Mir1 (microRNA 1) - Rat Genome Database

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Pathways
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Gene: Mir1 (microRNA 1) Rattus norvegicus
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Symbol: Mir1
Name: microRNA 1
RGD ID: 2325528
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in negative regulation of thyroid gland epithelial cell proliferation. Predicted to be located in extracellular space. Predicted to be part of RISC complex. Orthologous to human MIR1-2 (microRNA 1-2); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH 4'-epidoxorubicin; aflatoxin B1; amphetamine.
Type: ncrna
RefSeq Status: PROVISIONAL
Previously known as: rno-mir-1
RGD Orthologs
Human
Mouse
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8182,160,327 - 2,160,413 (-)NCBIGRCr8
mRatBN7.2181,887,537 - 1,887,623 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx182,117,172 - 2,117,258 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0182,904,873 - 2,904,959 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0182,119,054 - 2,119,140 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,054,933 - 2,055,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0182,087,912 - 2,087,998 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera181,767,328 - 1,767,414 (-)NCBICelera
Cytogenetic Map18p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac conduction system development  (ISO)
cell migration involved in coronary vasculogenesis  (ISO)
heart morphogenesis  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cardiac muscle cell proliferation  (ISO)
negative regulation of cardiac muscle hypertrophy  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of delayed rectifier potassium channel activity  (ISO)
negative regulation of endothelial cell differentiation  (ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of lipid biosynthetic process  (ISO)
negative regulation of membrane repolarization during cardiac muscle cell action potential  (ISO)
negative regulation of myoblast proliferation  (ISO)
negative regulation of thyroid gland epithelial cell proliferation  (IDA)
negative regulation of transporter activity  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane  (ISO)
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway  (ISO)
positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (ISO)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of mesoderm formation  (ISO)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
post-transcriptional regulation of gene expression  (ISO)
regulation of calcineurin-NFAT signaling cascade  (ISO)
regulation of cardiac muscle contraction  (ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (ISO)
regulation of translation  (ISO)
reversible differentiation  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MiR-320a contributes to atherogenesis by augmenting multiple risk factors and down-regulating SRF. Chen C, etal., J Cell Mol Med. 2015 May;19(5):970-85. doi: 10.1111/jcmm.12483. Epub 2015 Feb 27.
2. The role of microRNA-1 targeting of MAPK3 in myocardial ischemia-reperfusion injury in rats undergoing sevoflurane preconditioning via the PI3K/Akt pathway. Hao YL, etal., Am J Physiol Cell Physiol. 2018 Sep 1;315(3):C380-C388. doi: 10.1152/ajpcell.00310.2017. Epub 2018 May 9.
3. A TSH-CREB1-microRNA loop is required for thyroid cell growth. Leone V, etal., Mol Endocrinol. 2011 Oct;25(10):1819-30. doi: 10.1210/me.2011-0014. Epub 2011 Aug 4.
4. Identification of blood microRNAs associated to Parkinsonis disease. Margis R, etal., J Biotechnol. 2011 Mar 20;152(3):96-101. doi: 10.1016/j.jbiotec.2011.01.023. Epub 2011 Feb 3.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15361871   PMID:16274478   PMID:16381832   PMID:17397913   PMID:17604727   PMID:18801338   PMID:19188439   PMID:19245789   PMID:20403161   PMID:21406115   PMID:21690310   PMID:21753256  
PMID:22086007   PMID:22393433   PMID:23185045   PMID:23612897   PMID:23723006   PMID:23922949   PMID:24978894   PMID:25008997   PMID:25047835   PMID:25156787   PMID:25583113   PMID:25724682  
PMID:26065643   PMID:26111928   PMID:26166810   PMID:26253469   PMID:26380976   PMID:26646371   PMID:26691660   PMID:26699910   PMID:26830133   PMID:27076094   PMID:27381812   PMID:28000044  
PMID:28063219   PMID:28303410   PMID:29094045   PMID:29138674   PMID:29717493   PMID:30830529   PMID:30896796   PMID:31104265   PMID:31432395   PMID:32109943   PMID:32329822   PMID:32789575  
PMID:33215443   PMID:33604679   PMID:33867822   PMID:33964276   PMID:34955134   PMID:36645970   PMID:38149527  


Genomics

Comparative Map Data
Mir1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8182,160,327 - 2,160,413 (-)NCBIGRCr8
mRatBN7.2181,887,537 - 1,887,623 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx182,117,172 - 2,117,258 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0182,904,873 - 2,904,959 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0182,119,054 - 2,119,140 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0182,054,933 - 2,055,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0182,087,912 - 2,087,998 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera181,767,328 - 1,767,414 (-)NCBICelera
Cytogenetic Map18p13NCBI
MIR1-2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381821,829,004 - 21,829,088 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1821,829,004 - 21,829,088 (-)EnsemblGRCh38hg38GRCh38
GRCh371819,408,965 - 19,409,049 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361817,662,962 - 17,663,046 (-)NCBINCBI36Build 36hg18NCBI36
Celera1816,215,028 - 16,215,112 (-)NCBICelera
Cytogenetic Map18q11.2NCBI
HuRef1816,256,352 - 16,256,436 (-)NCBIHuRef
CHM1_11819,336,070 - 19,336,154 (-)NCBICHM1_1
T2T-CHM13v2.01822,014,052 - 22,014,136 (-)NCBIT2T-CHM13v2.0
Mir1a-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391810,785,481 - 10,785,552 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1810,785,481 - 10,785,552 (-)EnsemblGRCm39 Ensembl
GRCm381810,785,481 - 10,785,552 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1810,785,481 - 10,785,552 (-)EnsemblGRCm38mm10GRCm38
MGSCv371810,785,479 - 10,785,550 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1810,815,465 - 10,815,536 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map185.4NCBI
MIR1-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1766,214,380 - 66,214,438 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl766,214,366 - 66,214,450 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha765,668,956 - 65,669,014 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0766,279,106 - 66,279,164 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1765,945,036 - 65,945,094 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0765,967,964 - 65,968,022 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0766,268,331 - 66,268,389 (+)NCBIUU_Cfam_GSD_1.0

Variants

.
Variants in Mir1
1 total Variants
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Pax3rno-miR-1-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21730146
Kcnj2rno-miR-1-3pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI19775284
Hcn4rno-miR-1-3pMirtarbaseexternal_infoReporter assay//real-timeRT-PCR//Western blotFunctional MTI17516552
Hcn2rno-miR-1-3pMirtarbaseexternal_infoWestern blot;qRT-PCRFunctional MTI18458081
Igf1rno-miR-1-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI19245789
Igf1rno-miR-1-3pMirtarbaseexternal_infoELISAFunctional MTI (Weak)18801338
Hspa4rno-miR-1-3pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI17715156
Bcl2rno-miR-1-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI19506341
Arhgap32rno-miR-1-3pMirtarbaseexternal_infoGFP reporter assay//Immunocytochemistry//LuciferasNon-Functional MTI16260724
Anxa5rno-miR-1-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23436819
Calm3rno-miR-1-3pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)19188439
Gata4rno-miR-1-3pMirtarbaseexternal_infoWestern blot;qRT-PCRFunctional MTI19188439
Calm2rno-miR-1-3pMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCRFunctional MTI19188439

Predicted Targets
Summary Value
Count of predictions:11173
Count of gene targets:6313
Count of transcripts:6776
Interacting mature miRNAs:rno-miR-1-3p, rno-miR-1-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NR_032116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: NR_032116
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8182,160,327 - 2,160,413 (-)NCBI
mRatBN7.2181,887,537 - 1,887,623 (-)NCBI
Rnor_6.0182,054,933 - 2,055,019 (-)NCBI
Rnor_5.0182,087,912 - 2,087,998 (-)NCBI
Celera181,767,328 - 1,767,414 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325528 AgrOrtholog
BioCyc Gene G2FUF-8397 BioCyc
miRBase MI0003489 ENTREZGENE
NCBI Gene 100314077 ENTREZGENE
PhenoGen Mir1 PhenoGen
RNAcentral URS000075A423 RNACentral
  URS000075DD80 RNACentral
  URS000075E04C RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-09 Mir1  microRNA 1  Mir1  microRNA mir-1  Name updated 61478 APPROVED
2010-06-02 Mir1  microRNA mir-1      Symbol and Name status set to provisional 70820 PROVISIONAL