RGD Reference Report - Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy. - Rat Genome Database

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Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy.

Authors: Tomasello, G  Sciume, C  Rappa, F  Rodolico, V  Zerilli, M  Martorana, A  Cicero, G  De Luca, R  Damiani, P  Accardo, FM  Romeo, M  Farina, F  Bonaventura, G  Modica, G  Zummo, G  Conway de Macario, E  Macario, AJ  Cappello, F 
Citation: Tomasello G, etal., Eur J Histochem. 2011 Oct 24;55(4):e38. doi: 10.4081/ejh.2011.e38.
RGD ID: 5688753
Pubmed: PMID:22297444   (View Abstract at PubMed)
PMCID: PMC3284240   (View Article at PubMed Central)

Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) characterized by damage of large bowel mucosa and frequent extra-intestinal autoimmune comorbidities. The role played in IBD pathogenesis by molecular chaperones known to interact with components of the immune system involved in inflammation is unclear. We previously demonstrated that mucosal Hsp60 decreases in UC patients treated with conventional therapies (mesalazine, probiotics), suggesting that this chaperonin could be a reliable biomarker useful for monitoring response to treatment, and that it might play a role in pathogenesis. In the present work we investigated three other heat shock protein/molecular chaperones: Hsp10, Hsp70, and Hsp90. We found that the levels of these proteins are increased in UC patients at the time of diagnosis and decrease after therapy, supporting the notion that these proteins deserve attention in the study of the mechanisms that promote the development and maintenance of IBD, and as biomarkers of this disease (e.g., to monitor response to treatment at the histological level).

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
ulcerative colitis  IEP 5688753protein:increased expression:colon mucosa and epithelium (human)RGD 
ulcerative colitis  ISOHSPA4 (Homo sapiens)5688753; 5688753protein:increased expression:colon mucosa and epithelium (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hspa4  (heat shock protein family A (Hsp70) member 4)

Genes (Mus musculus)
Hspa4  (heat shock protein 4)

Genes (Homo sapiens)
HSPA4  (heat shock protein family A (Hsp70) member 4)


Additional Information