Aqp2 (aquaporin 2) - Rat Genome Database

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Gene: Aqp2 (aquaporin 2) Rattus norvegicus
Symbol: Aqp2
Name: aquaporin 2
RGD ID: 2142
Description: Enables PDZ domain binding activity; actin binding activity; and water transmembrane transporter activity. Involved in several processes, including actin filament depolymerization; cellular response to water deprivation; and response to glucagon. Located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and trans-Golgi network. Part of protein-containing complex. Used to study diabetes insipidus. Biomarker of hypertension and nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in nephrogenic diabetes insipidus and nephrogenic diabetes insipidus type 2. Orthologous to human AQP2 (aquaporin 2); PARTICIPATES IN vasopressin signaling pathway; vasopressin signaling pathway via receptor type 2; amiloride pharmacodynamics pathway; INTERACTS WITH (R)-noradrenaline; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
Previously known as: ADH water channel; AQP-2; AQP-CD; aquaporin 2 (collecting duct); aquaporin-2; aquaporin-CD; collecting duct water channel protein; MGC156502; water channel protein for renal collecting duct; WCH-CD
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr87132,590,286 - 132,595,321 (+)NCBIGRCr8
mRatBN7.27130,711,433 - 130,716,468 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7130,711,413 - 130,716,468 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7132,515,018 - 132,520,055 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07134,740,599 - 134,745,636 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07134,653,120 - 134,658,157 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07141,237,802 - 141,242,837 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7141,237,768 - 141,245,165 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X115,742,312 - 115,747,347 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47138,325,855 - 138,330,891 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17138,402,285 - 138,406,831 (+)NCBI
Celera7127,193,026 - 127,197,996 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function


References - curated
# Reference Title Reference Citation
1. Hemodynamic parameters during normal and hypertensive pregnancy in rats: evaluation of renal salt and water transporters. Abreu N, etal., Hypertens Pregnancy. 2008;27(1):49-63.
2. Aquaporin-2 and urea transporter-A1 are up-regulated in rats with type I diabetes mellitus. Bardoux P, etal., Diabetologia. 2001 May;44(5):637-45.
3. Large scale protein identification in intracellular aquaporin-2 vesicles from renal inner medullary collecting duct. Barile M, etal., Mol Cell Proteomics. 2005 Aug;4(8):1095-106. Epub 2005 May 18.
4. Regulation of the basolateral chloride/base exchangers AE1 and SLC26A7 in the kidney collecting duct in potassium depletion. Barone S, etal., Nephrol Dial Transplant. 2007 Dec;22(12):3462-70. Epub 2007 Sep 5.
5. Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption. Boone M and Deen PM, Pflugers Arch. 2008 Sep;456(6):1005-24. Epub 2008 Apr 23.
6. Characterization of V71M mutation in the aquaporin-2 gene causing nephrogenic diabetes insipidus. Bougacha-Elleuch N, etal., J Genet. 2008 Dec;87(3):279-82.
7. Urinary concentrating defect in hypothyroid rats: role of sodium, potassium, 2-chloride co-transporter, and aquaporins. Cadnapaphornchai MA, etal., J Am Soc Nephrol 2003 Mar;14(3):566-74.
8. Novel mutations underlying nephrogenic diabetes insipidus in Arab families. Carroll P, etal., Genet Med. 2006 Jul;8(7):443-7.
9. Modulation of aquaporin-2/vasopressin2 receptor kidney expression and tubular injury after endotoxin (lipopolysaccharide) challenge. Chagnon F, etal., Crit Care Med. 2008 Nov;36(11):3054-61.
10. Aquaporin-2 downregulation in kidney medulla of aging rats is posttranscriptional and is abolished by water deprivation. Combet S, etal., Am J Physiol Renal Physiol. 2008 Jun;294(6):F1408-14. Epub 2008 Mar 26.
11. Long-term aldosterone treatment induces decreased apical but increased basolateral expression of AQP2 in CCD of rat kidney. de Seigneux S, etal., Am J Physiol Renal Physiol. 2007 Jul;293(1):F87-99. Epub 2007 Mar 20.
12. Role of AQP2 during apoptosis in cortical collecting duct cells. Flamenco P, etal., Biol Cell. 2009 Apr;101(4):237-50.
13. Cloning and expression of apical membrane water channel of rat kidney collecting tubule. Fushimi K, etal., Nature 1993 Feb 11;361(6412):549-52.
14. Osmolarity and intracellular calcium regulate aquaporin2 expression through TonEBP in nucleus pulposus cells of the intervertebral disc. Gajghate S, etal., J Bone Miner Res. 2009 Jun;24(6):992-1001.
15. Role of AQP2 in activation of calcium entry by hypotonicity: implications in cell volume regulation. Galizia L, etal., Am J Physiol Renal Physiol. 2008 Mar;294(3):F582-90. Epub 2007 Dec 19.
16. Aquaporin-2, a regulated water channel, is expressed in apical membranes of rat distal colon epithelium. Gallardo P, etal., Am J Physiol Gastrointest Liver Physiol 2001 Sep;281(3):G856-63.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Characterization of D150E and G196D aquaporin-2 mutations responsible for nephrogenic diabetes insipidus: importance of a mild phenotype. Guyon C, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F489-98. Epub 2009 May 20.
20. Long term regulation of aquaporin-2 expression in vasopressin-responsive renal collecting duct principal cells. Hasler U, etal., J Biol Chem 2002 Mar 22;277(12):10379-86. Epub 2002 Jan 8.
21. Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells. Henn V, etal., J Biol Chem 2004 Jun 18;279(25):26654-65. Epub 2004 Mar 22.
22. Rapid isolation of tissue-specific genes from rat kidney. Hu E, etal., Exp Nephrol 2001 Mar-Apr;9(2):156-64.
23. Angiotensin II regulates V2 receptor and pAQP2 during ureteral obstruction. Jensen AM, etal., Am J Physiol Renal Physiol. 2009 Jan;296(1):F127-34. Epub 2008 Oct 29.
24. Repulsion between Lys258 and upstream arginines explains the missorting of the AQP2 mutant p.Glu258Lys in nephrogenic diabetes insipidus. Kamsteeg EJ, etal., Hum Mutat. 2009 Oct;30(10):1387-96.
25. Changes in renal medullary transport proteins during uncontrolled diabetes mellitus in rats. Kim D, etal., Am J Physiol Renal Physiol 2003 Aug;285(2):F303-9. Epub 2003 Apr 15.
26. Indomethacin enhances shuttling of aquaporin-2 despite decreased abundance in rat kidney. Kim SW, etal., J Am Soc Nephrol. 2004 Dec;15(12):2998-3005.
27. Urea transporter UT-A1 and aquaporin-2 proteins decrease in response to angiotensin II or norepinephrine-induced acute hypertension. Klein JD, etal., Am J Physiol Renal Physiol. 2006 Nov;291(5):F952-9. Epub 2006 Jun 20.
28. Urinary excretion of aquaporin-2 water channel in diabetic ketoacidosis. Kusaka I, etal., Nephron. 2002 May;91(1):167-9.
29. Aquaporins in the kidney. Kwon TH, etal., Handb Exp Pharmacol. 2009;(190):95-132. doi: 10.1007/978-3-540-79885-9_5.
30. Increased expression of renal aquaporin water channels in spontaneously hypertensive rats. Lee J, etal., Kidney Blood Press Res. 2006;29(1):18-23. Epub 2006 Mar 22.
31. Differential expression of aquaporins in the kidneys of streptozotocin-induced diabetic mice. Leung JC, etal., Nephrology (Carlton). 2005 Feb;10(1):63-72.
32. Downregulation of renal aquaporins in response to unilateral ureteral obstruction. Li C, etal., Am J Physiol Renal Physiol 2003 May;284(5):F1066-79.
33. Heat shock protein 70 interacts with aquaporin-2 and regulates its trafficking. Lu HA, etal., J Biol Chem. 2007 Sep 28;282(39):28721-32. Epub 2007 Jul 18.
34. Cell-biologic and functional analyses of five new Aquaporin-2 missense mutations that cause recessive nephrogenic diabetes insipidus. Marr N, etal., J Am Soc Nephrol. 2002 Sep;13(9):2267-77.
35. Congenital progressive hydronephrosis (cph) is caused by an S256L mutation in aquaporin-2 that affects its phosphorylation and apical membrane accumulation. McDill BW, etal., Proc Natl Acad Sci U S A. 2006 May 2;103(18):6952-7. Epub 2006 Apr 25.
36. Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells. McSorley T, etal., Eur J Cell Biol. 2006 Jul;85(7):673-8. Epub 2006 Feb 28.
37. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
38. Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cells. Moeller HB, etal., Kidney Int. 2009 Feb;75(3):295-303. Epub 2008 Oct 8.
39. Novel mutation of aquaporin-2 gene in a patient with congenital nephrogenic diabetes insipidus. Moon SS, etal., Endocr J. 2009;56(7):905-10. Epub 2009 May 20.
40. Importance of the mercury-sensitive cysteine on function and routing of AQP1 and AQP2 in oocytes. Mulders SM, etal., Am J Physiol. 1997 Sep;273(3 Pt 2):F451-6.
41. Decrease in urinary excretion of aquaporin-2 associated with impaired urinary concentrating ability in diabetic nephropathy. Nakamura T, etal., Nephron. 2002 Oct;92(2):445-8.
42. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
43. Compensatory increase in AQP2, p-AQP2, and AQP3 expression in rats with diabetes mellitus. Nejsum LN, etal., Am J Physiol Renal Physiol 2001 Apr;280(4):F715-26.
44. Functional requirement of aquaporin-5 in plasma membranes of sweat glands. Nejsum LN, etal., Proc Natl Acad Sci U S A 2002 Jan 8;99(1):511-516.
45. Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: mechanisms for aquaporin 2 down-regulation and cellular proliferation. Nielsen J, etal., Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3634-9. Epub 2008 Feb 22.
46. Water channel aquaporin-2 directly binds to actin. Noda Y, etal., Biochem Biophys Res Commun 2004 Sep 24;322(3):740-5.
47. Identification of a multiprotein "motor" complex binding to water channel aquaporin-2. Noda Y, etal., Biochem Biophys Res Commun. 2005 May 20;330(4):1041-7.
48. Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1. Noda Y, etal., FEBS Lett. 2004 Jun 18;568(1-3):139-45.
49. Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking. Noda Y, etal., J Cell Biol. 2008 Aug 11;182(3):587-601. Epub 2008 Aug 4.
50. AKAP220 colocalizes with AQP2 in the inner medullary collecting ducts. Okutsu R, etal., Kidney Int. 2008 Dec;74(11):1429-33. Epub 2008 Aug 13.
51. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
52. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
53. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
54. Vasopressin V(2)-receptor-dependent regulation of AQP2 expression in Brattleboro rats. Promeneur D, etal., Am J Physiol Renal Physiol. 2000 Aug;279(2):F370-82.
55. Cloning of rat and mouse aquaporin-2 gene promoters and identification of a negative cis-regulatory element. Rai T, etal., Am J Physiol 1997 Aug;273(2 Pt 2):F264-73.
56. GOA pipeline RGD automated data pipeline
57. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
58. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
59. Aquaporin-2 transcript is differentially regulated by dietary salt in Sprague-Dawley and Dahl SS/Jr rats. Roxas B, etal., Biochem Biophys Res Commun 2002 Aug 23;296(3):755.
60. p.R254Q mutation in the aquaporin-2 water channel causing dominant nephrogenic diabetes insipidus is due to a lack of arginine vasopressin-induced phosphorylation. Savelkoul PJ, etal., Hum Mutat. 2009 Oct;30(10):E891-903.
61. Nephrogenic diabetes insipidus in mice caused by deleting COOH-terminal tail of aquaporin-2. Shi PP, etal., Am J Physiol Renal Physiol. 2007 May;292(5):F1334-44. Epub 2007 Jan 16.
62. Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation. Sohara E, etal., Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14217-22. Epub 2006 Sep 12.
63. Expression, localization, and regulation of aquaporin-1 to -3 in rat urothelia. Spector DA, etal., Am J Physiol Renal Physiol 2002 Jun;282(6):F1034-42.
64. Novel treatment for lithium-induced nephrogenic diabetes insipidus rat model using the Sendai-virus vector carrying aquaporin 2 gene. Suga H, etal., Endocrinology. 2008 Nov;149(11):5803-10. Epub 2008 Jul 24.
65. Compound heterozygous mutation of aquaporin 2 gene in woman patient with congenital nephrogenic diabetes insipidus. Tsutsumi Z, etal., Intern Med. 2009;48(6):437-40. Epub 2009 Mar 16.
66. Expression of aquaporin water channels in rat taste buds. Watson KJ, etal., Chem Senses. 2007 Jun;32(5):411-21. Epub 2007 Mar 5.
67. Vasopressin-independent regulation of collecting duct aquaporin-2 in food deprivation. Wilke C, etal., Kidney Int. 2005 Jan;67(1):201-16.
68. Mouse model of inducible nephrogenic diabetes insipidus produced by floxed aquaporin-2 gene deletion. Yang B, etal., Am J Physiol Renal Physiol. 2006 Aug;291(2):F465-72. Epub 2006 Jan 24.
69. Neonatal mortality in an aquaporin-2 knock-in mouse model of recessive nephrogenic diabetes insipidus. Yang B, etal., J Biol Chem 2001 Jan 26;276(4):2775-9. Epub 2000 Oct 16.
70. Aquaporin 2 expression increased by glucagon in normal rat inner medullary collecting ducts. Yano Y, etal., Am J Physiol Renal Physiol. 2009 Jan;296(1):F54-9. Epub 2008 Oct 1.
71. Potential role of purinergic signaling in lithium-induced nephrogenic diabetes insipidus. Zhang Y, etal., Am J Physiol Renal Physiol. 2009 May;296(5):F1194-201. Epub 2009 Feb 25.
72. Identification of phosphorylation-dependent binding partners of aquaporin-2 using protein mass spectrometry. Zwang NA, etal., J Proteome Res. 2009 Mar;8(3):1540-54.
Additional References at PubMed
PMID:1373524   PMID:1510932   PMID:3184310   PMID:7505572   PMID:7508187   PMID:7530250   PMID:8140421   PMID:8584435   PMID:9369468   PMID:9405233   PMID:9806845   PMID:9829975  
PMID:10191086   PMID:10318966   PMID:10322639   PMID:10510269   PMID:10564231   PMID:11001937   PMID:11034202   PMID:11076974   PMID:11423561   PMID:11573934   PMID:12084581   PMID:12388395  
PMID:12422412   PMID:12477932   PMID:12524527   PMID:14605277   PMID:14675036   PMID:14701836   PMID:15075200   PMID:15089964   PMID:15153553   PMID:15200427   PMID:15213068   PMID:15326289  
PMID:15338864   PMID:15489334   PMID:15509592   PMID:15536172   PMID:15550389   PMID:15585668   PMID:15625084   PMID:15632412   PMID:15644488   PMID:15723124   PMID:15859948   PMID:15948717  
PMID:16046477   PMID:16174867   PMID:16387092   PMID:16501490   PMID:16550485   PMID:16596446   PMID:16641100   PMID:16672318   PMID:16684923   PMID:16899541   PMID:16928804   PMID:16985212  
PMID:17178220   PMID:17264983   PMID:17409310   PMID:17626240   PMID:17628981   PMID:17699554   PMID:17700641   PMID:17940347   PMID:18177483   PMID:18202181   PMID:18287043   PMID:18419953  
PMID:18501347   PMID:18502184   PMID:18505797   PMID:18511455   PMID:18606813   PMID:18618131   PMID:18655911   PMID:18664568   PMID:18703515   PMID:18762715   PMID:19040709   PMID:19056867  
PMID:19300448   PMID:19515809   PMID:19656910   PMID:19776175   PMID:19794145   PMID:20089674   PMID:20107111   PMID:20130117   PMID:20432437   PMID:20724536   PMID:21038660   PMID:21112289  
PMID:21178974   PMID:21251048   PMID:21251984   PMID:21479884   PMID:21511701   PMID:21525134   PMID:21677414   PMID:21768374   PMID:21938744   PMID:22028046   PMID:22375059   PMID:22587908  
PMID:22786728   PMID:23171819   PMID:23376485   PMID:23533145   PMID:23706747   PMID:23986519   PMID:24531898   PMID:24700872   PMID:24733887   PMID:24944200   PMID:25658446   PMID:25694485  
PMID:25762220   PMID:25858778   PMID:25977473   PMID:26062878   PMID:26674602   PMID:27022218   PMID:27191152   PMID:27402760   PMID:27405971   PMID:27784696   PMID:27889609   PMID:28139295  
PMID:28381458   PMID:28668390   PMID:28754689   PMID:29046292   PMID:29243846   PMID:29357442   PMID:29797427   PMID:30009821   PMID:30021346   PMID:30488437   PMID:30551379   PMID:31691500  
PMID:31811544   PMID:32000538   PMID:32113684   PMID:32165443   PMID:32413996   PMID:33094506   PMID:34360801   PMID:35054947   PMID:35068345   PMID:35386692   PMID:35918145  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr87132,590,286 - 132,595,321 (+)NCBIGRCr8
mRatBN7.27130,711,433 - 130,716,468 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7130,711,413 - 130,716,468 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7132,515,018 - 132,520,055 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07134,740,599 - 134,745,636 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07134,653,120 - 134,658,157 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07141,237,802 - 141,242,837 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7141,237,768 - 141,245,165 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X115,742,312 - 115,747,347 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47138,325,855 - 138,330,891 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17138,402,285 - 138,406,831 (+)NCBI
Celera7127,193,026 - 127,197,996 (+)NCBICelera
Cytogenetic Map7q36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381249,950,737 - 49,958,878 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1249,950,737 - 49,958,878 (+)EnsemblGRCh38hg38GRCh38
GRCh371250,344,520 - 50,352,661 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361248,630,796 - 48,638,931 (+)NCBINCBI36Build 36hg18NCBI36
Build 341248,630,795 - 48,638,929NCBI
Celera1249,140,628 - 49,148,768 (+)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1247,376,094 - 47,384,234 (+)NCBIHuRef
CHM1_11250,310,689 - 50,318,825 (+)NCBICHM1_1
T2T-CHM13v2.01249,913,728 - 49,921,869 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391599,476,937 - 99,482,426 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1599,476,936 - 99,482,428 (+)EnsemblGRCm39 Ensembl
GRCm381599,579,056 - 99,584,545 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1599,579,055 - 99,584,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv371599,409,487 - 99,414,976 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361599,407,106 - 99,412,579 (+)NCBIMGSCv36mm8
Celera15101,734,478 - 101,739,943 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.13NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955547547,064 - 555,958 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955547547,770 - 555,764 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21044,229,814 - 44,238,063 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11244,226,576 - 44,234,741 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01238,796,300 - 38,804,559 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11239,690,289 - 39,698,397 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1239,690,289 - 39,698,397 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1274,743,127 - 4,750,907 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl274,743,127 - 4,750,907 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2741,505,816 - 41,513,596 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0274,793,697 - 4,801,488 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl274,793,697 - 4,801,488 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1274,758,676 - 4,766,460 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,748,491 - 4,756,279 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02741,900,444 - 41,908,227 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494565,528,160 - 65,536,193 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365127,628,495 - 7,634,107 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365127,628,677 - 7,633,344 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl515,863,486 - 15,868,565 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1515,862,739 - 15,868,565 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2516,090,821 - 16,095,902 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11146,179,783 - 46,188,631 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1146,180,387 - 46,188,712 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037199,932,873 - 199,941,797 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248162,335,471 - 2,340,828 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248162,332,477 - 2,340,797 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Aqp2
17 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:302
Count of miRNA genes:183
Interacting mature miRNAs:217
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27130,716,276 - 130,716,459 (+)MAPPERmRatBN7.2
Rnor_6.07141,242,646 - 141,242,828NCBIRnor6.0
Rnor_5.0X115,747,156 - 115,747,338UniSTSRnor5.0
RGSC_v3.47138,330,700 - 138,330,882UniSTSRGSC3.4
Celera7127,197,805 - 127,197,987UniSTS
Cytogenetic Map7q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27130,716,256 - 130,716,444 (+)MAPPERmRatBN7.2
Rnor_6.07141,242,626 - 141,242,813NCBIRnor6.0
Rnor_5.0X115,747,136 - 115,747,323UniSTSRnor5.0
RGSC_v3.47138,330,680 - 138,330,867UniSTSRGSC3.4
Celera7127,197,785 - 127,197,972UniSTS
RH 3.4 Map71076.2UniSTS
Cytogenetic Map7q36UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 29 1
Low 2 8
Below cutoff 1 5 2 5 2 1 2 2 2 10 10 1


RefSeq Acc Id: ENSRNOT00000091717   ⟹   ENSRNOP00000074297
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7130,711,413 - 130,716,468 (+)Ensembl
Rnor_6.0 Ensembl7141,237,768 - 141,245,165 (+)Ensembl
RefSeq Acc Id: NM_012909   ⟹   NP_037041
Rat AssemblyChrPosition (strand)Source
GRCr87132,590,286 - 132,595,321 (+)NCBI
mRatBN7.27130,711,433 - 130,716,468 (+)NCBI
Rnor_6.07141,237,802 - 141,242,837 (+)NCBI
Rnor_5.0X115,742,312 - 115,747,347 (+)NCBI
RGSC_v3.47138,325,855 - 138,330,891 (+)RGD
Celera7127,193,026 - 127,197,996 (+)RGD
RefSeq Acc Id: NP_037041   ⟸   NM_012909
- UniProtKB: P34080 (UniProtKB/Swiss-Prot),   A1A5L4 (UniProtKB/Swiss-Prot),   A6KCG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074297   ⟸   ENSRNOT00000091717

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P34080-F1-model_v2 AlphaFold P34080 1-271 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695644
Promoter ID:EPDNEW_R6169
Type:single initiation site
Description:aquaporin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.07141,237,790 - 141,237,850EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2142 AgrOrtholog
BioCyc Gene G2FUF-32067 BioCyc
Ensembl Genes ENSRNOG00000054378 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091717 ENTREZGENE
  ENSRNOT00000091717.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aquaporin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_transptr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25386 UniProtKB/Swiss-Prot
  PTHR19139 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aqp2 PhenoGen
  MINTRINSICP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054378 RatGTEx
Superfamily-SCOP SSF81338 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K7Q2_RAT UniProtKB/TrEMBL
UniProt Secondary A1A5L4 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 Aqp2  aquaporin 2  Aqp2  aquaporin 2 (collecting duct)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Aqp2  aquaporin 2 (collecting duct)  Aqp2  aquaporin 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Aqp2  aquaporin 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized in the outer lining of the epithelial cell membrane of the urothelia 628378
gene_disease mutation is linked to the autosomal recessive nephrogenic diabetes insipidous (NDI) 625535
gene_disease increased levels may curtail water loss in inner medullary (IM) tip during uncontrolled diabetes mellitus (DM) 1298676
gene_disease decreased levels in hypothyroid model may contribute to urinary concentrating defect 704374
gene_expression expressed in kidney collecting duct principal cells 70240
gene_function water channel protein 67997
gene_function water channel protein 625535
gene_homology promoter has high sequence homology to that of human aquaporin-2 1298549
gene_other coding sequences are identical in Sprague-Dawley and Dahl salt sensitive (SS/Jr) rats but on high versus basal NaCl diets, mRNA is 5-fold reduced in Sprague-Dawley while mRNA is 3-fold increased in Dahl salt sensitive (SS/Jr) strain 625535
gene_pathway degradation mechanism involves proteasomal and lysosomal pathways 1298675
gene_process plays a role in salt adaptation 625535
gene_process channel is constitutively active and activity does not change with different pH 625535
gene_process chief target for vasopressin regulation of collecting water permeability 625535
gene_process mediates antidiuretic hormone [8-arginine]vasopressin (AVP)-dependent water reabsorption regulation in renal collecting duct primary cell line 1298675
gene_regulation regulated by circulating vasopressin 628378
gene_regulation promoter sequence contains a novel cis-element that modulates a negative regulatory function 1298549