Nfkbia (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha) - Rat Genome Database
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Gene: Nfkbia (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha) Mus musculus
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Symbol: Nfkbia
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
RGD ID: 10975
MGI Page MGI
Description: Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system; jaw; and naris. Used to study Sjogren's syndrome and atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including hematologic cancer (multiple); hepatitis C; hepatocellular carcinoma; hypohidrotic ectodermal dysplasia; and prostate cancer. Orthologous to human NFKBIA (NFKB inhibitor alpha); PARTICIPATES IN adenosine signaling pathway; ceramide signaling pathway; interleukin-23 signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-catechin; (+)-pilocarpine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI462015; I(Kappa)B(alpha); I-kappa-B-alpha; I-kappaBalpha; ikappaBalpha; ikB-alpha; NF-kappa-B inhibitor alpha; Nfk; Nfkbi; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha; nuclear factor of kappa light polyp gene enhancer in B-cell 1; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391255,536,194 - 55,539,432 (-)NCBIGRCm39mm39
GRCm39 Ensembl1255,536,195 - 55,539,432 (-)Ensembl
GRCm381255,489,409 - 55,492,647 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1255,489,410 - 55,492,647 (-)EnsemblGRCm38mm10GRCm38
MGSCv371256,590,396 - 56,593,634 (-)NCBIGRCm37mm9NCBIm37
MGSCv361256,407,974 - 56,410,713 (-)NCBImm8
Celera1256,639,004 - 56,642,123 (-)NCBICelera
Cytogenetic Map12C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (EXP,ISO)
(+)-artemisinin  (ISO)
(+)-catechin  (EXP,ISO)
(+)-pilocarpine  (EXP,ISO)
(+)-Tetrandrine  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (EXP)
(5Z,8Z,11Z,13E)-15-HETE  (EXP,ISO)
(R)-mevalonic acid  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
1'-acetoxychavicol acetate  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (EXP)
1,4-dithiothreitol  (EXP,ISO)
1,4-phenylenediamine  (ISO)
1,7-dimethylxanthine  (EXP)
1,8-cineole  (ISO)
1-bromopropane  (EXP,ISO)
1-hydroxy-2-naphthoic acid  (EXP)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
15-oxo-ETE  (ISO)
17-hydroxyjolkinolide B  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP,ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-acetamidofluorene  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-acetyloxy-4-(trifluoromethyl)benzoic acid  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-aminopurine  (EXP)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-butoxyethanol  (EXP)
2-hydroxyethyl methacrylate  (ISO)
2-tert-butylhydroquinone  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,3',5'-triiodo-L-thyronine  (ISO)
3,3',5'-triiodothyronine  (ISO)
3-(1H-indol-3-yl)propanoic acid  (ISO)
3-aminobenzamide  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-mercaptopropanoic acid  (EXP)
3-methylcatechol  (EXP)
3-methylcholanthrene  (EXP)
3-phenylprop-2-enal  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP,ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (EXP)
4-phenylbutyric acid  (EXP,ISO)
5,6,7-trimethoxyflavone  (EXP)
5-(1,4-diazepane-1-sulfonyl)isoquinoline  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7-ketocholesterol  (ISO)
[6]-Shogaol  (EXP,ISO)
acetaldehyde  (ISO)
acetic acid  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
adenosine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
AH23848  (ISO)
alachlor  (EXP)
albuterol  (ISO)
alcohol  (EXP)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldehydo-D-ribose  (EXP)
Alkannin  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alvocidib  (ISO)
amifostine  (EXP,ISO)
amiloride  (ISO)
amiodarone  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amorolfine  (ISO)
amphetamine  (ISO)
amphibole asbestos  (ISO)
Anacardic acid  (ISO)
anethole  (ISO)
aniline  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimony(0)  (ISO)
ANTIMYCIN  (ISO)
antimycin A  (EXP)
antirheumatic drug  (ISO)
antroquinonol  (ISO)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
aprepitant  (ISO)
aripiprazole  (ISO)
aristolochic acid  (EXP)
arjunolic acid  (EXP,ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asarone  (EXP)
astilbin  (ISO)
astragaloside IV  (ISO)
ATP  (ISO)
atrazine  (ISO)
auranofin  (EXP)
aureusidin  (EXP)
azadirachtin A  (ISO)
B 581  (ISO)
baicalein  (EXP)
baicalin  (ISO)
bathocuproine disulfonic acid  (ISO)
belinostat  (ISO)
benazepril  (ISO)
benzamide  (EXP)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Berbamine  (ISO)
berberine  (EXP)
Bergenin  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-endorphin  (ISO)
beta-naphthoflavone  (ISO)
betulinic acid  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisdemethoxycurcumin  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
brazilein  (ISO)
butenafine  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
caffeine  (EXP)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (ISO)
capsiate  (ISO)
carbon atom  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (EXP)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (ISO)
carmustine  (ISO)
carnosic acid  (EXP,ISO)
carnosine  (ISO)
Carnosol  (ISO)
carrageenan  (ISO)
casticin  (ISO)
catechol  (EXP)
cefaloridine  (ISO)
celecoxib  (ISO)
ceruletide  (ISO)
chalcone  (EXP)
Chikusetsusaponin-IV  (ISO)
chlorobenzene  (ISO)
chlorogenic acid  (EXP,ISO)
chloropicrin  (ISO)
chloroquine  (EXP,ISO)
chlorpyrifos  (ISO)
cholic acid  (EXP)
choline  (ISO)
chondroitin sulfate  (ISO)
chromium(6+)  (EXP,ISO)
chrysene  (EXP)
chrysin  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (EXP)
cilostazol  (ISO)
cisplatin  (EXP,ISO)
citronellol  (EXP,ISO)
clenbuterol  (ISO)
clofibrate  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
Cryptotanshinone  (ISO)
cudraflavone B  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cytochalasin D  (ISO)
D-glucose  (EXP,ISO)
D-ribofuranose  (EXP)
daidzein  (EXP)
DDE  (ISO)
Decursin  (EXP)
Deguelin  (EXP,ISO)
Dehydrodiisoeugenol  (EXP)
demethoxycurcumin  (EXP)
deoxycholic acid  (ISO)
deoxynivalenol  (EXP,ISO)
Deoxyschizandrin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diethyl maleate  (EXP)
digitoxin  (ISO)
dihydroartemisinin  (ISO)
diiodine  (ISO)
dimemorfan  (EXP)
dimethyl sulfoxide  (ISO)
diminazene diaceturate  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
diosmetin  (EXP)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dipyridamole  (EXP)
disulfiram  (EXP,ISO)
dobutamine  (ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
edaravone  (ISO)
elemental carbon  (ISO)
elemental selenium  (EXP,ISO)
emodin  (EXP,ISO)
enalapril  (EXP)
endosulfan  (EXP,ISO)
enzyme inhibitor  (ISO)
eriodictyol  (EXP,ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ethylbenzene  (ISO)
etoposide  (ISO)
eugenol  (EXP,ISO)
eupatilin  (EXP)
Evodiamine  (ISO)
fasudil hydrochloride  (EXP,ISO)
fenofibrate  (ISO)
fentanyl  (ISO)
ferroheme b  (ISO)
fisetin  (ISO)
Flavokawain A  (EXP)
flavone  (ISO)
fluoxetine  (EXP,ISO)
fluticasone  (ISO)</