RGD Reference Report - miR-22 targets YWHAZ to inhibit metastasis of hepatocellular carcinoma and its down-regulation predicts a poor survival. - Rat Genome Database

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miR-22 targets YWHAZ to inhibit metastasis of hepatocellular carcinoma and its down-regulation predicts a poor survival.

Authors: Chen, Ming  Hu, Wei  Xiong, Chen-Ling  Qu, Zhen  Yin, Chang-Qing  Wang, Yu-Hui  Luo, Chang-Liang  Guan, Qing  Yuan, Chun-Hui  Wang, Fu-Bing 
Citation: Chen M, etal., Oncotarget. 2016 Dec 6;7(49):80751-80764. doi: 10.18632/oncotarget.13037.
RGD ID: 14700875
Pubmed: PMID:27811373   (View Abstract at PubMed)
PMCID: PMC5348352   (View Article at PubMed Central)
DOI: DOI:10.18632/oncotarget.13037   (Journal Full-text)

Many miRNAs are associated with the carcinogenesis of hepatocellular carcinoma (HCC) and some exhibit potential prognostic value. In this study, to further confirm the prognostic value of miRNAs in HCC, we employed miRNA-sequencing data of tumor tissues of 372 HCC patients released by The Cancer Genome Atlas (TCGA) and identified 3 miRNAs including miR-22, miR-9-1 and miR-9-2 could be used as independent predictors for HCC prognostic evaluation. As a tumor-suppressive miRNA, miR-22 was down-regulated in HCC tissues. This down-regulation correlated with tumor vascular invasion, Edmondson-Steiner grade, TNM stage, and AFP level. Moreover, biofunctional investigations revealed that miR-22 significantly attenuated cellular proliferation, migration and invasion of HCC cells. Additionally, through gene expression profiles and bioinformatics analysis, YWHAZ was identified to be a direct target of miR-22 and its overexpression partially counteracted the inhibitory effects of miR-22 on HCC cells. Finally, molecular studies further confirmed that miR-22 promoted the accumulation of FOXO3a in nucleus and subsequently reversed invasive phenotype of HCC cells by repressing YWHAZ-mediated AKT phosphorylation. Taken together, these data demonstrate that miR-22 exhibits tumor-suppressive effects in HCC cells by regulating YWHAZ/AKT/FOXO3a signaling and might be used as an independent prognostic indicator for HCC patients.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MIR22Humanhepatocellular carcinoma disease_progressionIEP  RGD 
Mir22Mousehepatocellular carcinoma disease_progressionISOMIR22 (Homo sapiens) RGD 
Mir22Rathepatocellular carcinoma disease_progressionISOMIR22 (Homo sapiens) RGD 
YWHAZHumanhepatocellular carcinoma severityIEP  RGD 
YwhazRathepatocellular carcinoma severityISOYWHAZ (Homo sapiens) RGD 
YwhazMousehepatocellular carcinoma severityISOYWHAZ (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mir22  (microRNA 22)
Ywhaz  (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta)

Genes (Mus musculus)
Mir22  (microRNA 22)
Ywhaz  (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide)

Genes (Homo sapiens)
MIR22  (microRNA 22)
YWHAZ  (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta)


Additional Information