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Gene: Fbln1 (fibulin 1) Rattus norvegicus

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Symbol:

Fbln1

Name:

fibulin 1

RGD ID:

1308667

Description:

Predicted to enable several functions, including fibrinogen binding activity; fibronectin binding activity; and integrin binding activity. Predicted to be an extracellular matrix structural constituent. Involved in embryo implantation. Predicted to be located in basement membrane; elastic fiber; and extracellular space. Orthologous to human FBLN1 (fibulin 1); INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Fbln1 protein-like; fibulin-1; LOC100362423; LOC315191

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FBLN1 (fibulin 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Fbln1 (fibulin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Fbln1 (fibulin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FBLN1 (fibulin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FBLN1 (fibulin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fbln1 (fibulin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FBLN1 (fibulin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FBLN1 (fibulin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fbln1 (fibulin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SCGB1D2 (secretoglobin family 1D member 2)	HGNC	OMA
Homo sapiens (human):	SCGB1D1 (secretoglobin family 1D member 1)	HGNC	OMA
Homo sapiens (human):	SCGB1D4 (secretoglobin family 1D member 4)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	FBLN1 (fibulin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Fbln1 (fibulin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fbln1 (fibulin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	fbl-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	fbln1	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	118,190,347 - 118,269,965 (+)	NCBI		GRCr8
mRatBN7.2	7	116,310,582 - 116,390,075 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	116,310,582 - 116,390,075 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	118,061,437 - 118,140,654 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	120,287,178 - 120,366,397 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	120,256,616 - 120,335,836 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	126,096,793 - 126,176,468 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	126,096,793 - 126,176,468 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	125,810,696 - 125,890,371 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	123,208,154 - 123,287,289 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	123,242,385 - 123,321,516 (+)	NCBI
Celera	7	112,608,514 - 112,687,953 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fbln1	Rat	Autosomal Recessive Syndrome of Syndactyly, Undescended Testes and Central Nervous System Defects		ISO	RGD:1318572	8554872	ClinVar Annotator: match by term: Autosomal recessive syndrome of syndactyly, undescended testes and central nervous more ...	ClinVar	PMID:24084572
Fbln1	Rat	fetal akinesia deformation sequence syndrome 1		ISO	RGD:1318572	8554872	ClinVar Annotator: match by term: Fetal akinesia deformation sequence 1	ClinVar	PMID:25741868\|PMID:28492532\|PMID:31680123
Fbln1	Rat	intellectual disability		ISO	RGD:1318572	8554872	ClinVar Annotator: match by term: Intellectual disability	ClinVar
Fbln1	Rat	Phelan-McDermid syndrome		ISO	RGD:1318572	8554872	ClinVar Annotator: match by term: Phelan-McDermid syndrome	ClinVar
Fbln1	Rat	Synpolydactyly 2		ISO	RGD:1318572	8554872	ClinVar Annotator: match by term: FBLN1-related condition \| ClinVar Annotator: match by term: SYNPOLYDACTYLY, 3/3-PRIME/4, more ...	ClinVar	PMID:25741868\|PMID:28492532

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fbln1	Rat	endometriosis		ISO	RGD:1318572	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:20864642
Fbln1	Rat	Prostatic Neoplasms		ISO	RGD:1318572	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:17929269
Fbln1	Rat	Synpolydactyly 2		ISO	RGD:1318572	11554173	CTD Direct Evidence: marker/mechanism	CTD

Imported Disease Annotations - OMIM

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fbln1	Rat	Synpolydactyly 2		ISO	RGD:1318572	7240710		OMIM

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fbln1	Rat	1,2-dimethylhydrazine	increases expression	EXP		6480464	1,2-Dimethylhydrazine results in increased expression of FBLN1 mRNA	CTD	PMID:27840820
Fbln1	Rat	1,2-dimethylhydrazine	multiple interactions	ISO	RGD:1318573	6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of FBLN1 mRNA	CTD	PMID:22206623
Fbln1	Rat	1-naphthyl isothiocyanate	increases expression	EXP		6480464	1-Naphthylisothiocyanate results in increased expression of FBLN1 mRNA	CTD	PMID:30723492
Fbln1	Rat	17beta-estradiol	increases expression	ISO	RGD:1318572	6480464	Estradiol results in increased expression of FBLN1 mRNA	CTD	PMID:23019147\|PMID:25321415
Fbln1	Rat	17beta-estradiol	increases expression	EXP		6480464	Estradiol results in increased expression of FBLN1 mRNA	CTD	PMID:32145629
Fbln1	Rat	17beta-estradiol	multiple interactions	EXP		6480464	[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of FBLN1 mRNA	CTD	PMID:32741896
Fbln1	Rat	17beta-estradiol 3-benzoate	multiple interactions	EXP		6480464	[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of FBLN1 mRNA	CTD	PMID:32741896
Fbln1	Rat	2,2',5,5'-tetrachlorobiphenyl	decreases expression	EXP		6480464	2,5,2',5'-tetrachlorobiphenyl results in decreased expression of FBLN1 mRNA	CTD	PMID:23829299
Fbln1	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1318573	6480464	Tetrachlorodibenzodioxin affects the expression of FBLN1 mRNA	CTD	PMID:21570461
Fbln1	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of FBLN1 mRNA	CTD	PMID:33387578
Fbln1	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1318572	6480464	Tetrachlorodibenzodioxin affects the expression of FBLN1 mRNA	CTD	PMID:36370075
Fbln1	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	EXP		6480464	Tetrachlorodibenzodioxin affects the expression of FBLN1 mRNA	CTD	PMID:34747641
Fbln1	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of FBLN1 mRNA	CTD	PMID:32109520
Fbln1	Rat	3,4-methylenedioxymethamphetamine	increases expression	ISO	RGD:1318573	6480464	N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of FBLN1 mRNA	CTD	PMID:20188158
Fbln1	Rat	3-isobutyl-1-methyl-7H-xanthine	multiple interactions	ISO	RGD:1318572	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ...	CTD	PMID:28628672
Fbln1	Rat	3-Nitrobenzanthrone	decreases expression	ISO	RGD:1318572	6480464	3-nitrobenzanthrone results in decreased expression of FBLN1 mRNA	CTD	PMID:34036453
Fbln1	Rat	4,4'-sulfonyldiphenol	increases expression	ISO	RGD:1318573	6480464	bisphenol S results in increased expression of FBLN1 mRNA	CTD	PMID:30951980
Fbln1	Rat	4,4'-sulfonyldiphenol	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ...	CTD	PMID:36041667
Fbln1	Rat	4-phenylbutyric acid	increases expression	ISO	RGD:1318572	6480464	4-phenylbutyric acid results in increased expression of FBLN1 mRNA	CTD	PMID:14583596
Fbln1	Rat	5-azacytidine	increases expression	ISO	RGD:1318572	6480464	Azacitidine results in increased expression of FBLN1 mRNA	CTD	PMID:21245298
Fbln1	Rat	5-fluorouracil	affects expression	ISO	RGD:1318572	6480464	Fluorouracil affects the expression of FBLN1 mRNA	CTD	PMID:15205334
Fbln1	Rat	5-fluorouracil	increases expression	ISO	RGD:1318572	6480464	Fluorouracil results in increased expression of FBLN1 mRNA	CTD	PMID:17039268
Fbln1	Rat	6-propyl-2-thiouracil	increases expression	EXP		6480464	Propylthiouracil results in increased expression of FBLN1 mRNA	CTD	PMID:24780913
Fbln1	Rat	6alpha-methylprednisolone	increases expression	ISO	RGD:1318572	6480464	Methylprednisolone results in increased expression of FBLN1 mRNA	CTD	PMID:19192274
Fbln1	Rat	8-Br-cAMP	increases expression	ISO	RGD:1318572	6480464	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of FBLN1 mRNA	CTD	PMID:15774544
Fbln1	Rat	acetamide	increases expression	EXP		6480464	acetamide results in increased expression of FBLN1 mRNA	CTD	PMID:31881176
Fbln1	Rat	acrylamide	decreases expression	EXP		6480464	Acrylamide results in decreased expression of FBLN1 mRNA	CTD	PMID:28959563
Fbln1	Rat	acrylamide	decreases expression	ISO	RGD:1318572	6480464	Acrylamide results in decreased expression of FBLN1 mRNA	CTD	PMID:32763439
Fbln1	Rat	aflatoxin B1	increases expression	EXP		6480464	Aflatoxin B1 results in increased expression of FBLN1 mRNA	CTD	PMID:23630614\|PMID:25378103
Fbln1	Rat	aflatoxin B1	increases expression	ISO	RGD:1318572	6480464	Aflatoxin B1 results in increased expression of FBLN1 mRNA	CTD	PMID:32234424
Fbln1	Rat	aflatoxin B1	affects methylation	ISO	RGD:1318572	6480464	Aflatoxin B1 affects the methylation of FBLN1 intron	CTD	PMID:30157460
Fbln1	Rat	all-trans-retinoic acid	increases expression	ISO	RGD:1318573	6480464	Tretinoin results in increased expression of FBLN1 mRNA	CTD	PMID:16604517
Fbln1	Rat	amphotericin B	increases expression	ISO	RGD:1318572	6480464	Amphotericin B analog results in increased expression of FBLN1 mRNA	CTD	PMID:28534445
Fbln1	Rat	arsane	multiple interactions	ISO	RGD:1318572	6480464	[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of FBLN1 more ...	CTD	PMID:39836092
Fbln1	Rat	arsenic atom	multiple interactions	ISO	RGD:1318572	6480464	[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of FBLN1 more ...	CTD	PMID:39836092
Fbln1	Rat	arsenous acid	increases expression	ISO	RGD:1318572	6480464	Arsenic Trioxide results in increased expression of FBLN1 mRNA	CTD	PMID:25555879
Fbln1	Rat	arsenous acid	multiple interactions	ISO	RGD:1318572	6480464	[Arsenic Trioxide co-treated with Ascorbic Acid] results in increased expression of FBLN1 mRNA	CTD	PMID:25555879
Fbln1	Rat	azathioprine	increases expression	ISO	RGD:1318572	6480464	Azathioprine results in increased expression of FBLN1 mRNA	CTD	PMID:19192274
Fbln1	Rat	belinostat	decreases expression	ISO	RGD:1318572	6480464	belinostat results in decreased expression of FBLN1 mRNA	CTD	PMID:26272509
Fbln1	Rat	belinostat	multiple interactions	ISO	RGD:1318572	6480464	[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ...	CTD	PMID:27188386
Fbln1	Rat	benzo[a]pyrene	multiple interactions	ISO	RGD:1318573	6480464	Benzo(a)pyrene promotes the reaction [AHR protein binds to FBLN1 promoter]	CTD	PMID:19654925
Fbln1	Rat	benzo[a]pyrene	increases expression	ISO	RGD:1318572	6480464	Benzo(a)pyrene results in increased expression of FBLN1 mRNA	CTD	PMID:32234424
Fbln1	Rat	benzo[a]pyrene	increases methylation	ISO	RGD:1318573	6480464	Benzo(a)pyrene results in increased methylation of FBLN1 exon; Benzo(a)pyrene results in increased methylation of FBLN1 more ...	CTD	PMID:27901495
Fbln1	Rat	benzo[a]pyrene	decreases methylation	ISO	RGD:1318572	6480464	Benzo(a)pyrene results in decreased methylation of FBLN1 promoter	CTD	PMID:27901495
Fbln1	Rat	benzo[a]pyrene	affects methylation	ISO	RGD:1318572	6480464	Benzo(a)pyrene affects the methylation of FBLN1 intron	CTD	PMID:30157460
Fbln1	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:1318573	6480464	Benzo(a)pyrene results in decreased expression of FBLN1 mRNA	CTD	PMID:21569818
Fbln1	Rat	benzo[e]pyrene	decreases methylation	ISO	RGD:1318572	6480464	benzo(e)pyrene results in decreased methylation of FBLN1 intron	CTD	PMID:30157460
Fbln1	Rat	bis(2-ethylhexyl) phthalate	increases expression	ISO	RGD:1318572	6480464	Diethylhexyl Phthalate results in increased expression of FBLN1 mRNA	CTD	PMID:31163220
Fbln1	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of FBLN1 mRNA	CTD	PMID:25181051\|PMID:30816183\|PMID:32528016\|PMID:34947998\|PMID:38750585
Fbln1	Rat	bisphenol A	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ...	CTD	PMID:36041667
Fbln1	Rat	bisphenol A	decreases methylation	ISO	RGD:1318572	6480464	bisphenol A results in decreased methylation of FBLN1 gene	CTD	PMID:31601247
Fbln1	Rat	bisphenol A	decreases expression	ISO	RGD:1318573	6480464	bisphenol A results in decreased expression of FBLN1 mRNA	CTD	PMID:37894381
Fbln1	Rat	bisphenol A	affects expression	ISO	RGD:1318572	6480464	bisphenol A affects the expression of FBLN1 mRNA	CTD	PMID:30903817
Fbln1	Rat	bisphenol A	increases expression	ISO	RGD:1318572	6480464	bisphenol A results in increased expression of FBLN1 mRNA	CTD	PMID:29275510
Fbln1	Rat	bisphenol A	increases expression	ISO	RGD:1318573	6480464	bisphenol A results in increased expression of FBLN1 mRNA	CTD	PMID:30951980\|PMID:37105096
Fbln1	Rat	bisphenol A	multiple interactions	ISO	RGD:1318572	6480464	[bisphenol A co-treated with Fulvestrant] results in increased methylation of FBLN1 gene; [INS protein co-treated more ...	CTD	PMID:28628672\|PMID:31601247
Fbln1	Rat	bisphenol F	multiple interactions	ISO	RGD:1318572	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ...	CTD	PMID:28628672
Fbln1	Rat	bisphenol F	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ...	CTD	PMID:36041667
Fbln1	Rat	bisphenol F	increases expression	ISO	RGD:1318573	6480464	bisphenol F results in increased expression of FBLN1 mRNA	CTD	PMID:30951980
Fbln1	Rat	butan-1-ol	multiple interactions	ISO	RGD:1318572	6480464	[[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic more ...	CTD	PMID:29432896
Fbln1	Rat	cadmium acetate	decreases expression	ISO	RGD:1318572	6480464	cadmium acetate results in decreased expression of FBLN1 mRNA	CTD	PMID:18155341
Fbln1	Rat	cadmium atom	multiple interactions	ISO	RGD:1318573	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of FBLN1 more ...	CTD	PMID:37325564
Fbln1	Rat	cadmium dichloride	increases expression	ISO	RGD:1318572	6480464	Cadmium Chloride results in increased expression of FBLN1 mRNA	CTD	PMID:38382870
Fbln1	Rat	cadmium dichloride	multiple interactions	ISO	RGD:1318573	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of FBLN1 more ...	CTD	PMID:37325564
Fbln1	Rat	calcitriol	decreases expression	ISO	RGD:1318572	6480464	Calcitriol results in decreased expression of FBLN1 mRNA	CTD	PMID:26485663
Fbln1	Rat	cantharidin	decreases expression	ISO	RGD:1318573	6480464	Cantharidin results in decreased expression of FBLN1 mRNA	CTD	PMID:36907384
Fbln1	Rat	carbon nanotube	affects expression	ISO	RGD:1318573	6480464	Nanotubes, Carbon affects the expression of FBLN1 mRNA	CTD	PMID:25554681
Fbln1	Rat	carbon nanotube	decreases expression	ISO	RGD:1318573	6480464	Nanotubes, Carbon analog results in decreased expression of FBLN1 mRNA	CTD	PMID:25554681
Fbln1	Rat	cefaloridine	increases expression	EXP		6480464	Cephaloridine results in increased expression of FBLN1 mRNA	CTD	PMID:18500788
Fbln1	Rat	chlormequat chloride	increases expression	EXP		6480464	Chlormequat results in increased expression of FBLN1 protein	CTD	PMID:34958886
Fbln1	Rat	chromium(6+)	affects expression	ISO	RGD:1318573	6480464	chromium hexavalent ion affects the expression of FBLN1 mRNA	CTD	PMID:28472532
Fbln1	Rat	cobalt dichloride	decreases secretion	ISO	RGD:1318572	6480464	cobaltous chloride results in decreased secretion of FBLN1 protein	CTD	PMID:22079246
Fbln1	Rat	copper atom	increases expression	EXP		6480464	Copper deficiency results in increased expression of FBLN1 mRNA	CTD	PMID:26033743
Fbln1	Rat	copper atom	decreases expression	EXP		6480464	Copper results in decreased expression of FBLN1 mRNA	CTD	PMID:30556269
Fbln1	Rat	copper atom	multiple interactions	EXP		6480464	[Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBLN1 mRNA; [Copper deficiency co-treated more ...	CTD	PMID:22276220
Fbln1	Rat	copper(0)	increases expression	EXP		6480464	Copper deficiency results in increased expression of FBLN1 mRNA	CTD	PMID:26033743
Fbln1	Rat	copper(0)	decreases expression	EXP		6480464	Copper results in decreased expression of FBLN1 mRNA	CTD	PMID:30556269
Fbln1	Rat	copper(0)	multiple interactions	EXP		6480464	[Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBLN1 mRNA; [Copper deficiency co-treated more ...	CTD	PMID:22276220
Fbln1	Rat	copper(II) chloride	decreases expression	ISO	RGD:1318572	6480464	cupric chloride results in decreased expression of FBLN1 mRNA	CTD	PMID:38568856
Fbln1	Rat	copper(II) sulfate	decreases expression	ISO	RGD:1318572	6480464	Copper Sulfate results in decreased expression of FBLN1 mRNA	CTD	PMID:19549813
Fbln1	Rat	corosolic acid	increases expression	ISO	RGD:1318572	6480464	corosolic acid results in increased expression of FBLN1 mRNA	CTD	PMID:37939859
Fbln1	Rat	Cuprizon	increases expression	EXP		6480464	Cuprizone results in increased expression of FBLN1 mRNA	CTD	PMID:26577399\|PMID:27523638
Fbln1	Rat	cytarabine	decreases expression	ISO	RGD:1318572	6480464	Cytarabine results in decreased expression of FBLN1 mRNA	CTD	PMID:21198554
Fbln1	Rat	decabromodiphenyl ether	decreases expression	EXP		6480464	decabromobiphenyl ether results in decreased expression of FBLN1 mRNA	CTD	PMID:23640034
Fbln1	Rat	dexamethasone	increases expression	ISO	RGD:1318573	6480464	Dexamethasone results in increased expression of FBLN1 mRNA	CTD	PMID:22733784
Fbln1	Rat	dexamethasone	multiple interactions	ISO	RGD:1318572	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ...	CTD	PMID:28628672
Fbln1	Rat	diallyl trisulfide	increases expression	EXP		6480464	diallyl trisulfide results in increased expression of FBLN1 mRNA	CTD	PMID:34014027
Fbln1	Rat	diarsenic trioxide	increases expression	ISO	RGD:1318572	6480464	Arsenic Trioxide results in increased expression of FBLN1 mRNA	CTD	PMID:25555879
Fbln1	Rat	diarsenic trioxide	multiple interactions	ISO	RGD:1318572	6480464	[Arsenic Trioxide co-treated with Ascorbic Acid] results in increased expression of FBLN1 mRNA	CTD	PMID:25555879
Fbln1	Rat	dibenz[a,h]anthracene	increases expression	ISO	RGD:1318573	6480464	1,2,5,6-dibenzanthracene results in increased expression of FBLN1 mRNA	CTD	PMID:26377693
Fbln1	Rat	dimethylarsinic acid	decreases expression	EXP		6480464	Cacodylic Acid results in decreased expression of FBLN1 mRNA	CTD	PMID:37567419
Fbln1	Rat	dioxygen	multiple interactions	ISO	RGD:1318573	6480464	[sulforaphane affects the susceptibility to Oxygen] which affects the expression of FBLN1 mRNA	CTD	PMID:30529165
Fbln1	Rat	dioxygen	multiple interactions	EXP		6480464	[Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in decreased expression more ...	CTD	PMID:33729688
Fbln1	Rat	diquat	decreases expression	ISO	RGD:1318573	6480464	Diquat results in decreased expression of FBLN1 mRNA	CTD	PMID:36851058
Fbln1	Rat	diuron	increases expression	EXP		6480464	Diuron results in increased expression of FBLN1 mRNA	CTD	PMID:21551480
Fbln1	Rat	dorsomorphin	multiple interactions	ISO	RGD:1318572	6480464	[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ...	CTD	PMID:27188386
Fbln1	Rat	doxorubicin	increases expression	ISO	RGD:1318573	6480464	Doxorubicin results in increased expression of FBLN1 mRNA	CTD	PMID:15033991
Fbln1	Rat	doxorubicin	decreases expression	ISO	RGD:1318572	6480464	Doxorubicin results in decreased expression of FBLN1 mRNA	CTD	PMID:29803840
Fbln1	Rat	doxorubicin	affects expression	ISO	RGD:1318572	6480464	Doxorubicin affects the expression of FBLN1 mRNA	CTD	PMID:15205334
Fbln1	Rat	elemental selenium	increases expression	ISO	RGD:1318572	6480464	Selenium results in increased expression of FBLN1 mRNA	CTD	PMID:19244175
Fbln1	Rat	endosulfan	decreases expression	EXP		6480464	Endosulfan results in decreased expression of FBLN1 mRNA	CTD	PMID:29391264
Fbln1	Rat	ethanol	increases expression	ISO	RGD:1318573	6480464	Ethanol results in increased expression of FBLN1 mRNA	CTD	PMID:30319688
Fbln1	Rat	folic acid	multiple interactions	ISO	RGD:1318573	6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of FBLN1 mRNA	CTD	PMID:22206623
Fbln1	Rat	fulvestrant	increases methylation	ISO	RGD:1318572	6480464	Fulvestrant results in increased methylation of FBLN1 gene	CTD	PMID:31601247
Fbln1	Rat	fulvestrant	multiple interactions	ISO	RGD:1318572	6480464	[bisphenol A co-treated with Fulvestrant] results in increased methylation of FBLN1 gene	CTD	PMID:31601247
Fbln1	Rat	furan	increases expression	EXP		6480464	furan results in increased expression of FBLN1 mRNA	CTD	PMID:27387713
Fbln1	Rat	genistein	increases expression	ISO	RGD:1318572	6480464	Genistein results in increased expression of FBLN1 mRNA	CTD	PMID:23019147
Fbln1	Rat	glycidyl methacrylate	decreases expression	ISO	RGD:1318572	6480464	glycidyl methacrylate results in decreased expression of FBLN1 protein	CTD	PMID:36641056
Fbln1	Rat	hydrogen cyanide	decreases expression	ISO	RGD:1318573	6480464	Hydrogen Cyanide results in decreased expression of FBLN1 mRNA	CTD	PMID:33914522
Fbln1	Rat	hydrogen peroxide	affects expression	ISO	RGD:1318572	6480464	Hydrogen Peroxide affects the expression of FBLN1 mRNA	CTD	PMID:20044591
Fbln1	Rat	indometacin	multiple interactions	ISO	RGD:1318572	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] more ...	CTD	PMID:28628672
Fbln1	Rat	inulin	multiple interactions	ISO	RGD:1318573	6480464	[perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of FBLN1 mRNA	CTD	PMID:36331819
Fbln1	Rat	isotretinoin	increases expression	ISO	RGD:1318572	6480464	Isotretinoin results in increased expression of FBLN1 mRNA	CTD	PMID:20436886
Fbln1	Rat	ivermectin	decreases expression	ISO	RGD:1318572	6480464	Ivermectin results in decreased expression of FBLN1 protein	CTD	PMID:32959892
Fbln1	Rat	L-ascorbic acid	increases expression	ISO	RGD:1318572	6480464	Ascorbic Acid results in increased expression of FBLN1 mRNA	CTD	PMID:25555879
Fbln1	Rat	L-ascorbic acid	multiple interactions	ISO	RGD:1318572	6480464	[arsenic trioxide co-treated with Ascorbic Acid] results in increased expression of FBLN1 mRNA	CTD	PMID:25555879
Fbln1	Rat	medroxyprogesterone acetate	increases expression	ISO	RGD:1318572	6480464	Medroxyprogesterone Acetate results in increased expression of FBLN1 mRNA; Medroxyprogesterone Acetate results in increased expression more ...	CTD	PMID:15774544
Fbln1	Rat	medroxyprogesterone acetate	multiple interactions	ISO	RGD:1318572	6480464	Mifepristone inhibits the reaction [Medroxyprogesterone Acetate results in increased expression of FBLN1 mRNA]	CTD	PMID:15774544
Fbln1	Rat	menadione	affects expression	ISO	RGD:1318572	6480464	Vitamin K 3 affects the expression of FBLN1 mRNA	CTD	PMID:20044591
Fbln1	Rat	methapyrilene	decreases methylation	ISO	RGD:1318572	6480464	Methapyrilene results in decreased methylation of FBLN1 intron	CTD	PMID:30157460
Fbln1	Rat	methotrexate	increases expression	ISO	RGD:1318572	6480464	Methotrexate results in increased expression of FBLN1 mRNA	CTD	PMID:19192274
Fbln1	Rat	methylmercury chloride	increases expression	ISO	RGD:1318572	6480464	methylmercuric chloride results in increased expression of FBLN1 mRNA	CTD	PMID:23179753
Fbln1	Rat	microcystin-LR	increases expression	EXP		6480464	cyanoginosin LR results in increased expression of FBLN1 mRNA	CTD	PMID:34740672
Fbln1	Rat	mifepristone	multiple interactions	ISO	RGD:1318572	6480464	Mifepristone inhibits the reaction [Medroxyprogesterone Acetate results in increased expression of FBLN1 mRNA]	CTD	PMID:15774544
Fbln1	Rat	mifepristone	decreases expression	ISO	RGD:1318572	6480464	Mifepristone results in decreased expression of FBLN1 mRNA	CTD	PMID:17584828
Fbln1	Rat	monosodium L-glutamate	decreases expression	ISO	RGD:1318573	6480464	Sodium Glutamate results in decreased expression of FBLN1 mRNA	CTD	PMID:22078008
Fbln1	Rat	N,N-diethyl-m-toluamide	multiple interactions	EXP		6480464	[Permethrin co-treated with DEET] affects the methylation of FBLN1 gene	CTD	PMID:33148267
Fbln1	Rat	N-methyl-4-phenylpyridinium	increases expression	ISO	RGD:1318573	6480464	1-Methyl-4-phenylpyridinium results in increased expression of FBLN1 protein	CTD	PMID:26558463
Fbln1	Rat	N-nitrosodiethylamine	increases expression	ISO	RGD:1318573	6480464	Diethylnitrosamine results in increased expression of FBLN1 mRNA	CTD	PMID:17854601
Fbln1	Rat	N-nitrosodiethylamine	multiple interactions	ISO	RGD:1318573	6480464	RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of FBLN1 mRNA]	CTD	PMID:17854601
Fbln1	Rat	okadaic acid	decreases expression	ISO	RGD:1318572	6480464	Okadaic Acid results in decreased expression of FBLN1 mRNA	CTD	PMID:38832940
Fbln1	Rat	ozone	multiple interactions	ISO	RGD:1318573	6480464	[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased more ...	CTD	PMID:34911549
Fbln1	Rat	paracetamol	affects expression	ISO	RGD:1318573	6480464	Acetaminophen affects the expression of FBLN1 mRNA	CTD	PMID:17562736
Fbln1	Rat	paracetamol	increases expression	EXP		6480464	Acetaminophen results in increased expression of FBLN1 mRNA	CTD	PMID:33387578
Fbln1	Rat	paracetamol	increases expression	ISO	RGD:1318572	6480464	Acetaminophen results in increased expression of FBLN1 mRNA	CTD	PMID:22230336
Fbln1	Rat	PCB138	decreases expression	EXP		6480464	2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of FBLN1 mRNA	CTD	PMID:23829299
Fbln1	Rat	pentane-2,3-dione	decreases expression	EXP		6480464	2,3-pentanedione results in decreased expression of FBLN1 mRNA	CTD	PMID:25710175
Fbln1	Rat	perfluorohexanesulfonic acid	decreases expression	ISO	RGD:1318573	6480464	perfluorohexanesulfonic acid results in decreased expression of FBLN1 mRNA	CTD	PMID:37995155
Fbln1	Rat	perfluorooctane-1-sulfonic acid	multiple interactions	ISO	RGD:1318573	6480464	[perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of FBLN1 mRNA	CTD	PMID:36331819
Fbln1	Rat	perfluorooctanoic acid	increases expression	ISO	RGD:1318573	6480464	perfluorooctanoic acid results in increased expression of FBLN1 protein	CTD	PMID:36214631
Fbln1	Rat	permethrin	multiple interactions	EXP		6480464	[Permethrin co-treated with DEET] affects the methylation of FBLN1 gene	CTD	PMID:33148267
Fbln1	Rat	phenobarbital	multiple interactions	ISO	RGD:1318573	6480464	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of FBLN1 mRNA]	CTD	PMID:19482888
Fbln1	Rat	phenobarbital	increases expression	ISO	RGD:1318573	6480464	Phenobarbital results in increased expression of FBLN1 mRNA	CTD	PMID:19482888
Fbln1	Rat	phenylmercury acetate	decreases expression	ISO	RGD:1318572	6480464	Phenylmercuric Acetate results in decreased expression of FBLN1 mRNA	CTD	PMID:26272509
Fbln1	Rat	phenylmercury acetate	multiple interactions	ISO	RGD:1318572	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Fbln1	Rat	pioglitazone	increases expression	ISO	RGD:1318572	6480464	Pioglitazone results in increased expression of FBLN1 mRNA	CTD	PMID:30031879
Fbln1	Rat	pirinixic acid	decreases expression	ISO	RGD:1318573	6480464	pirinixic acid results in decreased expression of FBLN1 mRNA	CTD	PMID:17426115
Fbln1	Rat	potassium chromate	decreases expression	ISO	RGD:1318572	6480464	potassium chromate(VI) results in decreased expression of FBLN1 mRNA	CTD	PMID:22714537
Fbln1	Rat	potassium cyanide	increases expression	ISO	RGD:1318573	6480464	Potassium Cyanide results in increased expression of FBLN1 mRNA	CTD	PMID:33914522
Fbln1	Rat	potassium dichromate	increases expression	ISO	RGD:1318573	6480464	Potassium Dichromate results in increased expression of FBLN1 mRNA	CTD	PMID:23608068
Fbln1	Rat	potassium dichromate	increases expression	ISO	RGD:1318572	6480464	Potassium Dichromate results in increased expression of FBLN1 protein	CTD	PMID:23718831
Fbln1	Rat	prednisolone	increases expression	ISO	RGD:1318572	6480464	Prednisolone results in increased expression of FBLN1 mRNA	CTD	PMID:19192274
Fbln1	Rat	progesterone	increases expression	ISO	RGD:1318572	6480464	Progesterone results in increased expression of FBLN1 mRNA	CTD	PMID:15774544
Fbln1	Rat	sarin	decreases expression	ISO	RGD:1318572	6480464	Sarin results in decreased expression of FBLN1 mRNA	CTD	PMID:19522546
Fbln1	Rat	SB 431542	multiple interactions	ISO	RGD:1318572	6480464	[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression more ...	CTD	PMID:27188386
Fbln1	Rat	selenium atom	increases expression	ISO	RGD:1318572	6480464	Selenium results in increased expression of FBLN1 mRNA	CTD	PMID:19244175
Fbln1	Rat	silicon dioxide	decreases expression	ISO	RGD:1318572	6480464	Silicon Dioxide analog results in decreased expression of FBLN1 mRNA	CTD	PMID:25895662
Fbln1	Rat	silicon dioxide	increases expression	ISO	RGD:1318572	6480464	Silicon Dioxide analog results in increased expression of FBLN1 mRNA	CTD	PMID:23806026
Fbln1	Rat	sirolimus	increases expression	EXP		6480464	Sirolimus results in increased expression of FBLN1 mRNA	CTD	PMID:21865292
Fbln1	Rat	sodium arsenite	decreases expression	ISO	RGD:1318572	6480464	sodium arsenite results in decreased expression of FBLN1 mRNA	CTD	PMID:22714537
Fbln1	Rat	sodium arsenite	increases expression	ISO	RGD:1318573	6480464	sodium arsenite results in increased expression of FBLN1 mRNA	CTD	PMID:37682722
Fbln1	Rat	sodium arsenite	multiple interactions	ISO	RGD:1318572	6480464	[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of FBLN1 more ...	CTD	PMID:39836092
Fbln1	Rat	sodium arsenite	decreases methylation	ISO	RGD:1318572	6480464	sodium arsenite results in decreased methylation of FBLN1 intron	CTD	PMID:32844245
Fbln1	Rat	sodium arsenite	increases expression	ISO	RGD:1318572	6480464	sodium arsenite results in increased expression of FBLN1 mRNA	CTD	PMID:29301061\|PMID:32844245
Fbln1	Rat	sodium arsenite	decreases expression	ISO	RGD:1318573	6480464	sodium arsenite results in decreased expression of FBLN1 mRNA	CTD	PMID:18812580
Fbln1	Rat	sodium aurothiomalate	increases expression	ISO	RGD:1318572	6480464	Gold Sodium Thiomalate results in increased expression of FBLN1 mRNA	CTD	PMID:19192274
Fbln1	Rat	Soman	increases expression	EXP		6480464	Soman results in increased expression of FBLN1 mRNA	CTD	PMID:19281266
Fbln1	Rat	sulforaphane	multiple interactions	ISO	RGD:1318573	6480464	[sulforaphane affects the susceptibility to Oxygen] which affects the expression of FBLN1 mRNA	CTD	PMID:30529165
Fbln1	Rat	sunitinib	decreases expression	ISO	RGD:1318572	6480464	Sunitinib results in decreased expression of FBLN1 mRNA	CTD	PMID:31533062
Fbln1	Rat	tacrolimus hydrate	increases expression	EXP		6480464	Tacrolimus results in increased expression of FBLN1 mRNA	CTD	PMID:21865292
Fbln1	Rat	temozolomide	increases expression	ISO	RGD:1318572	6480464	Temozolomide results in increased expression of FBLN1 mRNA	CTD	PMID:31758290
Fbln1	Rat	tert-butyl hydroperoxide	decreases expression	ISO	RGD:1318572	6480464	tert-Butylhydroperoxide results in decreased expression of FBLN1 mRNA	CTD	PMID:15336504
Fbln1	Rat	testosterone	multiple interactions	EXP		6480464	[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of FBLN1 mRNA	CTD	PMID:32741896
Fbln1	Rat	tetrachloromethane	increases expression	EXP		6480464	Carbon Tetrachloride results in increased expression of FBLN1 mRNA	CTD	PMID:31150632
Fbln1	Rat	tetrathiomolybdate(2-)	multiple interactions	EXP		6480464	[Copper deficiency co-treated with tetrathiomolybdate] results in decreased expression of FBLN1 mRNA; [Copper deficiency co-treated more ...	CTD	PMID:22276220
Fbln1	Rat	thioacetamide	increases expression	EXP		6480464	Thioacetamide results in increased expression of FBLN1 mRNA	CTD	PMID:23411599
Fbln1	Rat	titanium dioxide	decreases expression	ISO	RGD:1318573	6480464	titanium dioxide results in decreased expression of FBLN1 mRNA	CTD	PMID:23557971\|PMID:27760801
Fbln1	Rat	titanium dioxide	decreases methylation	ISO	RGD:1318573	6480464	titanium dioxide results in decreased methylation of FBLN1 gene	CTD	PMID:35295148
Fbln1	Rat	trichloroethene	decreases expression	ISO	RGD:1318573	6480464	Trichloroethylene results in decreased expression of FBLN1 mRNA	CTD	PMID:25549359
Fbln1	Rat	trichostatin A	multiple interactions	ISO	RGD:1318572	6480464	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Fbln1	Rat	trichostatin A	increases expression	ISO	RGD:1318572	6480464	trichostatin A results in increased expression of FBLN1 mRNA	CTD	PMID:24935251\|PMID:26272509\|PMID:27188386
Fbln1	Rat	triclosan	increases expression	ISO	RGD:1318572	6480464	Triclosan results in increased expression of FBLN1 mRNA	CTD	PMID:30510588
Fbln1	Rat	trimellitic anhydride	decreases expression	ISO	RGD:1318573	6480464	trimellitic anhydride results in decreased expression of FBLN1 mRNA	CTD	PMID:19042947
Fbln1	Rat	tunicamycin	decreases expression	ISO	RGD:1318572	6480464	Tunicamycin results in decreased expression of FBLN1 mRNA	CTD	PMID:22378314
Fbln1	Rat	valproic acid	decreases expression	ISO	RGD:1318572	6480464	Valproic Acid results in decreased expression of FBLN1 mRNA	CTD	PMID:23179753\|PMID:24935251\|PMID:28001369
Fbln1	Rat	valproic acid	affects expression	ISO	RGD:1318572	6480464	Valproic Acid affects the expression of FBLN1 mRNA	CTD	PMID:25979313
Fbln1	Rat	valproic acid	increases expression	ISO	RGD:1318573	6480464	Valproic Acid results in increased expression of FBLN1 mRNA	CTD	PMID:24896083
Fbln1	Rat	vinclozolin	decreases expression	EXP		6480464	vinclozolin results in decreased expression of FBLN1 mRNA	CTD	PMID:23034163
Fbln1	Rat	vitamin E	increases expression	ISO	RGD:1318572	6480464	Vitamin E results in increased expression of FBLN1 mRNA	CTD	PMID:19244175
Fbln1	Rat	vorinostat	multiple interactions	ISO	RGD:1318572	6480464	[NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ...	CTD	PMID:27188386
Fbln1	Rat	zoledronic acid	increases expression	ISO	RGD:1318572	6480464	zoledronic acid results in increased expression of FBLN1 mRNA; zoledronic acid results in increased expression more ...	CTD	PMID:24714768\|PMID:28871336

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fbln1	Rat	blood coagulation, fibrin clot formation	involved_in	ISO	RGD:1318572	1624291	PMID:7642629	RGD	PMID:7642629
Fbln1	Rat	blood coagulation, fibrin clot formation	involved_in	IEA	UniProtKB:P23142\|ensembl:ENSP00000331544	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fbln1	Rat	embryo implantation		IEP		1598926		RGD
Fbln1	Rat	extracellular matrix organization	involved_in	IEA	InterPro:IPR017048	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Fbln1	Rat	extracellular matrix organization	acts_upstream_of_or_within	IEA	UniProtKB:Q08879\|ensembl:ENSMUSP00000054583	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fbln1	Rat	extracellular matrix organization	acts_upstream_of_or_within	ISO	RGD:1318573	1624291	PMID:18757743	RGD	PMID:18757743
Fbln1	Rat	extracellular matrix organization	involved_in	IBA	MGI:95487\|PANTHER:PTN008602194\|ZFIN:ZDB-GENE-990415-73	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Fbln1	Rat	integrin-mediated signaling pathway	NOT\|involved_in	ISO	RGD:1318572	1624291	PMID:11792823	RGD	PMID:11792823
Fbln1	Rat	negative regulation of cell adhesion	involved_in	ISO	RGD:1318572	1624291	PMID:11792823	RGD	PMID:11792823
Fbln1	Rat	negative regulation of cell adhesion	involved_in	IEA	UniProtKB:P23142\|ensembl:ENSP00000331544	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fbln1	Rat	negative regulation of cell motility	involved_in	ISO	RGD:1318572	1624291	PMID:11792823	RGD	PMID:11792823
Fbln1	Rat	negative regulation of cell motility	involved_in	IEA	UniProtKB:P23142\|ensembl:ENSP00000331544	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fbln1	Rat	negative regulation of ERK1 and ERK2 cascade	involved_in	ISO	RGD:1318572	1624291	PMID:11792823	RGD	PMID:11792823
Fbln1	Rat	negative regulation of ERK1 and ERK2 cascade	involved_in	IEA	UniProtKB:P23142\|ensembl:ENSP00000331544	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fbln1	Rat	negative regulation of protein phosphorylation	involved_in	ISO	RGD:1318572	1624291	PMID:11792823	RGD	PMID:11792823
Fbln1	Rat	negative regulation of stem cell proliferation	involved_in	ISO	RGD:1318572	1624291	PMID:11238726	RGD	PMID:11238726
Fbln1	Rat	negative regulation of stem cell proliferation	involved_in	IEA	UniProtKB:P23142\|ensembl:ENSP00000331544	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fbln1	Rat	negative regulation of substrate adhesion-dependent cell spreading	involved_in	ISO	RGD:1318572	1624291	PMID:11792823	RGD	PMID:11792823
Fbln1	Rat	negative regulation of substrate adhesion-dependent cell spreading	involved_in	IEA	UniProtKB:P23142\|ensembl:ENSP00000331544	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fbln1	Rat	negative regulation of transforming growth factor beta production	involved_in	ISO	RGD:1318572,UniProtKB:P23142-4	1624291	PMID:25834989	RGD	PMID:25834989
Fbln1	Rat	positive regulation of fibroblast proliferation	involved_in	ISO	RGD:1318572,UniProtKB:P23142-4	1624291	PMID:25834989	RGD	PMID:25834989
Fbln1	Rat	positive regulation of gene expression	involved_in	ISO	RGD:1318572,UniProtKB:P23142-4	1624291	PMID:25834989	RGD	PMID:25834989
Fbln1	Rat	positive regulation of substrate-dependent cell migration, cell attachment to substrate	involved_in	ISO	RGD:1318572,UniProtKB:P23142-4	1624291	PMID:25834989	RGD	PMID:25834989

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fbln1	Rat	basement membrane	located_in	ISO	RGD:1318573	1624291	PMID:16061471	RGD	PMID:16061471
Fbln1	Rat	basement membrane	located_in	IEA	UniProtKB:Q08879\|ensembl:ENSMUSP00000054583	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fbln1	Rat	elastic fiber	located_in	ISO	RGD:1318572	1624291	PMID:7534784	RGD	PMID:7534784
Fbln1	Rat	elastic fiber	located_in	IEA	UniProtKB:P23142\|ensembl:ENSP00000331544	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fbln1	Rat	extracellular matrix	located_in	ISO	RGD:1318572	1624291	PMID:2269669	RGD	PMID:2269669
Fbln1	Rat	extracellular matrix	located_in	IEA	UniProtKB:P23142\|ensembl:ENSP00000331544	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fbln1	Rat	extracellular region	located_in	IEA	InterPro:IPR000020	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Fbln1	Rat	extracellular region	located_in	IEA	UniProtKB-KW:KW-0964	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Fbln1	Rat	extracellular space	located_in	ISO	RGD:1318572	1624291	PMID:2269669	RGD	PMID:2269669
Fbln1	Rat	extracellular space	NOT\|located_in	ISO	RGD:1318572	1624291	PMID:25661773	RGD	PMID:25661773

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fbln1	Rat	calcium ion binding	enables	ISO	RGD:1318572	1624291	PMID:9278415	RGD	PMID:9278415
Fbln1	Rat	calcium ion binding	enables	IEA	UniProtKB:P23142\|ensembl:ENSP00000331544	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fbln1	Rat	calcium ion binding	enables	IEA	InterPro:IPR001881\|InterPro:IPR018097	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Fbln1	Rat	extracellular matrix structural constituent	enables	ISO	RGD:1318572	1624291	PMID:2269669	RGD	PMID:2269669
Fbln1	Rat	extracellular matrix structural constituent	enables	IEA	UniProtKB:P23142\|ensembl:ENSP00000331544	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fbln1	Rat	fibrinogen binding	enables	ISO	RGD:1318572	1624291	UniProtKB:P02676 PMID:7642629	RGD	PMID:7642629
Fbln1	Rat	fibrinogen binding	enables	IEA	UniProtKB:P23142\|ensembl:ENSP00000331544	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fbln1	Rat	fibronectin binding	enables	ISO	RGD:1318572	1624291	UniProtKB:P02751 PMID:1400330, PMID:9278415	RGD	PMID:1400330\|PMID:9278415
Fbln1	Rat	fibronectin binding	enables	IEA	UniProtKB:P23142\|ensembl:ENSP00000331544	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fbln1	Rat	identical protein binding	enables	ISO	RGD:1318572	1624291	UniProtKB:P23142 PMID:1400330, PMID:25661773, PMID:9278415	RGD	PMID:1400330\|PMID:25661773\|PMID:9278415
Fbln1	Rat	identical protein binding	enables	IEA	UniProtKB:P23142\|ensembl:ENSP00000331544	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fbln1	Rat	integrin binding	enables	ISO	RGD:1318572	1624291	UniProtKB:P05556 PMID:25661773	RGD	PMID:25661773
Fbln1	Rat	integrin binding	enables	ISO	RGD:1318572\|UniProtKB:P23142-1\|UniProtKB:P23142-4	1624291	PMID:25661773	RGD	PMID:25661773
Fbln1	Rat	integrin binding	enables	IEA	UniProtKB:P23142\|ensembl:ENSP00000331544	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fbln1	Rat	peptidase activator activity	enables	IEA	InterPro:IPR017048	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Fbln1	Rat	peptidase activator activity	enables	IEA	UniProtKB:Q08879\|ensembl:ENSMUSP00000054583	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fbln1	Rat	peptidase activator activity	enables	ISO	RGD:1318573	1624291	PMID:16061471	RGD	PMID:16061471
Fbln1	Rat	protein binding	enables	ISO	RGD:1318572,UniProtKB:P23142-4	1624291	UniProtKB:O43609\|UniProtKB:P05067\|UniProtKB:P29279\|UniProtKB:P42830\|UniProtKB:P48745\|UniProtKB:P49639\|UniProtKB:P52815\|UniProtKB:P54252\|UniProtKB:Q02548\|UniProtKB:Q02930-3\|UniProtKB:Q3LHN2\|UniProtKB:Q5BKT4\|UniProtKB:Q5T751\|UniProtKB:Q5T754\|UniProtKB:Q5T7P2\|UniProtKB:Q5T7P3\|UniProtKB:Q5TA76\|UniProtKB:Q5TCM9\|UniProtKB:Q6FHY5\|UniProtKB:Q8IUC1\|UniProtKB:Q8IWZ5\|UniProtKB:Q8IXW0\|UniProtKB:Q8N2U9\|UniProtKB:Q96FE5\|UniProtKB:Q9H9P5-5\|UniProtKB:Q9UIJ7\|UniProtKB:Q9UKJ5 PMID:32296183, PMID:32814053, PMID:9927660	RGD	PMID:32296183\|PMID:32814053\|PMID:9927660
Fbln1	Rat	protein binding	enables	ISO	RGD:1318573	1624291	PR:P97857\|PR:Q61282 PMID:16061471	RGD	PMID:16061471
Fbln1	Rat	protein binding	enables	ISO	RGD:1318572	1624291	UniProtKB:P05067 PMID:11238726	RGD	PMID:11238726
Fbln1	Rat	protein binding	enables	ISO	RGD:1318572,UniProtKB:P23142-1	1624291	UniProtKB:P03126\|UniProtKB:P06463\|UniProtKB:P06931\|UniProtKB:P17386 PMID:12200142	RGD	PMID:12200142
Fbln1	Rat	protein-containing complex binding	enables	ISO	RGD:1318572	1624291	ComplexPortal:CPX-1922 PMID:7642629	RGD	PMID:7642629
Fbln1	Rat	protein-containing complex binding	enables	IEA	UniProtKB:P23142\|ensembl:ENSP00000331544	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Disease Annotations Click to see Annotation Detail View

Autosomal Recessive Syndrome of Syndactyly, Undescended Testes and Central Nervous System Defects (ISO)

endometriosis (ISO)

fetal akinesia deformation sequence syndrome 1 (ISO)

intellectual disability (ISO)

Phelan-McDermid syndrome (ISO)

Prostatic Neoplasms (ISO)

Synpolydactyly 2 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (EXP,ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,2',5,5'-tetrachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-Nitrobenzanthrone (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

4-phenylbutyric acid (ISO)

5-azacytidine (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

6alpha-methylprednisolone (ISO)

8-Br-cAMP (ISO)

acetamide (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

amphotericin B (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

azathioprine (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP,ISO)

butan-1-ol (ISO)

cadmium acetate (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

cantharidin (ISO)

carbon nanotube (ISO)

cefaloridine (EXP)

chlormequat chloride (EXP)

chromium(6+) (ISO)

cobalt dichloride (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) chloride (ISO)

copper(II) sulfate (ISO)

corosolic acid (ISO)

Cuprizon (EXP)

cytarabine (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

diallyl trisulfide (EXP)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (ISO)

dimethylarsinic acid (EXP)

dioxygen (EXP,ISO)

diquat (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

endosulfan (EXP)

ethanol (ISO)

folic acid (ISO)

fulvestrant (ISO)

furan (EXP)

genistein (ISO)

glycidyl methacrylate (ISO)

hydrogen cyanide (ISO)

hydrogen peroxide (ISO)

indometacin (ISO)

inulin (ISO)

isotretinoin (ISO)

ivermectin (ISO)

L-ascorbic acid (ISO)

medroxyprogesterone acetate (ISO)

menadione (ISO)

methapyrilene (ISO)

methotrexate (ISO)

methylmercury chloride (ISO)

microcystin-LR (EXP)

mifepristone (ISO)

monosodium L-glutamate (ISO)

N,N-diethyl-m-toluamide (EXP)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodiethylamine (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

PCB138 (EXP)

pentane-2,3-dione (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

permethrin (EXP)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pioglitazone (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

potassium cyanide (ISO)

potassium dichromate (ISO)

prednisolone (ISO)

progesterone (ISO)

sarin (ISO)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sirolimus (EXP)

sodium arsenite (ISO)

sodium aurothiomalate (ISO)

Soman (EXP)

sulforaphane (ISO)

sunitinib (ISO)

tacrolimus hydrate (EXP)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (EXP)

tetrachloromethane (EXP)

tetrathiomolybdate(2-) (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (ISO)

trichostatin A (ISO)

triclosan (ISO)

trimellitic anhydride (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vitamin E (ISO)

vorinostat (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood coagulation, fibrin clot formation (IEA,ISO)

embryo implantation (IEP)

extracellular matrix organization (IBA,IEA,ISO)

integrin-mediated signaling pathway (ISO)

negative regulation of cell adhesion (IEA,ISO)

negative regulation of cell motility (IEA,ISO)

negative regulation of ERK1 and ERK2 cascade (IEA,ISO)

negative regulation of protein phosphorylation (ISO)

negative regulation of stem cell proliferation (IEA,ISO)

negative regulation of substrate adhesion-dependent cell spreading (IEA,ISO)

negative regulation of transforming growth factor beta production (ISO)

positive regulation of fibroblast proliferation (ISO)

positive regulation of gene expression (ISO)

positive regulation of substrate-dependent cell migration, cell attachment to substrate (ISO)

Cellular Component

basement membrane (IEA,ISO)

elastic fiber (IEA,ISO)

extracellular matrix (IEA,ISO)

extracellular region (IEA)

extracellular space (ISO)

Molecular Function

calcium ion binding (IEA,ISO)

extracellular matrix structural constituent (IEA,ISO)

fibrinogen binding (IEA,ISO)

fibronectin binding (IEA,ISO)

identical protein binding (IEA,ISO)

integrin binding (IEA,ISO)

peptidase activator activity (IEA,ISO)

protein binding (ISO)

protein-containing complex binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Cycle-dependent endometrial expression and hormonal regulation of the fibulin-1 gene.	Haendler B, etal., Mol Reprod Dev. 2004 Jul;68(3):279-87.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation
9.	Age-related changes of cardiac gene expression following myocardial ischemia/reperfusion.	Simkhovich BZ, etal., Arch Biochem Biophys. 2003 Dec 15;420(2):268-78.

Additional References at PubMed

PMID:1400330	PMID:2269669	PMID:7534784	PMID:7642629	PMID:9278415	PMID:9927660	PMID:11238726	PMID:11792823	PMID:12200142	PMID:12477932	PMID:16061471	PMID:18757743
PMID:19609566	PMID:20551380	PMID:23376485	PMID:23533145	PMID:24006456	PMID:25661773	PMID:25834989	PMID:27068509	PMID:32640908

Genomics

Comparative Map Data

Fbln1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	118,190,347 - 118,269,965 (+)	NCBI		GRCr8
mRatBN7.2	7	116,310,582 - 116,390,075 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	116,310,582 - 116,390,075 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	118,061,437 - 118,140,654 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	120,287,178 - 120,366,397 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	120,256,616 - 120,335,836 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	126,096,793 - 126,176,468 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	126,096,793 - 126,176,468 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	125,810,696 - 125,890,371 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	123,208,154 - 123,287,289 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	123,242,385 - 123,321,516 (+)	NCBI
Celera	7	112,608,514 - 112,687,953 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

FBLN1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	45,502,883 - 45,601,135 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	45,502,238 - 45,601,135 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	45,898,763 - 45,997,015 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	44,277,383 - 44,375,678 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	44,219,255 - 44,275,128	NCBI
Celera	22	29,809,689 - 29,909,644 (+)	NCBI		Celera
Cytogenetic Map	22	q13.31	NCBI
HuRef	22	28,859,953 - 28,942,412 (+)	NCBI		HuRef
CHM1_1	22	45,857,451 - 45,955,744 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	45,987,730 - 46,085,865 (+)	NCBI		T2T-CHM13v2.0

Fbln1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	85,090,150 - 85,170,495 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	85,090,150 - 85,170,736 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	85,205,949 - 85,286,294 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	85,205,949 - 85,286,535 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	85,036,438 - 85,116,724 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	85,033,777 - 85,113,422 (+)	NCBI		MGSCv36	mm8
Celera	15	87,331,933 - 87,412,210 (+)	NCBI		Celera
Cytogenetic Map	15	E2	NCBI
cM Map	15	40.27	NCBI

Fbln1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	29,837,134 - 29,912,222 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	29,837,134 - 29,911,313 (+)	NCBI	ChiLan1.0	ChiLan1.0

FBLN1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	55,327,942 - 55,426,786 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	58,026,827 - 58,125,277 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	26,390,379 - 26,488,737 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	44,583,632 - 44,666,696 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	44,582,843 - 44,666,011 (+)	Ensembl	panpan1.1		panPan2

FBLN1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	20,498,097 - 20,564,776 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	20,498,567 - 20,627,836 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	20,418,944 - 20,535,831 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	21,232,145 - 21,315,719 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	21,232,148 - 21,315,848 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	20,951,205 - 21,068,293 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	21,264,132 - 21,382,166 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	21,444,929 - 21,562,250 (-)	NCBI		UU_Cfam_GSD_1.0

Fbln1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	4,170,186 - 4,231,513 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936629	4,170,817 - 4,242,103 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936629	4,170,186 - 4,242,100 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FBLN1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	3,839,502 - 3,927,183 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	3,839,498 - 3,927,178 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	1,071,068 - 1,158,743 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FBLN1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	27,962,669 - 28,061,356 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	27,962,642 - 28,061,364 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	97,273,345 - 97,370,894 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fbln1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	4,109,478 - 4,190,066 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	4,109,478 - 4,189,987 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Fbln1
370 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	56
Count of miRNA genes:	45
Interacting mature miRNAs:	52
Transcripts:	ENSRNOT00000047234
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	111182207	135012528	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	80221299	124373579	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	102297359	133492884	Rat
2298475	Eau6	Experimental allergic uveoretinitis QTL 6		0.0029	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	7	84257275	129257275	Rat
71114	Niddm14	Non-insulin dependent diabetes mellitus QTL 14	4.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	84257275	129257275	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	91412594	129807172	Rat
70159	Bp61	Blood pressure QTL 61		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	103146217	116738842	Rat
1357339	Stl14	Serum triglyceride level QTL 14	3.45	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	112729683	133492707	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	73829340	130221005	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	83153392	128153392	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	81737938	126737938	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
2306821	Bp335	Blood pressure QTL 335		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	106571501	135012528	Rat
631663	Bw6	Body weight QTL 6	3.4		body mass (VT:0001259)	body weight (CMO:0000012)	7	111075573	134976056	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	86983365	131983365	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	80221299	125221299	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
2313102	Bmd79	Bone mineral density QTL 79	2.3	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	7	94811085	116738842	Rat
731174	Uae23	Urinary albumin excretion QTL 23	2.4	0.0042	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	7	104603555	135012528	Rat
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	112308254	133492884	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	69736226	117455174	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat

Markers in Region

AW524050

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	116,347,866 - 116,347,966 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	126,134,080 - 126,134,179	NCBI	Rnor6.0
Rnor_5.0	7	125,847,983 - 125,848,082	UniSTS	Rnor5.0
RGSC_v3.4	7	123,245,143 - 123,245,242	UniSTS	RGSC3.4
Celera	7	112,645,795 - 112,645,894	UniSTS
RH 3.4 Map	7	908.6	UniSTS
Cytogenetic Map	7	q34	UniSTS

Fbln1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	116,355,006 - 116,355,418 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	126,141,220 - 126,141,631	NCBI	Rnor6.0
Rnor_5.0	7	125,855,123 - 125,855,534	UniSTS	Rnor5.0
RGSC_v3.4	7	123,252,283 - 123,252,694	UniSTS	RGSC3.4
Celera	7	112,652,935 - 112,653,346	UniSTS
Cytogenetic Map	7	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001127547	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006242161	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC161973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000047234 ⟹ ENSRNOP00000046622

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	116,310,582 - 116,390,069 (+)	Ensembl
Rnor_6.0 Ensembl	7	126,096,793 - 126,176,468 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000088042 ⟹ ENSRNOP00000070552

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	116,310,582 - 116,383,452 (+)	Ensembl
Rnor_6.0 Ensembl	7	126,096,831 - 126,141,636 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102556 ⟹ ENSRNOP00000089007

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	116,324,600 - 116,390,075 (+)	Ensembl

RefSeq Acc Id:

NM_001127547 ⟹ NP_001121019

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	118,190,478 - 118,269,965 (+)	NCBI
mRatBN7.2	7	116,310,582 - 116,390,075 (+)	NCBI
Rnor_6.0	7	126,096,793 - 126,176,468 (+)	NCBI
Rnor_5.0	7	125,810,696 - 125,890,371 (+)	NCBI
RGSC_v3.4	7	123,208,154 - 123,287,289 (+)	RGD
Celera	7	112,608,514 - 112,687,953 (+)	RGD

Sequence:

show sequence

CCTCCTCCGGGCGGGATAATTGAACGCGGCGCGCAGGAGACTTGCGTTGGCTGCCCAGGCCCGG
CTTGATCGTGTAGCGGCTGCCCGCCGTGCTTTTGTCCGCCGCCCGAGCCCGCCAGCCCCAATGG
AGCGCCCCGCGCCGTCGCGCCTCGTCCCGCTGCCGCTGCTGCTGCTCGGCAGCCTCTCGCTGCT
GGCGGCCCGAGCGAATGCAGACATCTCCATGGAGGCTTGCTGCACGGAGGGAAATCAAATGGCT
AACCAGCACAGGGACTGCTCGCTCTCCTACACCTCAGAATCCAAGGAGTGCAGGATGGTCCAGG
AACAGTGTTGTCACAACCAACTGGAGGAGCTGCACTGTGCCACAGGCATCAACCTGGCCAGCGA
ACCAGACGGCTGCGCCTCCCTCCACAACTACAACAGTAGCCTCGAGACCATCTTCATAAAGAGG
TGCTGCCACTGTTGCATGCTGGGAAGGGCAGCCCAGGCCCGAGGCCAGACCTGTGAGCCCAACC
TCATGATAAGCTACCAGTGTGGACTGGTATTCCGTGCCTGCTGCGTGAAGGGACAGGAGAATTC
AGACTTTGTCAGAGGCGATGGTACGGACCTTCAGGACCCAGCTAAGATTCCTGAGGAGGAGGAA
CAAGAAGACCCATACCTGAACGACCGCTGTCGAGGTGGCGGGCCCTGTAAGCAGCAGTGCCGTG
ACACTGGGGATGAGGTCATCTGCTCTTGCTTTGTGGGCTACCAGCTGCAGTCGGATGGTGTCTC
CTGTGAAGATATCAATGAATGCATCACCGGCAGCCATAACTGCCGGCTGGGAGAATCCTGCATC
AACACAGTGGGCTCTTTCCGCTGCCAGCGGGACAGCAGCTGTGGGACTGGCTATGAGCTCACAG
AGGATAATAACTGCAAAGATATTGACGAGTGTGAGACTGGTATTCATAACTGCCCCCCCGATTT
TATCTGTCAGAATACTCTGGGATCCTTCCGTTGCAGACCCAAGCTGCAGTGCAAGAGCGGCTTT
ATACAGGATGCTCTAGGCAACTGCATTGATATCAATGAGTGTTTAAGTATCAGTGCCCCATGCC
CTGTGGGGCAGACATGCATCAATACAGAGGGCTCCTATACATGTCAGAAGAATGTGCCCAACTG
TGGCCGTGGATATCATCTCAACGAAGAGGGGACCCGCTGTGTTGACGTGGATGAGTGCTCACCA
CCAGCCGAGCCCTGTGGGAAGGGACACCACTGTTTGAACTCCCCCGGCAGCTTCCGCTGCGAGT
GCAAGGCCGGGTACTATTTTGATGGCATCAGCAGGACCTGTGTGGATATCAACGAGTGCCAGCG
CTATCCTGGGCGCCTGTGTGGCCACAAGTGTGAGAACACGCCAGGCTCCTACCACTGCAGCTGC
TCTGCGGGCTTCCGGCTGTCTGTGGACGGCCGGTCTTGTGAAGACGTGAACGAGTGCCTTAACA
GCCCTTGCAGCCAGGAGTGTGCTAACGTCTATGGCTCCTACCAGTGCTACTGCCGACGAGGTTA
TCAGCTCAGTGACGTGGACGGGGTCACCTGCGAAGATATTGATGAGTGTGCCCTGCCCACGGGG
GGTCACATCTGCTCCTACCGCTGCATCAACATCCCGGGAAGCTTCCAGTGCAGCTGTCCCTCAT
CCGGCTACAGGCTAGCTCCCAATGGTCGCAACTGCCAAGACATTGACGAGTGTGTGACCGGTAT
CCACAACTGTTCCATCAACGAGACCTGCTTCAACATCCAGGGCAGCTTCCGCTGTCTATCCTTC
GAGTGCCCTGAGAACTATCGCCGCTCTGCAGACACCTTTCGCCAAGAGAAGACAGACACCGTCC
GCTGCATCAAGTCTTGCCGTCCCACCGATGAGGCCTGCATGCGGGACCCTGTGCATACCGTCTC
CCACACTGTCATCTCCCTGCCCACCTTCCGAGAGTTCACCCGTCCGGAGGAGATCATCTTTCTG
AGGGCTGTCACGCCGCTGTATCCTGCCAACCAGGCTGACATCATCTTCGACATCACAGAAGGGA
ACCTTCGAGACTCCTTTGATATCATCAAGCGCTATGAGGACGGCATGACTGTGGGTGTCGTGCG
CCAAGTGCGGCCCATCGTGGGCCCATTTTATGCCGTCCTGAAGCTGGAGATGAACTACGTGTTG
GGAGGCGTGGTTTCCCACCGGAACGTCGTCAATGTGCATATCTTTGTCTCTGAGTACTGGTTCT
GAGGACCGGTTTGCAGCACGGCCAGGAGTGTACCCCTCCGCCTGGCCACGCCCTTGCTCCCAGT
GACTGCCAGGTGCCTGTCTGTACCCCTCGGGCGTTCCTTGGTGTTTCATGTTGGTTTGTAAGGC
CACATACATTAAGCTGAGCCACGTCACTTAAGTCCAGCTGACGTACTGTGCTGTTTAAACATTG
CTCAGTCATGTGGTTAAATCCTTGCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAATGCAAAG
GTCGAATTTTATTCTCTTTCCCTGCCTGTGGGCTAGGCAATGCTAAGGACCAATTGAAGGAGTT
TTCAAAGCAGCGCTCCACCCAAGAGCCAAGAGGTAGCCCTTCTCACTGAGTCTGCTTAAGGGGT
GACATTTTGGTACATATATATATATATATATATATATATATATATATATATATATATATATGAA
TATGAATGAGAAAAACCAACTGGGCTCTGTGTGCTTCAAACTGATGGCTGCTGTAGAGCGGTGC
ATAAATAAATATACAATAAATTCTCCCCAGAAGCA

hide sequence

RefSeq Acc Id:

XM_006242161 ⟹ XP_006242223

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	118,190,347 - 118,235,324 (+)	NCBI
mRatBN7.2	7	116,310,587 - 116,355,430 (+)	NCBI
Rnor_6.0	7	126,096,813 - 126,141,643 (+)	NCBI
Rnor_5.0	7	125,810,696 - 125,890,371 (+)	NCBI

Sequence:

show sequence

TGAACGCGGCGCGCAGGAGACTTGCGTTGGCTGCCCAGGCCCGGCTTGATCGTGTAGCGGCTGC
CCGCCGTGCTTTTGTCCGCCGCCCGAGCCCGCCAGCCCCAATGGAGCGCCCCGCGCCGTCGCGC
CTCGTCCCGCTGCCGCTGCTGCTGCTCGGCAGCCTCTCGCTGCTGGCGGCCCGAGCGAATGCAG
ACATCTCCATGGAGGCTTGCTGCACGGAGGGAAATCAAATGGCTAACCAGCACAGGGACTGCTC
GCTCTCCTACACCTCAGAATCCAAGGAGTGCAGGATGGTCCAGGAACAGTGTTGTCACAACCAA
CTGGAGGAGCTGCACTGTGCCACAGGCATCAACCTGGCCAGCGAACCAGACGGCTGCGCCTCCC
TCCACAACTACAACAGTAGCCTCGAGACCATCTTCATAAAGAGGTGCTGCCACTGTTGCATGCT
GGGAAGGGCAGCCCAGGCCCGAGGCCAGACCTGTGAGCCCAACCTCATGATAAGCTACCAGTGT
GGACTGGTATTCCGTGCCTGCTGCGTGAAGGGACAGGAGAATTCAGACTTTGTCAGAGGCGATG
GTACGGACCTTCAGGACCCAGCTAAGATTCCTGAGGAGGAGGAACAAGAAGACCCATACCTGAA
CGACCGCTGTCGAGGTGGCGGGCCCTGTAAGCAGCAGTGCCGTGACACTGGGGATGAGGTCATC
TGCTCTTGCTTTGTGGGCTACCAGCTGCAGTCGGATGGTGTCTCCTGTGAAGATATCAATGAAT
GCATCACCGGCAGCCATAACTGCCGGCTGGGAGAATCCTGCATCAACACAGTGGGCTCTTTCCG
CTGCCAGCGGGACAGCAGCTGTGGGACTGGCTATGAGCTCACAGAGGATAATAACTGCAAAGAT
ATTGACGAGTGTGAGACTGGTATTCATAACTGCCCCCCCGATTTTATCTGTCAGAATACTCTGG
GATCCTTCCGTTGCAGACCCAAGCTGCAGTGCAAGAGCGGCTTTATACAGGATGCTCTAGGCAA
CTGCATTGATATCAATGAGTGTTTAAGTATCAGTGCCCCATGCCCTGTGGGGCAGACATGCATC
AATACAGAGGGCTCCTATACATGTCAGAAGAATGTGCCCAACTGTGGCCGTGGATATCATCTCA
ACGAAGAGGGGACCCGCTGTGTTGACGTGGATGAGTGCTCACCACCAGCCGAGCCCTGTGGGAA
GGGACACCACTGTTTGAACTCCCCCGGCAGCTTCCGCTGCGAGTGCAAGGCCGGGTACTATTTT
GATGGCATCAGCAGGACCTGTGTGGATATCAACGAGTGCCAGCGCTATCCTGGGCGCCTGTGTG
GCCACAAGTGTGAGAACACGCCAGGCTCCTACCACTGCAGCTGCTCTGCGGGCTTCCGGCTGTC
TGTGGACGGCCGGTCTTGTGAAGACGTGAACGAGTGCCTTAACAGCCCTTGCAGCCAGGAGTGT
GCTAACGTCTATGGCTCCTACCAGTGCTACTGCCGACGAGGTTATCAGCTCAGTGACGTGGACG
GGGTCACCTGCGAAGATATTGATGAGTGTGCCCTGCCCACGGGGGGTCACATCTGCTCCTACCG
CTGCATCAACATCCCGGGAAGCTTCCAGTGCAGCTGTCCCTCATCCGGCTACAGGCTAGCTCCC
AATGGTCGCAACTGCCAAGACATTGACGAGTGTGTGACCGGTATCCACAACTGTTCCATCAACG
AGACCTGCTTCAACATCCAGGGCAGCTTCCGCTGTCTATCCTTCGAGTGCCCTGAGAACTATCG
CCGCTCTGCAGACACCCGCTGTGAGCGCTTGCCTTGCCATGAGAACCAGGAGTGCCCCAGGCTG
CCTCTGAGAATAACCTACTACCACCTCTCTTTCCCCACCAACATCCAAGTGCCCGCGGTGGTTT
TCCGCATGGGCCCTTCCAGTGCTGTCCCTGGGGACAGCATGCAGCTGGCCATCACCGCTGGCAA
TGAGGAGGGCTTTTTCACCACCCGAAAGGTGAGCCACCACAGTGGGGTGGTGGCCCTCACCAGG
CCCATCCCTGAGCCCAGGGACTTGCTCCTGACCGTCACGATGGATCTTTATCGCCACGGCACAG
TCAGCTCCTTTGTGGCCAAGCTTTATATTTTCGTGTTTGCAGAGCTCTGAGTGCTTGCTTGGGT
CCTGGGCACTCCCTCTTGTTGCTTTCCCACCCTCGGGGTTCTAATAAACTCGCAGCAGCCATCC
CAAGAGCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001121019	(Get FASTA)	NCBI Sequence Viewer
	XP_006242223	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI61973	(Get FASTA)	NCBI Sequence Viewer
	EDM15584	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000046622
	ENSRNOP00000046622.4
	ENSRNOP00000070552.2
	ENSRNOP00000089007.1
	ENSRNOP00000109223

RefSeq Acc Id:	NP_001121019 ⟸ NM_001127547
- Peptide Label:	precursor
- UniProtKB:	A6HTD8 (UniProtKB/TrEMBL), A0A0G2JY81 (UniProtKB/TrEMBL)
- Sequence:	show sequence MERPAPSRLVPLPLLLLGSLSLLAARANADISMEACCTEGNQMANQHRDCSLSYTSESKECRMV QEQCCHNQLEELHCATGINLASEPDGCASLHNYNSSLETIFIKRCCHCCMLGRAAQARGQTCEP NLMISYQCGLVFRACCVKGQENSDFVRGDGTDLQDPAKIPEEEEQEDPYLNDRCRGGGPCKQQC RDTGDEVICSCFVGYQLQSDGVSCEDINECITGSHNCRLGESCINTVGSFRCQRDSSCGTGYEL TEDNNCKDIDECETGIHNCPPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAP CPVGQTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECSPPAEPCGKGHHCLNSPGSFRC ECKAGYYFDGISRTCVDINECQRYPGRLCGHKCENTPGSYHCSCSAGFRLSVDGRSCEDVNECL NSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCP SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGSFRCLSFECPENYRRSADTFRQEKTDT VRCIKSCRPTDEACMRDPVHTVSHTVISLPTFREFTRPEEIIFLRAVTPLYPANQADIIFDITE GNLRDSFDIIKRYEDGMTVGVVRQVRPIVGPFYAVLKLEMNYVLGGVVSHRNVVNVHIFVSEYW F hide sequence

RefSeq Acc Id:	XP_006242223 ⟸ XM_006242161
- Peptide Label:	isoform X1
- UniProtKB:	B1WC21 (UniProtKB/TrEMBL), D3ZQ25 (UniProtKB/TrEMBL)
- Sequence:	show sequence MERPAPSRLVPLPLLLLGSLSLLAARANADISMEACCTEGNQMANQHRDCSLSYTSESKECRMV QEQCCHNQLEELHCATGINLASEPDGCASLHNYNSSLETIFIKRCCHCCMLGRAAQARGQTCEP NLMISYQCGLVFRACCVKGQENSDFVRGDGTDLQDPAKIPEEEEQEDPYLNDRCRGGGPCKQQC RDTGDEVICSCFVGYQLQSDGVSCEDINECITGSHNCRLGESCINTVGSFRCQRDSSCGTGYEL TEDNNCKDIDECETGIHNCPPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAP CPVGQTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECSPPAEPCGKGHHCLNSPGSFRC ECKAGYYFDGISRTCVDINECQRYPGRLCGHKCENTPGSYHCSCSAGFRLSVDGRSCEDVNECL NSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCP SSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGSFRCLSFECPENYRRSADTRCERLPCH ENQECPRLPLRITYYHLSFPTNIQVPAVVFRMGPSSAVPGDSMQLAITAGNEEGFFTTRKVSHH SGVVALTRPIPEPRDLLLTVTMDLYRHGTVSSFVAKLYIFVFAEL hide sequence

Ensembl Acc Id:

ENSRNOP00000046622 ⟸ ENSRNOT00000047234

Ensembl Acc Id:

ENSRNOP00000070552 ⟸ ENSRNOT00000088042

Ensembl Acc Id:

ENSRNOP00000089007 ⟸ ENSRNOT00000102556

Protein Domains

Anaphylatoxin-like EGF-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZQ25-F1-model_v2	AlphaFold	D3ZQ25	1-705	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695575

Promoter ID:

EPDNEW_R6090

Type:

multiple initiation site

Name:

Fbln1_1

Description:

fibulin 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	126,096,837 - 126,096,897	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308667	AgrOrtholog
BioCyc Gene	G2FUF-32556	BioCyc
Ensembl Genes	ENSRNOG00000014137	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000047234	ENTREZGENE
	ENSRNOT00000047234.5	UniProtKB/TrEMBL
	ENSRNOT00000088042.2	UniProtKB/TrEMBL
	ENSRNOT00000102556.1	UniProtKB/TrEMBL
	ENSRNOT00000136577	ENTREZGENE
Gene3D-CATH	Laminin	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:9029287	IMAGE-MGC_LOAD
InterPro	Anaphylatoxin/fibulin	UniProtKB/TrEMBL
	cEGF	UniProtKB/TrEMBL
	ECM_structural_protein	UniProtKB/TrEMBL
	EGF-type_Asp/Asn_hydroxyl_site	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	EGF_Ca-bd	UniProtKB/TrEMBL
	EGF_Ca-bd_CS	UniProtKB/TrEMBL
	Fibulin-1	UniProtKB/TrEMBL
	Fibulin_C	UniProtKB/TrEMBL
	Growth_fac_rcpt_N_dom	UniProtKB/TrEMBL
	Nephronectin_domain	UniProtKB/TrEMBL
	NOTCH1_EGF-like	UniProtKB/TrEMBL
KEGG Report	rno:315191	UniProtKB/TrEMBL
MGC_CLONE	MGC:187782	IMAGE-MGC_LOAD
NCBI Gene	315191	ENTREZGENE
PANTHER	ADHESION G PROTEIN-COUPLED RECEPTOR E1	UniProtKB/TrEMBL
	EGF-LIKE DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	FIBRILLIN-1	UniProtKB/TrEMBL
	PA14 DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
Pfam	ANATO	UniProtKB/TrEMBL
	cEGF	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	Fibulin_C	UniProtKB/TrEMBL
PhenoGen	Fbln1	PhenoGen
PIRSF	Fibulin-1	UniProtKB/TrEMBL
PROSITE	ANAPHYLATOXIN_1	UniProtKB/TrEMBL
	ANAPHYLATOXIN_2	UniProtKB/TrEMBL
	ASX_HYDROXYL	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000014137	RatGTEx
SMART	ANATO	UniProtKB/TrEMBL
	EGF	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
Superfamily-SCOP	EGF/Laminin	UniProtKB/TrEMBL
	SSF57184	UniProtKB/TrEMBL
UniProt	A0A0G2JY81	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AAN5_RAT	UniProtKB/TrEMBL
	A6HTD8	ENTREZGENE, UniProtKB/TrEMBL
	B1WC21	ENTREZGENE, UniProtKB/TrEMBL
	D3ZQ25	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-29	Fbln1	fibulin 1	LOC100362423	Fbln1 protein-like	Data merged from RGD:2318165	737654	PROVISIONAL
2010-05-05	LOC100362423	Fbln1 protein-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-04-30	Fbln1	fibulin 1	Fbln1_predicted	fibulin 1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Fbln1_predicted	fibulin 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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