Hspa4 (heat shock protein family A (Hsp70) member 4) - Rat Genome Database

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Gene: Hspa4 (heat shock protein family A (Hsp70) member 4) Rattus norvegicus
Symbol: Hspa4
Name: heat shock protein family A (Hsp70) member 4
RGD ID: 628878
Description: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of angiogenesis; and regulation of microglial cell activation. Located in lipid droplet. Used to study adult respiratory distress syndrome and middle cerebral artery infarction. Biomarker of Parkinson's disease and liver benign neoplasm. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to human HSPA4 (heat shock protein family A (Hsp70) member 4); PARTICIPATES IN cortisol signaling pathway; estrogen signaling pathway; antigen processing and presentation pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
Previously known as: heat shock 70 kDa protein 4; heat shock protein 4; heat shock protein family A member 4; Hsp110; Hsp70; irp94; ischemia responsive 94 kDa protein
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81037,908,866 - 37,951,994 (-)NCBIGRCr8
mRatBN7.21037,408,025 - 37,449,080 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,408,025 - 37,449,001 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,101,220 - 42,141,891 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,591,248 - 41,631,920 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,094,962 - 37,135,636 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01038,601,624 - 38,642,397 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,601,624 - 38,642,397 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,383,101 - 38,424,016 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41038,705,629 - 38,749,058 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11038,712,058 - 38,755,488 (-)NCBI
Celera1036,756,477 - 36,796,741 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3'-Dichlorobenzidine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
albendazole  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP,ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
casticin  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
clofibrate  (ISO)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (EXP)
geldanamycin  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
isobutyl nitrite  (ISO)
ivermectin  (ISO)
linalool  (ISO)
lycopene  (EXP)
manganese(II) sulfate  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
Mitotane  (EXP)
motexafin gadolinium  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosomorpholine  (EXP)
nonanoic acid  (ISO)
Nonidet P-40  (ISO)
oxidopamine  (EXP)
paracetamol  (ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP)
propiconazole  (EXP)
Propiverine  (EXP)
prostaglandin A1  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tanespimycin  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Black currant phytoconstituents exert chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis by suppression of the inflammatory response. Bishayee A, etal., Mol Carcinog. 2011 Dec 27. doi: 10.1002/mc.21860.
2. Convergent sets of data from in vivo and in vitro methods point to an active role of Hsp60 in chronic obstructive pulmonary disease pathogenesis. Cappello F, etal., PLoS One. 2011;6(11):e28200. Epub 2011 Nov 28.
3. Administration of carnosine in the treatment of acute spinal cord injury. Di Paola R, etal., Biochem Pharmacol. 2011 Nov 15;82(10):1478-89. Epub 2011 Jul 20.
4. Short-term follow-up of chagasic patients after benznidazole treatment using multiple serological markers. Fernandez-Villegas A, etal., BMC Infect Dis. 2011 Jul 31;11:206.
5. BAG3 protein is overexpressed in human glioblastoma and is a potential target for therapy. Festa M, etal., Am J Pathol. 2011 Jun;178(6):2504-12. Epub 2011 May 10.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Elevated HSP27, HSP70 and HSP90 alpha in chronic obstructive pulmonary disease: markers for immune activation and tissue destruction. Hacker S, etal., Clin Lab. 2009;55(1-2):31-40.
9. Hsp70 regulates the interaction between the peroxisome targeting signal type 1 (PTS1)-receptor Pex5p and PTS1. Harano T, etal., Biochem J. 2001 Jul 1;357(Pt 1):157-65.
10. Riluzole prevents morphine-induced apoptosis in rat cerebral cortex. Hassanzadeh K, etal., Pharmacol Rep. 2011;63(3):697-707.
11. Mildronate as a regulator of protein expression in a rat model of Parkinson's disease. Isajevs S, etal., Medicina (Kaunas). 2011;47(10):552-9.
12. Heat shock protein 70 is translocated to lipid droplets in rat adipocytes upon heat stimulation. Jiang H, etal., Biochim Biophys Acta. 2007 Jan;1771(1):66-74. Epub 2006 Nov 15.
13. Developmental immunolocalization of heat shock protein 70 (HSP70) in epithelial cell of rat kidney. Kang SS, etal., Histol Histopathol. 2011 Nov;26(11):1363-73.
14. HSP70 protein promotes survival of C6 and U87 glioma cells by inhibition of ATF5 degradation. Li G, etal., J Biol Chem. 2011 Jun 10;286(23):20251-9. Epub 2011 Apr 25.
15. Therapeutic efficacy of trehalose eye drops for treatment of murine dry eye induced by an intelligently controlled environmental system. Li J, etal., Mol Vis. 2012;18:317-29. Epub 2012 Feb 4.
16. TLR2 ligand induces protection against cerebral ischemia/reperfusion injury via activation of phosphoinositide 3-kinase/Akt signaling. Lu C, etal., J Immunol. 2011 Aug 1;187(3):1458-66. Epub 2011 Jun 27.
17. Initiation but no execution - modulation of peripheral blood lymphocyte apoptosis in rheumatoid arthritis - a potential role for heat shock protein 70. Moodley D, etal., J Inflamm (Lond). 2011 Nov 3;8(1):30.
18. The dual behavior of heat shock protein 70 and asymmetric dimethylarginine in relation to serum CRP levels in type 2 diabetes. Nakhjavani M, etal., Gene. 2012 Feb 13.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. Chaperoning of glucocorticoid receptors. Pratt WB, etal., Handb Exp Pharmacol. 2006;(172):111-38.
21. Increase in periosteal angiogenesis through heat shock conditioning. Rana M, etal., Head Face Med. 2011 Nov 18;7:22.
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy and its regulation by lipoic acid. Santos JM and Kowluru RA, Invest Ophthalmol Vis Sci. 2011 Nov 11;52(12):8791-8. Print 2011.
26. Anti-inflammatory effects of -shogaol: potential roles of HDAC inhibition and HSP70 induction. Shim S, etal., Food Chem Toxicol. 2011 Nov;49(11):2734-40. Epub 2011 Aug 16.
27. Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions. Smith DF and Toft DO, Mol Endocrinol. 2008 Oct;22(10):2229-40. Epub 2008 May 1.
28. Hyperthermia assists survival of astrocytes from oxidative-mediated necrotic cell death. Thomas G, etal., Cell Mol Biol (Noisy-le-grand) 2002 Mar;48(2):191-8.
29. Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy. Tomasello G, etal., Eur J Histochem. 2011 Oct 24;55(4):e38. doi: 10.4081/ejh.2011.e38.
30. Hypobaric Hypoxia Preconditioning Attenuates Experimental Heatstroke Syndromes via Preinduction of Heat Shock Protein 70. Wang LC, etal., Am J Med Sci. 2012 Jan 12.
31. Adenoviral transfer of HSP-70 into pulmonary epithelium ameliorates experimental acute respiratory distress syndrome. Weiss YG, etal., J Clin Invest. 2002 Sep;110(6):801-6.
32. [Effect of benzo pyrene on HSP70 expression in rat cortical neurons in vitro]. Xu G and Zheng J, Wei Sheng Yan Jiu. 2011 Jul;40(4):437-40.
33. Molecular cloning of a novel member of the HSP110 family of genes, ischemia-responsive protein 94 kDa (irp94), expressed in rat brain after transient forebrain ischemia. Yagita Y, etal., J Neurochem 1999 Apr;72(4):1544-51.
34. Altered expression of heat shock protein 110 family members in mouse hippocampal neurons following trimethyltin treatment in vivo and in vitro. Yoneyama M, etal., Neuropharmacology. 2008 Oct;55(5):693-703. Epub 2008 Jun 13.
35. Valproic acid-mediated neuroprotection in retinal ischemia injury via histone deacetylase inhibition and transcriptional activation. Zhang Z, etal., Exp Eye Res. 2012 Jan;94(1):98-108. Epub 2011 Nov 28.
36. Immunolocalization of Toll-like receptors 2 and 4 as well as their endogenous ligand, heat shock protein 70, in rat traumatic brain injury. Zhang Z, etal., Neuroimmunomodulation. 2012;19(1):10-9. Epub 2011 Nov 7.
37. Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke. Zheng Z, etal., J Cereb Blood Flow Metab. 2008 Jan;28(1):53-63. Epub 2007 May 2.
Additional References at PubMed
PMID:9488468   PMID:12145311   PMID:12857439   PMID:12870667   PMID:14688209   PMID:15033773   PMID:15540463   PMID:15644312   PMID:15744251   PMID:15877948   PMID:16116448   PMID:16254606  
PMID:16291818   PMID:16297314   PMID:16297316   PMID:16472926   PMID:16710168   PMID:16731649   PMID:16781812   PMID:16854843   PMID:17103089   PMID:17278880   PMID:17441510   PMID:17552876  
PMID:17640624   PMID:17763949   PMID:18087244   PMID:18159002   PMID:18178852   PMID:18182047   PMID:18280260   PMID:18316783   PMID:18388575   PMID:18446816   PMID:18528785   PMID:18534054  
PMID:18601975   PMID:18644837   PMID:18668351   PMID:18759001   PMID:18856196   PMID:19095035   PMID:19182904   PMID:19208651   PMID:19244585   PMID:19268660   PMID:19333137   PMID:19352207  
PMID:19401463   PMID:19543852   PMID:19570893   PMID:19785543   PMID:19788071   PMID:19897899   PMID:20083167   PMID:20137302   PMID:20426530   PMID:20458337   PMID:20465949   PMID:20559625  
PMID:20971094   PMID:21097414   PMID:21109264   PMID:21231916   PMID:21276792   PMID:21356360   PMID:21391123   PMID:21439793   PMID:21499258   PMID:21515294   PMID:21913551   PMID:21941782  
PMID:21953294   PMID:22022600   PMID:22039956   PMID:22082260   PMID:22132083   PMID:22156356   PMID:22350213   PMID:22438294   PMID:22505291   PMID:22513040   PMID:22526757   PMID:22683596  
PMID:22871113   PMID:23064900   PMID:23315814   PMID:23356498   PMID:23479759   PMID:23612524   PMID:23965991   PMID:24141017   PMID:24496673   PMID:25002582   PMID:25412361   PMID:25470523  
PMID:25535743   PMID:25571843   PMID:26053851   PMID:26165998   PMID:26279425   PMID:26316108   PMID:26874210   PMID:26903063   PMID:27009470   PMID:27169499   PMID:27216364   PMID:28368329  
PMID:29037410   PMID:29374537   PMID:29476059   PMID:32357304   PMID:32917949   PMID:35456946   PMID:37200358  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81037,908,866 - 37,951,994 (-)NCBIGRCr8
mRatBN7.21037,408,025 - 37,449,080 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,408,025 - 37,449,001 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,101,220 - 42,141,891 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,591,248 - 41,631,920 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,094,962 - 37,135,636 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01038,601,624 - 38,642,397 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,601,624 - 38,642,397 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,383,101 - 38,424,016 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41038,705,629 - 38,749,058 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11038,712,058 - 38,755,488 (-)NCBI
Celera1036,756,477 - 36,796,741 (-)NCBICelera
Cytogenetic Map10q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh385133,052,013 - 133,106,449 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5133,052,013 - 133,106,449 (+)EnsemblGRCh38hg38GRCh38
GRCh375132,387,705 - 132,442,141 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,415,561 - 132,468,608 (+)NCBINCBI36Build 36hg18NCBI36
Build 345132,415,560 - 132,468,608NCBI
Celera5128,517,326 - 128,569,460 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,579,243 - 127,632,290 (+)NCBIHuRef
CHM1_15131,820,919 - 131,874,036 (+)NCBICHM1_1
T2T-CHM13v2.05133,562,175 - 133,626,191 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391153,150,641 - 53,191,306 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,150,641 - 53,191,284 (-)EnsemblGRCm39 Ensembl
GRCm381153,259,814 - 53,300,479 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,259,814 - 53,300,457 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,073,316 - 53,113,981 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,104,997 - 53,143,812 (-)NCBIMGSCv36mm8
Celera1157,839,531 - 57,880,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.91NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554084,379,825 - 4,423,381 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554084,379,825 - 4,422,710 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v24128,358,202 - 128,410,864 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15126,497,801 - 126,552,375 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05128,463,186 - 128,517,563 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,619,076 - 134,673,658 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,619,076 - 134,673,658 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11121,290,603 - 21,363,701 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1121,290,621 - 21,505,122 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1120,116,763 - 20,164,574 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01122,073,430 - 22,146,303 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1122,073,445 - 22,146,281 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,814,567 - 20,862,388 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,662,175 - 20,709,970 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01121,304,890 - 21,352,758 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213115,084,886 - 115,130,573 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,087,604 - 2,133,355 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,087,650 - 2,133,343 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl2135,345,867 - 135,391,108 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12135,345,724 - 135,391,112 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,866,335 - 140,911,632 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12335,862,817 - 35,917,490 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,862,814 - 35,918,287 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603442,023,595 - 42,078,723 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473339,021,738 - 39,068,132 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473339,022,511 - 39,068,153 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Hspa4
135 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir1rno-miR-1-3pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI17715156

Predicted Target Of
Summary Value
Count of predictions:197
Count of miRNA genes:141
Interacting mature miRNAs:167
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21037,427,084 - 37,427,272 (+)MAPPERmRatBN7.2
Rnor_6.01038,620,867 - 38,621,054NCBIRnor6.0
Rnor_5.01038,402,344 - 38,402,531UniSTSRnor5.0
RGSC_v3.41038,726,246 - 38,726,433UniSTSRGSC3.4
Celera1036,775,119 - 36,775,306UniSTS
RH 3.4 Map10403.4UniSTS
Cytogenetic Map10q22UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21037,419,445 - 37,420,560 (+)MAPPERmRatBN7.2
Rnor_6.01038,613,230 - 38,614,344NCBIRnor6.0
Rnor_5.01038,394,707 - 38,395,821UniSTSRnor5.0
RGSC_v3.41038,717,051 - 38,718,165UniSTSRGSC3.4
Cytogenetic Map10q22UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000023628   ⟹   ENSRNOP00000023628
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1037,408,025 - 37,449,001 (-)Ensembl
Rnor_6.0 Ensembl1038,601,624 - 38,642,397 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094819   ⟹   ENSRNOP00000082426
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1037,408,025 - 37,449,001 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111861   ⟹   ENSRNOP00000091981
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1037,408,025 - 37,439,941 (-)Ensembl
RefSeq Acc Id: NM_153629   ⟹   NP_705893
Rat AssemblyChrPosition (strand)Source
GRCr81037,908,866 - 37,949,835 (-)NCBI
mRatBN7.21037,408,025 - 37,449,001 (-)NCBI
Rnor_6.01038,601,624 - 38,642,397 (-)NCBI
Rnor_5.01038,383,101 - 38,424,016 (-)NCBI
RGSC_v3.41038,705,629 - 38,749,058 (-)RGD
Celera1036,756,477 - 36,796,741 (-)RGD
RefSeq Acc Id: XM_039085314   ⟹   XP_038941242
Rat AssemblyChrPosition (strand)Source
GRCr81037,908,866 - 37,951,994 (-)NCBI
mRatBN7.21037,409,756 - 37,449,080 (-)NCBI
RefSeq Acc Id: NP_705893   ⟸   NM_153629
- UniProtKB: O88600 (UniProtKB/Swiss-Prot),   F1LRV4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023628   ⟸   ENSRNOT00000023628
RefSeq Acc Id: XP_038941242   ⟸   XM_039085314
- Peptide Label: isoform X1
- UniProtKB: F1LRV4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000082426   ⟸   ENSRNOT00000094819
RefSeq Acc Id: ENSRNOP00000091981   ⟸   ENSRNOT00000111861

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88600-F1-model_v2 AlphaFold O88600 1-840 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697173
Promoter ID:EPDNEW_R7697
Type:initiation region
Description:heat shock protein family A member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01038,642,420 - 38,642,480EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628878 AgrOrtholog
BioCyc Gene G2FUF-25149 BioCyc
Ensembl Genes ENSRNOG00000016596 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055029517 UniProtKB/Swiss-Prot
  ENSRNOG00060020791 UniProtKB/Swiss-Prot
  ENSRNOG00065005468 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023628 ENTREZGENE
  ENSRNOT00000023628.4 UniProtKB/TrEMBL
  ENSRNOT00000094819.1 UniProtKB/TrEMBL
  ENSRNOT00000111861.1 UniProtKB/TrEMBL
  ENSRNOT00055051127 UniProtKB/Swiss-Prot
  ENSRNOT00060036017 UniProtKB/Swiss-Prot
  ENSRNOT00065008100 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.420.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSPA4_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:266759 UniProtKB/Swiss-Prot
Pfam HSP70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hspa4 PhenoGen
PROSITE HSP70_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016596 RatGTEx
  ENSRNOG00055029517 RatGTEx
  ENSRNOG00060020791 RatGTEx
  ENSRNOG00065005468 RatGTEx
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF100934 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP74_RAT UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Hspa4  heat shock protein family A (Hsp70) member 4  Hspa4  heat shock protein family A member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Hspa4  heat shock protein family A member 4  Hspa4  heat shock protein 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Hspa4  heat shock protein 4    heat shock 70 kDa protein 4  Name updated 1299863 APPROVED
2003-02-27 Hspa4  heat shock 70 kDa protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is increased following exposure to elevated temperatures 633151