Nfkbia (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha) - Rat Genome Database

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Gene: Nfkbia (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha) Mus musculus
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Symbol: Nfkbia
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
RGD ID: 10975
MGI Page MGI
Description: Enables transcription regulator inhibitor activity. Involved in B cell receptor signaling pathway; negative regulation of canonical NF-kappaB signal transduction; and positive regulation of transcription initiation by RNA polymerase II. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; negative regulation of Notch signaling pathway; and pattern recognition receptor signaling pathway. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and naris. Used to study Sjogren's syndrome and atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including childhood-onset asthma; ectodermal dysplasia and immunodeficiency 2; hematologic cancer (multiple); hepatitis B; and lung disease (multiple). Orthologous to human NFKBIA (NFKB inhibitor alpha).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI462015; I(Kappa)B(alpha); I-kappa-B-alpha; I-kappaBalpha; ikappaBalpha; ikB-alpha; NF-kappa-B inhibitor alpha; Nfk; Nfkbi; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha; nuclear factor of kappa light polyp gene enhancer in B-cell 1; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391255,536,194 - 55,539,432 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1255,536,195 - 55,539,432 (-)EnsemblGRCm39 Ensembl
GRCm381255,489,409 - 55,492,647 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1255,489,410 - 55,492,647 (-)EnsemblGRCm38mm10GRCm38
MGSCv371256,590,396 - 56,593,634 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361256,407,974 - 56,410,713 (-)NCBIMGSCv36mm8
Celera1256,639,004 - 56,642,123 (-)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1224.0NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute necrotizing pancreatitis  (ISO)
Adenoviridae Infections  (ISO)
alcoholic hepatitis  (ISO)
arteriosclerosis  (ISO)
atopic dermatitis  (IAGP)
brain ischemia  (ISO)
Brain-Lung-Thyroid Syndrome  (ISO)
Breast Neoplasms  (ISO)
bronchopulmonary dysplasia  (ISO)
Cardiac Fibrosis  (ISO)
Cerebral Hemorrhage  (ISO)
childhood-onset asthma  (ISO)
Chronic Hepatitis B  (ISO)
COVID-19  (ISO)
cryptorchidism  (IEP)
Cytomegalovirus Infections  (ISO)
Deficiency of Interleukin-1 Receptor Antagonist  (ISO)
diarrhea  (ISO)
diffuse large B-cell lymphoma  (ISO)
ectodermal dysplasia and immunodeficiency 2  (ISO)
encephalitis  (ISO)
endometriosis  (ISO)
Endotoxemia  (IEP,IMP)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
gastritis  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Hemorrhagic Shock  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
Hodgkin's lymphoma  (ISO)
hypertension  (ISO)
Intestinal Reperfusion Injury  (ISO)
lung cancer  (ISO)
Lung Injury  (ISO)
melanoma  (ISO)
middle cerebral artery infarction  (ISO)
multiple myeloma  (ISO)
Murine Acquired Immunodeficiency Syndrome  (IEP)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephrotic syndrome  (ISO)
pancreatic cancer  (ISO)
Pneumococcal Infections  (ISO)
pneumonia  (ISO)
pre-malignant neoplasm  (ISO)
Pregnancy Complications  (ISO)
primary immunodeficiency disease  (ISO)
prostate adenocarcinoma  (IDA,ISO)
prostate cancer  (ISO)
psoriasis  (ISO)
pulmonary emphysema  (ISO)
pulmonary tuberculosis  (ISO)
Sarcopenia  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
Sjogren's syndrome  (IAGP,IMP)
Spinal Cord Injuries  (ISO)
toxic shock syndrome  (ISO)
toxoplasmosis  (ISO)
Transplant Rejection  (IEP,ISO)
vasculitis  (ISO)
Ventilator-Induced Lung Injury  (ISO)
Viral Bronchiolitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-catechin  (EXP,ISO)
(+)-Erythraline  (EXP)
(+)-pilocarpine  (EXP,ISO)
(+)-Tetrandrine  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-Arctigenin  (EXP)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(20S)-ginsenoside Rg3  (ISO)
(20S)-ginsenoside Rh2  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (EXP)
(5Z,8Z,11Z,13E)-15-HETE  (EXP,ISO)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (EXP)
1'-acetoxychavicol acetate  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (EXP)
1,4-dithiothreitol  (EXP,ISO)
1,4-phenylenediamine  (ISO)
1,7-dimethylxanthine  (EXP)
1,8-cineole  (ISO)
1-bromopropane  (EXP,ISO)
1-hydroxy-2-naphthoic acid  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
15-oxo-ETE  (ISO)
17-hydroxyjolkinolide B  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (EXP)
2''-galloylhyperin  (EXP)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP,ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-acetamidofluorene  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-acetyloxy-4-(trifluoromethyl)benzoic acid  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-aminopurine  (EXP)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-butoxyethanol  (EXP)
2-Hydroxy-4-trifluoromethyl benzoic acid  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-tert-butylhydroquinone  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,3',5'-triiodo-L-thyronine  (ISO)
3,3',5'-triiodothyronine  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-(1H-indol-3-yl)propanoic acid  (ISO)
3-aminobenzamide  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-mercaptopropanoic acid  (EXP)
3-methylcatechol  (EXP)
3-methylcholanthrene  (EXP)
3-phenylprop-2-enal  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP,ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (EXP)
4-nitrophenol  (EXP)
4-phenylbutyric acid  (EXP,ISO)
5,6,7-trimethoxyflavone  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-ketocholesterol  (ISO)
[6]-Shogaol  (EXP,ISO)
acetaldehyde  (ISO)
acetic acid  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (ISO)
Aciculatin  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
adenosine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
AH23848  (ISO)
alachlor  (EXP)
albuterol  (ISO)
alcohol  (EXP)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldehydo-D-ribose  (EXP)
Alkannin  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alpha-phellandrene  (ISO)
Alternaramide  (EXP)
alvocidib  (ISO)
amifostine  (EXP,ISO)
amiloride  (ISO)
amiodarone  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
Ammothamnine  (EXP)
amorolfine  (ISO)
amphetamine  (ISO)
amphibole asbestos  (ISO)
andrographolide  (ISO)
Anemoside B4  (EXP)
anethole  (ISO)
aniline  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimony(0)  (ISO)
ANTIMYCIN  (ISO)
antimycin A  (EXP)
antirheumatic drug  (ISO)
antroquinonol  (ISO)
Apicularen A  (EXP)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
apremilast  (ISO)
aprepitant  (ISO)
Arctiin  (EXP)
aripiprazole  (ISO)
aristolochic acid A  (EXP)
aristolochic acids  (ISO)
arjunolic acid  (EXP,ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asarone  (EXP)
astilbin  (ISO)
astragaloside IV  (ISO)
ATP  (ISO)
Atractylodin  (EXP,ISO)
atrazine  (ISO)
auranofin  (EXP)
aureusidin  (EXP)
azadirachtin A  (ISO)
B 581  (ISO)
baicalein  (EXP)
baicalin  (ISO)
Bardoxolone methyl  (EXP,ISO)
bathocuproine disulfonic acid  (ISO)
belinostat  (ISO)
benazepril  (ISO)
benzamide  (EXP)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Berbamine  (ISO)
berberine  (EXP,ISO)
Bergenin  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-Elemonic acid  (ISO)
beta-endorphin  (ISO)
beta-naphthoflavone  (ISO)
betulinic acid  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisdemethoxycurcumin  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
brazilein  (ISO)
bromoacetate  (ISO)
butenafine  (ISO)
butyric acid  (EXP)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
caffeine  (EXP)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
Calphostin C  (EXP)
cannabidiol  (ISO)
capsaicin  (ISO)
capsiate  (ISO)
carbon atom  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (ISO)
carfilzomib  (ISO)
carmustine  (ISO)
carnosic acid  (EXP,ISO)
carnosine  (ISO)
Carnosol  (ISO)
carrageenan  (ISO)
casticin  (ISO)
catechol  (EXP)
cefaloridine  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
ceritinib  (ISO)
ceruletide  (ISO)
CGP 52608  (ISO)
chalcone  (EXP)
chelerythrine  (EXP)
Chikusetsusaponin-IV  (ISO)
chlorobenzene  (ISO)
chlorogenic acid  (EXP,ISO)
chloropicrin  (ISO)
chloroquine  (EXP,ISO)
chlorpyrifos  (ISO)
cholic acid  (EXP)
choline  (ISO)
chondroitin sulfate  (ISO)
chromium(6+)  (EXP,ISO)
chrysene  (EXP)
chrysin  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (EXP)
cilostazol  (ISO)
cisplatin  (EXP,ISO)
citronellol  (EXP,ISO)
clenbuterol  (ISO)
clofibrate  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP,ISO)
corn oil  (EXP)
corosolic acid  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
corynoline  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
Cryptotanshinone  (ISO)
cudraflavone B  (ISO)
cudratricusxanthone A  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
D-ribofuranose  (EXP)
daidzein  (EXP)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
Decursin  (EXP)
deferiprone  (ISO)
deguelin  (ISO)
Dehydrodiisoeugenol  (EXP)
demethoxycurcumin  (EXP)
deoxycholic acid  (ISO)
deoxynivalenol  (EXP,ISO)
Deoxyschizandrin  (ISO)
desferrioxamine B  (ISO)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diallyl disulfide  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dieckol  (EXP)
dieldrin  (ISO)
diethyl maleate  (EXP,ISO)
digitoxin  (ISO)
dihydroartemisinin  (ISO)
diiodine  (ISO)
dimemorfan  (EXP)
dimethyl sulfoxide  (ISO)
diminazene diaceturate  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
diosmetin  (EXP)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dipyridamole  (EXP)
diquat  (ISO)
disulfiram  (EXP,ISO)
dizocilpine maleate  (ISO)
dobutamine  (ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
edaravone  (ISO)
elemental carbon  (ISO)
elemental selenium  (EXP,ISO)
emamectin benzoate  (ISO)
emodin  (EXP,ISO)
enalapril  (EXP)
endosulfan  (EXP,ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
eriodictyol  (EXP,ISO)
erlotinib hydrochloride  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethylbenzene  (ISO)
etoposide  (ISO)
eugenol  (EXP,ISO)
eupatilin  (EXP)
Evodiamine  (ISO)
Fargesin  (EXP)
fasudil  (EXP,ISO)
fenofibrate  (ISO)
fentanyl  (ISO)
ferroheme b  (EXP,ISO)
ferulic acid  (EXP)
fisetin  (ISO)
Flavokawain A  (EXP)
flavone  (ISO)
fluoxetine  (EXP,ISO)
fluticasone  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
formic acid  (EXP)
formononetin  (ISO)
Fraxinellone  (ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
fumaric acid  (EXP)
furan  (EXP,ISO)
galangin  (ISO)
gamma-hexachlorocyclohexane  (ISO)
Ganoderic acid A  (EXP)
Gastrodin  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
Geraniin  (EXP,ISO)
geraniol  (EXP,ISO)
Gingerenone A  (ISO)
gingerol  (ISO)
Ginkgolide C  (ISO)
ginsenoside Re  (EXP,ISO)
ginsenoside Rg1  (EXP)
glafenine  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP)
glycidol  (ISO)
glycine  (EXP)
glycyrol  (EXP)
glycyrrhetinate  (EXP,ISO)
glycyrrhetinic acid  (EXP,ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP)
graphene oxide  (ISO)
guggulsterone  (ISO)
halothane  (ISO)
helenalin  (EXP,ISO)
heme b  (EXP,ISO)
herbimycin  (EXP)
hexadecanoic acid  (EXP,ISO)
histamine  (ISO)
homocysteine  (ISO)
homoeriodictyol  (EXP)
Honokiol  (ISO)
HU-308  (EXP,ISO)
hyaluronic acid  (ISO)
hydrogen cyanide  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
hydroquinone  (EXP,ISO)
hydroxychloroquine  (ISO)
hydroxysafflor yellow A  (ISO)
hydroxyurea  (ISO)
ibrutinib  (ISO)
ibuprofen  (ISO)
icariin  (EXP)
indirubin-3'-monoxime  (ISO)
indole-3-butyric acid  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
indoprofen  (EXP,ISO)
ionomycin  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron dextran  (ISO)
iron dichloride  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoeugenol  (EXP)
isoliquiritigenin  (EXP,ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP)
Isorhapontigenin  (ISO)
isothiocyanate  (EXP)
isovitexin  (ISO)
itraconazole  (ISO)
kaempferol  (EXP,ISO)
kaempferol 3-O-beta-D-glucoside  (EXP)
ketamine  (ISO)
ketoconazole  (ISO)
KN-93  (ISO)
kojic acid  (ISO)
KT 5823  (ISO)
kuwanone G  (EXP)
kynurenic acid  (EXP)
L-1,4-dithiothreitol  (EXP,ISO)
L-365260  (EXP)
L-ascorbic acid  (ISO)
L-cysteine  (ISO)
L-gamma-glutamyl-L-cysteine  (EXP)
L-proline betaine  (ISO)
lactacystin  (ISO)
lansoprazole  (ISO)
lead diacetate  (EXP)
lead nitrate  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
Leonurine  (EXP,ISO)
levofloxacin  (EXP,ISO)
Licochalcone B  (EXP)
lipoarabinomannan  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP,ISO)
lipoxin A4  (EXP)
lithium carbonate  (EXP)
lithium chloride  (ISO)
lithocholic acid  (ISO)
lonafarnib  (ISO)
loperamide  (ISO)
Lucidone  (ISO)
Luliconazole  (ISO)
luteolin  (EXP,ISO)
luzindole  (ISO)
LY294002  (ISO)
lycopene  (ISO)
Macrosphelide B  (EXP)
Magnolol  (EXP)
maneb  (EXP)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
masoprocol  (ISO)
melamine  (ISO)
melatonin  (ISO)
melittin  (EXP,ISO)
meloxicam  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
metformin  (ISO)
methadone  (ISO)
methamphetamine  (EXP,ISO)
methoxychlor  (ISO)
Methyl palmitate  (EXP)
methylisothiazolinone  (ISO)
methyllycaconitine  (EXP)
mevalonic acid  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (EXP)
monotropein  (EXP)
morphine  (ISO)
muramyl dipeptide  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-dimethylacetamide  (EXP)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP,ISO)
Narciclasine  (EXP)
naringin  (EXP)
Neferine  (ISO)
neoastilbin  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (EXP,ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nifedipine  (ISO)
nilotinib  (ISO)
nitric oxide  (EXP)
nitrogen mustard  (ISO)
nitroprusside  (EXP,ISO)
nonane  (ISO)
notoginsenoside R1  (EXP,ISO)
NS-398  (ISO)
o-anisidine  (ISO)
o-xylene  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
oleanolic acid  (ISO)
Olmesartan medoxomil  (ISO)
omeprazole  (ISO)
oroxylin A  (EXP)
osthole  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
p-tolualdehyde  (EXP)
paclitaxel  (ISO)
paeoniflorin  (EXP,ISO)
Paeonol  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
patchouli alcohol  (EXP,ISO)
pentachlorophenol  (ISO)
Pentoxifylline  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
pevonedistat  (EXP,ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
phenylbutazone  (ISO)
phenylephrine  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
picolinic acid  (ISO)
piperine  (EXP,ISO)
pipoxolan  (EXP)
pirinixic acid  (EXP)
platycodin D  (ISO)
poly(I:C)  (ISO)
potassium cyanide  (EXP)
potassium dichromate  (ISO)
Praeruptorin A  (EXP)
prasugrel hydrochloride  (ISO)
prodigiosin  (EXP)
progesterone  (ISO)
propiconazole  (EXP)
propofol  (ISO)
prostaglandin E1  (ISO)
prostaglandin E2  (EXP,ISO)
prunetin  (EXP)
pterostilbene  (EXP,ISO)
puerarin  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (EXP)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quercitrin  (ISO)
quinomethionate  (ISO)
quizartinib  (ISO)
raloxifene  (EXP,ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
rebaudioside A  (EXP)
resolvin D1  (EXP)
resolvin D2  (EXP)
resveratrol  (EXP,ISO)
retinyl acetate  (EXP)
Rhynchophylline  (ISO)
rimexolone  (ISO)
ritonavir  (ISO)
romidepsin  (ISO)
rosmarinic acid  (EXP,ISO)
rotenone  (EXP,ISO)
rubiadin  (ISO)
rubimaillin  (ISO)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-homocysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
Salidroside  (EXP)
Salinomycin  (ISO)
Salmeterol xinafoate  (ISO)
Sanggenon C  (EXP)
sappanchalcone  (ISO)
SB 203580  (EXP,ISO)
SCH 23390  (ISO)
scoparone  (ISO)
selenium atom  (EXP,ISO)
serpentine asbestos  (ISO)
sesquiterpene  (ISO)
sevoflurane  (ISO)
shikimic acid  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (EXP)
sincalide  (ISO)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
SM-164  (ISO)
sodium acetate trihydrate  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sodium nitrite  (ISO)
sodium propionate  (EXP)
Sodium salicylate  (ISO)
Soman  (ISO)
Sophocarpine  (EXP)
Sophoricoside  (EXP)
sorafenib  (ISO)
soyasaponin I  (EXP)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (EXP,ISO)
succimer  (EXP)
sucrose  (EXP)
sulfasalazine  (EXP,ISO)
sulforaphane  (EXP,ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
synephrine  (EXP)
syringin  (EXP)
T-2 toxin  (EXP)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
Tanshinone I  (EXP,ISO)
taurine  (EXP,ISO)
taurocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
tebufenpyrad  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
tenofovir disoproxil fumarate  (ISO)
terbinafine  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP,ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (ISO)
theophylline  (ISO)
thioacetamide  (EXP,ISO)
thiopental  (ISO)
Timosaponin b ii  (EXP)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
topotecan  (ISO)
trans-anethole  (ISO)
trans-chalcone  (EXP)
trans-isoeugenol  (EXP)
trelagliptin  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trilobatin  (EXP)
trimethyltin  (EXP)
Triptolide  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
tungsten  (ISO)
Tylophorine  (ISO)
tyrphostin AG 1478  (ISO)
umbelliferone  (ISO)
undecan-2-one  (EXP,ISO)
ursodeoxycholic acid  (EXP)
ursolic acid  (ISO)
valproic acid  (EXP,ISO)
vanadyl sulfate  (ISO)
venom  (ISO)
vildagliptin  (EXP)
vincaleukoblastine  (ISO)
vinclozolin  (ISO)
vitamin E  (EXP,ISO)
Vitisin A  (EXP)
vorinostat  (ISO)
wedelolactone  (ISO)
withaferin A  (ISO)
wogonin  (EXP)
wortmannin  (EXP,ISO)
Xanthorrhizol  (ISO)
Y-27632  (EXP,ISO)
zearalenone  (EXP,ISO)
zerumbone  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP,ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zingerone  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell receptor signaling pathway  (IDA)
canonical NF-kappaB signal transduction  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to tumor necrosis factor  (IBA,IDA)
cytoplasmic sequestering of NF-kappaB  (ISO)
interleukin-1-mediated signaling pathway  (ISO)
leukocyte migration involved in inflammatory response  (ISO)
lipopolysaccharide-mediated signaling pathway  (IDA)
liver regeneration  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (IDA,ISO)
negative regulation of lipid storage  (ISO)
negative regulation of macrophage derived foam cell differentiation  (ISO)
negative regulation of myeloid cell differentiation  (IMP)
negative regulation of Notch signaling pathway  (IMP)
non-canonical NF-kappaB signal transduction  (ISO)
Notch signaling pathway  (IMP)
nucleotide-binding oligomerization domain containing 1 signaling pathway  (IDA)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (IDA)
positive regulation of cholesterol efflux  (ISO)
positive regulation of DNA-templated transcription  (IMP)
positive regulation of inflammatory response  (ISO)
positive regulation of protein metabolic process  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription initiation by RNA polymerase II  (IMP)
protein import into nucleus  (IDA)
regulation of cell population proliferation  (IDA)
regulation of gene expression  (IMP)
response to ethanol  (ISO)
response to exogenous dsRNA  (IDA)
response to lipopolysaccharide  (IDA)
response to muramyl dipeptide  (IDA)
response to muscle stretch  (IDA)
response to organic cyclic compound  (ISO)
toll-like receptor 4 signaling pathway  (IBA,IDA,ISO)
tumor necrosis factor-mediated signaling pathway  (ISO)

Cellular Component
cytoplasm  (IDA,ISO)
cytosol  (IBA,IDA,ISO)
nucleus  (IDA,ISO)
plasma membrane  (ISO)
protein-containing complex  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell differentiation  (IAGP)
abnormal cell differentiation  (IAGP)
abnormal cell physiology  (IAGP)
abnormal circulating cytokine level  (IAGP)
abnormal epidermis stratum basale morphology  (IAGP)
abnormal epidermis stratum corneum morphology  (IAGP)
abnormal epidermis stratum granulosum morphology  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal granulocyte differentiation  (IAGP)
abnormal granulocyte morphology  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal keratinocyte morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal marginal zone B cell morphology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal skin condition  (IAGP)
abnormal T cell activation  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell number  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
absent spleen germinal center  (IAGP)
acanthosis  (IAGP)
anemia  (IAGP)
autoimmune response  (IAGP)
chronic inflammation  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased B-2 B cell number  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased CD4-positive, alpha-beta memory T cell number  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased follicular B cell number  (IAGP)
decreased IgA level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2b level  (IAGP)
decreased immature B cell number  (IAGP)
decreased marginal zone B cell number  (IAGP)
decreased mature B cell number  (IAGP)
decreased Peyer's patch number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased T cell proliferation  (IAGP)
decreased thymocyte number  (IAGP)
decreased transitional stage T2 B cell number  (IAGP)
dermatitis  (IAGP)
dry skin  (IAGP)
extramedullary hematopoiesis  (IAGP)
flaky skin  (IAGP)
hyperkeratosis  (IAGP)
increased activated T cell number  (IAGP)
increased activation-induced B cell apoptosis  (IAGP)
increased anti-insulin autoantibody level  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased B cell apoptosis  (IAGP)
increased B cell proliferation  (IAGP)
increased bone marrow cell number  (IAGP)
increased circulating interleukin-1 alpha level  (IAGP)
increased circulating interleukin-17 level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased double-positive T cell number  (IAGP)
increased granulocyte number  (IAGP)
increased IgA level  (IAGP)
increased IgE level  (IAGP)
increased IgG level  (IAGP)
increased immature B cell number  (IAGP)
increased leukocyte cell number  (IAGP)
increased macrophage cell number  (IAGP)
increased memory T cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased pre-B cell number  (IAGP)
increased pro-B cell number  (IAGP)
increased single-positive T cell number  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased T cell apoptosis  (IAGP)
increased T cell proliferation  (IAGP)
increased thymocyte number  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
reddish skin  (IAGP)
scaly skin  (IAGP)
small Peyer's patches  (IAGP)
small spleen  (IAGP)
spleen atrophy  (IAGP)
spontaneous skin ulceration  (IAGP)
thymus atrophy  (IAGP)
References

References - curated
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9. Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through up-regulation of NF-kappaB/COX-2/PGE2. Chen J, etal., Hum Reprod. 2012 Sep;27(9):2585-97. doi: 10.1093/humrep/des254. Epub 2012 Jul 9.
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15. Genetic variation on the NFKB1 genes associates with the outcomes of HCV infection among Chinese Han population. Fan HZ, etal., Infect Genet Evol. 2018 Nov;65:210-215. doi: 10.1016/j.meegid.2018.07.031. Epub 2018 Jul 26.
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19. Polymorphisms in NFKB1 and NFKBIA Genes Modulate the Risk of Developing Prostate Cancer among Han Chinese. Han X, etal., Med Sci Monit. 2015 Jun 12;21:1707-15. doi: 10.12659/MSM.893471.
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21. IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C. He Y, etal., Carcinogenesis. 2009 Nov;30(11):1916-22. doi: 10.1093/carcin/bgp226. Epub 2009 Oct 1.
22. A Constitutive Intrinsic Inflammatory Signaling Circuit Composed of miR-196b, Meis2, PPP3CC, and p65 Drives Prostate Cancer Castration Resistance. Jeong JH, etal., Mol Cell. 2017 Jan 5;65(1):154-167. doi: 10.1016/j.molcel.2016.11.034. Epub 2016 Dec 29.
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25. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
26. NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis. Kühnel F, etal., J Biol Chem. 2000 Mar 3;275(9):6421-7. doi: 10.1074/jbc.275.9.6421.
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33. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
34. MGDs mouse GO annotations MGD data from the GO Consortium
35. MGD IEA MGD IEA
36. Combination gene therapy for glioblastoma involving herpes simplex virus vector-mediated codelivery of mutant IkappaBalpha and HSV thymidine kinase. Moriuchi S, etal., Cancer Gene Ther. 2005 May;12(5):487-96. doi: 10.1038/sj.cgt.7700816.
37. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
38. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
39. Identification of polymorphisms of the IkappaBalpha gene associated with an increased risk of multiple myeloma. Parker KM, etal., Cancer Genet Cytogenet. 2002 Aug;137(1):43-8.
40. Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter. Peng B, etal., Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15193-8. doi: 10.1073/pnas.1005533107. Epub 2010 Aug 9.
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43. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
44. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
45. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
46. Mouse MP Annotation Import Pipeline RGD automated import pipeline
47. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
48. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
49. Anti-inflammatory effects of celecoxib in rat lungs with smoke-induced emphysema. Roh GS, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Aug;299(2):L184-91. Epub 2010 May 14.
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51. Genetic susceptibility to invasive pneumococcal disease. Sangil A, etal., Infect Genet Evol. 2018 Apr;59:126-131. doi: 10.1016/j.meegid.2018.01.024. Epub 2018 Jan 31.
52. Chromium picolinate and chromium histidinate protects against renal dysfunction by modulation of NF-kappaB pathway in high-fat diet fed and Streptozotocin-induced diabetic rats. Selcuk MY, etal., Nutr Metab (Lond). 2012 Apr 8;9:30. doi: 10.1186/1743-7075-9-30.
53. Whole grape intake impacts cardiac peroxisome proliferator-activated receptor and nuclear factor kappaB activity and cytokine expression in rats with diastolic dysfunction. Seymour EM, etal., Hypertension. 2010 May;55(5):1179-85. doi: 10.1161/HYPERTENSIONAHA.109.149393. Epub 2010 Mar 15.
54. Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents. Sheehan M, etal., Mol Pharmacol. 2002 May;61(5):953-63. doi: 10.1124/mol.61.5.953.
55. Antioxidant enzymatically modified isoquercitrin suppresses the development of liver preneoplastic lesions in rats induced by beta-naphthoflavone. Shimada Y, etal., Toxicology. 2010 Feb 9;268(3):213-8. doi: 10.1016/j.tox.2009.12.019. Epub 2010 Jan 5.
56. Constitutive activation of P I3 K-Akt and NF-kappaB during prostate cancer progression in autochthonous transgenic mouse model. Shukla S, etal., Prostate. 2005 Aug 1;64(3):224-39.
57. A novel NFKBIA variant substituting serine 36 of IκBα causes immunodeficiency with warts, bronchiectasis and juvenile rheumatoid arthritis in the absence of ectodermal dysplasia. Sogkas G, etal., Clin Immunol. 2020 Jan;210:108269. doi: 10.1016/j.clim.2019.108269. Epub 2019 Nov 1.
58. Haplotypic structure across the I kappa B alpha gene (NFKBIA) and association with multiple myeloma. Spink CF, etal., Cancer Lett. 2007 Feb 8;246(1-2):92-9. Epub 2006 Mar 15.
59. Epithelial NF-kappaB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activation. Tang Y, etal., Am J Pathol. 2010 Jan;176(1):158-67. doi: 10.2353/ajpath.2010.090548. Epub 2009 Dec 11.
60. [Regulatory effect of IkappaBalpha on NF-kappaB activity during viral gene transactivation in patients with steroid responsive simple nephrotic syndrome]. Tao YH, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Mar;38(2):230-3.
61. Inhibition of NF-kappa B activity in T and NK cells results in defective effector cell expansion and production of IFN-gamma required for resistance to Toxoplasma gondii. Tato CM, etal., J Immunol. 2003 Mar 15;170(6):3139-46. doi: 10.4049/jimmunol.170.6.3139.
62. Activation of TLR4-mediated NFkappaB signaling in hemorrhagic brain in rats. Teng W, etal., Mediators Inflamm. 2009;2009:473276. doi: 10.1155/2009/473276. Epub 2010 Jan 31.
63. Mutational analysis of the IkappaBalpha gene in activated B cell-like diffuse large B-cell lymphoma. Thomas RK, etal., Br J Haematol. 2004 Jul;126(1):50-4.
64. Regulation of nuclear factor-kappa B and its inhibitor I kappa B-alpha/MAD-3 in monocytes by Mycobacterium tuberculosis and during human tuberculosis. Toossi Z, etal., J Immunol. 1997 Oct 15;159(8):4109-16.
65. Mechanical ventilation modulates TLR4 and IRAK-3 in a non-infectious, ventilator-induced lung injury model. Villar J, etal., Respir Res. 2010 Mar 3;11:27. doi: 10.1186/1465-9921-11-27.
66. Proanthocyanidins from grape seeds modulates the nuclear factor-kappa B signal transduction pathways in rats with TNBS-induced recurrent ulcerative colitis. Wang YH, etal., Int Immunopharmacol. 2011 Oct;11(10):1620-7. doi: 10.1016/j.intimp.2011.05.024. Epub 2011 Jun 12.
67. Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner. Xu W, etal., Toxicol Appl Pharmacol. 2017 Jan 15;315:23-34. doi: 10.1016/j.taap.2016.12.001. Epub 2016 Dec 6.
68. The effects of PDTC plus leflunomide and cyclosporine on the NF-kappaB signaling pathway in mouse-to-rat cardiac xenografts. Yang G, etal., J Huazhong Univ Sci Technolog Med Sci. 2009 Apr;29(2):202-6. doi: 10.1007/s11596-009-0213-2. Epub 2009 Apr 28.
69. Hyperbaric oxygen reduces inflammatory response in acute pancreatitis by inhibiting NF-kappaB activation. Yu X, etal., Eur Surg Res. 2009;42(2):130-5. doi: 10.1159/000196164. Epub 2009 Jan 28.
70. Gastrodin Ameliorates Acute Rejection via IRE1α/TRAF2/NF-κB in Rats Receiving Liver Allografts. Yuan F, etal., Biomed Res Int. 2019 Nov 20;2019:9276831. doi: 10.1155/2019/9276831. eCollection 2019.
71. A novel peptide ghrelin inhibits neural remodeling after myocardial infarction in rats. Yuan MJ, etal., Eur J Pharmacol. 2009 Sep 15;618(1-3):52-7. doi: 10.1016/j.ejphar.2009.07.015. Epub 2009 Jul 17.
72. Polymorphisms in NF-¿B pathway genes & their association with risk of lung cancer in the Chinese population. Zhang JW, etal., Pak J Med Sci. 2015 Nov-Dec;31(6):1411-6. doi: 10.12669/pjms.316.7935.
73. Effect of functional nuclear factor-kappaB genetic polymorphisms on hepatitis B virus persistence and their interactions with viral mutations on the risk of hepatocellular carcinoma. Zhang Q, etal., Ann Oncol. 2014 Dec;25(12):2413-2419. doi: 10.1093/annonc/mdu451. Epub 2014 Sep 15.
74. ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy. Zhao J, etal., Front Immunol. 2019 Nov 5;10:2531. doi: 10.3389/fimmu.2019.02531. eCollection 2019.
75. Protection of carbon monoxide-releasing molecule against lung injury induced by limb ischemia-reperfusion. Zhou JL, etal., Chin J Traumatol. 2009 Apr;12(2):71-6.
76. Peroxisome proliferator activator receptor-gamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J2 and ciglitazone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathways. Zingarelli B, etal., J Immunol. 2003 Dec 15;171(12):6827-37. doi: 10.4049/jimmunol.171.12.6827.
Additional References at PubMed
PMID:1339305   PMID:1740450   PMID:7552992   PMID:7590249   PMID:7603567   PMID:7867065   PMID:7936653   PMID:7963540   PMID:8628301   PMID:8642348   PMID:8662753   PMID:8858144  
PMID:8864120   PMID:8887559   PMID:8914937   PMID:9186501   PMID:9223278   PMID:9597130   PMID:9743524   PMID:9854797   PMID:10097128   PMID:10195896   PMID:10199915   PMID:10349636  
PMID:10702415   PMID:10748240   PMID:10790373   PMID:10922068   PMID:11009421   PMID:11042159   PMID:11067893   PMID:11076861   PMID:11130978   PMID:11133232   PMID:11179036   PMID:11221845  
PMID:11241200   PMID:11359934   PMID:11880364   PMID:11896578   PMID:11913973   PMID:12083419   PMID:12167702   PMID:12397017   PMID:12424381   PMID:12477932   PMID:12589049   PMID:12843402  
PMID:12872135   PMID:12896983   PMID:12920239   PMID:12938156   PMID:14585967   PMID:14610273   PMID:14665694   PMID:14676146   PMID:14741691   PMID:14763901   PMID:14764534   PMID:14767066  
PMID:14960276   PMID:14966265   PMID:14978074   PMID:14991073   PMID:15020231   PMID:15071597   PMID:15102471   PMID:15161102   PMID:15251865   PMID:15294950   PMID:15317747   PMID:15479644  
PMID:15489334   PMID:15536134   PMID:15618518   PMID:15671248   PMID:15692051   PMID:15714207   PMID:15811852   PMID:15820254   PMID:15845452   PMID:15858576   PMID:15879100   PMID:15923614  
PMID:15989949   PMID:15998793   PMID:16141072   PMID:16141073   PMID:16163708   PMID:16166517   PMID:16199483   PMID:16231352   PMID:16260626   PMID:16322095   PMID:16371367   PMID:16452166  
PMID:16481354   PMID:16648481   PMID:16737960   PMID:16804897   PMID:16928772   PMID:16931600   PMID:17098744   PMID:17158449   PMID:17202411   PMID:17237376   PMID:17254973   PMID:17307728  
PMID:17310217   PMID:17367755   PMID:17392377   PMID:17486138   PMID:17491656   PMID:17692539   PMID:17878344   PMID:18056349   PMID:18070894   PMID:18194271   PMID:18233957   PMID:18233961  
PMID:18261938   PMID:18287559   PMID:18321726   PMID:18378686   PMID:18395765   PMID:18401342   PMID:18505784   PMID:18544347   PMID:18566250   PMID:18604869   PMID:18676814   PMID:18701501  
PMID:18981184   PMID:19091594   PMID:19299176   PMID:19349372   PMID:19414010   PMID:19487661   PMID:19524538   PMID:19614983   PMID:19672210   PMID:19796012   PMID:19890047   PMID:19931640  
PMID:19933270   PMID:20020511   PMID:20153290   PMID:20211142   PMID:20385620   PMID:20412781   PMID:20442316   PMID:20581820   PMID:20634424   PMID:20661182   PMID:20661281   PMID:20663042  
PMID:20682784   PMID:20740013   PMID:20797629   PMID:20811394   PMID:21098220   PMID:21152039   PMID:21156791   PMID:21176770   PMID:21267068   PMID:21333553   PMID:21411734   PMID:21439970  
PMID:21454528   PMID:21606193   PMID:21617130   PMID:21632113   PMID:21646597   PMID:21658309   PMID:21677750   PMID:21706061   PMID:21737317   PMID:21765415   PMID:21814576   PMID:21862579  
PMID:21873635   PMID:21874024   PMID:22037600   PMID:22134901   PMID:22203995   PMID:22318993   PMID:22402282   PMID:22445657   PMID:22633953   PMID:22974489   PMID:22988430   PMID:23041330  
PMID:23086447   PMID:23172686   PMID:23239958   PMID:23262141   PMID:23431057   PMID:23435124   PMID:23776228   PMID:23850221   PMID:23951545   PMID:24176090   PMID:24271119   PMID:24349514  
PMID:24614212   PMID:24748603   PMID:24824215   PMID:24952961   PMID:24973451   PMID:25063677   PMID:25209981   PMID:25533482   PMID:25601653   PMID:25815426   PMID:25862560   PMID:25881508  
PMID:25937534   PMID:26110849   PMID:26758846   PMID:26816005   PMID:27184845   PMID:27381259   PMID:27497284   PMID:27830706   PMID:27923915   PMID:28063927   PMID:28358362   PMID:29091322  
PMID:29180744   PMID:29438518   PMID:29596938   PMID:30101837   PMID:30397032   PMID:31146259   PMID:31323030   PMID:31447347   PMID:31736383   PMID:32037545   PMID:32044112   PMID:32155320  
PMID:32222043   PMID:32270911   PMID:32750042   PMID:32968282   PMID:33459422   PMID:33979588   PMID:34133916   PMID:34140389   PMID:34751748   PMID:36166646   PMID:36634736   PMID:36640323  
PMID:36651806   PMID:36914768   PMID:36915206   PMID:37828624  


Genomics

Comparative Map Data
Nfkbia
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391255,536,194 - 55,539,432 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1255,536,195 - 55,539,432 (-)EnsemblGRCm39 Ensembl
GRCm381255,489,409 - 55,492,647 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1255,489,410 - 55,492,647 (-)EnsemblGRCm38mm10GRCm38
MGSCv371256,590,396 - 56,593,634 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361256,407,974 - 56,410,713 (-)NCBIMGSCv36mm8
Celera1256,639,004 - 56,642,123 (-)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1224.0NCBI
NFKBIA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381435,401,513 - 35,404,749 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1435,401,079 - 35,404,749 (-)EnsemblGRCh38hg38GRCh38
GRCh371435,870,719 - 35,873,955 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361434,940,468 - 34,943,695 (-)NCBINCBI36Build 36hg18NCBI36
Build 341434,940,467 - 34,943,695NCBI
Celera1415,734,587 - 15,737,850 (-)NCBICelera
Cytogenetic Map14q13.2NCBI
HuRef1415,984,422 - 15,987,685 (-)NCBIHuRef
CHM1_11435,870,469 - 35,873,713 (-)NCBICHM1_1
T2T-CHM13v2.01429,589,207 - 29,592,460 (-)NCBIT2T-CHM13v2.0
Nfkbia
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8678,593,844 - 78,597,307 (-)NCBIGRCr8
mRatBN7.2672,858,713 - 72,861,941 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl672,858,712 - 72,861,941 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx673,278,856 - 73,282,085 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0673,585,214 - 73,588,443 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0673,013,851 - 73,017,079 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0676,267,227 - 76,270,457 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl676,267,228 - 76,270,457 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0685,803,990 - 85,807,223 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4675,729,302 - 75,732,475 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1675,732,430 - 75,735,531 (-)NCBI
Celera671,699,196 - 71,702,411 (-)NCBICelera
Cytogenetic Map6q23NCBI
Nfkbia
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540925,691,534 - 25,697,520 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540925,691,673 - 25,695,151 (+)NCBIChiLan1.0ChiLan1.0
NFKBIA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21536,715,927 - 36,722,262 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11435,932,430 - 35,936,014 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01416,155,331 - 16,158,588 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11434,337,307 - 34,340,225 (-)NCBIpanpan1.1PanPan1.1panPan2
NFKBIA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1814,100,203 - 14,103,453 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl814,100,671 - 14,103,433 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha813,896,355 - 13,899,624 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0814,206,293 - 14,209,091 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl814,206,278 - 14,209,055 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1813,907,872 - 13,911,144 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0813,972,973 - 13,976,235 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0814,262,614 - 14,265,883 (-)NCBIUU_Cfam_GSD_1.0
Nfkbia
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864046,031,901 - 46,035,295 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364949,537,008 - 9,541,612 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364949,537,793 - 9,541,187 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFKBIA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl764,507,822 - 64,511,277 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1764,508,119 - 64,510,754 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2769,417,685 - 69,420,320 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7q15-q21NCBI
NFKBIA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12412,211,619 - 12,216,185 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2412,210,281 - 12,214,854 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660531,174,276 - 1,178,183 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfkbia
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248381,384,204 - 1,390,205 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248381,384,337 - 1,387,602 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nfkbia
87 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:179
Count of miRNA genes:138
Interacting mature miRNAs:154
Transcripts:ENSMUST00000021413
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12541844077031203Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
1302172Skts5_mskin tumor susceptibility 5 (mouse)Not determined122214886656149016Mouse
1301989Hdlq18_mHDL QTL 18 (mouse)Not determined122916068563160884Mouse
1300636Gct2_mgranulosa cell tumorigenesis 2 (mouse)Not determined122916068563160884Mouse
4141843Moen3_mmodifier of engrailed QTL 3 (mouse)Not determined122980158463801733Mouse
14747008Mancz10_mmandible centroid size 10 (mouse)122986352263863522Mouse
10402492Dipa8_mdrug induced psychomotor activation 8 (mouse)Not determined123493387268934019Mouse
1300818Bbaa10_mB.burgdorferi-associated arthritis 10 (mouse)Not determined123509100465511019Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124169317590887526Mouse
1357757Lnopy2_mlens opacity 2 (mouse)Not determined125284662686846796Mouse
1357749Vtbt13_mvertebral trabecular bone trait 13 (mouse)Not determined125313200287132145Mouse
12904004Opfaq11_mopen field activity QTL 11 (mouse)125315562457276756Mouse
12832727Ahrq1_mairway hyperresponsiveness QTL 1 (mouse)125469591082665939Mouse
12903999Opfaq8_mopen field activity QTL 8 (mouse)125490765357870585Mouse

Markers in Region
AI462015  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381255,489,494 - 55,489,793UniSTSGRCm38
MGSCv371256,590,481 - 56,590,780UniSTSGRCm37
Celera1256,639,089 - 56,639,388UniSTS
Cytogenetic Map12C1-C3UniSTS
Whitehead/MRC_RH12569.73UniSTS
PMC116348P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381255,490,652 - 55,491,167UniSTSGRCm38
MGSCv371256,591,639 - 56,592,154UniSTSGRCm37
Celera1256,640,247 - 56,640,762UniSTS
Cytogenetic Map12C1-C3UniSTS
PMC152658P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381255,490,428 - 55,491,276UniSTSGRCm38
MGSCv371256,591,415 - 56,592,263UniSTSGRCm37
Celera1256,640,023 - 56,640,871UniSTS
Cytogenetic Map12C1-C3UniSTS
NFKBIA  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381255,490,418 - 55,490,589UniSTSGRCm38
MGSCv371256,591,405 - 56,591,576UniSTSGRCm37
Celera1256,640,013 - 56,640,184UniSTS
Cytogenetic Map12C1-C3UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000021413   ⟹   ENSMUSP00000021413
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1255,536,195 - 55,539,432 (-)Ensembl
GRCm38.p6 Ensembl1255,489,410 - 55,492,647 (-)Ensembl
RefSeq Acc Id: ENSMUST00000219869
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1255,537,192 - 55,538,595 (-)Ensembl
GRCm38.p6 Ensembl1255,490,407 - 55,491,810 (-)Ensembl
RefSeq Acc Id: NM_010907   ⟹   NP_035037
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391255,536,194 - 55,539,432 (-)NCBI
GRCm381255,489,409 - 55,492,647 (-)ENTREZGENE
MGSCv371256,590,396 - 56,593,634 (-)RGD
Celera1256,639,004 - 56,642,123 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035037   ⟸   NM_010907
- UniProtKB: Q3UB40 (UniProtKB/Swiss-Prot),   Q3U9W9 (UniProtKB/Swiss-Prot),   Q80ZX5 (UniProtKB/Swiss-Prot),   Q9Z1E3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000021413   ⟸   ENSMUST00000021413

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1E3-F1-model_v2 AlphaFold Q9Z1E3 1-314 view protein structure

Promoters
RGD ID:8678298
Promoter ID:EPDNEW_M17180
Type:initiation region
Name:Nfkbia_1
Description:Mus musculus nuclear factor of kappa light polypeptide gene enhancerin B cells inhibitor, alpha , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381255,492,595 - 55,492,655EPDNEW
RGD ID:6848614
Promoter ID:MM_TRO:2046
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:MTR007722.12.764.3
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361256,591,086 - 56,592,442 (-)MPROMDB
RGD ID:6823224
Promoter ID:MM_KWN:11682
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_010907
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361256,593,421 - 56,594,492 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104741 AgrOrtholog
Ensembl Genes ENSMUSG00000021025 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000021413 ENTREZGENE
  ENSMUST00000021413.9 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
KEGG Report mmu:18035 UniProtKB/Swiss-Prot
MGD MGI:104741 ENTREZGENE
NCBI Gene 18035 ENTREZGENE
PANTHER NF-KAPPA-B INHIBITOR ALPHA UniProtKB/Swiss-Prot
  NF-KAPPA-B INHIBITOR ALPHA UniProtKB/Swiss-Prot
Pfam Ank_2 UniProtKB/Swiss-Prot
  Ank_5 UniProtKB/Swiss-Prot
PhenoGen Nfkbia PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
SMART ANK UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot
UniProt IKBA_MOUSE UniProtKB/Swiss-Prot
  Q3U9W9 ENTREZGENE
  Q3UB40 ENTREZGENE
  Q80ZX5 ENTREZGENE
  Q9Z1E3 ENTREZGENE
UniProt Secondary Q3U9W9 UniProtKB/Swiss-Prot
  Q3UB40 UniProtKB/Swiss-Prot
  Q80ZX5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-02-07 Nfkbia  nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha  Nfkbia  nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha  Symbol and/or name change 5135510 APPROVED