Aqp6 (aquaporin 6) - Rat Genome Database

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Gene: Aqp6 (aquaporin 6) Rattus norvegicus
Analyze
Symbol: Aqp6
Name: aquaporin 6
RGD ID: 71100
Description: Enables nitrate transmembrane transporter activity. Involved in nitrate transmembrane transport. Predicted to be located in transport vesicle membrane. Predicted to be active in apical plasma membrane. Orthologous to human AQP6 (aquaporin 6); PARTICIPATES IN water transport pathway; INTERACTS WITH 3-chloropropane-1,2-diol; 3H-1,2-dithiole-3-thione; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AQP-6; aquaporin 6, kidney specific; aquaporin-6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27130,732,216 - 130,735,149 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7130,633,579 - 130,735,194 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl7130,633,579 - 130,735,194 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7132,535,805 - 132,538,735 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07134,761,384 - 134,764,315 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07134,673,911 - 134,676,841 (+)NCBIRnor_WKY
Rnor_6.07141,258,585 - 141,261,518 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7141,258,584 - 141,261,735 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X115,763,288 - 115,766,221 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47138,347,266 - 138,350,199 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17138,423,702 - 138,426,636 (+)NCBI
Celera7127,213,574 - 127,216,507 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63. Ikeda M, etal., J Biol Chem 2002 Oct 18;277(42):39873-9.
4. Aquaporins in the kidney. Kwon TH, etal., Handb Exp Pharmacol. 2009;(190):95-132. doi: 10.1007/978-3-540-79885-9_5.
5. Cloning of a novel rat kidney cDNA homologous to CHIP28 and WCH-CD water channels. Ma T, etal., Biochem Biophys Res Commun 1993 Dec 15;197(2):654-9.
6. Gene Data Set MGD Curation, June 12, 2002
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia. Yasui M, etal., Proc Natl Acad Sci U S A 1999 May 11;96(10):5808-13.
Additional References at PubMed
PMID:8812490   PMID:12522663   PMID:15671159   PMID:16179736   PMID:18188600   PMID:19811639   PMID:21185908   PMID:21851171   PMID:23183829   PMID:26526333   PMID:34211055  


Genomics

Comparative Map Data
Aqp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27130,732,216 - 130,735,149 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7130,633,579 - 130,735,194 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl7130,633,579 - 130,735,194 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7132,535,805 - 132,538,735 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07134,761,384 - 134,764,315 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07134,673,911 - 134,676,841 (+)NCBIRnor_WKY
Rnor_6.07141,258,585 - 141,261,518 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7141,258,584 - 141,261,735 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X115,763,288 - 115,766,221 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47138,347,266 - 138,350,199 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17138,423,702 - 138,426,636 (+)NCBI
Celera7127,213,574 - 127,216,507 (+)NCBICelera
Cytogenetic Map7q36NCBI
AQP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381249,972,947 - 49,977,139 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1249,967,194 - 49,977,139 (+)EnsemblGRCh38hg38GRCh38
GRCh371250,366,730 - 50,370,922 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361248,652,887 - 48,657,189 (+)NCBINCBI36Build 36hg18NCBI36
Build 341248,652,891 - 48,657,189NCBI
Celera1249,162,741 - 49,167,043 (+)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1247,398,122 - 47,402,424 (+)NCBIHuRef
CHM1_11250,332,778 - 50,337,080 (+)NCBICHM1_1
T2T-CHM13v2.01249,935,958 - 49,940,150 (+)NCBIT2T-CHM13v2.0
Aqp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391599,495,891 - 99,503,359 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1599,499,281 - 99,503,358 (+)EnsemblGRCm39 Ensembl
GRCm381599,598,468 - 99,605,478 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1599,601,400 - 99,605,477 (+)EnsemblGRCm38mm10GRCm38
MGSCv371599,431,831 - 99,435,908 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361599,429,434 - 99,433,511 (+)NCBIMGSCv36mm8
Celera15101,756,793 - 101,760,851 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.13NCBI
Aqp6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955547567,152 - 571,895 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955547567,152 - 570,880 (+)NCBIChiLan1.0ChiLan1.0
AQP6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11239,672,067 - 39,676,636 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1239,672,067 - 39,676,636 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01238,739,047 - 38,782,659 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
AQP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1274,727,732 - 4,731,828 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl274,727,725 - 4,731,316 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2741,527,817 - 41,531,698 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0274,775,594 - 4,779,476 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl274,776,786 - 4,789,859 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1274,740,579 - 4,744,460 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,730,402 - 4,734,285 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02741,922,470 - 41,926,347 (+)NCBIUU_Cfam_GSD_1.0
Aqp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494565,511,431 - 65,514,075 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365127,650,724 - 7,653,274 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365127,650,755 - 7,653,399 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AQP6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,887,966 - 15,890,805 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1515,888,080 - 15,892,113 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2516,068,162 - 16,071,435 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AQP6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11146,199,907 - 46,207,010 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037199,914,619 - 199,919,218 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aqp6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248162,316,668 - 2,319,650 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248162,314,660 - 2,319,649 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:291
Count of miRNA genes:185
Interacting mature miRNAs:205
Transcripts:ENSRNOT00000000323
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat

Markers in Region
Aqp6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27130,732,444 - 130,733,848 (+)MAPPERmRatBN7.2
Rnor_6.07141,258,814 - 141,260,217NCBIRnor6.0
Rnor_5.0X115,763,517 - 115,764,920UniSTSRnor5.0
RGSC_v3.47138,347,495 - 138,348,898UniSTSRGSC3.4
Celera7127,213,803 - 127,215,206UniSTS
Cytogenetic Map7q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system nervous system renal system reproductive system respiratory system
High
Medium 23
Low 8 1 6 1
Below cutoff 1 33 6 10 8 13 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000083570   ⟹   ENSRNOP00000071627
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7130,633,579 - 130,735,194 (+)Ensembl
Rnor_6.0 Ensembl7141,258,584 - 141,261,735 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098480   ⟹   ENSRNOP00000092300
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7130,633,579 - 130,734,950 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109729   ⟹   ENSRNOP00000092023
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7130,633,579 - 130,735,194 (+)Ensembl
RefSeq Acc Id: NM_022181   ⟹   NP_071517
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27130,732,216 - 130,735,149 (+)NCBI
Rnor_6.07141,258,585 - 141,261,518 (+)NCBI
Rnor_5.0X115,763,288 - 115,766,221 (+)NCBI
RGSC_v3.47138,347,266 - 138,350,199 (+)RGD
Celera7127,213,574 - 127,216,507 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_071517 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD29856 (Get FASTA)   NCBI Sequence Viewer  
  EDL86979 (Get FASTA)   NCBI Sequence Viewer  
  Q9WTY0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_071517   ⟸   NM_022181
- UniProtKB: Q9WTY0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071627   ⟸   ENSRNOT00000083570
RefSeq Acc Id: ENSRNOP00000092023   ⟸   ENSRNOT00000109729
RefSeq Acc Id: ENSRNOP00000092300   ⟸   ENSRNOT00000098480

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WTY0-F1-model_v2 AlphaFold Q9WTY0 1-276 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695646
Promoter ID:EPDNEW_R6171
Type:initiation region
Name:Aqp6_1
Description:aquaporin 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07141,258,562 - 141,258,622EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71100 AgrOrtholog
BioCyc Gene G2FUF-32065 BioCyc
Ensembl Genes ENSRNOG00000053181 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000063448 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000071627.2 UniProtKB/TrEMBL
  ENSRNOP00000092023.1 UniProtKB/TrEMBL
  ENSRNOP00000092300 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000083570.2 UniProtKB/TrEMBL
  ENSRNOT00000098480 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000109729.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aquaporin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_transptr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29170 UniProtKB/Swiss-Prot
NCBI Gene 29170 ENTREZGENE
PANTHER PTHR19139 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19139:SF113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aqp6 PhenoGen
PRINTS AQUAPORIN6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MINTRINSICP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81338 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AGD2_RAT UniProtKB/TrEMBL
  AQP6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Aqp6  aquaporin 6  Aqp6  aquaporin 6, kidney specific  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Aqp6  aquaporin 6, kidney specific  Aqp6  aquaporin 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Aqp6  aquaporin 6      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of the aquaporin family of plasma membrane channels 631875