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Gene: Apaf1 (apoptotic peptidase activating factor 1) Rattus norvegicus
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Symbol: Apaf1
Name: apoptotic peptidase activating factor 1
Description: Exhibits heat shock protein binding activity and identical protein binding activity. Involved in several processes, including aging; cardiac muscle cell apoptotic process; and protein homooligomerization. Localizes to the apoptosome. Used to study visual epilepsy. Biomarker of brain ischemia; colon cancer; middle cerebral artery infarction; and muscular atrophy. Orthologous to human APAF1 (apoptotic peptidase activating factor 1); PARTICIPATES IN intrinsic apoptotic pathway; Alzheimer's disease pathway; amyotrophic lateral sclerosis pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: apaf-1; apoptotic protease activating factor 1; apoptotic protease-activating factor 1
Orthologs:
Homo sapiens (human) : APAF1 (apoptotic peptidase activating factor 1)  HGNC  Alliance
Mus musculus (house mouse) : Apaf1 (apoptotic peptidase activating factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apaf1 (apoptotic peptidase activating factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : APAF1 (apoptotic peptidase activating factor 1)
Canis lupus familiaris (dog) : APAF1 (apoptotic peptidase activating factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apaf1 (apoptotic peptidase activating factor 1)
Sus scrofa (pig) : APAF1 (apoptotic peptidase activating factor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0731,699,309 - 31,784,192 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0731,791,073 - 31,872,984 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4727,932,908 - 28,020,533 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1727,953,178 - 28,040,804 (-)NCBI
Celera722,620,761 - 22,706,298 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Apaf1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620575
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.