Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Nfkbia (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha) Mus musculus
Analyze
Symbol: Nfkbia
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
Description: Predicted to have several functions, including NF-kappaB binding activity; nuclear localization sequence binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including lipopolysaccharide-mediated signaling pathway; negative regulation of Notch signaling pathway; and pattern recognition receptor signaling pathway. Localizes to the cytosol and nucleus. Used to study Sjogren's syndrome and atopic dermatitis. Human ortholog(s) of this gene implicated in hematologic cancer (multiple); hypohidrotic ectodermal dysplasia; lung cancer; melanoma; and prostate cancer. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system; jaw; and naris. Orthologous to human NFKBIA (NFKB inhibitor alpha); PARTICIPATES IN adenosine signaling pathway; ceramide signaling pathway; interleukin-23 signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-catechin; (+)-pilocarpine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI462015; I(Kappa)B(alpha); I-kappa-B-alpha; I-kappaBalpha; ikappaBalpha; ikB-alpha; NF-kappa-B inhibitor alpha; Nfkbi; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha; nuclear factor of kappa light polyp gene enhancer in B-cell 1; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Orthologs:
Homo sapiens (human) : NFKBIA (NFKB inhibitor alpha)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nfkbia (NFKB inhibitor alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nfkbia (NFKB inhibitor alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : NFKBIA (NFKB inhibitor alpha)
Canis lupus familiaris (dog) : NFKBIA (NFKB inhibitor alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nfkbia (NFKB inhibitor alpha)
Sus scrofa (pig) : NFKBIA (NFKB inhibitor alpha)
Chlorocebus sabaeus (green monkey) : NFKBIA (NFKB inhibitor alpha)
Heterocephalus glaber (naked mole-rat) : Nfkbia (NFKB inhibitor alpha)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1255,489,410 - 55,492,647 (-)Ensembl
GRCm381255,489,409 - 55,492,647 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371256,590,396 - 56,593,634 (-)NCBIGRCm37mm9NCBIm37
MGSCv361256,407,974 - 56,410,713 (-)NCBImm8
Celera1256,639,004 - 56,642,123 (-)NCBICelera
Cytogenetic Map12 C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations