HSPA4 (heat shock protein family A (Hsp70) member 4) - Rat Genome Database

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Gene: HSPA4 (heat shock protein family A (Hsp70) member 4) Homo sapiens
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Symbol: HSPA4
Name: heat shock protein family A (Hsp70) member 4
RGD ID: 733190
HGNC Page HGNC:5237
Description: Predicted to enable adenyl-nucleotide exchange factor activity. Involved in chaperone-mediated protein complex assembly and protein insertion into mitochondrial outer membrane. Located in cytosol and extracellular exosome. Implicated in Chagas disease. Biomarker of chronic obstructive pulmonary disease; rheumatoid arthritis; type 2 diabetes mellitus; and ulcerative colitis.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: APG-2; epididymis secretory sperm binding protein Li 5a; heat shock 70 kDa protein 4; heat shock 70-related protein APG-2; heat shock 70kD protein 4; heat shock 70kDa protein 4; heat shock protein, 110 kDa; HEL-S-5a; HS24/P52; hsp70; hsp70 RY; hsp70RY; HSPH2; MGC131852; RY
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385133,052,013 - 133,106,449 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5133,052,013 - 133,106,449 (+)EnsemblGRCh38hg38GRCh38
GRCh375132,387,705 - 132,442,141 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,415,561 - 132,468,608 (+)NCBINCBI36Build 36hg18NCBI36
Build 345132,415,560 - 132,468,608NCBI
Celera5128,517,326 - 128,569,460 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,579,243 - 127,632,290 (+)NCBIHuRef
CHM1_15131,820,919 - 131,874,036 (+)NCBICHM1_1
T2T-CHM13v2.05133,562,175 - 133,626,191 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
3,3'-Dichlorobenzidine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
albendazole  (EXP)
all-trans-retinoic acid  (EXP)
amitrole  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (EXP)
aristolochic acid A  (EXP)
Aroclor 1254  (ISO)
arsenous acid  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calciol  (ISO)
cannabidiol  (EXP)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
casticin  (ISO)
chloropicrin  (EXP)
chlorpyrifos  (ISO)
clofibrate  (ISO)
clotrimazole  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
curcumin  (EXP)
cyclosporin A  (EXP)
DDT  (ISO)
deguelin  (EXP)
diarsenic trioxide  (EXP)
disulfiram  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
elemental selenium  (EXP)
enzyme inhibitor  (EXP)
ethanol  (ISO)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
FR900359  (EXP)
fulvestrant  (EXP)
gamma-hexachlorocyclohexane  (ISO)
geldanamycin  (EXP)
gentamycin  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
isobutyl nitrite  (ISO)
ivermectin  (EXP)
linalool  (EXP)
lycopene  (ISO)
manganese(II) sulfate  (ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (EXP)
methylmercury chloride  (EXP)
methylparaben  (EXP)
Mitotane  (ISO)
motexafin gadolinium  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-nitrosomorpholine  (ISO)
nonanoic acid  (ISO)
Nonidet P-40  (EXP)
oxidopamine  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl isothiocyanate  (EXP)
picoxystrobin  (EXP)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
Propiverine  (ISO)
prostaglandin A1  (ISO)
quercetin  (EXP,ISO)
raloxifene  (EXP)
resveratrol  (EXP)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sarin  (EXP)
SB 431542  (EXP)
selenium atom  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
succimer  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (EXP)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tanespimycin  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
thiostrepton  (EXP)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (EXP)
tunicamycin  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vitamin E  (EXP)
vorinostat  (EXP)
zearalenone  (ISO)
zinc acetate  (EXP)
zinc atom  (EXP)
zinc pyrithione  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Black currant phytoconstituents exert chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis by suppression of the inflammatory response. Bishayee A, etal., Mol Carcinog. 2011 Dec 27. doi: 10.1002/mc.21860.
2. Convergent sets of data from in vivo and in vitro methods point to an active role of Hsp60 in chronic obstructive pulmonary disease pathogenesis. Cappello F, etal., PLoS One. 2011;6(11):e28200. Epub 2011 Nov 28.
3. Administration of carnosine in the treatment of acute spinal cord injury. Di Paola R, etal., Biochem Pharmacol. 2011 Nov 15;82(10):1478-89. Epub 2011 Jul 20.
4. Short-term follow-up of chagasic patients after benznidazole treatment using multiple serological markers. Fernandez-Villegas A, etal., BMC Infect Dis. 2011 Jul 31;11:206.
5. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
6. Elevated HSP27, HSP70 and HSP90 alpha in chronic obstructive pulmonary disease: markers for immune activation and tissue destruction. Hacker S, etal., Clin Lab. 2009;55(1-2):31-40.
7. Mildronate as a regulator of protein expression in a rat model of Parkinson's disease. Isajevs S, etal., Medicina (Kaunas). 2011;47(10):552-9.
8. Therapeutic efficacy of trehalose eye drops for treatment of murine dry eye induced by an intelligently controlled environmental system. Li J, etal., Mol Vis. 2012;18:317-29. Epub 2012 Feb 4.
9. TLR2 ligand induces protection against cerebral ischemia/reperfusion injury via activation of phosphoinositide 3-kinase/Akt signaling. Lu C, etal., J Immunol. 2011 Aug 1;187(3):1458-66. Epub 2011 Jun 27.
10. Initiation but no execution - modulation of peripheral blood lymphocyte apoptosis in rheumatoid arthritis - a potential role for heat shock protein 70. Moodley D, etal., J Inflamm (Lond). 2011 Nov 3;8(1):30.
11. The dual behavior of heat shock protein 70 and asymmetric dimethylarginine in relation to serum CRP levels in type 2 diabetes. Nakhjavani M, etal., Gene. 2012 Feb 13.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. Chaperoning of glucocorticoid receptors. Pratt WB, etal., Handb Exp Pharmacol. 2006;(172):111-38.
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions. Smith DF and Toft DO, Mol Endocrinol. 2008 Oct;22(10):2229-40. Epub 2008 May 1.
17. Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy. Tomasello G, etal., Eur J Histochem. 2011 Oct 24;55(4):e38. doi: 10.4081/ejh.2011.e38.
18. Hypobaric Hypoxia Preconditioning Attenuates Experimental Heatstroke Syndromes via Preinduction of Heat Shock Protein 70. Wang LC, etal., Am J Med Sci. 2012 Jan 12.
19. Adenoviral transfer of HSP-70 into pulmonary epithelium ameliorates experimental acute respiratory distress syndrome. Weiss YG, etal., J Clin Invest. 2002 Sep;110(6):801-6.
20. Altered expression of heat shock protein 110 family members in mouse hippocampal neurons following trimethyltin treatment in vivo and in vitro. Yoneyama M, etal., Neuropharmacology. 2008 Oct;55(5):693-703. Epub 2008 Jun 13.
21. Immunolocalization of Toll-like receptors 2 and 4 as well as their endogenous ligand, heat shock protein 70, in rat traumatic brain injury. Zhang Z, etal., Neuroimmunomodulation. 2012;19(1):10-9. Epub 2011 Nov 7.
22. Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke. Zheng Z, etal., J Cereb Blood Flow Metab. 2008 Jan;28(1):53-63. Epub 2007 May 2.
Additional References at PubMed
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PMID:19952398   PMID:19995547   PMID:20012529   PMID:20020773   PMID:20026329   PMID:20029029   PMID:20053985   PMID:20069064   PMID:20132183   PMID:20146531   PMID:20156966   PMID:20164180  
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PMID:25789959   PMID:25796446   PMID:25798051   PMID:25857363   PMID:25864199   PMID:25881670   PMID:25921289   PMID:25959826   PMID:26010904   PMID:26022179   PMID:26050647   PMID:26165468  
PMID:26183779   PMID:26186194   PMID:26198046   PMID:26246424   PMID:26286954   PMID:26344197   PMID:26414348   PMID:26439863   PMID:26439956   PMID:26446645   PMID:26485645   PMID:26496610  
PMID:26527279   PMID:26549023   PMID:26556859   PMID:26559972   PMID:26565746   PMID:26618866   PMID:26638075   PMID:26752685   PMID:26777405   PMID:26782485   PMID:26784015   PMID:26831064  
PMID:26847302   PMID:26865365   PMID:26874923   PMID:26886023   PMID:26923191   PMID:26936937   PMID:26972000   PMID:27025967   PMID:27034005   PMID:27075190   PMID:27091568   PMID:27109633  
PMID:27129500   PMID:27137183   PMID:27137634   PMID:27187154   PMID:27327135   PMID:27342126   PMID:27464702   PMID:27465491   PMID:27483141   PMID:27576135   PMID:27591049   PMID:27599502  
PMID:27609421   PMID:27616763   PMID:27684187   PMID:27708256   PMID:27751915   PMID:27831465   PMID:27868339   PMID:27941812   PMID:28052117   PMID:28054753   PMID:28079882   PMID:28089446  
PMID:28122311   PMID:28146421   PMID:28192510   PMID:28246355   PMID:28291803   PMID:28302793   PMID:28330616   PMID:28367089   PMID:28443643   PMID:28453394   PMID:28497897   PMID:28504929  
PMID:28514442   PMID:28515276   PMID:28561026   PMID:28581483   PMID:28627586   PMID:28675297   PMID:28716533   PMID:28754656   PMID:28784015   PMID:28842558   PMID:28848092   PMID:28859986  
PMID:28927264   PMID:29067554   PMID:29084938   PMID:29101097   PMID:29117863   PMID:29128334   PMID:29167402   PMID:29180628   PMID:29229926   PMID:29242247   PMID:29255093   PMID:29259226  
PMID:29274099   PMID:29290964   PMID:29311808   PMID:29317501   PMID:29331416   PMID:29395067   PMID:29404895   PMID:29434293   PMID:29438905   PMID:29442021   PMID:29467282   PMID:29491085  
PMID:29507755   PMID:29509794   PMID:29564676   PMID:29568061   PMID:29763298   PMID:29772540   PMID:29845934   PMID:29846670   PMID:29930177   PMID:29986884   PMID:29991511   PMID:30021884  
PMID:30098457   PMID:30099725   PMID:30196744   PMID:30209976   PMID:30245753   PMID:30277474   PMID:30337218   PMID:30349055   PMID:30413534   PMID:30442662   PMID:30446660   PMID:30455355  
PMID:30463901   PMID:30485823   PMID:30521813   PMID:30543447   PMID:30559338   PMID:30575818   PMID:30591555   PMID:30614112   PMID:30632067   PMID:30643287   PMID:30645756   PMID:30700418  
PMID:30833792   PMID:30862844   PMID:30865286   PMID:30911017   PMID:30947809   PMID:30948266   PMID:30981628   PMID:31059266   PMID:31073040   PMID:31081062   PMID:31091453   PMID:31189917  
PMID:31239290   PMID:31300519   PMID:31320752   PMID:31327756   PMID:31430337   PMID:31497350   PMID:31500722   PMID:31501420   PMID:31521893   PMID:31536960   PMID:31558706   PMID:31577950  
PMID:31586073   PMID:31659016   PMID:31665637   PMID:31669268   PMID:31685992   PMID:31759081   PMID:31792442   PMID:31906756   PMID:31918818   PMID:31980649   PMID:31988151   PMID:32041778  
PMID:32084385   PMID:32097779   PMID:32108453   PMID:32127624   PMID:32129710   PMID:32163396   PMID:32198203   PMID:32296183   PMID:32315177   PMID:32322062   PMID:32332101   PMID:32347575  
PMID:32358783   PMID:32483383   PMID:32513696   PMID:32552912   PMID:32687490   PMID:32696179   PMID:32699135   PMID:32745066   PMID:32807901   PMID:32838362   PMID:32850835   PMID:32874188  
PMID:32876904   PMID:32917949   PMID:32946066   PMID:33084814   PMID:33111431   PMID:33139698   PMID:33177717   PMID:33177718   PMID:33239621   PMID:33306668   PMID:33334891   PMID:33431889  
PMID:33542414   PMID:33545068   PMID:33567341   PMID:33571422   PMID:33574241   PMID:33619536   PMID:33644029   PMID:33658435   PMID:33672238   PMID:33711283   PMID:33762435   PMID:33775711  
PMID:33822413   PMID:33908654   PMID:33916271   PMID:33957083   PMID:33961781   PMID:33991504   PMID:34079125   PMID:34156462   PMID:34240781   PMID:34244482   PMID:34244565   PMID:34299191  
PMID:34428256   PMID:34462429   PMID:34499769   PMID:34528172   PMID:34542825   PMID:34591612   PMID:34642328   PMID:34677749   PMID:34709727   PMID:34728620   PMID:34870550   PMID:34909679  
PMID:35013218   PMID:35053410   PMID:35061295   PMID:35124280   PMID:35140242   PMID:35256949   PMID:35271311   PMID:35395848   PMID:35442158   PMID:35446349   PMID:35530310   PMID:35546148  
PMID:35562734   PMID:35563538   PMID:35628491   PMID:35652686   PMID:35657686   PMID:35676246   PMID:35676659   PMID:35687106   PMID:35704671   PMID:35760815   PMID:35767179   PMID:35776542  
PMID:35777956   PMID:35831314   PMID:35831895   PMID:35883419   PMID:35944360   PMID:36027913   PMID:36055981   PMID:36057605   PMID:36078164   PMID:36114006   PMID:36167183   PMID:36168627  
PMID:36170818   PMID:36215168   PMID:36225252   PMID:36261009   PMID:36282215   PMID:36339263   PMID:36385105   PMID:36424410   PMID:36517590   PMID:36530572   PMID:36597993   PMID:36736316  
PMID:36762613   PMID:36830641   PMID:36833281   PMID:36929488   PMID:36931492   PMID:36987811   PMID:37390645   PMID:37418085   PMID:37536630   PMID:37774976   PMID:37827155   PMID:37930617  
PMID:37932471   PMID:38062957   PMID:38093134   PMID:38113892   PMID:38172120   PMID:38266641  


Genomics

Comparative Map Data
HSPA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385133,052,013 - 133,106,449 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5133,052,013 - 133,106,449 (+)EnsemblGRCh38hg38GRCh38
GRCh375132,387,705 - 132,442,141 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,415,561 - 132,468,608 (+)NCBINCBI36Build 36hg18NCBI36
Build 345132,415,560 - 132,468,608NCBI
Celera5128,517,326 - 128,569,460 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,579,243 - 127,632,290 (+)NCBIHuRef
CHM1_15131,820,919 - 131,874,036 (+)NCBICHM1_1
T2T-CHM13v2.05133,562,175 - 133,626,191 (+)NCBIT2T-CHM13v2.0
Hspa4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,150,641 - 53,191,306 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,150,641 - 53,191,284 (-)EnsemblGRCm39 Ensembl
GRCm381153,259,814 - 53,300,479 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,259,814 - 53,300,457 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,073,316 - 53,113,981 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,104,997 - 53,143,812 (-)NCBIMGSCv36mm8
Celera1157,839,531 - 57,880,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.91NCBI
Hspa4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81037,908,866 - 37,951,994 (-)NCBIGRCr8
mRatBN7.21037,408,025 - 37,449,080 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,408,025 - 37,449,001 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,101,220 - 42,141,891 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,591,248 - 41,631,920 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,094,962 - 37,135,636 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01038,601,624 - 38,642,397 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,601,624 - 38,642,397 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,383,101 - 38,424,016 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41038,705,629 - 38,749,058 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11038,712,058 - 38,755,488 (-)NCBI
Celera1036,756,477 - 36,796,741 (-)NCBICelera
Cytogenetic Map10q22NCBI
Hspa4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554084,379,825 - 4,423,381 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554084,379,825 - 4,422,710 (+)NCBIChiLan1.0ChiLan1.0
HSPA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24128,358,202 - 128,410,864 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15126,497,801 - 126,552,375 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05128,463,186 - 128,517,563 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,619,076 - 134,673,658 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,619,076 - 134,673,658 (+)Ensemblpanpan1.1panPan2
HSPA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11121,290,603 - 21,363,701 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1121,290,621 - 21,505,122 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1120,116,763 - 20,164,574 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01122,073,430 - 22,146,303 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1122,073,445 - 22,146,281 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,814,567 - 20,862,388 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,662,175 - 20,709,970 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01121,304,890 - 21,352,758 (+)NCBIUU_Cfam_GSD_1.0
Hspa4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,084,886 - 115,130,573 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,087,604 - 2,133,355 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,087,650 - 2,133,343 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2135,345,867 - 135,391,108 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12135,345,724 - 135,391,112 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,866,335 - 140,911,632 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSPA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,862,817 - 35,917,490 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,862,814 - 35,918,287 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603442,023,595 - 42,078,723 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hspa4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473339,021,738 - 39,068,132 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473339,022,511 - 39,068,153 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HSPA4
35 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh38/hg38 5q31.1(chr5:132816203-135383158)x1 copy number loss See cases [RCV000052113] Chr5:132816203..135383158 [GRCh38]
Chr5:132151895..134718848 [GRCh37]
Chr5:132179794..134746747 [NCBI36]
Chr5:5q31.1
pathogenic
GRCh38/hg38 5q31.1(chr5:132301874-134187817)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053312]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053312]|See cases [RCV000053312] Chr5:132301874..134187817 [GRCh38]
Chr5:131637567..133523508 [GRCh37]
Chr5:131665466..133551407 [NCBI36]
Chr5:5q31.1
uncertain significance
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2
pathogenic
NM_002154.3(HSPA4):c.1289A>G (p.Lys430Arg) single nucleotide variant Malignant melanoma [RCV000066628] Chr5:133089606 [GRCh38]
Chr5:132425298 [GRCh37]
Chr5:132453197 [NCBI36]
Chr5:5q31.1
not provided
GRCh38/hg38 5q31.1(chr5:131626503-135815054)x1 copy number loss See cases [RCV000135442] Chr5:131626503..135815054 [GRCh38]
Chr5:130962196..135150743 [GRCh37]
Chr5:130990095..135178642 [NCBI36]
Chr5:5q31.1
pathogenic
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3
likely benign
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3
pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV002231249]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2
pathogenic
GRCh37/hg19 5q31.1(chr5:131484039-132998360)x3 copy number gain Blepharophimosis [RCV000677199] Chr5:131484039..132998360 [GRCh37]
Chr5:5q31.1
uncertain significance
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q23.2-31.2(chr5:126377719-136270989)x1 copy number loss not provided [RCV000762739] Chr5:126377719..136270989 [GRCh37]
Chr5:5q23.2-31.2
likely pathogenic
NM_002154.4(HSPA4):c.1304A>G (p.Tyr435Cys) single nucleotide variant Inborn genetic diseases [RCV003245360] Chr5:133089621 [GRCh38]
Chr5:132425313 [GRCh37]
Chr5:5q31.1
uncertain significance
NM_002154.4(HSPA4):c.1651-10A>G single nucleotide variant not provided [RCV000949918] Chr5:133096088 [GRCh38]
Chr5:132431780 [GRCh37]
Chr5:5q31.1
benign
NM_002154.4(HSPA4):c.2086C>T (p.Pro696Ser) single nucleotide variant not provided [RCV000966348] Chr5:133101807 [GRCh38]
Chr5:132437499 [GRCh37]
Chr5:5q31.1
benign
NM_002154.4(HSPA4):c.96C>T (p.Asp32=) single nucleotide variant not provided [RCV000899496] Chr5:133052346 [GRCh38]
Chr5:132388038 [GRCh37]
Chr5:5q31.1
benign
NM_002154.4(HSPA4):c.1946C>G (p.Thr649Ser) single nucleotide variant not provided [RCV000949501] Chr5:133099561 [GRCh38]
Chr5:132435253 [GRCh37]
Chr5:5q31.1
benign
NM_002154.4(HSPA4):c.594A>C (p.Val198=) single nucleotide variant not provided [RCV000948301] Chr5:133074057 [GRCh38]
Chr5:132409749 [GRCh37]
Chr5:5q31.1
benign
NM_002154.4(HSPA4):c.528A>G (p.Ala176=) single nucleotide variant not provided [RCV000924315] Chr5:133073328 [GRCh38]
Chr5:132409020 [GRCh37]
Chr5:5q31.1
likely benign
NM_002154.4(HSPA4):c.664-4T>A single nucleotide variant not provided [RCV000964990] Chr5:133076650 [GRCh38]
Chr5:132412342 [GRCh37]
Chr5:5q31.1
benign
NM_002154.4(HSPA4):c.826T>C (p.Leu276=) single nucleotide variant not provided [RCV000887402] Chr5:133076816 [GRCh38]
Chr5:132412508 [GRCh37]
Chr5:5q31.1
benign
NM_002154.4(HSPA4):c.1672G>A (p.Asp558Asn) single nucleotide variant Inborn genetic diseases [RCV003267771] Chr5:133096119 [GRCh38]
Chr5:132431811 [GRCh37]
Chr5:5q31.1
uncertain significance
NM_002154.4(HSPA4):c.2515A>G (p.Ile839Val) single nucleotide variant Inborn genetic diseases [RCV003247942] Chr5:133104428 [GRCh38]
Chr5:132440120 [GRCh37]
Chr5:5q31.1
uncertain significance
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance
NM_002154.4(HSPA4):c.2271G>C (p.Leu757Phe) single nucleotide variant Inborn genetic diseases [RCV003269784] Chr5:133103978 [GRCh38]
Chr5:132439670 [GRCh37]
Chr5:5q31.1
uncertain significance
NM_002154.4(HSPA4):c.1262C>G (p.Ser421Cys) single nucleotide variant Inborn genetic diseases [RCV003269055] Chr5:133089579 [GRCh38]
Chr5:132425271 [GRCh37]
Chr5:5q31.1
uncertain significance
NM_002154.4(HSPA4):c.2069A>G (p.Gln690Arg) single nucleotide variant Inborn genetic diseases [RCV003250891] Chr5:133101790 [GRCh38]
Chr5:132437482 [GRCh37]
Chr5:5q31.1
uncertain significance
NM_002154.4(HSPA4):c.453A>G (p.Ala151=) single nucleotide variant not provided [RCV000881289] Chr5:133073253 [GRCh38]
Chr5:132408945 [GRCh37]
Chr5:5q31.1
benign
GRCh37/hg19 5q23.3-31.1(chr5:127800418-134002686) copy number loss Neurodevelopmental disorder and language delay with or without structural brain abnormalities [RCV003236718] Chr5:127800418..134002686 [GRCh37]
Chr5:5q23.3-31.1
pathogenic
NM_002154.4(HSPA4):c.1237G>T (p.Gly413Trp) single nucleotide variant Inborn genetic diseases [RCV003242718] Chr5:133089154 [GRCh38]
Chr5:132424846 [GRCh37]
Chr5:5q31.1
uncertain significance
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910) copy number gain not specified [RCV002053526] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3
pathogenic
GRCh37/hg19 5q31.1-31.2(chr5:132031902-137623639) copy number loss not specified [RCV002053530] Chr5:132031902..137623639 [GRCh37]
Chr5:5q31.1-31.2
pathogenic
GRCh37/hg19 5q31.1(chr5:132181132-132605222)x3 copy number gain not provided [RCV001827742] Chr5:132181132..132605222 [GRCh37]
Chr5:5q31.1
uncertain significance
NM_002154.4(HSPA4):c.2161G>T (p.Asp721Tyr) single nucleotide variant Inborn genetic diseases [RCV002752044] Chr5:133103868 [GRCh38]
Chr5:132439560 [GRCh37]
Chr5:5q31.1
uncertain significance
NM_002154.4(HSPA4):c.2301G>C (p.Glu767Asp) single nucleotide variant Inborn genetic diseases [RCV002692890] Chr5:133104008 [GRCh38]
Chr5:132439700 [GRCh37]
Chr5:5q31.1
uncertain significance
NM_002154.4(HSPA4):c.2461G>A (p.Gly821Ser) single nucleotide variant Inborn genetic diseases [RCV002767028] Chr5:133104374 [GRCh38]
Chr5:132440066 [GRCh37]
Chr5:5q31.1
uncertain significance
NM_002154.4(HSPA4):c.969T>G (p.Ser323Arg) single nucleotide variant Inborn genetic diseases [RCV002767342] Chr5:133086842 [GRCh38]
Chr5:132422534 [GRCh37]
Chr5:5q31.1
uncertain significance
NM_002154.4(HSPA4):c.1961A>G (p.Asp654Gly) single nucleotide variant Inborn genetic diseases [RCV002960898] Chr5:133099576 [GRCh38]
Chr5:132435268 [GRCh37]
Chr5:5q31.1
uncertain significance
NM_002154.4(HSPA4):c.1670A>G (p.Lys557Arg) single nucleotide variant Inborn genetic diseases [RCV002878253] Chr5:133096117 [GRCh38]
Chr5:132431809 [GRCh37]
Chr5:5q31.1
uncertain significance
NM_002154.4(HSPA4):c.829A>T (p.Met277Leu) single nucleotide variant Inborn genetic diseases [RCV002940881] Chr5:133076819 [GRCh38]
Chr5:132412511 [GRCh37]
Chr5:5q31.1
uncertain significance
NM_002154.4(HSPA4):c.1741A>G (p.Ile581Val) single nucleotide variant Inborn genetic diseases [RCV003190656] Chr5:133096188 [GRCh38]
Chr5:132431880 [GRCh37]
Chr5:5q31.1
uncertain significance
NM_002154.4(HSPA4):c.316A>T (p.Met106Leu) single nucleotide variant Inborn genetic diseases [RCV003220397] Chr5:133070383 [GRCh38]
Chr5:132406075 [GRCh37]
Chr5:5q31.1
uncertain significance
NM_002154.4(HSPA4):c.191T>C (p.Val64Ala) single nucleotide variant Inborn genetic diseases [RCV003386273] Chr5:133067442 [GRCh38]
Chr5:132403134 [GRCh37]
Chr5:5q31.1
uncertain significance
NM_002154.4(HSPA4):c.1596A>T (p.Glu532Asp) single nucleotide variant Inborn genetic diseases [RCV003370148] Chr5:133092735 [GRCh38]
Chr5:132428427 [GRCh37]
Chr5:5q31.1
uncertain significance
NM_002154.4(HSPA4):c.1567C>G (p.Gln523Glu) single nucleotide variant Inborn genetic diseases [RCV003370147] Chr5:133092706 [GRCh38]
Chr5:132428398 [GRCh37]
Chr5:5q31.1
uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR30C2hsa-miR-30c-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI22842562
MIR30C1hsa-miR-30c-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI22842562

Predicted Target Of
Summary Value
Count of predictions:877
Count of miRNA genes:608
Interacting mature miRNAs:683
Transcripts:ENST00000304858, ENST00000504328, ENST00000514825
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-147123  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,393,446 - 132,393,726UniSTSGRCh37
Build 365132,421,345 - 132,421,625RGDNCBI36
Celera5128,523,112 - 128,523,392RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,585,028 - 127,585,308UniSTS
TNG Radiation Hybrid Map561135.0UniSTS
HSPA4_7803  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,440,258 - 132,440,843UniSTSGRCh37
Build 365132,468,157 - 132,468,742RGDNCBI36
Celera5128,569,009 - 128,569,594RGD
HuRef5127,631,839 - 127,632,424UniSTS
SHGC-35073  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,440,796 - 132,440,927UniSTSGRCh37
Build 365132,468,695 - 132,468,826RGDNCBI36
Celera5128,569,547 - 128,569,678RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,632,377 - 127,632,508UniSTS
GeneMap99-GB4 RH Map5503.44UniSTS
Whitehead-RH Map5420.0UniSTS
NCBI RH Map5839.9UniSTS
GeneMap99-G3 RH Map55084.0UniSTS
RH65703  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,424,834 - 132,425,374UniSTSGRCh37
Build 365132,452,733 - 132,453,273RGDNCBI36
Celera5128,553,413 - 128,553,953RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,616,416 - 127,616,956UniSTS
GeneMap99-GB4 RH Map5510.63UniSTS
STS-R11513  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,439,941 - 132,440,131UniSTSGRCh37
Build 365132,467,840 - 132,468,030RGDNCBI36
Celera5128,568,692 - 128,568,882RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,631,522 - 127,631,712UniSTS
GeneMap99-GB4 RH Map5501.96UniSTS
HSPA4  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,439,655 - 132,440,112UniSTSGRCh37
Celera5128,568,406 - 128,568,863UniSTS
HuRef5127,631,236 - 127,631,693UniSTS
STS-H93522  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q31.1UniSTS
HuRef5127,615,795 - 127,615,947UniSTS
GeneMap99-GB4 RH Map5502.26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2435 2620 1678 577 1702 417 4355 2090 3565 405 1459 1613 174 1 1202 2788 5 2
Low 4 371 48 47 249 48 2 107 169 14 1 1 2 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_002154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054352493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB023420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB209151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC113410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK057015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC126122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC126124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG723797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ431980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU171424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU686725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF145856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ224293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L12723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X67640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X67643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000304858   ⟹   ENSP00000302961
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5133,052,013 - 133,106,449 (+)Ensembl
RefSeq Acc Id: ENST00000504328
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5133,076,043 - 133,088,495 (+)Ensembl
RefSeq Acc Id: ENST00000514825
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5133,101,596 - 133,104,477 (+)Ensembl
RefSeq Acc Id: ENST00000615899   ⟹   ENSP00000478102
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5133,052,241 - 133,103,908 (+)Ensembl
RefSeq Acc Id: ENST00000617074   ⟹   ENSP00000481686
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5133,052,128 - 133,103,949 (+)Ensembl
RefSeq Acc Id: NM_002154   ⟹   NP_002145
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385133,052,013 - 133,106,449 (+)NCBI
GRCh375132,387,662 - 132,440,709 (+)ENTREZGENE
Build 365132,415,561 - 132,468,608 (+)NCBI Archive
HuRef5127,579,243 - 127,632,290 (+)ENTREZGENE
CHM1_15131,820,919 - 131,874,036 (+)NCBI
T2T-CHM13v2.05133,571,755 - 133,626,191 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054352493   ⟹   XP_054208468
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05133,562,175 - 133,626,191 (+)NCBI
Protein Sequences
Protein RefSeqs NP_002145 (Get FASTA)   NCBI Sequence Viewer  
  XP_054208468 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA02807 (Get FASTA)   NCBI Sequence Viewer  
  AAH02526 (Get FASTA)   NCBI Sequence Viewer  
  AAI10862 (Get FASTA)   NCBI Sequence Viewer  
  AAI26123 (Get FASTA)   NCBI Sequence Viewer  
  AAI26125 (Get FASTA)   NCBI Sequence Viewer  
  AAP36039 (Get FASTA)   NCBI Sequence Viewer  
  ACI45985 (Get FASTA)   NCBI Sequence Viewer  
  BAA75062 (Get FASTA)   NCBI Sequence Viewer  
  BAD92388 (Get FASTA)   NCBI Sequence Viewer  
  BAF98753 (Get FASTA)   NCBI Sequence Viewer  
  BAF98762 (Get FASTA)   NCBI Sequence Viewer  
  BAF98766 (Get FASTA)   NCBI Sequence Viewer  
  BAF98778 (Get FASTA)   NCBI Sequence Viewer  
  BAG57963 (Get FASTA)   NCBI Sequence Viewer  
  BAG58655 (Get FASTA)   NCBI Sequence Viewer  
  BAG60110 (Get FASTA)   NCBI Sequence Viewer  
  BAG61610 (Get FASTA)   NCBI Sequence Viewer  
  BAG61859 (Get FASTA)   NCBI Sequence Viewer  
  BAG62435 (Get FASTA)   NCBI Sequence Viewer  
  BAG64438 (Get FASTA)   NCBI Sequence Viewer  
  BAG65366 (Get FASTA)   NCBI Sequence Viewer  
  CAA47885 (Get FASTA)   NCBI Sequence Viewer  
  CAA47886 (Get FASTA)   NCBI Sequence Viewer  
  EAW62294 (Get FASTA)   NCBI Sequence Viewer  
  EAW62295 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000302961
  ENSP00000302961.2
GenBank Protein P34932 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_002145   ⟸   NM_002154
- UniProtKB: Q2TAL4 (UniProtKB/Swiss-Prot),   O95756 (UniProtKB/Swiss-Prot),   Q9BUK9 (UniProtKB/Swiss-Prot),   P34932 (UniProtKB/Swiss-Prot),   B4DH02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000478102   ⟸   ENST00000615899
RefSeq Acc Id: ENSP00000481686   ⟸   ENST00000617074
RefSeq Acc Id: ENSP00000302961   ⟸   ENST00000304858
RefSeq Acc Id: XP_054208468   ⟸   XM_054352493
- Peptide Label: isoform X1
- UniProtKB: Q2TAL4 (UniProtKB/Swiss-Prot),   P34932 (UniProtKB/Swiss-Prot),   O95756 (UniProtKB/Swiss-Prot),   Q9BUK9 (UniProtKB/Swiss-Prot),   B4DH02 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P34932-F1-model_v2 AlphaFold P34932 1-840 view protein structure

Promoters
RGD ID:6803263
Promoter ID:HG_KWN:51097
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000321956,   OTTHUMT00000251011
Position:
Human AssemblyChrPosition (strand)Source
Build 365132,415,121 - 132,415,621 (+)MPROMDB
RGD ID:6815525
Promoter ID:HG_MRA:12951
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:AK311316,   AK315887
Position:
Human AssemblyChrPosition (strand)Source
Build 365132,455,796 - 132,456,296 (+)MPROMDB
RGD ID:6870572
Promoter ID:EPDNEW_H8451
Type:initiation region
Name:HSPA4_1
Description:heat shock protein family A member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385133,052,034 - 133,052,094EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5237 AgrOrtholog
COSMIC HSPA4 COSMIC
Ensembl Genes ENSG00000170606 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000304858 ENTREZGENE
  ENST00000304858.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.30.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.420.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000170606 GTEx
HGNC ID HGNC:5237 ENTREZGENE
Human Proteome Map HSPA4 Human Proteome Map
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSPA4_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3308 UniProtKB/Swiss-Prot
NCBI Gene 3308 ENTREZGENE
OMIM 601113 OMIM
PANTHER HEAT SHOCK 70 KDA PROTEIN 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSC70CB, ISOFORM G-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HSP70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29503 PharmGKB
PRINTS HEATSHOCK70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HSP70_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Actin-like ATPase domain UniProtKB/TrEMBL
  Heat shock protein 70kD (HSP70), C-terminal subdomain UniProtKB/TrEMBL
  Heat shock protein 70kD (HSP70), peptide-binding domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF100934 UniProtKB/Swiss-Prot
  SSF53067 UniProtKB/Swiss-Prot
UniProt B4DH02 ENTREZGENE, UniProtKB/TrEMBL
  HSP74_HUMAN UniProtKB/Swiss-Prot
  O95756 ENTREZGENE
  P34932 ENTREZGENE
  Q2TAL4 ENTREZGENE
  Q9BUK9 ENTREZGENE
UniProt Secondary O95756 UniProtKB/Swiss-Prot
  Q2TAL4 UniProtKB/Swiss-Prot
  Q9BUK9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 HSPA4  heat shock protein family A (Hsp70) member 4    heat shock 70kDa protein 4  Symbol and/or name change 5135510 APPROVED