Dnm1 (dynamin 1) - Rat Genome Database

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Gene: Dnm1 (dynamin 1) Rattus norvegicus
Analyze
Symbol: Dnm1
Name: dynamin 1
RGD ID: 71096
Description: Enables several functions, including D2 dopamine receptor binding activity; SH3 domain binding activity; and nitric-oxide synthase binding activity. Involved in G protein-coupled receptor internalization; positive regulation of synaptic vesicle endocytosis; and response to amyloid-beta. Located in several cellular components, including Golgi apparatus; synaptic vesicle; and varicosity. Part of protein-containing complex. Is active in presynaptic endocytic zone membrane. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 31. Orthologous to human DNM1 (dynamin 1); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B-dynamin; D100; Dnm; dynamin, brain; dynamin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2315,604,782 - 15,648,654 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl315,604,784 - 15,648,538 (-)Ensembl
Rnor_6.0311,338,081 - 11,382,043 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,338,083 - 11,382,043 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0316,686,951 - 16,730,913 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,434,778 - 11,478,452 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1311,331,147 - 11,374,785 (-)NCBI
Celera310,349,401 - 10,391,382 (-)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
1. Ahn S, etal., J Biol Chem 2002 Jul 19;277(29):26642-51.
2. Anggono V and Robinson PJ, J Neurochem. 2007 Aug;102(3):931-43. Epub 2007 Apr 16.
3. Anggono V, etal., Nat Neurosci. 2006 Jun;9(6):752-60. doi: 10.1038/nn1695. Epub 2006 Apr 30.
4. Asinof S, etal., Neurobiol Dis. 2016 Nov;95:1-11. doi: 10.1016/j.nbd.2016.06.014. Epub 2016 Jun 28.
5. Baillat G, etal., J Biol Chem 2002 May 24;277(21):18961-6.
6. Cao H, etal., Mol Biol Cell. 1998 Sep;9(9):2595-609.
7. Cao Y, etal., J Alzheimers Dis. 2010;22(1):329-42. doi: 10.3233/JAD-2010-100162.
8. Cestra G, etal., Methods Enzymol. 2005;404:537-45.
9. Cestra G, etal., Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1731-6. Epub 2005 Jan 19.
10. Chen-Hwang MC, etal., J Biol Chem 2002 May 17;277(20):17597-604.
11. Ford MG, etal., Nature. 2011 Sep 18;477(7366):561-6. doi: 10.1038/nature10441.
12. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. GOA data from the GO Consortium
14. Goel M, etal., Pflugers Arch. 2005 Oct;451(1):87-98. Epub 2005 Jul 16.
15. Gray NW, etal., Curr Biol. 2003 Mar 18;13(6):510-5.
16. Hyndman KA, etal., Am J Physiol Renal Physiol. 2011 Apr 13.
17. Ikeuchi Y, etal., Cell Rep. 2013 Sep 12;4(5):879-89. doi: 10.1016/j.celrep.2013.07.042. Epub 2013 Aug 29.
18. Jiang S, etal., Cell Signal. 2006 Sep;18(9):1439-46. Epub 2006 Jan 18.
19. Kabbani N, etal., Cell Signal. 2004 Apr;16(4):497-503.
20. Kim Y, etal., J Neurosci. 2005 Oct 12;25(41):9515-23.
21. Krendel M, etal., FEBS Lett. 2007 Feb 20;581(4):644-50. Epub 2007 Jan 18.
22. Lai MM, etal., J Biol Chem. 2000 Nov 3;275(44):34017-20.
23. Lee S, etal., EMBO J. 2006 Oct 18;25(20):4983-95. Epub 2006 Sep 21.
24. Lin JW, etal., Nat Neurosci. 2000 Dec;3(12):1282-90.
25. Lu J, etal., Neuron. 2007 Sep 20;55(6):874-89.
26. MGD Curation, June 12, 2002
27. MGD data from the GO Consortium
28. NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. Obar RA, etal., Nature 1990 Sep 20;347(6290):256-61.
30. Okamoto M, etal., J Biol Chem 1999 Jun 25;274(26):18446-54.
31. OMIM Disease Annotation Pipeline
32. Pipeline to import KEGG annotations from KEGG into RGD
33. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
34. Qualmann B and Kelly RB, J Cell Biol 2000 Mar 6;148(5):1047-62.
35. Qualmann B, etal., Mol Biol Cell 1999 Feb;10(2):501-13.
36. Ramjaun AR, etal., J Biol Chem 2001 Aug 3;276(31):28913-9.
37. RGD automated data pipeline
38. RGD automated import pipeline for gene-chemical interactions
39. Ringstad N, etal., Proc Natl Acad Sci U S A 1997 Aug 5;94(16):8569-74.
40. Rufer AC, etal., J Mol Biol. 2009 Jul 31;390(5):939-50. doi: 10.1016/j.jmb.2009.05.025. Epub 2009 May 21.
41. Saheki Y and De Camilli P, Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a005645. doi: 10.1101/cshperspect.a005645.
42. Salazar MA, etal., J Biol Chem. 2003 Dec 5;278(49):49031-43. doi: 10.1074/jbc.M308104200. Epub 2003 Sep 22.
43. Suginta W, etal., Biochem J. 2001 Oct 1;359(Pt 1):55-64.
44. Takei K, etal., Nature. 1995 Mar 9;374(6518):186-90. doi: 10.1038/374186a0.
45. Tian Q, etal., Neurosci Bull. 2012 Oct;28(5):483-92. doi: 10.1007/s12264-012-1257-z. Epub 2012 Jul 13.
46. Tosoni D and Cestra G, FEBS Lett. 2009 Jan 22;583(2):293-300. doi: 10.1016/j.febslet.2008.12.047. Epub 2008 Dec 29.
47. Wang G, etal., Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1295-300. Epub 2006 Jan 23.
48. Wigge P, etal., Mol Biol Cell 1997 Oct;8(10):2003-15.
49. Zanner R, etal., J Cell Sci. 2004 May 1;117(Pt 11):2369-76.
50. Zhan Y, etal., J Biol Chem. 2005 May 6;280(18):18015-24. Epub 2005 Feb 22.
Additional References at PubMed
PMID:8402898   PMID:9182529   PMID:9195986   PMID:9341169   PMID:9694653   PMID:9736607   PMID:9742220   PMID:9813051   PMID:10206341   PMID:10430869   PMID:10521508   PMID:10908605  
PMID:11856729   PMID:11879655   PMID:12606338   PMID:14704270   PMID:14985338   PMID:15123615   PMID:15252117   PMID:15287745   PMID:15581494   PMID:15834155   PMID:15953416   PMID:16141317  
PMID:16864575   PMID:16903783   PMID:17463283   PMID:17499934   PMID:17525220   PMID:17634366   PMID:17681954   PMID:19222995   PMID:19706678   PMID:20107062   PMID:20127811   PMID:20160074  
PMID:20428113   PMID:20448150   PMID:20526333   PMID:20700106   PMID:20700442   PMID:21112282   PMID:21307259   PMID:21689597   PMID:21730063   PMID:21927000   PMID:21957258   PMID:21962517  
PMID:22120110   PMID:22681889   PMID:22871113   PMID:23103755   PMID:23260429   PMID:23533145   PMID:23687302   PMID:23716698   PMID:23746204   PMID:23785143   PMID:23999152   PMID:24643165  
PMID:26302298   PMID:29476059   PMID:29604406   PMID:30069048   PMID:32357304  


Genomics

Comparative Map Data
Dnm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2315,604,782 - 15,648,654 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl315,604,784 - 15,648,538 (-)Ensembl
Rnor_6.0311,338,081 - 11,382,043 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,338,083 - 11,382,043 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0316,686,951 - 16,730,913 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,434,778 - 11,478,452 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1311,331,147 - 11,374,785 (-)NCBI
Celera310,349,401 - 10,391,382 (-)NCBICelera
Cytogenetic Map3p12NCBI
DNM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9128,191,655 - 128,255,248 (+)EnsemblGRCh38hg38GRCh38
GRCh389128,203,379 - 128,255,244 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379130,965,658 - 131,017,523 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369130,005,484 - 130,057,348 (+)NCBINCBI36hg18NCBI36
Build 349128,045,216 - 128,097,081NCBI
Celera9101,616,559 - 101,668,431 (+)NCBI
Cytogenetic Map9q34.11NCBI
HuRef9100,579,095 - 100,630,981 (+)NCBIHuRef
CHM1_19131,116,687 - 131,168,550 (+)NCBICHM1_1
Dnm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,198,483 - 32,243,361 (-)NCBIGRCm39mm39
GRCm39 Ensembl232,198,483 - 32,243,350 (-)Ensembl
GRCm38232,308,471 - 32,353,349 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,308,471 - 32,353,338 (-)EnsemblGRCm38mm10GRCm38
MGSCv37232,163,991 - 32,208,824 (-)NCBIGRCm37mm9NCBIm37
MGSCv36232,130,480 - 32,175,282 (-)NCBImm8
Celera232,012,962 - 32,058,530 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Dnm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955570752,335 - 781,770 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955570752,335 - 781,770 (+)NCBIChiLan1.0ChiLan1.0
DNM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19128,008,224 - 128,045,224 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9128,004,508 - 128,044,690 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0999,324,385 - 99,376,262 (+)NCBIMhudiblu_PPA_v0panPan3
DNM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,252,802 - 55,298,244 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,252,347 - 55,298,244 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,447,720 - 54,493,024 (-)NCBI
ROS_Cfam_1.0956,174,435 - 56,220,232 (-)NCBI
UMICH_Zoey_3.1954,934,788 - 54,980,303 (-)NCBI
UNSW_CanFamBas_1.0955,249,424 - 55,295,001 (-)NCBI
UU_Cfam_GSD_1.0955,340,932 - 55,386,497 (-)NCBI
Dnm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947196,001,590 - 196,029,515 (+)NCBI
SpeTri2.0NW_00493648715,767,897 - 15,797,722 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,653,039 - 268,702,223 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,653,045 - 268,702,233 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,643,339 - 302,692,544 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,874,098 - 9,927,737 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl129,878,966 - 9,927,744 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660796,308,667 - 6,359,204 (+)NCBIVero_WHO_p1.0
Dnm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247606,605,902 - 6,646,575 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
BF386076  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2315,608,065 - 15,608,245 (+)MAPPERmRatBN7.2
Rnor_6.0311,341,356 - 11,341,535NCBIRnor6.0
Rnor_5.0316,690,226 - 16,690,405UniSTSRnor5.0
RGSC_v3.4311,438,051 - 11,438,230UniSTSRGSC3.4
Celera310,352,676 - 10,352,855UniSTS
RH 3.4 Map385.71UniSTS
Cytogenetic Map3p11UniSTS
AW533536  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2315,623,503 - 15,623,700 (+)MAPPERmRatBN7.2
Rnor_6.0311,357,004 - 11,357,200NCBIRnor6.0
Rnor_5.0316,705,874 - 16,706,070UniSTSRnor5.0
RGSC_v3.4311,453,415 - 11,453,611UniSTSRGSC3.4
RH 3.4 Map372.6UniSTS
Cytogenetic Map3p11UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir140rno-miR-140-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18845019

Predicted Target Of
Summary Value
Count of predictions:590
Count of miRNA genes:209
Interacting mature miRNAs:240
Transcripts:ENSRNOT00000042762, ENSRNOT00000047921, ENSRNOT00000064039, ENSRNOT00000068349
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 5 2 2 70 26 32 3
Low 3 39 52 39 19 39 8 11 4 9 9 8 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_080689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005501756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005501757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005501758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X54531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000047921   ⟹   ENSRNOP00000041582
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,608,553 - 15,648,538 (-)Ensembl
Rnor_6.0 Ensembl311,338,611 - 11,382,004 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000064039   ⟹   ENSRNOP00000060845
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,604,793 - 15,648,538 (-)Ensembl
Rnor_6.0 Ensembl311,338,083 - 11,382,043 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097377   ⟹   ENSRNOP00000080068
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,608,469 - 15,648,538 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102787   ⟹   ENSRNOP00000091634
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,604,793 - 15,648,538 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110861   ⟹   ENSRNOP00000095659
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,604,784 - 15,648,538 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115917   ⟹   ENSRNOP00000093707
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,608,541 - 15,648,538 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118464   ⟹   ENSRNOP00000092707
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,604,784 - 15,648,538 (-)Ensembl
RefSeq Acc Id: NM_080689   ⟹   NP_542420
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2315,604,791 - 15,648,538 (-)NCBI
Rnor_6.0311,338,081 - 11,382,043 (-)NCBI
Rnor_5.0316,686,951 - 16,730,913 (-)NCBI
RGSC_v3.4311,434,778 - 11,478,452 (-)RGD
Celera310,349,401 - 10,391,382 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104140   ⟹   XP_038960068
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2315,604,782 - 15,648,650 (-)NCBI
RefSeq Acc Id: XM_039104141   ⟹   XP_038960069
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2315,604,782 - 15,648,652 (-)NCBI
RefSeq Acc Id: XM_039104142   ⟹   XP_038960070
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2315,604,782 - 15,648,650 (-)NCBI
RefSeq Acc Id: XM_039104143   ⟹   XP_038960071
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2315,604,782 - 15,648,652 (-)NCBI
RefSeq Acc Id: XM_039104144   ⟹   XP_038960072
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2315,604,782 - 15,648,649 (-)NCBI
RefSeq Acc Id: XM_039104145   ⟹   XP_038960073
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2315,604,782 - 15,648,651 (-)NCBI
RefSeq Acc Id: XM_039104147   ⟹   XP_038960075
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2315,604,782 - 15,648,653 (-)NCBI
RefSeq Acc Id: XM_039104148   ⟹   XP_038960076
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2315,604,782 - 15,648,654 (-)NCBI
RefSeq Acc Id: XM_039104149   ⟹   XP_038960077
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2315,604,782 - 15,648,649 (-)NCBI
RefSeq Acc Id: XM_039104150   ⟹   XP_038960078
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2315,604,782 - 15,648,649 (-)NCBI
RefSeq Acc Id: XM_039104151   ⟹   XP_038960079
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2315,605,849 - 15,648,649 (-)NCBI
RefSeq Acc Id: XM_039104152   ⟹   XP_038960080
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2315,604,782 - 15,648,651 (-)NCBI
RefSeq Acc Id: XR_005501756
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2315,604,782 - 15,648,649 (-)NCBI
RefSeq Acc Id: XR_005501757
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2315,604,782 - 15,648,649 (-)NCBI
RefSeq Acc Id: XR_005501758
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2315,604,782 - 15,648,649 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_542420   ⟸   NM_080689
- UniProtKB: P21575 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000041582   ⟸   ENSRNOT00000047921
RefSeq Acc Id: ENSRNOP00000060845   ⟸   ENSRNOT00000064039
RefSeq Acc Id: XP_038960076   ⟸   XM_039104148
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038960075   ⟸   XM_039104147
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038960071   ⟸   XM_039104143
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038960069   ⟸   XM_039104141
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038960073   ⟸   XM_039104145
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038960080   ⟸   XM_039104152
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038960070   ⟸   XM_039104142
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038960068   ⟸   XM_039104140
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038960072   ⟸   XM_039104144
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038960077   ⟸   XM_039104149
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038960078   ⟸   XM_039104150
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038960079   ⟸   XM_039104151
- Peptide Label: isoform X10
RefSeq Acc Id: ENSRNOP00000092707   ⟸   ENSRNOT00000118464
RefSeq Acc Id: ENSRNOP00000093707   ⟸   ENSRNOT00000115917
RefSeq Acc Id: ENSRNOP00000091634   ⟸   ENSRNOT00000102787
RefSeq Acc Id: ENSRNOP00000095659   ⟸   ENSRNOT00000110861
RefSeq Acc Id: ENSRNOP00000080068   ⟸   ENSRNOT00000097377
Protein Domains
Dynamin-type G   GED   PH

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691982
Promoter ID:EPDNEW_R2507
Type:initiation region
Name:Dnm1_1
Description:dynamin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0311,382,098 - 11,382,158EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71096 AgrOrtholog
BIND 119589
  130460
  130589
  134462
  134465
Ensembl Genes ENSRNOG00000033835 Ensembl, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000041582 UniProtKB/Swiss-Prot
  ENSRNOP00000060845 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000047921 UniProtKB/Swiss-Prot
  ENSRNOT00000064039 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro DNM1 UniProtKB/Swiss-Prot
  Dynamin_central UniProtKB/Swiss-Prot
  Dynamin_GTPase UniProtKB/Swiss-Prot
  Dynamin_GTPase_CS UniProtKB/Swiss-Prot
  Dynamin_SF UniProtKB/Swiss-Prot
  G_DYNAMIN_dom UniProtKB/Swiss-Prot
  GED UniProtKB/Swiss-Prot
  GED_dom UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
KEGG Report rno:140694 UniProtKB/Swiss-Prot
NCBI Gene 140694 ENTREZGENE
PANTHER PTHR11566 UniProtKB/Swiss-Prot
  PTHR11566:SF32 UniProtKB/Swiss-Prot
Pfam Dynamin_M UniProtKB/Swiss-Prot
  Dynamin_N UniProtKB/Swiss-Prot
  GED UniProtKB/Swiss-Prot
  PF00169 UniProtKB/Swiss-Prot
PhenoGen Dnm1 PhenoGen
PRINTS DYNAMIN UniProtKB/Swiss-Prot
PROSITE G_DYNAMIN_1 UniProtKB/Swiss-Prot
  G_DYNAMIN_2 UniProtKB/Swiss-Prot
  GED UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
SMART DYNc UniProtKB/Swiss-Prot
  GED UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt DYN1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Dnm1  dynamin 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a highly conserved GTPase domain, a pleckstrin homology domain, a GTPase effector domain, and a proline-rich domain at the C terminus 625468
gene_function large GTPase 625468
gene_physical_interaction phosphorylation by Dyrk mediates the interaction with SH3 domain-containing proteins 625468
gene_physical_interaction interacts primarily through its pleckstrin homology domain and proline-rich domain with a large array of cellular components including proteins participating in endocytosis, maintenance of the cytoskeleton, and signal transduction 625468
gene_physical_interaction phosphorylation inhibits interaction with amphiphysin and endophilin 1 and the subsequent incorporation into the endocytic apparatus and enhances the interaction with Grb2 625468
gene_process plays an essential role in clathrin-mediated endocytosis and synaptic vesicle recycling 625468
gene_process major substrate for the Dual Specificity Yak1-related kinase (Dyrk) 625468
gene_product 100 kDa protein 625468