Dnm1 (dynamin 1) - Rat Genome Database
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Gene: Dnm1 (dynamin 1) Rattus norvegicus
Analyze
Symbol: Dnm1
Name: dynamin 1
RGD ID: 71096
Description: Exhibits several functions, including D2 dopamine receptor binding activity; SH3 domain binding activity; and nitric-oxide synthase binding activity. Involved in G protein-coupled receptor internalization; positive regulation of synaptic vesicle endocytosis; and response to amyloid-beta. Localizes to several cellular components, including presynaptic endocytic zone membrane; synaptic vesicle; and varicosity. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 31. Orthologous to human DNM1 (dynamin 1); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B-dynamin; D100; Dnm; dynamin, brain; dynamin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0311,338,081 - 11,382,043 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,338,083 - 11,382,043 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0316,686,951 - 16,730,913 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,434,778 - 11,478,452 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1311,331,147 - 11,374,785 (-)NCBI
Celera310,349,401 - 10,391,382 (-)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
1. Ahn S, etal., J Biol Chem 2002 Jul 19;277(29):26642-51.
2. Anggono V and Robinson PJ, J Neurochem. 2007 Aug;102(3):931-43. Epub 2007 Apr 16.
3. Anggono V, etal., Nat Neurosci. 2006 Jun;9(6):752-60. doi: 10.1038/nn1695. Epub 2006 Apr 30.
4. Asinof S, etal., Neurobiol Dis. 2016 Nov;95:1-11. doi: 10.1016/j.nbd.2016.06.014. Epub 2016 Jun 28.
5. Baillat G, etal., J Biol Chem 2002 May 24;277(21):18961-6.
6. Cao H, etal., Mol Biol Cell. 1998 Sep;9(9):2595-609.
7. Cao Y, etal., J Alzheimers Dis. 2010;22(1):329-42. doi: 10.3233/JAD-2010-100162.
8. Cestra G, etal., Methods Enzymol. 2005;404:537-45.
9. Cestra G, etal., Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1731-6. Epub 2005 Jan 19.
10. Chen-Hwang MC, etal., J Biol Chem 2002 May 17;277(20):17597-604.
11. Ford MG, etal., Nature. 2011 Sep 18;477(7366):561-6. doi: 10.1038/nature10441.
12. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. GOA data from the GO Consortium
14. Goel M, etal., Pflugers Arch. 2005 Oct;451(1):87-98. Epub 2005 Jul 16.
15. Gray NW, etal., Curr Biol. 2003 Mar 18;13(6):510-5.
16. Hyndman KA, etal., Am J Physiol Renal Physiol. 2011 Apr 13.
17. Ikeuchi Y, etal., Cell Rep. 2013 Sep 12;4(5):879-89. doi: 10.1016/j.celrep.2013.07.042. Epub 2013 Aug 29.
18. Jiang S, etal., Cell Signal. 2006 Sep;18(9):1439-46. Epub 2006 Jan 18.
19. Kabbani N, etal., Cell Signal. 2004 Apr;16(4):497-503.
20. Kim Y, etal., J Neurosci. 2005 Oct 12;25(41):9515-23.
21. Krendel M, etal., FEBS Lett. 2007 Feb 20;581(4):644-50. Epub 2007 Jan 18.
22. Lai MM, etal., J Biol Chem. 2000 Nov 3;275(44):34017-20.
23. Lee S, etal., EMBO J. 2006 Oct 18;25(20):4983-95. Epub 2006 Sep 21.
24. Lin JW, etal., Nat Neurosci. 2000 Dec;3(12):1282-90.
25. Lu J, etal., Neuron. 2007 Sep 20;55(6):874-89.
26. MGD Curation, June 12, 2002
27. MGD data from the GO Consortium
28. NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. Obar RA, etal., Nature 1990 Sep 20;347(6290):256-61.
30. Okamoto M, etal., J Biol Chem 1999 Jun 25;274(26):18446-54.
31. OMIM Disease Annotation Pipeline
32. Pipeline to import KEGG annotations from KEGG into RGD
33. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
34. Qualmann B and Kelly RB, J Cell Biol 2000 Mar 6;148(5):1047-62.
35. Qualmann B, etal., Mol Biol Cell 1999 Feb;10(2):501-13.
36. Ramjaun AR, etal., J Biol Chem 2001 Aug 3;276(31):28913-9.
37. RGD automated data pipeline
38. RGD automated import pipeline for gene-chemical interactions
39. Ringstad N, etal., Proc Natl Acad Sci U S A 1997 Aug 5;94(16):8569-74.
40. Rufer AC, etal., J Mol Biol. 2009 Jul 31;390(5):939-50. doi: 10.1016/j.jmb.2009.05.025. Epub 2009 May 21.
41. Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
42. Salazar MA, etal., J Biol Chem. 2003 Dec 5;278(49):49031-43. doi: 10.1074/jbc.M308104200. Epub 2003 Sep 22.
43. Suginta W, etal., Biochem J. 2001 Oct 1;359(Pt 1):55-64.
44. Takei K, etal., Nature. 1995 Mar 9;374(6518):186-90. doi: 10.1038/374186a0.
45. Tian Q, etal., Neurosci Bull. 2012 Oct;28(5):483-92. doi: 10.1007/s12264-012-1257-z. Epub 2012 Jul 13.
46. Tosoni D and Cestra G, FEBS Lett. 2009 Jan 22;583(2):293-300. doi: 10.1016/j.febslet.2008.12.047. Epub 2008 Dec 29.
47. Wang G, etal., Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1295-300. Epub 2006 Jan 23.
48. Wigge P, etal., Mol Biol Cell 1997 Oct;8(10):2003-15.
49. Zanner R, etal., J Cell Sci. 2004 May 1;117(Pt 11):2369-76.
50. Zhan Y, etal., J Biol Chem. 2005 May 6;280(18):18015-24. Epub 2005 Feb 22.
Additional References at PubMed
PMID:8402898   PMID:9182529   PMID:9195986   PMID:9341169   PMID:9694653   PMID:9736607   PMID:9742220   PMID:9813051   PMID:10206341   PMID:10430869   PMID:10521508   PMID:10908605  
PMID:11856729   PMID:11879655   PMID:14704270   PMID:14985338   PMID:15123615   PMID:15252117   PMID:15287745   PMID:15581494   PMID:15834155   PMID:15953416   PMID:16141317   PMID:16864575  
PMID:16903783   PMID:17463283   PMID:17499934   PMID:17525220   PMID:17634366   PMID:17681954   PMID:19222995   PMID:19706678   PMID:20107062   PMID:20127811   PMID:20160074   PMID:20428113  
PMID:20448150   PMID:20526333   PMID:20700106   PMID:20700442   PMID:21112282   PMID:21307259   PMID:21689597   PMID:21730063   PMID:21927000   PMID:21957258   PMID:21962517   PMID:22120110  
PMID:22681889   PMID:22871113   PMID:23103755   PMID:23260429   PMID:23533145   PMID:23687302   PMID:23716698   PMID:23746204   PMID:23785143   PMID:23999152   PMID:24643165   PMID:26302298  
PMID:29476059   PMID:29604406   PMID:30069048  


Genomics

Comparative Map Data
Dnm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0311,338,081 - 11,382,043 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,338,083 - 11,382,043 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0316,686,951 - 16,730,913 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,434,778 - 11,478,452 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1311,331,147 - 11,374,785 (-)NCBI
Celera310,349,401 - 10,391,382 (-)NCBICelera
Cytogenetic Map3p12NCBI
DNM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9128,191,655 - 128,255,248 (+)EnsemblGRCh38hg38GRCh38
GRCh389128,203,379 - 128,255,244 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379130,965,634 - 131,017,528 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369130,005,484 - 130,057,348 (+)NCBINCBI36hg18NCBI36
Build 349128,045,216 - 128,097,081NCBI
Celera9101,616,559 - 101,668,431 (+)NCBI
Cytogenetic Map9q34.11NCBI
HuRef9100,579,095 - 100,630,981 (+)NCBIHuRef
CHM1_19131,116,658 - 131,168,550 (+)NCBICHM1_1
Dnm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,198,483 - 32,243,361 (-)NCBIGRCm39mm39
GRCm38232,308,471 - 32,353,349 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,308,471 - 32,353,338 (-)EnsemblGRCm38mm10GRCm38
MGSCv37232,163,991 - 32,208,824 (-)NCBIGRCm37mm9NCBIm37
MGSCv36232,130,480 - 32,175,282 (-)NCBImm8
Celera232,012,962 - 32,058,530 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Dnm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955570752,335 - 781,770 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955570752,335 - 781,770 (+)NCBIChiLan1.0ChiLan1.0
DNM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19128,008,224 - 128,045,224 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9128,004,508 - 128,044,690 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0999,324,385 - 99,376,262 (+)NCBIMhudiblu_PPA_v0panPan3
DNM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl955,252,347 - 55,298,244 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1955,252,802 - 55,298,244 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dnm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648715,767,897 - 15,797,722 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,653,039 - 268,702,223 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,653,045 - 268,702,233 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,643,339 - 302,692,544 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNM1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,874,098 - 9,927,737 (-)NCBI
ChlSab1.1 Ensembl129,878,966 - 9,927,744 (-)Ensembl
Dnm1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247606,605,902 - 6,646,575 (-)NCBI

Position Markers
BF386076  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0311,341,356 - 11,341,535NCBIRnor6.0
Rnor_5.0316,690,226 - 16,690,405UniSTSRnor5.0
RGSC_v3.4311,438,051 - 11,438,230UniSTSRGSC3.4
Celera310,352,676 - 10,352,855UniSTS
Cytogenetic Map3p11UniSTS
RH 3.4 Map385.71UniSTS
AW533536  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0311,357,004 - 11,357,200NCBIRnor6.0
Rnor_5.0316,705,874 - 16,706,070UniSTSRnor5.0
RGSC_v3.4311,453,415 - 11,453,611UniSTSRGSC3.4
Cytogenetic Map3p11UniSTS
RH 3.4 Map372.6UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3125786001Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3128136884Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3128500807Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3128500807Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3128500807Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3128500807Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3132972944Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3137891710Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3139773425Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3195176874Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3263142133477544Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3263142148562146Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3328592928136884Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3328592928136884Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)3565463925105730Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3600074834394365Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3600074834394365Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3600074834394365Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)3600074851687917Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)3600074851687917Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)3600086634394121Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)3600086634394121Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)3600086634394121Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31009408193415837Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31011931879772001Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir140rno-miR-140-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18845019

Predicted Target Of
Summary Value
Count of predictions:590
Count of miRNA genes:209
Interacting mature miRNAs:240
Transcripts:ENSRNOT00000042762, ENSRNOT00000047921, ENSRNOT00000064039, ENSRNOT00000068349
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 5 2 2 70 26 32 3
Low 3 39 52 39 19 39 8 11 4 9 9 8 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000047921   ⟹   ENSRNOP00000041582
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl311,338,611 - 11,382,004 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000064039   ⟹   ENSRNOP00000060845
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl311,338,083 - 11,382,043 (-)Ensembl
RefSeq Acc Id: NM_080689   ⟹   NP_542420
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0311,338,081 - 11,382,043 (-)NCBI
Rnor_5.0316,686,951 - 16,730,913 (-)NCBI
RGSC_v3.4311,434,778 - 11,478,452 (-)RGD
Celera310,349,401 - 10,391,382 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_542420   ⟸   NM_080689
- UniProtKB: P21575 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000041582   ⟸   ENSRNOT00000047921
RefSeq Acc Id: ENSRNOP00000060845   ⟸   ENSRNOT00000064039
Protein Domains
Dynamin-type G   GED   PH

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691982
Promoter ID:EPDNEW_R2507
Type:initiation region
Name:Dnm1_1
Description:dynamin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0311,382,098 - 11,382,158EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71096 AgrOrtholog
BIND 119589
  130460
  130589
  134462
  134465
Ensembl Genes ENSRNOG00000033835 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000041582 UniProtKB/Swiss-Prot
  ENSRNOP00000060845 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000047921 UniProtKB/Swiss-Prot
  ENSRNOT00000064039 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
InterPro DNM1 UniProtKB/Swiss-Prot
  Dynamin_central UniProtKB/Swiss-Prot
  Dynamin_GTPase UniProtKB/Swiss-Prot
  Dynamin_GTPase_CS UniProtKB/Swiss-Prot
  Dynamin_SF UniProtKB/Swiss-Prot
  G_DYNAMIN_dom UniProtKB/Swiss-Prot
  GED UniProtKB/Swiss-Prot
  GED_dom UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
KEGG Report rno:140694 UniProtKB/Swiss-Prot
NCBI Gene 140694 ENTREZGENE
PANTHER PTHR11566 UniProtKB/Swiss-Prot
  PTHR11566:SF32 UniProtKB/Swiss-Prot
Pfam Dynamin_M UniProtKB/Swiss-Prot
  Dynamin_N UniProtKB/Swiss-Prot
  GED UniProtKB/Swiss-Prot
  PF00169 UniProtKB/Swiss-Prot
PhenoGen Dnm1 PhenoGen
PRINTS DYNAMIN UniProtKB/Swiss-Prot
PROSITE G_DYNAMIN_1 UniProtKB/Swiss-Prot
  G_DYNAMIN_2 UniProtKB/Swiss-Prot
  GED UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
SMART DYNc UniProtKB/Swiss-Prot
  GED UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt DYN1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Dnm1  dynamin 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a highly conserved GTPase domain, a pleckstrin homology domain, a GTPase effector domain, and a proline-rich domain at the C terminus 625468
gene_function large GTPase 625468
gene_physical_interaction phosphorylation by Dyrk mediates the interaction with SH3 domain-containing proteins 625468
gene_physical_interaction interacts primarily through its pleckstrin homology domain and proline-rich domain with a large array of cellular components including proteins participating in endocytosis, maintenance of the cytoskeleton, and signal transduction 625468
gene_physical_interaction phosphorylation inhibits interaction with amphiphysin and endophilin 1 and the subsequent incorporation into the endocytic apparatus and enhances the interaction with Grb2 625468
gene_process plays an essential role in clathrin-mediated endocytosis and synaptic vesicle recycling 625468
gene_process major substrate for the Dual Specificity Yak1-related kinase (Dyrk) 625468
gene_product 100 kDa protein 625468