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Gene: Cyp2c11 (cytochrome P450, subfamily 2, polypeptide 11) Rattus norvegicus
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Symbol: Cyp2c11
Name: cytochrome P450, subfamily 2, polypeptide 11
Description: Exhibits testosterone 16-alpha-hydroxylase activity. Predicted to be involved in several processes, including epoxygenase P450 pathway; exogenous drug catabolic process; and xenobiotic metabolic process. Predicted to localize to the cytoplasm and intracellular membrane-bounded organelle. Biomarker of end stage renal failure; hypertension; and mental depression. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); hypertension; and urinary bladder cancer. Orthologous to several human genes including CYP2C18 (cytochrome P450 family 2 subfamily C member 18); PARTICIPATES IN arachidonic acid metabolic pathway; linoleic acid metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (2-trans,6-trans)-farnesol; 1,2-dichloroethene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Cyp2c; Cyp2c11l; CYP2CII; CYPIIC11; cytochrome P-450(M-1); cytochrome P450 2C11; cytochrome P450 2C11-like; cytochrome P450 2c29; cytochrome P450, 2c29; cytochrome P450, subfamily 2, polypeptide 11-like; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase); cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 11; cytochrome P450-UT-2; cytochrome P450-UT-A; cytochrome P450H; LOC100911826; P-450(M-1); P450-UT-A; P450H; UT-2
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01257,676,172 - 258,004,428 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01265,418,158 - 265,454,574 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,281,320 - 243,320,945 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1233,852,614 - 233,888,873 (+)NCBICelera
Cytogenetic Map1q53NCBI
RH 3.4 Map11592.1RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cyp2c11
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2469
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.