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Gene: Hspa4 (heat shock protein family A (Hsp70) member 4) Rattus norvegicus
Symbol: Hspa4
Name: heat shock protein family A (Hsp70) member 4
RGD ID: 628878
Description: Exhibits RNA polymerase II transcription factor binding activity and activating transcription factor binding activity. Involved in several processes, including negative regulation of DNA binding activity; negative regulation of macromolecule metabolic process; and positive regulation of angiogenesis. Localizes to cytosol; lipid droplet; and nucleus. Used to study adult respiratory distress syndrome and middle cerebral artery infarction. Biomarker of Parkinson's disease and liver benign neoplasm. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to human HSPA4 (heat shock protein family A (Hsp70) member 4); PARTICIPATES IN cortisol signaling pathway; estrogen signaling pathway; antigen processing and presentation pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
Also known as: heat shock 70 kDa protein 4; heat shock protein 4; heat shock protein family A member 4; Hsp110; Hsp70; irp94; ischemia responsive 94 kDa protein
Homo sapiens (human) : HSPA4 (heat shock protein family A (Hsp70) member 4)  HGNC  Alliance
Mus musculus (house mouse) : Hspa4 (heat shock protein 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hspa4 (heat shock protein family A (Hsp70) member 4)
Pan paniscus (bonobo/pygmy chimpanzee) : HSPA4 (heat shock protein family A (Hsp70) member 4)
Canis lupus familiaris (dog) : HSPA4 (heat shock protein family A (Hsp70) member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspa4 (heat shock protein family A (Hsp70) member 4)
Sus scrofa (pig) : HSPA4 (heat shock protein family A (Hsp70) member 4)
Chlorocebus sabaeus (African green monkey) : HSPA4 (heat shock protein family A (Hsp70) member 4)
Heterocephalus glaber (naked mole-rat) : Hspa4 (heat shock protein family A (Hsp70) member 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01038,601,624 - 38,642,397 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,601,624 - 38,642,397 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,383,101 - 38,424,016 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41038,705,629 - 38,749,058 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11038,712,058 - 38,755,488 (-)NCBI
Celera1036,756,477 - 36,796,741 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Hspa4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628878
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.