 6480464 ochratoxin A results in decreased expression of CYP2D4 mRNA CTD PMID:12700408 omeprazole affects expression ISO RGD:620640 6480464 Omeprazole affects the expression of CYP2D4 mRNA CTD PMID:19483382 omeprazole decreases activity ISO RGD:736218 6480464 Omeprazole results in decreased activity of CYP2D6 protein CTD PMID:18420780 Ondansetron increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Ondansetron CTD PMID:12464242 Ondansetron affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of Ondansetron CTD PMID:15286053 Oxatomide decreases activity EXP 6480464 oxatomide results in decreased activity of CYP2D6 protein CTD PMID:15684493 oxycodone affects response to substance EXP 6480464 CYP2D6 gene polymorphism affects the susceptibility to Oxycodone CTD PMID:20590588 oxycodone multiple interactions EXP 6480464 [Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone CTD PMID:20590588 ozagrel increases metabolic processing ISO RGD:620640 6480464 CYP2D6 protein results in increased metabolism of ozagrel CTD PMID:17651725 ozagrel multiple interactions ISO RGD:620640 6480464 ozagrel promotes the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan], ozagrel results in increased expression of and results in increased activity of CYP2D6 protein CTD PMID:17651725 p-cresol increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of 4-cresol CTD PMID:16174805 paclitaxel decreases activity EXP 6480464 Paclitaxel results in decreased activity of CYP2D6 protein CTD PMID:19909766 paliperidone palmitate affects abundance EXP 6480464 CYP2D6 gene polymorphism affects the abundance of Paliperidone Palmitate, CYP2D6 protein affects the abundance of Paliperidone Palmitate CTD PMID:10639689 more ... paraquat decreases expression ISO RGD:736218 6480464 Paraquat results in decreased expression of CYP2D22 protein CTD PMID:22334051 paraquat multiple interactions ISO RGD:736218 6480464 Ketoconazole inhibits the reaction [Paraquat results in decreased expression of CYP2D22 protein], resveratrol inhibits the reaction [Paraquat results in decreased expression of CYP2D22 protein] CTD PMID:22334051 parathion affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of Parathion CTD PMID:12669189 paroxetine decreases metabolic processing EXP 6480464 CYP2D6 gene mutant form results in decreased metabolism of Paroxetine CTD PMID:15570195 paroxetine decreases activity EXP 6480464 Paroxetine results in decreased activity of CYP2D6 protein CTD PMID:12173784 more ... paroxetine increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Paroxetine CTD PMID:14639062 paroxetine multiple interactions EXP 6480464 [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased abundance of 4-hydroxy-N-desmethyltamoxifen more ... CTD PMID:10470702 more ... paroxetine increases response to substance EXP 6480464 CYP2D6 gene mutant form results in increased susceptibility to Paroxetine CTD PMID:15570195 pentamidine decreases activity EXP 6480464 Pentamidine results in decreased activity of CYP2D6 protein CTD PMID:11124226 perfluorooctane-1-sulfonic acid multiple interactions EXP 6480464 perfluorooctane sulfonic acid inhibits the reaction [CYP2D6 protein results in increased oxidation of bufuralol] CTD PMID:21964418 perfluorooctane-1-sulfonic acid affects expression ISO RGD:736218 6480464 perfluorooctane sulfonic acid affects the expression of CYP2D22 mRNA CTD PMID:19429403 perfluorooctanoic acid decreases expression ISO RGD:620640 6480464 perfluorooctanoic acid results in decreased expression of CYP2D4 mRNA CTD PMID:19162173 perfluorooctanoic acid decreases expression ISO RGD:736218 6480464 perfluorooctanoic acid results in decreased expression of CYP2D6 mRNA CTD PMID:17681415 perfluorooctanoic acid affects expression ISO RGD:736218 6480464 perfluorooctanoic acid affects the expression of CYP2D22 mRNA CTD PMID:19429403 perhexiline decreases response to substance EXP 6480464 CYP2D6 protein results in decreased susceptibility to Perhexiline CTD PMID:28762043 phenanthrene increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of phenanthrene CTD PMID:9429232 phencyclidine affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of Phencyclidine CTD PMID:16782764 phenobarbital decreases expression ISO RGD:620640 6480464 Phenobarbital results in decreased expression of CYP2D22 mRNA CTD PMID:20607812 phenobarbital decreases activity EXP 6480464 Phenobarbital results in decreased activity of CYP2D6 protein CTD PMID:19909766 phenthoate decreases activity EXP 6480464 phenthoate results in decreased activity of CYP2D6 protein CTD PMID:20183062 phenytoin multiple interactions EXP 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin CTD PMID:23397584 PhIP increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine CTD PMID:17279779 PhIP multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4 more ... CTD PMID:17279779 phlorizin increases expression ISO RGD:736218 6480464 Phlorhizin results in increased expression of CYP2D6 mRNA CTD PMID:22538082 pirinixic acid affects expression ISO RGD:620640 6480464 pirinixic acid affects the expression of CYP2D4 mRNA CTD PMID:19483382 pirinixic acid increases expression ISO RGD:736218 6480464 pirinixic acid results in increased expression of CYP2D22 mRNA CTD PMID:17426115 pirinixic acid decreases expression ISO RGD:736218 6480464 pirinixic acid results in decreased expression of CYP2D22 mRNA CTD PMID:20813756 pirinixic acid decreases expression ISO RGD:620640 6480464 pirinixic acid results in decreased expression of CYP2D4 mRNA CTD PMID:19162173 poly(styrene) multiple interactions EXP 6480464 styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP2D6 protein] CTD PMID:19909766 poly(styrene) decreases activity EXP 6480464 styrofoam analog results in decreased activity of CYP2D6 protein CTD PMID:19909766 potassium bromate affects expression ISO RGD:736218 6480464 potassium bromate affects the expression of CYP2D22 mRNA CTD PMID:27082013 potassium bromate multiple interactions ISO RGD:736218 6480464 [potassium bromate co-treated with bisphenol A] affects the expression of CYP2D22 mRNA more ... CTD PMID:27082013 potassium dichromate increases expression EXP 6480464 Potassium Dichromate results in increased expression of CYP2D6 mRNA CTD PMID:18332044 potassium dichromate increases expression ISO RGD:736218 6480464 Potassium Dichromate results in increased expression of CYP2D22 mRNA CTD PMID:23608068 primaquine affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of Primaquine CTD PMID:12920490 primaquine increases response to substance EXP 6480464 CYP2D6 protein results in increased susceptibility to Primaquine CTD PMID:26477383 primaquine increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Primaquine CTD PMID:19616568 primaquine multiple interactions EXP 6480464 [CYP2D6 protein results in increased expression of HBG2 protein] which affects the susceptibility to Primaquine CTD PMID:19616568 prochloraz decreases expression EXP 6480464 prochloraz results in decreased expression of CYP2D6 mRNA CTD PMID:20035023 proguanil decreases activity EXP 6480464 Proguanil results in decreased activity of CYP2D6 protein CTD PMID:11124226 promethazine decreases metabolic processing EXP 6480464 CYP2D6 gene polymorphism results in decreased metabolism of Promethazine CTD PMID:19814645 propafenone affects response to substance EXP 6480464 CYP2D6 protein mutant form affects the susceptibility to Propafenone CTD PMID:12421483 propranolol affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of Propranolol CTD PMID:15286053 propranolol increases oxidation EXP 6480464 CYP2D6 protein results in increased oxidation of Propranolol CTD PMID:19853591 propranolol increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Propranolol CTD PMID:12464242 , PMID:21184751 pyrantel affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of Pyrantel CTD PMID:12920490 pyrazinecarboxamide increases expression ISO RGD:620640 6480464 Pyrazinamide results in increased expression of CYP2D4 mRNA CTD PMID:22431067 pyrrolidines affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of Pyrrolidines CTD PMID:21053377 quercetin decreases activity EXP 6480464 Quercetin results in decreased activity of CYP2D6 protein CTD PMID:18420780 , PMID:29753067 quercetin decreases activity ISO RGD:736218 6480464 Quercetin results in decreased activity of CYP2D22 protein CTD PMID:18420780 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 quinidine multiple interactions EXP 6480464 [Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone more ... CTD PMID:11377097 more ... quinidine decreases activity ISO RGD:736218 6480464 Quinidine results in decreased activity of CYP2D6 protein CTD PMID:18420780 quinidine multiple interactions ISO RGD:620640 6480464 [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride CTD PMID:20669986 quinidine decreases activity EXP 6480464 Quinidine results in decreased activity of CYP2D6 gene mutant form, Quinidine results in decreased activity of CYP2D6 protein CTD PMID:11673748 more ... quinidine increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Quinidine CTD PMID:17702393 quinine multiple interactions ISO RGD:620640 6480464 Quinine inhibits the reaction [CYP2D6 protein results in increased oxidation of Chlorpyrifos] CTD PMID:14979094 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan] CTD PMID:20716633 resveratrol multiple interactions ISO RGD:736218 6480464 resveratrol inhibits the reaction [Paraquat results in decreased expression of CYP2D22 protein] CTD PMID:22334051 resveratrol decreases activity ISO RGD:736218 6480464 resveratrol results in decreased activity of CYP2D22 protein CTD PMID:18420780 resveratrol decreases activity EXP 6480464 resveratrol results in decreased activity of CYP2D6 protein CTD PMID:18420780 rifampicin increases expression EXP 6480464 Rifampin results in increased expression of CYP2D6 mRNA CTD PMID:19041851 rifampicin decreases expression ISO RGD:736218 6480464 Rifampin results in decreased expression of CYP2D22 mRNA CTD PMID:30503582 risperidone affects abundance EXP 6480464 CYP2D6 gene polymorphism affects the abundance of Risperidone, CYP2D6 protein affects the abundance of Risperidone CTD PMID:15089809 more ... risperidone decreases hydroxylation EXP 6480464 CYP2D6 gene polymorphism results in decreased hydroxylation of Risperidone CTD PMID:15565299 risperidone increases response to substance EXP 6480464 CYP2D6 protein results in increased susceptibility to Risperidone CTD PMID:23609392 risperidone increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Risperidone CTD PMID:16044105 more ... risperidone decreases metabolic processing EXP 6480464 CYP2D6 gene polymorphism results in decreased metabolism of Risperidone CTD PMID:17541883 risperidone affects response to substance EXP 6480464 CYP2D6 gene polymorphism affects the susceptibility to Risperidone, CYP2D6 protein polymorphism affects the susceptibility to Risperidone CTD PMID:15669884 , PMID:23609392 risperidone affects metabolic processing EXP 6480464 CYP2D6 gene polymorphism affects the metabolism of Risperidone, CYP2D6 protein affects the metabolism of Risperidone CTD PMID:15669884 more ... risperidone multiple interactions EXP 6480464 CYP2D6 gene polymorphism affects the metabolism of and affects the abundance of Risperidone, CYP2D6 protein affects the metabolism of and affects the abundance of Risperidone CTD PMID:10639689 , PMID:15260906 ritonavir affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of Ritonavir CTD PMID:15286053 rotenone increases expression ISO RGD:620640 6480464 Rotenone results in increased expression of CYP2D4 mRNA CTD PMID:28374803 safrole increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Safrole CTD PMID:20507880 safrole decreases activity EXP 6480464 Safrole results in decreased activity of CYP2D6 protein CTD PMID:15778010 safrole multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of Safrole] which results in increased abundance of 1'-hydroxysafrole CTD PMID:20507880 Salinomycin decreases activity EXP 6480464 salinomycin results in decreased activity of CYP2D6 protein CTD PMID:26282489 sarpogrelate decreases activity EXP 6480464 sarpogrelate metabolite results in decreased activity of CYP2D6 protein, sarpogrelate results in decreased activity of CYP2D6 protein CTD PMID:24167220 sarpogrelate multiple interactions EXP 6480464 sarpogrelate inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan], sarpogrelate metabolite inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan] CTD PMID:24167220 Senkirkine decreases expression EXP 6480464 senkirkine results in decreased expression of CYP2D6 mRNA CTD PMID:26100227 serpentine multiple interactions EXP 6480464 serpentine (alkaloid) inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan] CTD PMID:15930738 serpentine decreases activity EXP 6480464 serpentine (alkaloid) results in decreased activity of CYP2D6 protein CTD PMID:15930738 sertraline multiple interactions EXP 6480464 CYP2D6 protein results in decreased methylation of and results in increased metabolism of Sertraline CTD PMID:15547048 Shikonin decreases activity EXP 6480464 shikonin results in decreased activity of CYP2D6 protein CTD PMID:28941798 sibutramine decreases activity EXP 6480464 sibutramine results in decreased activity of CYP2D6 protein CTD PMID:23777987 simvastatin affects response to substance EXP 6480464 CYP2D6 polymorphism affects the susceptibility to Simvastatin CTD PMID:11753271 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of CYP2D6 protein CTD PMID:11368792 sodium dichromate decreases expression ISO RGD:620640 6480464 sodium bichromate results in decreased expression of CYP2D4 mRNA CTD PMID:25993096 sophoranone decreases activity EXP 6480464 sophoranone results in decreased activity of CYP2D6 protein CTD PMID:29753067 sparteine increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Sparteine CTD PMID:11907490 Sudan I increases oxidation EXP 6480464 CYP2D6 protein results in increased oxidation of 1-phenylazo-2-naphthol CTD PMID:17159775 Sudan I multiple interactions EXP 6480464 CYB5A protein inhibits the reaction [CYP2D6 protein results in increased oxidation of 1-phenylazo-2-naphthol] CTD PMID:17159775 sulindac multiple interactions ISO RGD:620640 6480464 [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CYP2D4 mRNA CTD PMID:20371263 tamoxifen multiple interactions EXP 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Tamoxifen more ... CTD PMID:20124171 more ... tamoxifen decreases activity ISO RGD:736218 6480464 Tamoxifen results in decreased activity of CYP2D6 protein CTD PMID:18420780 tamoxifen affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of Tamoxifen CTD PMID:15632378 more ... tamoxifen increases expression EXP 6480464 Tamoxifen results in increased expression of CYP2D6 protein CTD PMID:19812351 tamoxifen increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Tamoxifen CTD PMID:20123649 tamoxifen increases response to substance EXP 6480464 CYP2D6 gene polymorphism results in increased susceptibility to Tamoxifen, CYP2D6 protein results in increased susceptibility to Tamoxifen CTD PMID:19244106 , PMID:21152245 tamoxifen decreases response to substance EXP 6480464 CYP2D6 gene polymorphism results in decreased susceptibility to Tamoxifen CTD PMID:20309015 tamoxifen affects response to substance EXP 6480464 CYP2D6 gene polymorphism affects the susceptibility to Tamoxifen CTD PMID:19189210 , PMID:19189212 tegaserod increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of tegaserod CTD PMID:11560869 tegaserod decreases activity EXP 6480464 tegaserod results in decreased activity of CYP2D6 protein CTD PMID:11560869 tegaserod multiple interactions EXP 6480464 Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of tegaserod] CTD PMID:11560869 terbinafine decreases activity EXP 6480464 terbinafine results in decreased activity of CYP2D6 protein CTD PMID:24894748 terbinafine multiple interactions EXP 6480464 [terbinafine results in decreased activity of CYP2D6 protein] inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol] CTD PMID:24894748 testosterone decreases activity ISO RGD:736218 6480464 Testosterone results in decreased activity of CYP2D22 protein CTD PMID:18420780 tetrachloromethane increases expression ISO RGD:620640 6480464 Carbon Tetrachloride results in increased expression of CYP2D4 mRNA CTD PMID:12921627 tetrachloromethane decreases expression ISO RGD:736218 6480464 Carbon Tetrachloride results in decreased expression of CYP2D22 mRNA CTD PMID:17484886 , PMID:27339419 thioacetamide affects expression ISO RGD:620640 6480464 Thioacetamide affects the expression of CYP2D4 mRNA CTD PMID:19483382 thioacetamide multiple interactions ISO RGD:620640 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CYP2D22 mRNA CTD PMID:28943392 thioacetamide decreases expression ISO RGD:620640 6480464 Thioacetamide results in decreased expression of CYP2D4 mRNA CTD PMID:23411599 thioridazine multiple interactions EXP 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine, CYP2D6 protein results in increased metabolism of and results in increased activity of Thioridazine CTD PMID:19482014 , PMID:23397584 ticlopidine decreases activity EXP 6480464 Ticlopidine results in decreased activity of CYP2D6 protein CTD PMID:10759690 ticlopidine multiple interactions EXP 6480464 CYP2D6 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite CTD PMID:19170597 titanium dioxide increases expression ISO RGD:736218 6480464 titanium dioxide results in increased expression of CYP2D22 mRNA CTD PMID:23557971 , PMID:29264374 tofacitinib increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of tofacitinib CTD PMID:31414593 tolterodine tartrate multiple interactions EXP 6480464 Fluoxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Tolterodine Tartrate] CTD PMID:10583026 tolterodine tartrate affects metabolic processing EXP 6480464 CYP2D6 polymorphism affects the metabolism of Tolterodine Tartrate CTD PMID:28087463 tolterodine tartrate increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Tolterodine Tartrate CTD PMID:10583026 toluene affects expression ISO RGD:620640 6480464 Toluene affects the expression of CYP2D22 mRNA CTD PMID:18653662 toluene multiple interactions ISO RGD:620640 6480464 Toluene results in increased expression of and results in increased activity of CYP2D4 protein CTD PMID:14703099 toluene increases expression ISO RGD:620640 6480464 Toluene results in increased expression of CYP2D4 mRNA CTD PMID:14703099 tramadol affects response to substance EXP 6480464 CYP2D6 gene polymorphism affects the susceptibility to Tramadol, CYP2D6 protein affects the susceptibility to Tramadol CTD PMID:16497087 , PMID:16960721 tramadol affects methylation ISO RGD:736218 6480464 CYP2D6 protein affects the methylation of Tramadol CTD PMID:12893130 tramadol increases response to substance EXP 6480464 CYP2D6 gene mutant form results in increased susceptibility to Tramadol CTD PMID:18204346 tramadol increases metabolic processing EXP 6480464 CYP2D6 gene mutant form results in increased metabolism of Tramadol, CYP2D6 protein results in increased metabolism of Tramadol CTD PMID:18204346 more ... tramadol decreases methylation EXP 6480464 CYP2D6 protein results in decreased methylation of Tramadol CTD PMID:14624403 more ... tramadol decreases response to substance EXP 6480464 CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol CTD PMID:16960721 tramadol multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol more ... CTD PMID:18204346 , PMID:29555325 tramadol affects metabolic processing EXP 6480464 CYP2D6 gene mutant form affects the metabolism of Tramadol, CYP2D6 gene polymorphism affects the metabolism of Tramadol CTD PMID:12191703 more ... trans-cinnamic acid decreases activity EXP 6480464 cinnamic acid analog results in decreased activity of CYP2D6 protein CTD PMID:15072549 tranylcypromine multiple interactions EXP 6480464 Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 triclosan increases expression EXP 6480464 Triclosan results in increased expression of CYP2D6 mRNA CTD PMID:29849464 triflumuron increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of triflumuron CTD PMID:31082524 trimellitic anhydride decreases expression ISO RGD:736218 6480464 trimellitic anhydride results in decreased expression of CYP2D22 mRNA CTD PMID:19042947 troglitazone multiple interactions EXP 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to troglitazone CTD PMID:23397584 tryptamines decreases activity EXP 6480464 Tryptamines analog results in decreased activity of CYP2D6 protein CTD PMID:26599973 tryptamines multiple interactions EXP 6480464 [Tryptamines analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan CTD PMID:26599973 tyramine increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Tyramine CTD PMID:26763401 tyramine multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of Tyramine] which results in increased abundance of Dopamine CTD PMID:26763401 valdecoxib decreases expression ISO RGD:620640 6480464 valdecoxib results in decreased expression of CYP2D4 mRNA CTD PMID:24136188 valproic acid increases methylation EXP 6480464 Valproic Acid results in increased methylation of CYP2D6 gene CTD PMID:29154799 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of CYP2D6 mRNA CTD PMID:29501571 valproic acid affects expression ISO RGD:736218 6480464 Valproic Acid affects the expression of CYP2D22 mRNA CTD PMID:17292431 vancomycin increases expression ISO RGD:736218 6480464 Vancomycin results in increased expression of CYP2D22 mRNA CTD PMID:18930951 veliparib increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of veliparib CTD PMID:21436403 venlafaxine hydrochloride increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Venlafaxine Hydrochloride CTD PMID:10774634 more ... venlafaxine hydrochloride affects methylation EXP 6480464 CYP2D6 gene polymorphism affects the methylation of Venlafaxine Hydrochloride CTD PMID:10877013 , PMID:10933885 venlafaxine hydrochloride decreases methylation EXP 6480464 CYP2D6 protein results in decreased methylation of Venlafaxine Hydrochloride CTD PMID:10877013 , PMID:10933885 venlafaxine hydrochloride affects response to substance EXP 6480464 CYP2D6 protein affects the susceptibility to Venlafaxine Hydrochloride CTD PMID:17803873 venlafaxine hydrochloride decreases activity EXP 6480464 Venlafaxine Hydrochloride results in decreased activity of CYP2D6 protein CTD PMID:15632378 venlafaxine hydrochloride affects metabolic processing EXP 6480464 CYP2D6 gene mutant form affects the metabolism of Venlafaxine Hydrochloride, CYP2D6 gene polymorphism affects the metabolism of Venlafaxine Hydrochloride CTD PMID:10774634 more ... verapamil decreases activity ISO RGD:736218 6480464 Verapamil results in decreased activity of CYP2D22 protein, Verapamil results in decreased activity of CYP2D6 protein CTD PMID:18420780 vinclozolin decreases expression ISO RGD:620640 6480464 vinclozolin results in decreased expression of CYP2D4 mRNA CTD PMID:23034163 warfarin decreases activity EXP 6480464 Warfarin results in decreased activity of CYP2D6 protein CTD PMID:18420780 yohimbine affects metabolic processing EXP 6480464 CYP2D6 gene polymorphism affects the metabolism of Yohimbine CTD PMID:15289791 zinc atom increases expression EXP 6480464 Zinc deficiency results in increased expression of CYP2D6 mRNA CTD PMID:18356318 zinc(0) increases expression EXP 6480464 Zinc deficiency results in increased expression of CYP2D6 mRNA CTD PMID:18356318
Gene-Chemical Interaction Annotations