Ywhaz (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ywhaz (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta) Rattus norvegicus
Symbol: Ywhaz
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
RGD ID: 3980
Description: Predicted to enable several functions, including enzyme binding activity; protein sequestering activity; and transmembrane transporter binding activity. Involved in histamine secretion by mast cell; protein targeting to mitochondrion; and response to xenobiotic stimulus. Located in cell leading edge and perinuclear region of cytoplasm. Part of protein-containing complex. Is active in postsynaptic specialization. Biomarker of childhood absence epilepsy; hypertension; and visual epilepsy. Orthologous to human YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta); PARTICIPATES IN granulocyte-macrophage colony-stimulating factor signaling pathway; histone modification pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Previously known as: 14-3-3 protein zeta/delta; 14-3-3z; KCIP-1; mitochondrial import stimulation factor S1 subunit; protein kinase C inhibitor protein 1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2767,941,353 - 67,963,651 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl767,940,017 - 67,963,668 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx769,829,731 - 69,852,029 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0772,032,344 - 72,054,642 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0771,900,221 - 71,922,519 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0775,573,553 - 75,598,295 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl775,574,967 - 75,597,276 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0775,719,688 - 75,744,428 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4772,283,825 - 72,306,126 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1772,304,554 - 72,327,161 (-)NCBI
Celera765,020,398 - 65,042,696 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
captan  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (EXP)
dioxygen  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
fluoxetine  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
glucose  (ISO)
hypochlorous acid  (ISO)
ivermectin  (ISO)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
microcystin-LR  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nitroglycerin  (EXP)
ochratoxin A  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP)
PCB138  (EXP)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
prostaglandin F2alpha  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
sodium nitrate  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
triacsin C  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component


References - curated
# Reference Title Reference Citation
1. cDNA cloning and characterization of mitochondrial import stimulation factor (MSF) purified from rat liver cytosol. Alam R, etal., J Biochem (Tokyo) 1994 Aug;116(2):416-25.
2. Fluoxetine-induced up-regulation of 14-3-3zeta and tryptophan hydroxylase levels in RBL-2H3 cells. Baik SY, etal., Neurosci Lett. 2005 Feb 1;374(1):53-7.
3. Characterization of zetin 1/rBSPRY, a novel binding partner of 14-3-3 proteins. Birkenfeld J, etal., Biochem Biophys Res Commun 2003 Mar 14;302(3):526-33.
4. Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3 zeta. Birkenfeld J, etal., Biochem J. 2003 Jan 1;369(Pt 1):45-54.
5. miR-22 targets YWHAZ to inhibit metastasis of hepatocellular carcinoma and its down-regulation predicts a poor survival. Chen M, etal., Oncotarget. 2016 Dec 6;7(49):80751-80764. doi: 10.18632/oncotarget.13037.
6. Association of GABA(B) receptors and members of the 14-3-3 family of signaling proteins. Couve A, etal., Mol Cell Neurosci. 2001 Feb;17(2):317-28.
7. Changes in intracellular protein expression in cortex, thalamus and hippocampus in a genetic rat model of absence epilepsy. Danis O, etal., Brain Res Bull. 2011 Apr 5;84(6):381-8. doi: 10.1016/j.brainresbull.2011.02.002. Epub 2011 Feb 15.
8. Stimulation of 14-3-3 protein and its isoform on histamine secretion from permeabilized rat peritoneal mast cells. Fujii T and Ueeda T, Biol Pharm Bull. 2002 Dec;25(12):1524-7.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. 14-3-3 proteins within the hypothalamic-neurohypophyseal system of the osmotically stressed rat: transcriptomic and proteomic studies. Gouraud SS, etal., J Neuroendocrinol. 2007 Nov;19(11):913-22.
11. Proteomic response to acupuncture treatment in spontaneously hypertensive rats. Lai X, etal., PLoS One. 2012;7(9):e44216. doi: 10.1371/journal.pone.0044216. Epub 2012 Sep 12.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Readout of epigenetic modifications. Patel DJ and Wang Z, Annu Rev Biochem. 2013;82:81-118. doi: 10.1146/annurev-biochem-072711-165700.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Cloning and characterization of the epsilon and zeta isoforms of the 14-3-3 proteins. Roseboom PH, etal., DNA Cell Biol 1994 Jun;13(6):629-40.
20. Isoform- and subcellular fraction-specific differences in hippocampal 14-3-3 levels following experimentally evoked seizures and in human temporal lobe epilepsy. Schindler CK, etal., J Neurochem. 2006 Oct;99(2):561-9. Epub 2006 Sep 18.
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. Chloride intracellular channel protein CLIC4 (p64H1) binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms. Suginta W, etal., Biochem J. 2001 Oct 1;359(Pt 1):55-64.
23. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
24. Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. Thompson S, etal., J Biol Chem. 2011 Jun 3;286(22):19331-9. doi: 10.1074/jbc.M110.197707. Epub 2011 Apr 8.
25. Kainic acid induces 14-3-3 zeta expression in distinct regions of rat brain. van der Brug MP, etal., Brain Res 2002 Nov 22;956(1):110-5.
26. Molecular cloning of rat cDNAs for the zeta and theta subtypes of 14-3-3 protein and differential distributions of their mRNAs in the brain. Watanabe M, etal., Brain Res Mol Brain Res 1994 Aug;25(1-2):113-21.
Additional References at PubMed
PMID:8972907   PMID:10102273   PMID:12176995   PMID:12446771   PMID:12650640   PMID:14651853   PMID:15073173   PMID:15489334   PMID:15615787   PMID:16114898   PMID:16376338   PMID:16502470  
PMID:16854843   PMID:16959763   PMID:17455326   PMID:18029012   PMID:19014373   PMID:19056867   PMID:19190083   PMID:19199708   PMID:19289463   PMID:19451227   PMID:19725078   PMID:20332113  
PMID:20458337   PMID:20618440   PMID:21423176   PMID:21630459   PMID:22069327   PMID:22124272   PMID:22516433   PMID:22588126   PMID:22658674   PMID:22692127   PMID:22871113   PMID:23106098  
PMID:23533145   PMID:23580065   PMID:23936434   PMID:24206074   PMID:24367683   PMID:25468996   PMID:27401462   PMID:28259758   PMID:29118970   PMID:29476059   PMID:31024343   PMID:31904090  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2767,941,353 - 67,963,651 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl767,940,017 - 67,963,668 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx769,829,731 - 69,852,029 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0772,032,344 - 72,054,642 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0771,900,221 - 71,922,519 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0775,573,553 - 75,598,295 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl775,574,967 - 75,597,276 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0775,719,688 - 75,744,428 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4772,283,825 - 72,306,126 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1772,304,554 - 72,327,161 (-)NCBI
Celera765,020,398 - 65,042,696 (-)NCBICelera
Cytogenetic Map7q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh388100,916,523 - 100,953,382 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8100,916,523 - 100,953,388 (-)EnsemblGRCh38hg38GRCh38
GRCh378101,928,751 - 101,965,610 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368102,000,090 - 102,034,745 (-)NCBINCBI36Build 36hg18NCBI36
Build 348102,000,089 - 102,033,447NCBI
Celera898,115,836 - 98,150,667 (-)NCBICelera
Cytogenetic Map8q22.3NCBI
HuRef897,128,746 - 97,163,575 (-)NCBIHuRef
CHM1_18101,971,677 - 102,006,519 (-)NCBICHM1_1
T2T-CHM13v2.08102,042,222 - 102,079,082 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391536,770,505 - 36,803,228 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1536,771,014 - 36,797,173 (-)EnsemblGRCm39 Ensembl
GRCm381536,770,261 - 36,802,984 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1536,770,770 - 36,796,929 (-)EnsemblGRCm38mm10GRCm38
MGSCv371536,700,016 - 36,724,293 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361536,715,359 - 36,738,833 (-)NCBIMGSCv36mm8
Celera1537,392,750 - 37,416,932 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1514.56NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541716,047,263 - 16,072,854 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541716,047,263 - 16,070,506 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1893,806,633 - 93,841,368 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0897,560,251 - 97,595,117 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1899,730,393 - 99,765,559 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl899,730,393 - 99,762,990 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1132,729,404 - 2,764,422 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha132,728,046 - 2,764,406 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0132,885,028 - 2,921,415 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl132,884,653 - 2,921,431 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1132,728,699 - 2,765,052 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0132,841,194 - 2,877,738 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0132,857,979 - 2,894,557 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440530335,018,527 - 35,044,806 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647042,445,412 - 42,470,900 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647042,444,671 - 42,470,548 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl435,975,508 - 36,009,887 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1435,975,513 - 36,009,909 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2438,914,372 - 38,942,695 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1895,786,197 - 95,821,270 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl895,788,305 - 95,819,197 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603944,861,087 - 44,896,463 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046247637,722,275 - 7,723,482 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ywhaz
45 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:404
Count of miRNA genes:232
Interacting mature miRNAs:268
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2767,965,448 - 67,965,585 (+)MAPPERmRatBN7.2
Rnor_6.0775,599,074 - 75,599,210NCBIRnor6.0
Rnor_5.0775,745,207 - 75,745,343UniSTSRnor5.0
RGSC_v3.4772,307,924 - 72,308,060UniSTSRGSC3.4
Celera765,044,494 - 65,044,630UniSTS
RH 3.4 Map7639.9UniSTS
Cytogenetic Map7q22UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 52
Medium 3 43 57 41 19 41 8 11 22 35 41 11 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000035628   ⟹   ENSRNOP00000030885
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl767,941,393 - 67,963,668 (-)Ensembl
Rnor_6.0 Ensembl775,574,967 - 75,597,276 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080676   ⟹   ENSRNOP00000069366
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl767,940,017 - 67,961,970 (-)Ensembl
Rnor_6.0 Ensembl775,575,763 - 75,597,087 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096774   ⟹   ENSRNOP00000082109
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl767,940,017 - 67,963,622 (-)Ensembl
RefSeq Acc Id: NM_013011   ⟹   NP_037143
Rat AssemblyChrPosition (strand)Source
mRatBN7.2767,941,353 - 67,963,651 (-)NCBI
Rnor_6.0775,574,966 - 75,597,276 (-)NCBI
Rnor_5.0775,719,688 - 75,744,428 (-)NCBI
RGSC_v3.4772,283,825 - 72,306,126 (-)RGD
Celera765,020,398 - 65,042,696 (-)RGD
RefSeq Acc Id: NP_037143   ⟸   NM_013011
- UniProtKB: Q52KK1 (UniProtKB/Swiss-Prot),   Q6IRF4 (UniProtKB/Swiss-Prot),   P63102 (UniProtKB/Swiss-Prot),   A6HR34 (UniProtKB/TrEMBL),   A0A0G2JV65 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069366   ⟸   ENSRNOT00000080676
RefSeq Acc Id: ENSRNOP00000030885   ⟸   ENSRNOT00000035628
RefSeq Acc Id: ENSRNOP00000082109   ⟸   ENSRNOT00000096774
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63102-F1-model_v2 AlphaFold P63102 1-245 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695294
Promoter ID:EPDNEW_R5819
Type:initiation region
Description:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activationprotein, zeta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0775,597,310 - 75,597,370EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3980 AgrOrtholog
BioCyc Gene G2FUF-33637 BioCyc
Ensembl Genes ENSRNOG00000008195 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055024124 UniProtKB/Swiss-Prot
  ENSRNOG00060009040 UniProtKB/Swiss-Prot
  ENSRNOG00065003648 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000035628.6 UniProtKB/TrEMBL
  ENSRNOT00000080676.2 UniProtKB/TrEMBL
  ENSRNOT00000096774.1 UniProtKB/Swiss-Prot
  ENSRNOT00055041503 UniProtKB/Swiss-Prot
  ENSRNOT00060015247 UniProtKB/Swiss-Prot
  ENSRNOT00065005305 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 14-3-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  14-3-3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  14-3-3_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  14-3-3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25578 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18860 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 14-3-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ywhaz PhenoGen
PIRSF 14-3-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS 1433ZETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE 1433_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1433_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008195 RatGTEx
  ENSRNOG00055024124 RatGTEx
  ENSRNOG00060009040 RatGTEx
  ENSRNOG00065003648 RatGTEx
SMART 14_3_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204183
UniProt 1433Z_RAT UniProtKB/Swiss-Prot
UniProt Secondary P35215 UniProtKB/Swiss-Prot
  P70197 UniProtKB/Swiss-Prot
  P97286 UniProtKB/Swiss-Prot
  Q52KK1 UniProtKB/Swiss-Prot
  Q6IRF4 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-12-11 Ywhaz  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta  Ywhaz  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ywhaz  Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process may play a role in ATP-dependent protein depolymerization and unfolding 727986
gene_product member of the 14-3-3 protein family 727986