APAF1 (apoptotic peptidase activating factor 1) - Rat Genome Database

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Gene: APAF1 (apoptotic peptidase activating factor 1) Pan paniscus
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Symbol: APAF1
Name: apoptotic peptidase activating factor 1
RGD ID: 11977648
Description: ENCODES a protein that exhibits heat shock protein binding (ortholog); identical protein binding (ortholog); INVOLVED IN brain development (ortholog); cardiac muscle cell apoptotic process (ortholog); cell differentiation (ortholog); PARTICIPATES IN intrinsic apoptotic pathway; ASSOCIATED WITH Brain Injuries (ortholog); brain ischemia (ortholog); colon cancer (ortholog); FOUND IN apoptosome (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: apoptotic protease-activating factor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210106,708,019 - 106,797,626 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112106,704,415 - 106,791,255 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01296,224,515 - 96,311,246 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11299,637,622 - 99,726,946 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1299,637,622 - 99,726,939 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apoptosome  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA)
nucleus  (IEA)
protein-containing complex  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
APAF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210106,708,019 - 106,797,626 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112106,704,415 - 106,791,255 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01296,224,515 - 96,311,246 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11299,637,622 - 99,726,946 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1299,637,622 - 99,726,939 (+)Ensemblpanpan1.1panPan2
APAF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381298,645,290 - 98,735,433 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1298,645,149 - 98,735,433 (+)EnsemblGRCh38hg38GRCh38
GRCh371299,039,068 - 99,129,211 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361297,563,209 - 97,653,342 (+)NCBINCBI36Build 36hg18NCBI36
Build 341297,541,545 - 97,631,678NCBI
Celera1298,703,974 - 98,794,106 (+)NCBICelera
Cytogenetic Map12q23.1NCBI
HuRef1296,100,029 - 96,190,306 (+)NCBIHuRef
CHM1_11299,004,024 - 99,094,151 (+)NCBICHM1_1
T2T-CHM13v2.01298,618,230 - 98,708,377 (+)NCBIT2T-CHM13v2.0
Apaf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391090,825,173 - 90,918,688 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1090,825,173 - 90,918,632 (-)EnsemblGRCm39 Ensembl
GRCm381090,989,311 - 91,082,743 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1090,989,311 - 91,082,770 (-)EnsemblGRCm38mm10GRCm38
MGSCv371090,452,056 - 90,545,488 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361090,420,401 - 90,512,501 (-)NCBIMGSCv36mm8
Celera1092,983,615 - 93,080,742 (-)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1045.47NCBI
Apaf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8727,381,392 - 27,466,772 (-)NCBIGRCr8
mRatBN7.2725,494,143 - 25,579,540 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl725,494,609 - 25,579,540 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx727,489,053 - 27,573,980 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0729,651,444 - 29,736,367 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0729,428,845 - 29,513,775 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0731,699,309 - 31,784,192 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl731,699,885 - 31,784,192 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0731,791,073 - 31,872,984 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4727,932,908 - 28,020,533 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1727,953,178 - 28,040,804 (-)NCBI
Celera722,620,761 - 22,706,298 (-)NCBICelera
Cytogenetic Map7q13NCBI
Apaf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540534,623,267 - 34,693,677 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540534,619,780 - 34,693,616 (+)NCBIChiLan1.0ChiLan1.0
APAF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11538,026,893 - 38,160,842 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1538,028,132 - 38,114,987 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1538,408,276 - 38,554,051 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01538,689,945 - 38,835,971 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1538,689,948 - 38,780,498 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11537,961,882 - 38,107,501 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01538,054,503 - 38,200,556 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01538,328,187 - 38,474,238 (+)NCBIUU_Cfam_GSD_1.0
Apaf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494521,806,281 - 21,891,969 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649214,816,623 - 14,902,132 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649214,818,561 - 14,902,231 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APAF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl585,166,628 - 85,258,364 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1585,166,616 - 85,258,751 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2589,443,106 - 89,580,992 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APAF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11193,942,137 - 94,024,728 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1193,942,103 - 94,024,457 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037151,034,383 - 151,120,759 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apaf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247508,837,037 - 8,938,009 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247508,835,521 - 8,940,957 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000040024   ⟹   ENSPPAP00000017322
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1299,637,622 - 99,726,939 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000040030   ⟹   ENSPPAP00000017328
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1299,637,622 - 99,726,939 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000040042   ⟹   ENSPPAP00000017340
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1299,640,839 - 99,724,067 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000040049   ⟹   ENSPPAP00000017347
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1299,640,839 - 99,723,982 (+)Ensembl
RefSeq Acc Id: XM_003832607   ⟹   XP_003832655
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v210106,708,019 - 106,797,626 (+)NCBI
NHGRI_mPanPan112106,704,415 - 106,791,255 (+)NCBI
Mhudiblu_PPA_v01296,224,515 - 96,311,246 (+)NCBI
PanPan1.11299,637,622 - 99,726,946 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063593583   ⟹   XP_063449653
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v210106,708,020 - 106,727,840 (+)NCBI
RefSeq Acc Id: XR_008620471
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v210106,708,019 - 106,787,749 (+)NCBI
NHGRI_mPanPan112106,704,415 - 106,784,138 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003832655 (Get FASTA)   NCBI Sequence Viewer  
  XP_063449653 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000017322
  ENSPPAP00000017322.1
  ENSPPAP00000017328.1
  ENSPPAP00000017340.1
  ENSPPAP00000017347.1
RefSeq Acc Id: XP_003832655   ⟸   XM_003832607
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AIY1 (UniProtKB/TrEMBL),   A0A2R9AJS4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000017347   ⟸   ENSPPAT00000040049
Ensembl Acc Id: ENSPPAP00000017340   ⟸   ENSPPAT00000040042
Ensembl Acc Id: ENSPPAP00000017322   ⟸   ENSPPAT00000040024
Ensembl Acc Id: ENSPPAP00000017328   ⟸   ENSPPAT00000040030
RefSeq Acc Id: XP_063449653   ⟸   XM_063593583
- Peptide Label: isoform X2
Protein Domains
CARD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000031677 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000040024.1 UniProtKB/TrEMBL
  ENSPPAT00000040030.1 UniProtKB/TrEMBL
  ENSPPAT00000040042.1 UniProtKB/TrEMBL
  ENSPPAT00000040049.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.10.533.10 UniProtKB/TrEMBL
  1.10.8.430 UniProtKB/TrEMBL
  1.25.40.370 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro Apaf-1 UniProtKB/TrEMBL
  APAF1_C UniProtKB/TrEMBL
  APAF1_CARD_dom UniProtKB/TrEMBL
  APAF1_WHD UniProtKB/TrEMBL
  Apaf_helical UniProtKB/TrEMBL
  CARD UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  G-protein_beta_WD-40_rep UniProtKB/TrEMBL
  NB-ARC UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Quinoprotein_ADH-like_supfam UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report pps:100995524 UniProtKB/TrEMBL
NCBI Gene APAF1 ENTREZGENE
PANTHER APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 UniProtKB/TrEMBL
  APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 UniProtKB/TrEMBL
Pfam APAF-1-like_WHD UniProtKB/TrEMBL
  APAF1_C UniProtKB/TrEMBL
  CARD UniProtKB/TrEMBL
  NB-ARC UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PIRSF Apop_pept_activating-1 UniProtKB/TrEMBL
PRINTS DISEASERSIST UniProtKB/TrEMBL
  GPROTEINBRPT UniProtKB/TrEMBL
PROSITE CARD UniProtKB/TrEMBL
  WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF50978 UniProtKB/TrEMBL
  SSF50998 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A2R9AIY1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AJ02_PANPA UniProtKB/TrEMBL
  A0A2R9AJS4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9ANR2_PANPA UniProtKB/TrEMBL