Cyp2c23 (cytochrome P450, family 2, subfamily c, polypeptide 23) - Rat Genome Database

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Gene: Cyp2c23 (cytochrome P450, family 2, subfamily c, polypeptide 23) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp2c23
Name: cytochrome P450, family 2, subfamily c, polypeptide 23
RGD ID: 620370
Description: Enables arachidonate 11,12-epoxygenase activity and arachidonate 14,15-epoxygenase activity. Involved in epoxygenase P450 pathway; icosanoid biosynthetic process; and response to testosterone. Located in endoplasmic reticulum membrane; PARTICIPATES IN arachidonic acid metabolic pathway; linoleic acid metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-schisandrin B; (R,R,R)-alpha-tocopherol; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: arachidonic acid epoxygenase; CYPIIC23; cytochrome P450 2C23
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,838,427 - 252,863,081 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1252,838,433 - 252,863,067 (-)EnsemblGRCr8
mRatBN7.21242,889,218 - 242,913,869 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,889,224 - 242,913,858 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1251,039,613 - 251,064,198 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01257,736,346 - 257,760,929 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01250,389,765 - 250,414,350 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01263,778,510 - 263,803,166 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,778,516 - 263,803,150 (-)Ensemblrn6Rnor6.0
Rnor_5.01271,223,504 - 271,248,155 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41249,204,049 - 249,228,689 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1238,706,707 - 238,731,347 (-)NCBICelera
RGSC_v3.11249,462,900 - 249,487,526 (+)NCBI
Cytogenetic Map1q54NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Eicosapentaenoic acid metabolism by cytochrome P450 enzymes of the CYP2C subfamily. Barbosa-Sicard E, etal., Biochem Biophys Res Commun. 2005 Apr 22;329(4):1275-81. doi: 10.1016/j.bbrc.2005.02.103.
2. cDNA and deduced amino acid sequence of a novel cytochrome P-450 from female rat liver mRNA with high homology to P-450 IIC family. Cook EA, etal., Nucleic Acids Res 1990 Dec 11;18(23):7156.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. The kidney cytochrome P-450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading. Holla VR, etal., J Clin Invest. 1999 Sep;104(6):751-60. doi: 10.1172/JCI7013.
5. Identification of CYP2C23 expressed in rat kidney as an arachidonic acid epoxygenase. Imaoka S, etal., J Pharmacol Exp Ther. 1993 Nov;267(2):1012-6.
6. Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase. Karara A, etal., J Biol Chem 1993 Jun 25;268(18):13565-70.
7. A peroxisome proliferator-activated receptor-alpha activator induces renal CYP2C23 activity and protects from angiotensin II-induced renal injury. Muller DN, etal., Am J Pathol. 2004 Feb;164(2):521-32. doi: 10.1016/s0002-9440(10)63142-2.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Renal vascular cytochrome P450-derived eicosanoids in androgen-induced hypertension. Singh H and Schwartzman ML, Pharmacol Rep. 2008 Jan-Feb;60(1):29-37.
Additional References at PubMed
PMID:12477932   PMID:16415373   PMID:16849695   PMID:20595684   PMID:21187320   PMID:21843605   PMID:28212823  


Genomics

Variants

.
Variants in Cyp2c23
120 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:39
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000017840
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238398865255849249Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
RH127805  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21242,889,376 - 242,889,564 (+)MAPPERmRatBN7.2
Rnor_6.01263,778,669 - 263,778,856NCBIRnor6.0
Rnor_5.01271,223,663 - 271,223,850UniSTSRnor5.0
RGSC_v3.41249,228,343 - 249,228,530UniSTSRGSC3.4
Celera1238,706,866 - 238,707,053UniSTS
RH 3.4 Map11618.5UniSTS
Cytogenetic Map1q54UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 8 19 66 86 89 59 21 59 6 218 62 4 43 81 80 30 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000017840   ⟹   ENSRNOP00000017840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1252,838,433 - 252,863,067 (-)Ensembl
mRatBN7.2 Ensembl1242,889,224 - 242,913,858 (-)Ensembl
Rnor_6.0 Ensembl1263,778,516 - 263,803,150 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100726   ⟹   ENSRNOP00000089584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1242,896,789 - 242,913,858 (-)Ensembl
RefSeq Acc Id: NM_031839   ⟹   NP_114027
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,838,427 - 252,863,067 (-)NCBI
mRatBN7.21242,889,218 - 242,913,858 (-)NCBI
Rnor_6.01263,778,510 - 263,803,150 (-)NCBI
Rnor_5.01271,223,504 - 271,248,155 (-)NCBI
RGSC_v3.41249,204,049 - 249,228,689 (+)RGD
Celera1238,706,707 - 238,731,347 (-)RGD
Sequence:
RefSeq Acc Id: XM_017589785   ⟹   XP_017445274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,841,332 - 252,863,081 (-)NCBI
mRatBN7.21242,892,404 - 242,913,869 (-)NCBI
Rnor_6.01263,781,745 - 263,803,166 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_114027 (Get FASTA)   NCBI Sequence Viewer  
  XP_017445274 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA03716 (Get FASTA)   NCBI Sequence Viewer  
  AAH78707 (Get FASTA)   NCBI Sequence Viewer  
  EDL94269 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017840
GenBank Protein P24470 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_114027   ⟸   NM_031839
- UniProtKB: Q64534 (UniProtKB/Swiss-Prot),   Q63914 (UniProtKB/Swiss-Prot),   P24470 (UniProtKB/Swiss-Prot),   Q68G40 (UniProtKB/TrEMBL),   F7FDG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445274   ⟸   XM_017589785
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GI82 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017840   ⟸   ENSRNOT00000017840
Ensembl Acc Id: ENSRNOP00000089584   ⟸   ENSRNOT00000100726

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24470-F1-model_v2 AlphaFold P24470 1-494 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690932
Promoter ID:EPDNEW_R1457
Type:initiation region
Name:Cyp2c23_1
Description:cytochrome P450, family 2, subfamily c, polypeptide 23
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01263,803,135 - 263,803,195EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620370 AgrOrtholog
BioCyc Gene G2FUF-55614 BioCyc
Ensembl Genes ENSRNOG00000013291 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000017840 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7110580 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_fam2 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93122 IMAGE-MGC_LOAD
NCBI Gene 83790 ENTREZGENE
PANTHER CYTOCHROME P450 2C44 UniProtKB/Swiss-Prot
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp2c23 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013291 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0A8I6GI82 ENTREZGENE
  CP2CN_RAT UniProtKB/Swiss-Prot
  F7FDG2 ENTREZGENE, UniProtKB/TrEMBL
  P24470 ENTREZGENE
  Q63914 ENTREZGENE
  Q64534 ENTREZGENE
  Q68G40 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q63914 UniProtKB/Swiss-Prot
  Q64534 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Cyp2c23  cytochrome P450, family 2, subfamily c, polypeptide 23    arachidonic acid epoxygenase  Name updated 1299863 APPROVED
2002-08-07 Cyp2c23  arachidonic acid epoxygenase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in kidney and liver 727619