Aqp2 (aquaporin 2) - Rat Genome Database

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Gene: Aqp2 (aquaporin 2) Heterocephalus glaber
Analyze
Symbol: Aqp2
Name: aquaporin 2
RGD ID: 18930240
Description: ENCODES a protein that exhibits actin binding (ortholog); glycerol transmembrane transporter activity (ortholog); PDZ domain binding (ortholog); INVOLVED IN actin filament depolymerization (ortholog); actin filament organization (ortholog); cell volume homeostasis (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH cardiomyopathy (ortholog); diabetes insipidus (ortholog); diabetic ketoacidosis (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); clathrin-coated vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: aquaporin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248162,335,471 - 2,340,828 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248162,332,477 - 2,340,797 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Aqp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248162,335,471 - 2,340,828 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248162,332,477 - 2,340,797 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
AQP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381249,950,737 - 49,958,878 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1249,950,737 - 49,958,878 (+)EnsemblGRCh38hg38GRCh38
GRCh371250,344,520 - 50,352,661 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361248,630,796 - 48,638,931 (+)NCBINCBI36Build 36hg18NCBI36
Build 341248,630,795 - 48,638,929NCBI
Celera1249,140,628 - 49,148,768 (+)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1247,376,094 - 47,384,234 (+)NCBIHuRef
CHM1_11250,310,689 - 50,318,825 (+)NCBICHM1_1
T2T-CHM13v2.01249,913,728 - 49,921,869 (+)NCBIT2T-CHM13v2.0
Aqp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391599,476,937 - 99,482,426 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1599,476,936 - 99,482,428 (+)EnsemblGRCm39 Ensembl
GRCm381599,579,056 - 99,584,545 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1599,579,055 - 99,584,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv371599,409,487 - 99,414,976 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361599,407,106 - 99,412,579 (+)NCBIMGSCv36mm8
Celera15101,734,478 - 101,739,943 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.13NCBI
Aqp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87132,590,286 - 132,595,321 (+)NCBIGRCr8
mRatBN7.27130,711,433 - 130,716,468 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7130,711,413 - 130,716,468 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7132,515,018 - 132,520,055 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07134,740,599 - 134,745,636 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07134,653,120 - 134,658,157 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07141,237,802 - 141,242,837 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7141,237,768 - 141,245,165 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X115,742,312 - 115,747,347 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47138,325,855 - 138,330,891 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17138,402,285 - 138,406,831 (+)NCBI
Celera7127,193,026 - 127,197,996 (+)NCBICelera
Cytogenetic Map7q36NCBI
Aqp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955547547,064 - 555,958 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955547547,770 - 555,764 (+)NCBIChiLan1.0ChiLan1.0
AQP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21044,229,814 - 44,238,063 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11244,226,576 - 44,234,741 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01238,796,300 - 38,804,559 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11239,690,289 - 39,698,397 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1239,690,289 - 39,698,397 (-)Ensemblpanpan1.1panPan2
AQP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1274,743,127 - 4,750,907 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl274,743,127 - 4,750,907 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2741,505,816 - 41,513,596 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0274,793,697 - 4,801,488 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl274,793,697 - 4,801,488 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1274,758,676 - 4,766,460 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0274,748,491 - 4,756,279 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02741,900,444 - 41,908,227 (+)NCBIUU_Cfam_GSD_1.0
Aqp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494565,528,160 - 65,536,193 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365127,628,495 - 7,634,107 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365127,628,677 - 7,633,344 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AQP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl515,863,486 - 15,868,565 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1515,862,739 - 15,868,565 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2516,090,821 - 16,095,902 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AQP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11146,179,783 - 46,188,631 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1146,180,387 - 46,188,712 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037199,932,873 - 199,941,797 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000005831   ⟹   ENSHGLP00000005758
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248162,335,471 - 2,340,828 (-)Ensembl
RefSeq Acc Id: XM_004863006   ⟹   XP_004863063
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248162,335,366 - 2,340,774 (-)NCBI
RefSeq Acc Id: XM_004863007   ⟹   XP_004863064
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248162,332,477 - 2,340,774 (-)NCBI
RefSeq Acc Id: XM_013079067   ⟹   XP_012934521
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248162,332,477 - 2,340,797 (-)NCBI
RefSeq Acc Id: XM_013079068   ⟹   XP_012934522
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248162,332,477 - 2,340,782 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004863063 (Get FASTA)   NCBI Sequence Viewer  
  XP_004863064 (Get FASTA)   NCBI Sequence Viewer  
  XP_012934521 (Get FASTA)   NCBI Sequence Viewer  
  XP_012934522 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000005758
GenBank Protein JAO01670 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_012934521   ⟸   XM_013079067
- Peptide Label: isoform X1
RefSeq Acc Id: XP_012934522   ⟸   XM_013079068
- Peptide Label: isoform X4
RefSeq Acc Id: XP_004863064   ⟸   XM_004863007
- Peptide Label: isoform X3
RefSeq Acc Id: XP_004863063   ⟸   XM_004863006
- Peptide Label: isoform X2
- UniProtKB: A0A0N8EUC5 (UniProtKB/TrEMBL),   G5AU09 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000005758   ⟸   ENSHGLT00000005831


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000004210 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000005831 ENTREZGENE
Gene3D-CATH 1.20.1080.10 UniProtKB/TrEMBL
InterPro Aquaporin-like UniProtKB/TrEMBL
  Aquaporin_transptr UniProtKB/TrEMBL
  MIP UniProtKB/TrEMBL
  MIP_CS UniProtKB/TrEMBL
KEGG Report hgl:101706579 UniProtKB/TrEMBL
NCBI Gene Aqp2 ENTREZGENE
PANTHER AQUAPORIN-2 UniProtKB/TrEMBL
  PTHR19139 UniProtKB/TrEMBL
Pfam MIP UniProtKB/TrEMBL
PRINTS AQUAPORIN2 UniProtKB/TrEMBL
  MINTRINSICP UniProtKB/TrEMBL
PROSITE MIP UniProtKB/TrEMBL
Superfamily-SCOP SSF81338 UniProtKB/TrEMBL
UniProt A0A0N8EUC5 ENTREZGENE, UniProtKB/TrEMBL
  G5AU09 ENTREZGENE, UniProtKB/TrEMBL