Hspa4 (heat shock protein 4) - Rat Genome Database

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Gene: Hspa4 (heat shock protein 4) Mus musculus
Analyze
Symbol: Hspa4
Name: heat shock protein 4
RGD ID: 733191
MGI Page MGI
Description: Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity and adenyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including chaperone-mediated protein complex assembly; negative regulation of macromolecule metabolic process; and protein insertion into mitochondrial outer membrane. Predicted to be located in extracellular exosome and lipid droplet. Predicted to be active in cytosol and nucleus. Is expressed in cerebral cortex and genitourinary system. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to human HSPA4 (heat shock protein family A (Hsp70) member 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 70kD; 70kDa; AI317151; APG; APG-2; heat shock 70 kDa protein 4; heat shock 70-related protein APG-2; heat shock protein, 110 kDa; Hsp1; Hsp110; Hsp7; Hsp70RY; KIAA4025; mKIAA4025
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,150,641 - 53,191,306 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,150,641 - 53,191,284 (-)EnsemblGRCm39 Ensembl
GRCm381153,259,814 - 53,300,479 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,259,814 - 53,300,457 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,073,316 - 53,113,981 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,104,997 - 53,143,812 (-)NCBIMGSCv36mm8
Celera1157,839,531 - 57,880,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
3,3'-Dichlorobenzidine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
albendazole  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP,ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (EXP)
cannabidiol  (ISO)
carbon nanotube  (EXP)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
casticin  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
clofibrate  (EXP)
clotrimazole  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
DDT  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (ISO)
geldanamycin  (ISO)
gentamycin  (ISO)
glyphosate  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
isobutyl nitrite  (EXP)
ivermectin  (ISO)
linalool  (ISO)
lycopene  (ISO)
manganese(II) sulfate  (ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
Mitotane  (ISO)
motexafin gadolinium  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-nitrosomorpholine  (ISO)
nonanoic acid  (EXP)
Nonidet P-40  (ISO)
oxidopamine  (ISO)
paracetamol  (EXP)
PCB138  (ISO)
pentachlorophenol  (EXP)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
Propiverine  (ISO)
prostaglandin A1  (EXP)
quercetin  (EXP,ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
succimer  (EXP)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP)
tanespimycin  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
thiostrepton  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (EXP)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zearalenone  (EXP)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Black currant phytoconstituents exert chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis by suppression of the inflammatory response. Bishayee A, etal., Mol Carcinog. 2011 Dec 27. doi: 10.1002/mc.21860.
2. Convergent sets of data from in vivo and in vitro methods point to an active role of Hsp60 in chronic obstructive pulmonary disease pathogenesis. Cappello F, etal., PLoS One. 2011;6(11):e28200. Epub 2011 Nov 28.
3. Administration of carnosine in the treatment of acute spinal cord injury. Di Paola R, etal., Biochem Pharmacol. 2011 Nov 15;82(10):1478-89. Epub 2011 Jul 20.
4. Short-term follow-up of chagasic patients after benznidazole treatment using multiple serological markers. Fernandez-Villegas A, etal., BMC Infect Dis. 2011 Jul 31;11:206.
5. Elevated HSP27, HSP70 and HSP90 alpha in chronic obstructive pulmonary disease: markers for immune activation and tissue destruction. Hacker S, etal., Clin Lab. 2009;55(1-2):31-40.
6. Mildronate as a regulator of protein expression in a rat model of Parkinson's disease. Isajevs S, etal., Medicina (Kaunas). 2011;47(10):552-9.
7. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, etal., Hum Mol Genet 1998 Nov;7(12):1967-78.
8. Therapeutic efficacy of trehalose eye drops for treatment of murine dry eye induced by an intelligently controlled environmental system. Li J, etal., Mol Vis. 2012;18:317-29. Epub 2012 Feb 4.
9. TLR2 ligand induces protection against cerebral ischemia/reperfusion injury via activation of phosphoinositide 3-kinase/Akt signaling. Lu C, etal., J Immunol. 2011 Aug 1;187(3):1458-66. Epub 2011 Jun 27.
10. MGDs mouse GO annotations MGD data from the GO Consortium
11. Initiation but no execution - modulation of peripheral blood lymphocyte apoptosis in rheumatoid arthritis - a potential role for heat shock protein 70. Moodley D, etal., J Inflamm (Lond). 2011 Nov 3;8(1):30.
12. The dual behavior of heat shock protein 70 and asymmetric dimethylarginine in relation to serum CRP levels in type 2 diabetes. Nakhjavani M, etal., Gene. 2012 Feb 13.
13. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. Chaperoning of glucocorticoid receptors. Pratt WB, etal., Handb Exp Pharmacol. 2006;(172):111-38.
16. Mouse MP Annotation Import Pipeline RGD automated import pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions. Smith DF and Toft DO, Mol Endocrinol. 2008 Oct;22(10):2229-40. Epub 2008 May 1.
20. Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy. Tomasello G, etal., Eur J Histochem. 2011 Oct 24;55(4):e38. doi: 10.4081/ejh.2011.e38.
21. Hypobaric Hypoxia Preconditioning Attenuates Experimental Heatstroke Syndromes via Preinduction of Heat Shock Protein 70. Wang LC, etal., Am J Med Sci. 2012 Jan 12.
22. Adenoviral transfer of HSP-70 into pulmonary epithelium ameliorates experimental acute respiratory distress syndrome. Weiss YG, etal., J Clin Invest. 2002 Sep;110(6):801-6.
23. Altered expression of heat shock protein 110 family members in mouse hippocampal neurons following trimethyltin treatment in vivo and in vitro. Yoneyama M, etal., Neuropharmacology. 2008 Oct;55(5):693-703. Epub 2008 Jun 13.
24. Immunolocalization of Toll-like receptors 2 and 4 as well as their endogenous ligand, heat shock protein 70, in rat traumatic brain injury. Zhang Z, etal., Neuroimmunomodulation. 2012;19(1):10-9. Epub 2011 Nov 7.
25. Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke. Zheng Z, etal., J Cereb Blood Flow Metab. 2008 Jan;28(1):53-63. Epub 2007 May 2.
Additional References at PubMed
PMID:7797574   PMID:8185588   PMID:9161406   PMID:10087208   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11160382   PMID:11217851   PMID:12005543   PMID:12426373  
PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:15483628   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16944949   PMID:17934213   PMID:18089828   PMID:18287559  
PMID:18307411   PMID:18799693   PMID:19171884   PMID:20198334   PMID:20679486   PMID:21487003   PMID:21565611   PMID:21589869   PMID:21677750   PMID:21873635   PMID:22884543   PMID:23055941  
PMID:23980576   PMID:24012954   PMID:24156634   PMID:24903326   PMID:25330109   PMID:25437815   PMID:25655005   PMID:25737280   PMID:26427417   PMID:27889896   PMID:30068389   PMID:30196744  
PMID:30333137   PMID:30562941   PMID:30595499   PMID:31040226   PMID:32325033   PMID:32554809   PMID:34321999   PMID:35187538   PMID:35568953   PMID:36114006   PMID:36293380  


Genomics

Comparative Map Data
Hspa4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,150,641 - 53,191,306 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,150,641 - 53,191,284 (-)EnsemblGRCm39 Ensembl
GRCm381153,259,814 - 53,300,479 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,259,814 - 53,300,457 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,073,316 - 53,113,981 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,104,997 - 53,143,812 (-)NCBIMGSCv36mm8
Celera1157,839,531 - 57,880,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.91NCBI
HSPA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385133,052,013 - 133,106,449 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5133,052,013 - 133,106,449 (+)EnsemblGRCh38hg38GRCh38
GRCh375132,387,705 - 132,442,141 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,415,561 - 132,468,608 (+)NCBINCBI36Build 36hg18NCBI36
Build 345132,415,560 - 132,468,608NCBI
Celera5128,517,326 - 128,569,460 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,579,243 - 127,632,290 (+)NCBIHuRef
CHM1_15131,820,919 - 131,874,036 (+)NCBICHM1_1
T2T-CHM13v2.05133,562,175 - 133,626,191 (+)NCBIT2T-CHM13v2.0
Hspa4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81037,908,866 - 37,951,994 (-)NCBIGRCr8
mRatBN7.21037,408,025 - 37,449,080 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,408,025 - 37,449,001 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,101,220 - 42,141,891 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,591,248 - 41,631,920 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,094,962 - 37,135,636 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01038,601,624 - 38,642,397 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,601,624 - 38,642,397 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,383,101 - 38,424,016 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41038,705,629 - 38,749,058 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11038,712,058 - 38,755,488 (-)NCBI
Celera1036,756,477 - 36,796,741 (-)NCBICelera
Cytogenetic Map10q22NCBI
Hspa4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554084,379,825 - 4,423,381 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554084,379,825 - 4,422,710 (+)NCBIChiLan1.0ChiLan1.0
HSPA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24128,358,202 - 128,410,864 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15126,497,801 - 126,552,375 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05128,463,186 - 128,517,563 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,619,076 - 134,673,658 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,619,076 - 134,673,658 (+)Ensemblpanpan1.1panPan2
HSPA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11121,290,603 - 21,363,701 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1121,290,621 - 21,505,122 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1120,116,763 - 20,164,574 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01122,073,430 - 22,146,303 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1122,073,445 - 22,146,281 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,814,567 - 20,862,388 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,662,175 - 20,709,970 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01121,304,890 - 21,352,758 (+)NCBIUU_Cfam_GSD_1.0
Hspa4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,084,886 - 115,130,573 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,087,604 - 2,133,355 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,087,650 - 2,133,343 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2135,345,867 - 135,391,108 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12135,345,724 - 135,391,112 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,866,335 - 140,911,632 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSPA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,862,817 - 35,917,490 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,862,814 - 35,918,287 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603442,023,595 - 42,078,723 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hspa4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473339,021,738 - 39,068,132 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473339,022,511 - 39,068,153 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hspa4
1352 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:787
Count of miRNA genes:498
Interacting mature miRNAs:594
Transcripts:ENSMUST00000020630, ENSMUST00000139322, ENSMUST00000151854
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
10053675Eae44b_mexperimental allergic encephalomyelitis susceptibility 44b (mouse)Not determined113995072854094448Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
1300713Vmbic10_mventral midbrain iron content 10 (mouse)Not determined114277262654081064Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
4141770Tcpm1_mT-cell phenotype modifier 1 (mouse)Not determined5145247953615930Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse

Markers in Region
RH136154  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381153,260,982 - 53,261,179UniSTSGRCm38
MGSCv371153,074,484 - 53,074,681UniSTSGRCm37
Celera1157,840,699 - 57,840,896UniSTS
Cytogenetic Map11B1.3UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA203833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AEKQ02062115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI316935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK038627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL592489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW545353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA316420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF741432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN458707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000020630   ⟹   ENSMUSP00000020630
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1153,150,641 - 53,191,284 (-)Ensembl
GRCm38.p6 Ensembl1153,259,814 - 53,300,457 (-)Ensembl
RefSeq Acc Id: ENSMUST00000139322
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1153,153,707 - 53,158,068 (-)Ensembl
GRCm38.p6 Ensembl1153,262,880 - 53,267,241 (-)Ensembl
RefSeq Acc Id: ENSMUST00000151854
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1153,155,074 - 53,191,238 (-)Ensembl
GRCm38.p6 Ensembl1153,264,247 - 53,300,411 (-)Ensembl
RefSeq Acc Id: NM_008300   ⟹   NP_032326
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391153,150,641 - 53,191,306 (-)NCBI
GRCm381153,259,814 - 53,300,479 (-)ENTREZGENE
MGSCv371153,073,316 - 53,113,981 (-)RGD
Celera1157,839,531 - 57,880,195 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032326   ⟸   NM_008300
- UniProtKB: Q61316 (UniProtKB/Swiss-Prot),   Q3U2G2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000020630   ⟸   ENSMUST00000020630

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61316-F1-model_v2 AlphaFold Q61316 1-841 view protein structure

Promoters
RGD ID:6820316
Promoter ID:MM_KWN:7362
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_008300,   UC007IVR.1,   UC007IVS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361153,113,146 - 53,114,472 (-)MPROMDB
RGD ID:8674594
Promoter ID:EPDNEW_M15326
Type:initiation region
Name:Hspa4_1
Description:Mus musculus heat shock protein 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381153,300,419 - 53,300,479EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1342292 AgrOrtholog
Ensembl Genes ENSMUSG00000020361 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020630 ENTREZGENE
  ENSMUST00000020630.8 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.30.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.420.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSPA4_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15525 UniProtKB/TrEMBL
MGD MGI:1342292 ENTREZGENE
NCBI Gene 15525 ENTREZGENE
PANTHER HEAT SHOCK 70 KDA PROTEIN 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSC70CB, ISOFORM G-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HSP70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hspa4 PhenoGen
PRINTS HEATSHOCK70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HSP70_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF100934 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt HSP74_MOUSE UniProtKB/Swiss-Prot
  Q3U2G2 ENTREZGENE, UniProtKB/TrEMBL
  Q3UZ53_MOUSE UniProtKB/TrEMBL
  Q571M2_MOUSE UniProtKB/TrEMBL
  Q61316 ENTREZGENE
  Q8C6R3_MOUSE UniProtKB/TrEMBL
  Q99L75_MOUSE UniProtKB/TrEMBL