Hspa4 (heat shock protein family A (Hsp70) member 4) - Rat Genome Database

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Gene: Hspa4 (heat shock protein family A (Hsp70) member 4) Chinchilla lanigera
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Symbol: Hspa4
Name: heat shock protein family A (Hsp70) member 4
RGD ID: 9031057
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN chaperone-mediated protein complex assembly (ortholog); kidney development (ortholog); negative regulation of apoptotic process (ortholog); PARTICIPATES IN cortisol signaling pathway; estrogen signaling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); Brain Injuries (ortholog); Chagas disease (ortholog); FOUND IN cytosol (ortholog); extracellular exosome (ortholog); lipid droplet (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: heat shock 70 kDa protein 4; heat shock 70kDa protein 4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554084,379,825 - 4,423,381 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554084,379,825 - 4,422,710 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Hspa4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554084,379,825 - 4,423,381 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554084,379,825 - 4,422,710 (+)NCBIChiLan1.0ChiLan1.0
HSPA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385133,052,013 - 133,106,449 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5133,052,013 - 133,106,449 (+)EnsemblGRCh38hg38GRCh38
GRCh375132,387,705 - 132,442,141 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,415,561 - 132,468,608 (+)NCBINCBI36Build 36hg18NCBI36
Build 345132,415,560 - 132,468,608NCBI
Celera5128,517,326 - 128,569,460 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,579,243 - 127,632,290 (+)NCBIHuRef
CHM1_15131,820,919 - 131,874,036 (+)NCBICHM1_1
T2T-CHM13v2.05133,562,175 - 133,626,191 (+)NCBIT2T-CHM13v2.0
Hspa4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,150,641 - 53,191,306 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,150,641 - 53,191,284 (-)EnsemblGRCm39 Ensembl
GRCm381153,259,814 - 53,300,479 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,259,814 - 53,300,457 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,073,316 - 53,113,981 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,104,997 - 53,143,812 (-)NCBIMGSCv36mm8
Celera1157,839,531 - 57,880,195 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.91NCBI
Hspa4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81037,908,866 - 37,951,994 (-)NCBIGRCr8
mRatBN7.21037,408,025 - 37,449,080 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,408,025 - 37,449,001 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,101,220 - 42,141,891 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,591,248 - 41,631,920 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,094,962 - 37,135,636 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01038,601,624 - 38,642,397 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,601,624 - 38,642,397 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,383,101 - 38,424,016 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41038,705,629 - 38,749,058 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11038,712,058 - 38,755,488 (-)NCBI
Celera1036,756,477 - 36,796,741 (-)NCBICelera
Cytogenetic Map10q22NCBI
HSPA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24128,358,202 - 128,410,864 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15126,497,801 - 126,552,375 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05128,463,186 - 128,517,563 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,619,076 - 134,673,658 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,619,076 - 134,673,658 (+)Ensemblpanpan1.1panPan2
HSPA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11121,290,603 - 21,363,701 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1121,290,621 - 21,505,122 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1120,116,763 - 20,164,574 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01122,073,430 - 22,146,303 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1122,073,445 - 22,146,281 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,814,567 - 20,862,388 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,662,175 - 20,709,970 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01121,304,890 - 21,352,758 (+)NCBIUU_Cfam_GSD_1.0
Hspa4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,084,886 - 115,130,573 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,087,604 - 2,133,355 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,087,650 - 2,133,343 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2135,345,867 - 135,391,108 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12135,345,724 - 135,391,112 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,866,335 - 140,911,632 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSPA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,862,817 - 35,917,490 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,862,814 - 35,918,287 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603442,023,595 - 42,078,723 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hspa4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473339,021,738 - 39,068,132 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473339,022,511 - 39,068,153 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000020275   ⟹   ENSCLAP00000020082
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554084,379,825 - 4,423,381 (+)Ensembl
RefSeq Acc Id: XM_005376122   ⟹   XP_005376179
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554084,379,825 - 4,422,710 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005376179 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000020082
  ENSCLAP00000020082.1
RefSeq Acc Id: XP_005376179   ⟸   XM_005376122
- UniProtKB: A0A8C2YSI1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000020082   ⟸   ENSCLAT00000020275


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000013757 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000020275 ENTREZGENE
  ENSCLAT00000020275.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.10 UniProtKB/TrEMBL
  3.30.30.30 UniProtKB/TrEMBL
  3.30.420.40 UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/TrEMBL
  HSP70 UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/TrEMBL
  HSPA4_NBD UniProtKB/TrEMBL
NCBI Gene Hspa4 ENTREZGENE
PANTHER HEAT SHOCK 70 KDA PROTEIN 4 UniProtKB/TrEMBL
  HSC70CB, ISOFORM G-RELATED UniProtKB/TrEMBL
Pfam HSP70 UniProtKB/TrEMBL
PRINTS HEATSHOCK70 UniProtKB/TrEMBL
PROSITE HSP70_2 UniProtKB/TrEMBL
  HSP70_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF100920 UniProtKB/TrEMBL
  SSF100934 UniProtKB/TrEMBL
  SSF53067 UniProtKB/TrEMBL
UniProt A0A8C2YSI1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Hspa4  heat shock protein family A (Hsp70) member 4    heat shock 70kDa protein 4  Symbol and/or name change 5135510 APPROVED