HSPA4 (heat shock protein family A (Hsp70) member 4) - Rat Genome Database

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Gene: HSPA4 (heat shock protein family A (Hsp70) member 4) Homo sapiens
Analyze
Symbol: HSPA4
Name: heat shock protein family A (Hsp70) member 4
RGD ID: 733190
HGNC Page HGNC
Description: Predicted to have ATP binding activity. Involved in chaperone-mediated protein complex assembly and protein insertion into mitochondrial outer membrane. Localizes to cytosol and extracellular exosome. Implicated in Chagas disease. Biomarker of chronic obstructive pulmonary disease; rheumatoid arthritis; type 2 diabetes mellitus; and ulcerative colitis; PARTICIPATES IN antigen processing and presentation pathway; cortisol signaling pathway; estrogen signaling pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: APG-2; epididymis secretory sperm binding protein Li 5a; heat shock 70 kDa protein 4; heat shock 70-related protein APG-2; heat shock 70kD protein 4; heat shock 70kDa protein 4; heat shock protein, 110 kDa; HEL-S-5a; HS24/P52; hsp70; hsp70 RY; hsp70RY; HSPH2; MGC131852; RY
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5133,052,013 - 133,106,449 (+)EnsemblGRCh38hg38GRCh38
GRCh385133,052,013 - 133,106,449 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375132,387,705 - 132,442,141 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,415,561 - 132,468,608 (+)NCBINCBI36hg18NCBI36
Build 345132,415,560 - 132,468,608NCBI
Celera5128,517,326 - 128,569,460 (+)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5127,579,243 - 127,632,290 (+)NCBIHuRef
CHM1_15131,820,919 - 131,874,036 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
3,3'-Dichlorobenzidine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-fluorouracil  (EXP)
acrylamide  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
albendazole  (EXP)
ammonium chloride  (ISO)
amphibole asbestos  (EXP)
Aroclor 1254  (ISO)
arsenous acid  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calciol  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
casticin  (ISO)
chloropicrin  (EXP)
chlorpyrifos  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
curcumin  (EXP)
cyclosporin A  (EXP)
DDT  (ISO)
diarsenic trioxide  (EXP)
disulfiram  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
elemental selenium  (EXP)
enzyme inhibitor  (EXP)
ethanol  (ISO)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
fulvestrant  (EXP)
gamma-hexachlorocyclohexane  (ISO)
geldanamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
isobutyl nitrite  (ISO)
ivermectin  (EXP)
linalool  (EXP)
lycopene  (ISO)
manganese(II) sulfate  (ISO)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (EXP)
methylmercury chloride  (EXP)
methylparaben  (EXP)
Mitotane  (ISO)
motexafin gadolinium  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosomorpholine  (ISO)
nonanoic acid  (ISO)
Nonidet P-40  (EXP)
oxidopamine  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl isothiocyanate  (EXP)
pirinixic acid  (ISO)
progesterone  (ISO)
Propiverine  (ISO)
prostaglandin A1  (ISO)
quercetin  (EXP,ISO)
raloxifene  (EXP)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sarin  (EXP)
SB 431542  (EXP)
selenium atom  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
succimer  (ISO)
sulforaphane  (EXP)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tanespimycin  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
thiostrepton  (EXP)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (EXP)
tunicamycin  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vitamin E  (EXP)
vorinostat  (EXP)
zearalenone  (ISO)
zinc acetate  (EXP)
zinc atom  (EXP)
zinc pyrithione  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Bishayee A, etal., Mol Carcinog. 2011 Dec 27. doi: 10.1002/mc.21860.
2. Cappello F, etal., PLoS One. 2011;6(11):e28200. Epub 2011 Nov 28.
3. Di Paola R, etal., Biochem Pharmacol. 2011 Nov 15;82(10):1478-89. Epub 2011 Jul 20.
4. Fernandez-Villegas A, etal., BMC Infect Dis. 2011 Jul 31;11:206.
5. GOA_HUMAN data from the GO Consortium
6. Hacker S, etal., Clin Lab. 2009;55(1-2):31-40.
7. Isajevs S, etal., Medicina (Kaunas). 2011;47(10):552-9.
8. Li J, etal., Mol Vis. 2012;18:317-29. Epub 2012 Feb 4.
9. Lu C, etal., J Immunol. 2011 Aug 1;187(3):1458-66. Epub 2011 Jun 27.
10. Moodley D, etal., J Inflamm (Lond). 2011 Nov 3;8(1):30.
11. Nakhjavani M, etal., Gene. 2012 Feb 13.
12. Pipeline to import KEGG annotations from KEGG into RGD
13. Pratt WB, etal., Handb Exp Pharmacol. 2006;(172):111-38.
14. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. RGD automated import pipeline for gene-chemical interactions
16. Smith DF and Toft DO, Mol Endocrinol. 2008 Oct;22(10):2229-40. Epub 2008 May 1.
17. Tomasello G, etal., Eur J Histochem. 2011 Oct 24;55(4):e38. doi: 10.4081/ejh.2011.e38.
18. Wang LC, etal., Am J Med Sci. 2012 Jan 12.
19. Weiss YG, etal., J Clin Invest. 2002 Sep;110(6):801-6.
20. Yoneyama M, etal., Neuropharmacology. 2008 Oct;55(5):693-703. Epub 2008 Jun 13.
21. Zhang Z, etal., Neuroimmunomodulation. 2012;19(1):10-9. Epub 2011 Nov 7.
22. Zheng Z, etal., J Cereb Blood Flow Metab. 2008 Jan;28(1):53-63. Epub 2007 May 2.
Additional References at PubMed
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PMID:28859986   PMID:28927264   PMID:29067554   PMID:29084938   PMID:29101097   PMID:29117863   PMID:29128334   PMID:29167402   PMID:29180628   PMID:29229926   PMID:29242247   PMID:29255093  
PMID:29259226   PMID:29274099   PMID:29290964   PMID:29311808   PMID:29317501   PMID:29331416   PMID:29395067   PMID:29404895   PMID:29434293   PMID:29438905   PMID:29442021   PMID:29467282  
PMID:29491085   PMID:29507755   PMID:29509794   PMID:29564676   PMID:29568061   PMID:29763298   PMID:29772540   PMID:29845934   PMID:29846670   PMID:29930177   PMID:29986884   PMID:29991511  
PMID:30021884   PMID:30098457   PMID:30099725   PMID:30196744   PMID:30209976   PMID:30245753   PMID:30277474   PMID:30337218   PMID:30349055   PMID:30413534   PMID:30442662   PMID:30446660  
PMID:30455355   PMID:30463901   PMID:30485823   PMID:30521813   PMID:30543447   PMID:30559338   PMID:30575818   PMID:30591555   PMID:30614112   PMID:30632067   PMID:30643287   PMID:30645756  
PMID:30700418   PMID:30833792   PMID:30862844   PMID:30865286   PMID:30911017   PMID:30947809   PMID:30948266   PMID:31059266   PMID:31073040   PMID:31091453   PMID:31141701   PMID:31189917  
PMID:31239290   PMID:31300519   PMID:31320752   PMID:31327756   PMID:31430337   PMID:31497350   PMID:31500722   PMID:31501420   PMID:31521893   PMID:31536960   PMID:31558706   PMID:31577950  
PMID:31586073   PMID:31659016   PMID:31685992   PMID:31759081   PMID:31792442   PMID:31918818   PMID:31980649   PMID:32041778   PMID:32084385   PMID:32097779   PMID:32127624   PMID:32129710  
PMID:32163396   PMID:32198203   PMID:32296183   PMID:32332101   PMID:32687490   PMID:32699135   PMID:32838362   PMID:33084814   PMID:33177717   PMID:33177718   PMID:33431889   PMID:33574241  


Genomics

Comparative Map Data
HSPA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5133,052,013 - 133,106,449 (+)EnsemblGRCh38hg38GRCh38
GRCh385133,052,013 - 133,106,449 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375132,387,705 - 132,442,141 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,415,561 - 132,468,608 (+)NCBINCBI36hg18NCBI36
Build 345132,415,560 - 132,468,608NCBI
Celera5128,517,326 - 128,569,460 (+)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5127,579,243 - 127,632,290 (+)NCBIHuRef
CHM1_15131,820,919 - 131,874,036 (+)NCBICHM1_1
Hspa4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,150,641 - 53,191,306 (-)NCBIGRCm39mm39
GRCm39 Ensembl1153,150,641 - 53,191,284 (-)Ensembl
GRCm381153,259,814 - 53,300,479 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,259,814 - 53,300,457 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,073,316 - 53,113,981 (-)NCBIGRCm37mm9NCBIm37
MGSCv361153,104,997 - 53,143,812 (-)NCBImm8
Celera1157,839,531 - 57,880,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.91NCBI
Hspa4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21037,408,025 - 37,449,080 (-)NCBI
Rnor_6.0 Ensembl1038,601,624 - 38,642,397 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01038,601,624 - 38,642,397 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01038,383,101 - 38,424,016 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41038,705,629 - 38,749,058 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11038,712,058 - 38,755,488 (-)NCBI
Celera1036,756,477 - 36,796,741 (-)NCBICelera
Cytogenetic Map10q22NCBI
Hspa4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554084,379,825 - 4,423,381 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554084,379,825 - 4,422,710 (+)NCBIChiLan1.0ChiLan1.0
HSPA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15134,619,076 - 134,673,658 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,619,076 - 134,673,658 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05128,463,186 - 128,517,563 (+)NCBIMhudiblu_PPA_v0panPan3
HSPA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11121,290,603 - 21,363,701 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1121,290,621 - 21,505,122 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1120,116,763 - 20,164,574 (+)NCBI
ROS_Cfam_1.01122,073,430 - 22,146,303 (+)NCBI
UMICH_Zoey_3.11120,814,567 - 20,862,388 (+)NCBI
UNSW_CanFamBas_1.01120,662,175 - 20,709,970 (+)NCBI
UU_Cfam_GSD_1.01121,304,890 - 21,352,758 (+)NCBI
Hspa4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,084,886 - 115,130,573 (-)NCBI
SpeTri2.0NW_0049366472,087,650 - 2,133,343 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2135,305,749 - 135,394,185 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12135,345,724 - 135,391,112 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,866,335 - 140,911,632 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSPA4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,862,817 - 35,917,490 (+)NCBI
ChlSab1.1 Ensembl2335,862,814 - 35,918,287 (+)Ensembl
Hspa4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473339,022,511 - 39,068,153 (-)NCBI

Position Markers
SHGC-147123  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,393,446 - 132,393,726UniSTSGRCh37
Build 365132,421,345 - 132,421,625RGDNCBI36
Celera5128,523,112 - 128,523,392RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,585,028 - 127,585,308UniSTS
TNG Radiation Hybrid Map561135.0UniSTS
HSPA4_7803  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,440,258 - 132,440,843UniSTSGRCh37
Build 365132,468,157 - 132,468,742RGDNCBI36
Celera5128,569,009 - 128,569,594RGD
HuRef5127,631,839 - 127,632,424UniSTS
SHGC-35073  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,440,796 - 132,440,927UniSTSGRCh37
Build 365132,468,695 - 132,468,826RGDNCBI36
Celera5128,569,547 - 128,569,678RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,632,377 - 127,632,508UniSTS
GeneMap99-GB4 RH Map5503.44UniSTS
Whitehead-RH Map5420.0UniSTS
NCBI RH Map5839.9UniSTS
GeneMap99-G3 RH Map55084.0UniSTS
RH65703  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,424,834 - 132,425,374UniSTSGRCh37
Build 365132,452,733 - 132,453,273RGDNCBI36
Celera5128,553,413 - 128,553,953RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,616,416 - 127,616,956UniSTS
GeneMap99-GB4 RH Map5510.63UniSTS
STS-R11513  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,439,941 - 132,440,131UniSTSGRCh37
Build 365132,467,840 - 132,468,030RGDNCBI36
Celera5128,568,692 - 128,568,882RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,631,522 - 127,631,712UniSTS
GeneMap99-GB4 RH Map5501.96UniSTS
HSPA4  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375132,439,655 - 132,440,112UniSTSGRCh37
Celera5128,568,406 - 128,568,863UniSTS
HuRef5127,631,236 - 127,631,693UniSTS
STS-H93522  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q31.1UniSTS
HuRef5127,615,795 - 127,615,947UniSTS
GeneMap99-GB4 RH Map5502.26UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR30C2hsa-miR-30c-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI22842562
MIR30C1hsa-miR-30c-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI22842562

Predicted Target Of
Summary Value
Count of predictions:877
Count of miRNA genes:608
Interacting mature miRNAs:683
Transcripts:ENST00000304858, ENST00000504328, ENST00000514825
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2435 2620 1678 577 1702 417 4355 2090 3565 405 1459 1613 174 1 1202 2788 5 2
Low 4 371 48 47 249 48 2 107 169 14 1 1 2 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_002154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB023420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB209151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC113410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC126122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC126124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG723797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ431980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU171424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU686725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF145856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ224293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L12723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X67640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X67643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000304858   ⟹   ENSP00000302961
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5133,052,013 - 133,106,449 (+)Ensembl
RefSeq Acc Id: ENST00000504328
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5133,076,043 - 133,088,495 (+)Ensembl
RefSeq Acc Id: ENST00000514825
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5133,101,596 - 133,104,477 (+)Ensembl
RefSeq Acc Id: ENST00000615899   ⟹   ENSP00000478102
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5133,052,241 - 133,103,908 (+)Ensembl
RefSeq Acc Id: ENST00000617074   ⟹   ENSP00000481686
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5133,052,128 - 133,103,949 (+)Ensembl
RefSeq Acc Id: NM_002154   ⟹   NP_002145
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385133,052,013 - 133,106,449 (+)NCBI
GRCh375132,387,662 - 132,440,709 (+)ENTREZGENE
Build 365132,415,561 - 132,468,608 (+)NCBI Archive
HuRef5127,579,243 - 127,632,290 (+)ENTREZGENE
CHM1_15131,820,919 - 131,874,036 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002145   ⟸   NM_002154
- UniProtKB: P34932 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000478102   ⟸   ENST00000615899
RefSeq Acc Id: ENSP00000481686   ⟸   ENST00000617074
RefSeq Acc Id: ENSP00000302961   ⟸   ENST00000304858

Promoters
RGD ID:6803263
Promoter ID:HG_KWN:51097
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000321956,   OTTHUMT00000251011
Position:
Human AssemblyChrPosition (strand)Source
Build 365132,415,121 - 132,415,621 (+)MPROMDB
RGD ID:6815525
Promoter ID:HG_MRA:12951
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:AK311316,   AK315887
Position:
Human AssemblyChrPosition (strand)Source
Build 365132,455,796 - 132,456,296 (+)MPROMDB
RGD ID:6870572
Promoter ID:EPDNEW_H8451
Type:initiation region
Name:HSPA4_1
Description:heat shock protein family A member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385133,052,034 - 133,052,094EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh38/hg38 5q31.1(chr5:132816203-135383158)x1 copy number loss See cases [RCV000052113] Chr5:132816203..135383158 [GRCh38]
Chr5:132151895..134718848 [GRCh37]
Chr5:132179794..134746747 [NCBI36]
Chr5:5q31.1
pathogenic
GRCh38/hg38 5q31.1(chr5:132301874-134187817)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053312]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053312]|See cases [RCV000053312] Chr5:132301874..134187817 [GRCh38]
Chr5:131637567..133523508 [GRCh37]
Chr5:131665466..133551407 [NCBI36]
Chr5:5q31.1
uncertain significance
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2
pathogenic
NM_002154.3(HSPA4):c.1289A>G (p.Lys430Arg) single nucleotide variant Malignant melanoma [RCV000066628] Chr5:133089606 [GRCh38]
Chr5:132425298 [GRCh37]
Chr5:132453197 [NCBI36]
Chr5:5q31.1
not provided
GRCh38/hg38 5q31.1(chr5:131626503-135815054)x1 copy number loss See cases [RCV000135442] Chr5:131626503..135815054 [GRCh38]
Chr5:130962196..135150743 [GRCh37]
Chr5:130990095..135178642 [NCBI36]
Chr5:5q31.1
pathogenic
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3
likely benign
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3
pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2
pathogenic
GRCh37/hg19 5q31.1(chr5:131484039-132998360)x3 copy number gain Blepharophimosis [RCV000677199] Chr5:131484039..132998360 [GRCh37]
Chr5:5q31.1
uncertain significance
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q23.2-31.2(chr5:126377719-136270989)x1 copy number loss not provided [RCV000762739] Chr5:126377719..136270989 [GRCh37]
Chr5:5q23.2-31.2
likely pathogenic
NM_002154.4(HSPA4):c.1651-10A>G single nucleotide variant not provided [RCV000949918] Chr5:133096088 [GRCh38]
Chr5:132431780 [GRCh37]
Chr5:5q31.1
benign
NM_002154.4(HSPA4):c.2086C>T (p.Pro696Ser) single nucleotide variant not provided [RCV000966348] Chr5:133101807 [GRCh38]
Chr5:132437499 [GRCh37]
Chr5:5q31.1
benign
NM_002154.4(HSPA4):c.96C>T (p.Asp32=) single nucleotide variant not provided [RCV000899496] Chr5:133052346 [GRCh38]
Chr5:132388038 [GRCh37]
Chr5:5q31.1
benign
NM_002154.4(HSPA4):c.1946C>G (p.Thr649Ser) single nucleotide variant not provided [RCV000949501] Chr5:133099561 [GRCh38]
Chr5:132435253 [GRCh37]
Chr5:5q31.1
benign
NM_002154.4(HSPA4):c.594A>C (p.Val198=) single nucleotide variant not provided [RCV000948301] Chr5:133074057 [GRCh38]
Chr5:132409749 [GRCh37]
Chr5:5q31.1
benign
NM_002154.4(HSPA4):c.528A>G (p.Ala176=) single nucleotide variant not provided [RCV000924315] Chr5:133073328 [GRCh38]
Chr5:132409020 [GRCh37]
Chr5:5q31.1
likely benign
NM_002154.4(HSPA4):c.664-4T>A single nucleotide variant not provided [RCV000964990] Chr5:133076650 [GRCh38]
Chr5:132412342 [GRCh37]
Chr5:5q31.1
benign
NM_002154.4(HSPA4):c.826T>C (p.Leu276=) single nucleotide variant not provided [RCV000887402] Chr5:133076816 [GRCh38]
Chr5:132412508 [GRCh37]
Chr5:5q31.1
benign
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance
NM_002154.4(HSPA4):c.453A>G (p.Ala151=) single nucleotide variant not provided [RCV000881289] Chr5:133073253 [GRCh38]
Chr5:132408945 [GRCh37]
Chr5:5q31.1
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5237 AgrOrtholog
COSMIC HSPA4 COSMIC
Ensembl Genes ENSG00000170606 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000302961 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000478102 UniProtKB/TrEMBL
  ENSP00000481686 UniProtKB/TrEMBL
Ensembl Transcript ENST00000304858 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000615899 UniProtKB/TrEMBL
  ENST00000617074 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.34.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000170606 GTEx
HGNC ID HGNC:5237 ENTREZGENE
Human Proteome Map HSPA4 Human Proteome Map
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSPA4_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3308 UniProtKB/Swiss-Prot
NCBI Gene 3308 ENTREZGENE
OMIM 601113 OMIM
Pfam HSP70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29503 PharmGKB
PROSITE HSP70_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF100934 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WTS8_HUMAN UniProtKB/TrEMBL
  A0A087WYC1_HUMAN UniProtKB/TrEMBL
  HSP74_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O95756 UniProtKB/Swiss-Prot
  Q2TAL4 UniProtKB/Swiss-Prot
  Q9BUK9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 HSPA4  heat shock protein family A (Hsp70) member 4    heat shock 70kDa protein 4  Symbol and/or name change 5135510 APPROVED