APAF1 (apoptotic peptidase activating factor 1) - Rat Genome Database

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Gene: APAF1 (apoptotic peptidase activating factor 1) Pan paniscus
Analyze
Symbol: APAF1
Name: apoptotic peptidase activating factor 1
RGD ID: 11977648
Description: ENCODES a protein that exhibits heat shock protein binding (ortholog); identical protein binding (ortholog); INVOLVED IN brain development (ortholog); cardiac muscle cell apoptotic process (ortholog); cell differentiation (ortholog); PARTICIPATES IN intrinsic apoptotic pathway; ASSOCIATED WITH Brain Injuries (ortholog); brain ischemia (ortholog); colon cancer (ortholog); FOUND IN apoptosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: apoptotic protease-activating factor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210106,708,019 - 106,797,626 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112106,704,415 - 106,791,255 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01296,224,515 - 96,311,246 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11299,637,622 - 99,726,946 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1299,637,622 - 99,726,939 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
APAF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210106,708,019 - 106,797,626 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112106,704,415 - 106,791,255 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01296,224,515 - 96,311,246 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11299,637,622 - 99,726,946 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1299,637,622 - 99,726,939 (+)Ensemblpanpan1.1panPan2
APAF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381298,645,290 - 98,735,433 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1298,645,290 - 98,735,433 (+)EnsemblGRCh38hg38GRCh38
GRCh371299,039,068 - 99,129,211 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361297,563,209 - 97,653,342 (+)NCBINCBI36Build 36hg18NCBI36
Build 341297,541,545 - 97,631,678NCBI
Celera1298,703,974 - 98,794,106 (+)NCBICelera
Cytogenetic Map12q23.1NCBI
HuRef1296,100,029 - 96,190,306 (+)NCBIHuRef
CHM1_11299,004,024 - 99,094,151 (+)NCBICHM1_1
T2T-CHM13v2.01298,618,230 - 98,708,377 (+)NCBIT2T-CHM13v2.0
Apaf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391090,825,173 - 90,918,688 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1090,825,173 - 90,918,632 (-)EnsemblGRCm39 Ensembl
GRCm381090,989,311 - 91,082,743 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1090,989,311 - 91,082,770 (-)EnsemblGRCm38mm10GRCm38
MGSCv371090,452,056 - 90,545,488 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361090,420,401 - 90,512,501 (-)NCBIMGSCv36mm8
Celera1092,983,615 - 93,080,742 (-)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1045.47NCBI
Apaf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8727,381,392 - 27,466,772 (-)NCBIGRCr8
mRatBN7.2725,494,143 - 25,579,540 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl725,494,609 - 25,579,540 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx727,489,053 - 27,573,980 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0729,651,444 - 29,736,367 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0729,428,845 - 29,513,775 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0731,699,309 - 31,784,192 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl731,699,885 - 31,784,192 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0731,791,073 - 31,872,984 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4727,932,908 - 28,020,533 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1727,953,178 - 28,040,804 (-)NCBI
Celera722,620,761 - 22,706,298 (-)NCBICelera
Cytogenetic Map7q13NCBI
Apaf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540534,623,267 - 34,693,677 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540534,619,780 - 34,693,616 (+)NCBIChiLan1.0ChiLan1.0
APAF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11538,026,893 - 38,160,842 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1538,028,132 - 38,114,987 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1538,408,276 - 38,554,051 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01538,689,945 - 38,835,971 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1538,689,948 - 38,780,498 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11537,961,882 - 38,107,501 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01538,054,503 - 38,200,556 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01538,328,187 - 38,474,238 (+)NCBIUU_Cfam_GSD_1.0
Apaf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494521,806,281 - 21,891,969 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649214,816,623 - 14,902,132 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649214,818,561 - 14,902,231 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APAF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl585,166,628 - 85,258,364 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1585,166,616 - 85,258,751 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2589,443,106 - 89,580,992 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APAF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11193,942,137 - 94,024,728 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1193,942,103 - 94,024,457 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037151,034,383 - 151,120,759 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apaf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247508,837,037 - 8,938,009 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247508,835,521 - 8,940,957 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000040024   ⟹   ENSPPAP00000017322
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1299,637,622 - 99,726,939 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000040030   ⟹   ENSPPAP00000017328
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1299,637,622 - 99,726,939 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000040042   ⟹   ENSPPAP00000017340
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1299,640,839 - 99,724,067 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000040049   ⟹   ENSPPAP00000017347
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1299,640,839 - 99,723,982 (+)Ensembl
RefSeq Acc Id: XM_003832607   ⟹   XP_003832655
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v210106,708,019 - 106,797,626 (+)NCBI
NHGRI_mPanPan112106,704,415 - 106,791,255 (+)NCBI
Mhudiblu_PPA_v01296,224,515 - 96,311,246 (+)NCBI
PanPan1.11299,637,622 - 99,726,946 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063593583   ⟹   XP_063449653
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v210106,708,020 - 106,727,840 (+)NCBI
RefSeq Acc Id: XR_008620471
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v210106,708,019 - 106,787,749 (+)NCBI
NHGRI_mPanPan112106,704,415 - 106,784,138 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003832655 (Get FASTA)   NCBI Sequence Viewer  
  XP_063449653 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000017322
  ENSPPAP00000017322.1
  ENSPPAP00000017328.1
  ENSPPAP00000017340.1
  ENSPPAP00000017347.1
Reference Protein Sequences
RefSeq Acc Id: XP_003832655   ⟸   XM_003832607
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AIY1 (UniProtKB/TrEMBL),   A0A2R9AJS4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000017347   ⟸   ENSPPAT00000040049
RefSeq Acc Id: ENSPPAP00000017340   ⟸   ENSPPAT00000040042
RefSeq Acc Id: ENSPPAP00000017322   ⟸   ENSPPAT00000040024
RefSeq Acc Id: ENSPPAP00000017328   ⟸   ENSPPAT00000040030
RefSeq Acc Id: XP_063449653   ⟸   XM_063593583
- Peptide Label: isoform X2
Protein Domains
CARD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000031677 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000040024.1 UniProtKB/TrEMBL
  ENSPPAT00000040030.1 UniProtKB/TrEMBL
  ENSPPAT00000040042.1 UniProtKB/TrEMBL
  ENSPPAT00000040049.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.10.533.10 UniProtKB/TrEMBL
  1.10.8.430 UniProtKB/TrEMBL
  1.25.40.370 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro Apaf-1 UniProtKB/TrEMBL
  APAF1_C UniProtKB/TrEMBL
  APAF1_CARD_dom UniProtKB/TrEMBL
  APAF1_WHD UniProtKB/TrEMBL
  Apaf_helical UniProtKB/TrEMBL
  CARD UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  G-protein_beta_WD-40_rep UniProtKB/TrEMBL
  NB-ARC UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Quinoprotein_ADH-like_supfam UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report pps:100995524 UniProtKB/TrEMBL
NCBI Gene APAF1 ENTREZGENE
PANTHER APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 UniProtKB/TrEMBL
  APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 UniProtKB/TrEMBL
Pfam APAF-1-like_WHD UniProtKB/TrEMBL
  APAF1_C UniProtKB/TrEMBL
  CARD UniProtKB/TrEMBL
  NB-ARC UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PIRSF Apop_pept_activating-1 UniProtKB/TrEMBL
PRINTS DISEASERSIST UniProtKB/TrEMBL
  GPROTEINBRPT UniProtKB/TrEMBL
PROSITE CARD UniProtKB/TrEMBL
  WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF50978 UniProtKB/TrEMBL
  SSF50998 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A2R9AIY1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AJ02_PANPA UniProtKB/TrEMBL
  A0A2R9AJS4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9ANR2_PANPA UniProtKB/TrEMBL