Aqp2 (aquaporin 2) - Rat Genome Database

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Gene: Aqp2 (aquaporin 2) Rattus norvegicus
Analyze
Symbol: Aqp2
Name: aquaporin 2
RGD ID: 2142
Description: Exhibits PDZ domain binding activity; actin binding activity; and water transmembrane transporter activity. Involved in several processes, including actin filament depolymerization; cellular response to water deprivation; and response to glucagon. Localizes to several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and trans-Golgi network. Used to study diabetes insipidus. Biomarker of hypertension and nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in nephrogenic diabetes insipidus. Orthologous to human AQP2 (aquaporin 2); PARTICIPATES IN vasopressin signaling pathway; vasopressin signaling pathway via receptor type 2; amiloride pharmacodynamics pathway; INTERACTS WITH (R)-noradrenaline; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ADH water channel; AQP-2; AQP-CD; aquaporin 2 (collecting duct); aquaporin-2; aquaporin-CD; collecting duct water channel protein; MGC156502; water channel protein for renal collecting duct; WCH-CD
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27130,711,433 - 130,716,468 (+)NCBI
Rnor_6.0 Ensembl7141,237,768 - 141,245,165 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07141,237,802 - 141,242,837 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X115,742,312 - 115,747,347 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47138,325,855 - 138,330,891 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17138,402,285 - 138,406,831 (+)NCBI
Celera7127,193,026 - 127,197,996 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
1. Abreu N, etal., Hypertens Pregnancy. 2008;27(1):49-63.
2. Bardoux P, etal., Diabetologia. 2001 May;44(5):637-45.
3. Barile M, etal., Mol Cell Proteomics. 2005 Aug;4(8):1095-106. Epub 2005 May 18.
4. Barone S, etal., Nephrol Dial Transplant. 2007 Dec;22(12):3462-70. Epub 2007 Sep 5.
5. Boone M and Deen PM, Pflugers Arch. 2008 Sep;456(6):1005-24. Epub 2008 Apr 23.
6. Bougacha-Elleuch N, etal., J Genet. 2008 Dec;87(3):279-82.
7. Cadnapaphornchai MA, etal., J Am Soc Nephrol 2003 Mar;14(3):566-74.
8. Carroll P, etal., Genet Med. 2006 Jul;8(7):443-7.
9. Chagnon F, etal., Crit Care Med. 2008 Nov;36(11):3054-61.
10. Combet S, etal., Am J Physiol Renal Physiol. 2008 Jun;294(6):F1408-14. Epub 2008 Mar 26.
11. de Seigneux S, etal., Am J Physiol Renal Physiol. 2007 Jul;293(1):F87-99. Epub 2007 Mar 20.
12. Flamenco P, etal., Biol Cell. 2009 Apr;101(4):237-50.
13. Fushimi K, etal., Nature 1993 Feb 11;361(6412):549-52.
14. Gajghate S, etal., J Bone Miner Res. 2009 Jun;24(6):992-1001.
15. Galizia L, etal., Am J Physiol Renal Physiol. 2008 Mar;294(3):F582-90. Epub 2007 Dec 19.
16. Gallardo P, etal., Am J Physiol Gastrointest Liver Physiol 2001 Sep;281(3):G856-63.
17. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. GOA data from the GO Consortium
19. Guyon C, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F489-98. Epub 2009 May 20.
20. Hasler U, etal., J Biol Chem 2002 Mar 22;277(12):10379-86. Epub 2002 Jan 8.
21. Henn V, etal., J Biol Chem 2004 Jun 18;279(25):26654-65. Epub 2004 Mar 22.
22. Hu E, etal., Exp Nephrol 2001 Mar-Apr;9(2):156-64.
23. Jensen AM, etal., Am J Physiol Renal Physiol. 2009 Jan;296(1):F127-34. Epub 2008 Oct 29.
24. Kamsteeg EJ, etal., Hum Mutat. 2009 Oct;30(10):1387-96.
25. Kim D, etal., Am J Physiol Renal Physiol 2003 Aug;285(2):F303-9. Epub 2003 Apr 15.
26. Kim SW, etal., J Am Soc Nephrol. 2004 Dec;15(12):2998-3005.
27. Klein JD, etal., Am J Physiol Renal Physiol. 2006 Nov;291(5):F952-9. Epub 2006 Jun 20.
28. Kusaka I, etal., Nephron. 2002 May;91(1):167-9.
29. Kwon TH, etal., Handb Exp Pharmacol. 2009;(190):95-132. doi: 10.1007/978-3-540-79885-9_5.
30. Lee J, etal., Kidney Blood Press Res. 2006;29(1):18-23. Epub 2006 Mar 22.
31. Leung JC, etal., Nephrology (Carlton). 2005 Feb;10(1):63-72.
32. Li C, etal., Am J Physiol Renal Physiol 2003 May;284(5):F1066-79.
33. Lu HA, etal., J Biol Chem. 2007 Sep 28;282(39):28721-32. Epub 2007 Jul 18.
34. Marr N, etal., J Am Soc Nephrol. 2002 Sep;13(9):2267-77.
35. McDill BW, etal., Proc Natl Acad Sci U S A. 2006 May 2;103(18):6952-7. Epub 2006 Apr 25.
36. McSorley T, etal., Eur J Cell Biol. 2006 Jul;85(7):673-8. Epub 2006 Feb 28.
37. MGD data from the GO Consortium
38. Moeller HB, etal., Kidney Int. 2009 Feb;75(3):295-303. Epub 2008 Oct 8.
39. Moon SS, etal., Endocr J. 2009;56(7):905-10. Epub 2009 May 20.
40. Mulders SM, etal., Am J Physiol. 1997 Sep;273(3 Pt 2):F451-6.
41. Nakamura T, etal., Nephron. 2002 Oct;92(2):445-8.
42. NCBI rat LocusLink and RefSeq merged data July 26, 2002
43. Nejsum LN, etal., Am J Physiol Renal Physiol 2001 Apr;280(4):F715-26.
44. Nejsum LN, etal., Proc Natl Acad Sci U S A 2002 Jan 8;99(1):511-516.
45. Nielsen J, etal., Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3634-9. Epub 2008 Feb 22.
46. Noda Y, etal., Biochem Biophys Res Commun 2004 Sep 24;322(3):740-5.
47. Noda Y, etal., Biochem Biophys Res Commun. 2005 May 20;330(4):1041-7.
48. Noda Y, etal., FEBS Lett. 2004 Jun 18;568(1-3):139-45.
49. Noda Y, etal., J Cell Biol. 2008 Aug 11;182(3):587-601. Epub 2008 Aug 4.
50. Okutsu R, etal., Kidney Int. 2008 Dec;74(11):1429-33. Epub 2008 Aug 13.
51. OMIM Disease Annotation Pipeline
52. Pipeline to import KEGG annotations from KEGG into RGD
53. Pipeline to import SMPDB annotations from SMPDB into RGD
54. Promeneur D, etal., Am J Physiol Renal Physiol. 2000 Aug;279(2):F370-82.
55. Rai T, etal., Am J Physiol 1997 Aug;273(2 Pt 2):F264-73.
56. RGD automated data pipeline
57. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
58. RGD automated import pipeline for gene-chemical interactions
59. Roxas B, etal., Biochem Biophys Res Commun 2002 Aug 23;296(3):755.
60. Savelkoul PJ, etal., Hum Mutat. 2009 Oct;30(10):E891-903.
61. Shi PP, etal., Am J Physiol Renal Physiol. 2007 May;292(5):F1334-44. Epub 2007 Jan 16.
62. Sohara E, etal., Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14217-22. Epub 2006 Sep 12.
63. Spector DA, etal., Am J Physiol Renal Physiol 2002 Jun;282(6):F1034-42.
64. Suga H, etal., Endocrinology. 2008 Nov;149(11):5803-10. Epub 2008 Jul 24.
65. Tsutsumi Z, etal., Intern Med. 2009;48(6):437-40. Epub 2009 Mar 16.
66. Watson KJ, etal., Chem Senses. 2007 Jun;32(5):411-21. Epub 2007 Mar 5.
67. Wilke C, etal., Kidney Int. 2005 Jan;67(1):201-16.
68. Yang B, etal., Am J Physiol Renal Physiol. 2006 Aug;291(2):F465-72. Epub 2006 Jan 24.
69. Yang B, etal., J Biol Chem 2001 Jan 26;276(4):2775-9. Epub 2000 Oct 16.
70. Yano Y, etal., Am J Physiol Renal Physiol. 2009 Jan;296(1):F54-9. Epub 2008 Oct 1.
71. Zhang Y, etal., Am J Physiol Renal Physiol. 2009 May;296(5):F1194-201. Epub 2009 Feb 25.
72. Zwang NA, etal., J Proteome Res. 2009 Mar;8(3):1540-54.
Additional References at PubMed
PMID:1373524   PMID:1510932   PMID:3184310   PMID:7505572   PMID:7508187   PMID:7530250   PMID:8140421   PMID:8584435   PMID:9369468   PMID:9405233   PMID:9806845   PMID:9829975  
PMID:10191086   PMID:10318966   PMID:10322639   PMID:10510269   PMID:10564231   PMID:11001937   PMID:11034202   PMID:11076974   PMID:11423561   PMID:11573934   PMID:12084581   PMID:12388395  
PMID:12422412   PMID:12477932   PMID:12524527   PMID:14605277   PMID:14675036   PMID:14701836   PMID:15075200   PMID:15089964   PMID:15153553   PMID:15200427   PMID:15213068   PMID:15326289  
PMID:15338864   PMID:15489334   PMID:15509592   PMID:15536172   PMID:15550389   PMID:15585668   PMID:15625084   PMID:15632412   PMID:15644488   PMID:15723124   PMID:15859948   PMID:15948717  
PMID:16046477   PMID:16174867   PMID:16387092   PMID:16501490   PMID:16550485   PMID:16596446   PMID:16641100   PMID:16672318   PMID:16684923   PMID:16899541   PMID:16928804   PMID:16985212  
PMID:17178220   PMID:17264983   PMID:17409310   PMID:17626240   PMID:17628981   PMID:17699554   PMID:17700641   PMID:17940347   PMID:18177483   PMID:18202181   PMID:18287043   PMID:18419953  
PMID:18501347   PMID:18502184   PMID:18505797   PMID:18511455   PMID:18606813   PMID:18618131   PMID:18655911   PMID:18664568   PMID:18703515   PMID:18762715   PMID:19040709   PMID:19056867  
PMID:19300448   PMID:19515809   PMID:19656910   PMID:19776175   PMID:19794145   PMID:20089674   PMID:20107111   PMID:20130117   PMID:20432437   PMID:20724536   PMID:21038660   PMID:21112289  
PMID:21178974   PMID:21251048   PMID:21251984   PMID:21479884   PMID:21511701   PMID:21525134   PMID:21677414   PMID:21768374   PMID:21938744   PMID:22028046   PMID:22375059   PMID:22587908  
PMID:22786728   PMID:23171819   PMID:23376485   PMID:23533145   PMID:23706747   PMID:23986519   PMID:24531898   PMID:24700872   PMID:24733887   PMID:24944200   PMID:25658446   PMID:25694485  
PMID:25762220   PMID:25858778   PMID:25977473   PMID:26062878   PMID:26674602   PMID:27022218   PMID:27191152   PMID:27402760   PMID:27405971   PMID:27784696   PMID:27889609   PMID:28139295  
PMID:28381458   PMID:28668390   PMID:28754689   PMID:29046292   PMID:29243846   PMID:29357442   PMID:29797427   PMID:30009821   PMID:30021346   PMID:30488437   PMID:30551379   PMID:31691500  
PMID:31811544   PMID:32000538   PMID:32113684   PMID:32165443   PMID:32413996  


Genomics

Comparative Map Data
Aqp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27130,711,433 - 130,716,468 (+)NCBI
Rnor_6.0 Ensembl7141,237,768 - 141,245,165 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07141,237,802 - 141,242,837 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X115,742,312 - 115,747,347 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47138,325,855 - 138,330,891 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17138,402,285 - 138,406,831 (+)NCBI
Celera7127,193,026 - 127,197,996 (+)NCBICelera
Cytogenetic Map7q36NCBI
AQP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1249,950,741 - 49,958,881 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1249,950,737 - 49,958,878 (+)EnsemblGRCh38hg38GRCh38
GRCh381249,950,737 - 49,958,878 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371250,344,520 - 50,352,661 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361248,630,796 - 48,638,931 (+)NCBINCBI36hg18NCBI36
Build 341248,630,795 - 48,638,929NCBI
Celera1249,140,628 - 49,148,768 (+)NCBI
Cytogenetic Map12q13.12NCBI
HuRef1247,376,094 - 47,384,234 (+)NCBIHuRef
CHM1_11250,310,689 - 50,318,825 (+)NCBICHM1_1
Aqp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391599,476,937 - 99,482,426 (+)NCBIGRCm39mm39
GRCm39 Ensembl1599,476,936 - 99,482,428 (+)Ensembl
GRCm381599,579,056 - 99,584,545 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1599,579,055 - 99,584,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv371599,409,487 - 99,414,976 (+)NCBIGRCm37mm9NCBIm37
MGSCv361599,407,106 - 99,412,579 (+)NCBImm8
Celera15101,734,478 - 101,739,943 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.13NCBI
Aqp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955547547,064 - 555,958 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955547547,770 - 555,764 (+)NCBIChiLan1.0ChiLan1.0
AQP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11239,690,289 - 39,698,397 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1239,690,289 - 39,698,397 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01238,796,300 - 38,804,559 (-)NCBIMhudiblu_PPA_v0panPan3
AQP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1274,743,127 - 4,750,907 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl274,743,127 - 4,750,907 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2741,505,816 - 41,513,596 (+)NCBI
ROS_Cfam_1.0274,793,697 - 4,801,488 (-)NCBI
UMICH_Zoey_3.1274,758,676 - 4,766,460 (-)NCBI
UNSW_CanFamBas_1.0274,748,491 - 4,756,279 (-)NCBI
UU_Cfam_GSD_1.02741,900,444 - 41,908,227 (+)NCBI
Aqp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494565,528,160 - 65,536,193 (-)NCBI
SpeTri2.0NW_0049365127,628,677 - 7,633,344 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AQP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,863,303 - 15,868,565 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1515,862,739 - 15,868,565 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2516,090,821 - 16,095,902 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AQP2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11146,179,783 - 46,188,631 (+)NCBI
ChlSab1.1 Ensembl1146,180,387 - 46,188,712 (+)Ensembl
Aqp2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248162,332,477 - 2,340,797 (-)NCBI

Position Markers
RH94449  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07141,242,646 - 141,242,828NCBIRnor6.0
Rnor_5.0X115,747,156 - 115,747,338UniSTSRnor5.0
RGSC_v3.47138,330,700 - 138,330,882UniSTSRGSC3.4
Celera7127,197,805 - 127,197,987UniSTS
Cytogenetic Map7q36UniSTS
RH134997  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07141,242,626 - 141,242,813NCBIRnor6.0
Rnor_5.0X115,747,136 - 115,747,323UniSTSRnor5.0
RGSC_v3.47138,330,680 - 138,330,867UniSTSRGSC3.4
Celera7127,197,785 - 127,197,972UniSTS
RH 3.4 Map71076.2UniSTS
Cytogenetic Map7q36UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)771448715145729302Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7111519266143965591Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7121986439143965591Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7120746024145692398Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7129412003145729302Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7115922628145729302Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7114825174145729302Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)7106564316145729302Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7122421276143965415Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7121654760145729302Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)751251919145729302Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7100028953145729302Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)7100192194145192194Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)796630946141630946Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)791832949145158140Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)791832949145158140Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:302
Count of miRNA genes:183
Interacting mature miRNAs:217
Transcripts:ENSRNOT00000000324
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 29 1
Low 2 8
Below cutoff 1 5 2 5 2 1 2 2 2 10 10 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000091717   ⟹   ENSRNOP00000074297
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7141,237,768 - 141,245,165 (+)Ensembl
RefSeq Acc Id: NM_012909   ⟹   NP_037041
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27130,711,433 - 130,716,468 (+)NCBI
Rnor_6.07141,237,802 - 141,242,837 (+)NCBI
Rnor_5.0X115,742,312 - 115,747,347 (+)NCBI
RGSC_v3.47138,325,855 - 138,330,891 (+)RGD
Celera7127,193,026 - 127,197,996 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037041   ⟸   NM_012909
- Sequence:
RefSeq Acc Id: ENSRNOP00000074297   ⟸   ENSRNOT00000091717

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695644
Promoter ID:EPDNEW_R6169
Type:single initiation site
Name:Aqp2_1
Description:aquaporin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07141,237,790 - 141,237,850EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2142 AgrOrtholog
Ensembl Genes ENSRNOG00000054378 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000074297 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091717 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.20.1080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109642 IMAGE-MGC_LOAD
InterPro Aquaporin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_transptr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25386 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156502 IMAGE-MGC_LOAD
NCBI Gene 25386 ENTREZGENE
PANTHER PTHR19139 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aqp2 PhenoGen
PRINTS MINTRINSICP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81338 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K7Q2_RAT UniProtKB/TrEMBL
  AQP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A1A5L4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 Aqp2  aquaporin 2  Aqp2  aquaporin 2 (collecting duct)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Aqp2  aquaporin 2 (collecting duct)  Aqp2  aquaporin 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Aqp2  aquaporin 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized in the outer lining of the epithelial cell membrane of the urothelia 628378
gene_disease mutation is linked to the autosomal recessive nephrogenic diabetes insipidous (NDI) 625535
gene_disease increased levels may curtail water loss in inner medullary (IM) tip during uncontrolled diabetes mellitus (DM) 1298676
gene_disease decreased levels in hypothyroid model may contribute to urinary concentrating defect 704374
gene_expression expressed in kidney collecting duct principal cells 70240
gene_function water channel protein 67997
gene_function water channel protein 625535
gene_homology promoter has high sequence homology to that of human aquaporin-2 1298549
gene_other coding sequences are identical in Sprague-Dawley and Dahl salt sensitive (SS/Jr) rats but on high versus basal NaCl diets, mRNA is 5-fold reduced in Sprague-Dawley while mRNA is 3-fold increased in Dahl salt sensitive (SS/Jr) strain 625535
gene_pathway degradation mechanism involves proteasomal and lysosomal pathways 1298675
gene_process plays a role in salt adaptation 625535
gene_process channel is constitutively active and activity does not change with different pH 625535
gene_process chief target for vasopressin regulation of collecting water permeability 625535
gene_process mediates antidiuretic hormone [8-arginine]vasopressin (AVP)-dependent water reabsorption regulation in renal collecting duct primary cell line 1298675
gene_regulation regulated by circulating vasopressin 628378
gene_regulation promoter sequence contains a novel cis-element that modulates a negative regulatory function 1298549